Show InChIInChI=1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
Affinity DataKi: 0.0800nMAssay Description:Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390More data for this Ligand-Target Pair
Show SMILESCl.Fc1ccc(cc1)C(N1CCN(CCCNC(=O)c2ccncc2)CC1)c1ccc(F)cc1
Show InChIInChI=1S/C26H28F2N4O.ClH/c27-23-6-2-20(3-7-23)25(21-4-8-24(28)9-5-21)32-18-16-31(17-19-32)15-1-12-30-26(33)22-10-13-29-14-11-22;/h2-11,13-14,25H,1,12,15-19H2,(H,30,33);1H
Affinity DataKi: 0.0983nMAssay Description:Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Show InChIInChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
Affinity DataKi: 0.120nMAssay Description:Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudateputamen tissue from rat brainMore data for this Ligand-Target Pair
Show InChIInChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
Affinity DataKi: 0.210nMAssay Description:The compound was tested for binding affinity against Dopamine receptor D1 from rat striatal membranes, using [3H]-SCH- 23390 as radioligand.More data for this Ligand-Target Pair
Show InChIInChI=1S/C17H17BrClNO/c1-20-6-5-12-8-16(19)17(21)9-14(12)15(10-20)11-3-2-4-13(18)7-11/h2-4,7-9,15,21H,5-6,10H2,1H3
Affinity DataKi: 0.260nMAssay Description:Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudateputamen tissue from rat brainMore data for this Ligand-Target Pair
Show InChIInChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
Affinity DataKi: 0.300nMAssay Description:Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.More data for this Ligand-Target Pair
Show SMILESOCCN1CCN(CC\C=C2/c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1
Show InChIInChI=1S/C23H25F3N2OS/c24-23(25,26)17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)30-22)5-3-9-27-10-12-28(13-11-27)14-15-29/h1-2,4-8,16,29H,3,9-15H2/b18-5+
Show InChIInChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
Affinity DataKi: 0.390nMAssay Description:In vitro binding affinity of the compound towards Dopamine receptor D1 by displacing [125I]-FISCH radioligand in rat striatal homogenateMore data for this Ligand-Target Pair
Show InChIInChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
Affinity DataKi: 0.400nMAssay Description:In vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]-SCH-23,390 from rat striatal ...More data for this Ligand-Target Pair
Show InChIInChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
Affinity DataKi: 0.400nMAssay Description:Binding affinity towards dopamine receptor D1 using [3H]-SCH-23,390 was determined in rat striatal membranesChecked by AuthorMore data for this Ligand-Target Pair
Show SMILESNC[C@@H]1OC(Cc2c(O)c(O)ccc12)c1cccc(O)c1
Show InChIInChI=1S/C16H17NO4/c17-8-15-11-4-5-13(19)16(20)12(11)7-14(21-15)9-2-1-3-10(18)6-9/h1-6,14-15,18-20H,7-8,17H2/t14?,15-/m0/s1
Affinity DataKi: 0.490nMAssay Description:Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1More data for this Ligand-Target Pair
Show SMILESCN1CCc2cc(Cl)c(O)cc2C(C1)c1ccccc1C(=O)C1=CC=C[C@@H]1[Re](C=O)(C=O)C=O
Show InChIInChI=1S/C23H21ClNO2.3CHO.Re/c1-25-11-10-16-12-21(24)22(26)13-19(16)20(14-25)17-8-4-5-9-18(17)23(27)15-6-2-3-7-15;3*1-2;/h2-9,12-13,20,26H,10-11,14H2,1H3;3*1H;
Affinity DataKi: 0.610nMAssay Description:Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudateputamen tissue from rat brainMore data for this Ligand-Target Pair
LigandBDBM81927(CAS_60756-96-9 | Lu 12-331 | Pifluthixol)
Show SMILESOCCC1CCN(CC\C=C2\c3ccc(F)cc3Sc3ccc(cc23)C(F)(F)F)CC1
Show InChIInChI=1S/C24H25F4NOS/c25-18-4-5-20-19(2-1-10-29-11-7-16(8-12-29)9-13-30)21-14-17(24(26,27)28)3-6-22(21)31-23(20)15-18/h2-6,14-16,30H,1,7-13H2/b19-2-
Show SMILESFc1ccc(cc1)C(=O)CCCN1C2CN3CCN(CCCC(=O)c4ccc(F)cc4)CC3CC2c2ccccc12
Show InChIInChI=1S/C34H37F2N3O2/c35-26-13-9-24(10-14-26)33(40)7-3-17-37-19-20-38-23-32-30(21-28(38)22-37)29-5-1-2-6-31(29)39(32)18-4-8-34(41)25-11-15-27(36)16-12-25/h1-2,5-6,9-16,28,30,32H,3-4,7-8,17-23H2
Show InChIInChI=1S/C17H17BrClNO/c1-20-7-6-11-8-16(19)17(21)9-13(11)14(10-20)12-4-2-3-5-15(12)18/h2-5,8-9,14,21H,6-7,10H2,1H3
Affinity DataKi: 0.700nMAssay Description:Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudateputamen tissue from rat brainMore data for this Ligand-Target Pair
Show InChIInChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
Affinity DataKi: 0.730nMAssay Description:Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.More data for this Ligand-Target Pair
Show InChIInChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
Affinity DataKi: 0.741nMAssay Description:Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.More data for this Ligand-Target Pair
Show SMILESCN(CC=C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1
Show InChIInChI=1S/C19H21NO/c1-3-11-20(2)18-12-15-9-10-16(21)13-17(15)19(18)14-7-5-4-6-8-14/h3-10,13,18-19,21H,1,11-12H2,2H3/t18-,19-/m1/s1
Affinity DataKi: 0.790nMAssay Description:Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.More data for this Ligand-Target Pair
Show SMILESCN(CC=C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1
Show InChIInChI=1S/C19H21NO/c1-3-11-20(2)18-12-15-9-10-16(21)13-17(15)19(18)14-7-5-4-6-8-14/h3-10,13,18-19,21H,1,11-12H2,2H3/t18-,19-/m1/s1
Affinity DataKi: 0.790nMAssay Description:Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.More data for this Ligand-Target Pair
Show SMILESClc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl
Show InChIInChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)
Affinity DataKi: 0.800nMAssay Description:Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryMore data for this Ligand-Target Pair
Show SMILESCCCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1
Show InChIInChI=1S/C19H23NO/c1-3-11-20(2)18-12-15-9-10-16(21)13-17(15)19(18)14-7-5-4-6-8-14/h4-10,13,18-19,21H,3,11-12H2,1-2H3/t18-,19-/m1/s1
Affinity DataKi: 0.900nMAssay Description:Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.More data for this Ligand-Target Pair
Show SMILESCCCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1
Show InChIInChI=1S/C19H23NO/c1-3-11-20(2)18-12-15-9-10-16(21)13-17(15)19(18)14-7-5-4-6-8-14/h4-10,13,18-19,21H,3,11-12H2,1-2H3/t18-,19-/m1/s1
Affinity DataKi: 0.900nMAssay Description:Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.More data for this Ligand-Target Pair
Show SMILESCC(C)(C)[C@]1(O)CCN2C[C@H]3c4ccccc4CCc4cccc([C@@H]2C1)c34
Show InChIInChI=1S/C25H31NO/c1-24(2,3)25(27)13-14-26-16-21-19-9-5-4-7-17(19)11-12-18-8-6-10-20(23(18)21)22(26)15-25/h4-10,21-22,27H,11-16H2,1-3H3/t21-,22-,25-/m0/s1
3D Structure (crystal)
