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TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50550633(CHEMBL4763515)
Affinity DataIC50:  0.200nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50550634(CHEMBL4791366)
Affinity DataIC50:  1.20nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50550631(CHEMBL4756657)
Affinity DataIC50:  2.40nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM24184((3-aminopropyl)phosphinic acid | 3-aminopropylphos...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50550632(CHEMBL4787614)
Affinity DataIC50:  4.90nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1(Human)
Broad Institute of Mit and Harvard

Curated by ChEMBL
LigandPNGBDBM50435128(CHEMBL2391908)
Affinity DataIC50:  6.40nMAssay Description:Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM24185((3-aminopropyl)(methyl)phosphinic acid | 3-Apmpa |...)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50570461(CHEMBL4847170)
Affinity DataIC50:  13nMAssay Description:Agonist activity at human GABAB expressed in HEK293T cells co-transfected with human CaV2.2 channel assessed as inhibition of CaV2.2-mediated Ba2+ pe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032964((R)-4-Amino-3-(4-chloro-phenyl)-butyric acid | 4-A...)
Affinity DataIC50:  15nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM24186((3-amino-2-hydroxypropyl)phosphinic acid | 3-amino...)
Affinity DataIC50:  18nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50550638(CHEMBL4762233)
Affinity DataIC50:  19nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50550636(CHEMBL4745449)
Affinity DataIC50:  19nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50570462(CHEMBL4856595)
Affinity DataIC50:  21nMAssay Description:Agonist activity at human GABAB expressed in HEK293T cells co-transfected with human CaV2.2 channel assessed as inhibition of CaV2.2-mediated Ba2+ pe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50550639(CHEMBL4740566)
Affinity DataIC50:  23nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM24183(4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic a...)
Affinity DataIC50:  25nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM24189(3-aminopropylphosphinic derivative, (R)-4 | 3-amin...)
Affinity DataIC50:  29nMAssay Description:Inhibition of [3H]-CGP-27,492 binding to cat Gamma-aminobutyric acid type B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM24182(4-amino-3-(4-chlorophenyl)butanoic acid | Baclofen...)
Affinity DataIC50:  35nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032958(CHEMBL430501 | [3-Amino-2-(4-chloro-phenyl)-propyl...)
Affinity DataIC50:  39nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032971((3-Amino-1-methyl-propyl)-methyl-phosphinic acid |...)
Affinity DataIC50:  166nMAssay Description:Inhibition of [3H]-CGP-27,492 binding to cat Gamma-aminobutyric acid type B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032962(((Z)-3-Amino-propenyl)-phosphinic acid | CGP38593 ...)
Affinity DataIC50:  280nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032959(CHEMBL111378 | [3-Amino-2-(4-fluoro-phenyl)-propyl...)
Affinity DataIC50:  360nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032970((3-Amino-butyl)-phosphinic acid | CHEMBL113907)
Affinity DataIC50:  500nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50007118(4-Amino-3-(5-chloro-thiophen-2-yl)-butyric acid | ...)
Affinity DataIC50:  610nMAssay Description:Binding affinity to GABA-B receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032975((3-Amino-2-methyl-propyl)-phosphinic acid | CHEMBL...)
Affinity DataIC50:  780nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032977((3-Amino-2-phenyl-propyl)-phosphinic acid | CHEMBL...)
Affinity DataIC50:  880nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032967((3-Amino-1-methyl-propyl)-phosphinic acid | CHEMBL...)
Affinity DataIC50:  920nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50550637(CHEMBL4780501)
Affinity DataIC50: >1.00E+3nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50550635(CHEMBL4785671)
Affinity DataIC50: >1.00E+3nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50286226(3-Amino-2-(4-chloro-phenyl)-propane-1-sulfinic aci...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of Gamma-aminobutyric acid type B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032972((3-Amino-propyl)-ethyl-phosphinic acid | CGP-36216...)
Affinity DataIC50:  1.35E+3nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032963((S)-4-Amino-3-(4-chloro-phenyl)-butyric acid | BAC...)
Affinity DataIC50:  1.77E+3nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032962(((Z)-3-Amino-propenyl)-phosphinic acid | CGP38593 ...)
Affinity DataIC50:  4.41E+3nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032965(((R)-3-Amino-2-hydroxy-butyl)-phosphinic acid | CH...)
Affinity DataIC50:  1.28E+4nMAssay Description:Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50497817(CHEMBL3326376)
Affinity DataIC50:  2.13E+4nMAssay Description:Negative allosteric modulation of recombinant HA-tagged GB1 subunit/Flag-tagged GB2 subunit receptor (unknown origin) expressed in HEK293 cells co-ex...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50286225(3-Amino-2-(4-chloro-phenyl)-propane-1-sulfonic aci...)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibition of Gamma-aminobutyric acid type B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50497816(CHEMBL3326377)
Affinity DataIC50:  3.79E+4nMAssay Description:Negative allosteric modulation of recombinant HA-tagged GB1 subunit/Flag-tagged GB2 subunit receptor (unknown origin) expressed in HEK293 cells co-ex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50032982((3-Amino-propyl)-butyl-phosphinic acid | 3-aminopr...)
Affinity DataIC50:  3.80E+4nMAssay Description:Antagonist activity at human recombinant GABAb 1b/2 receptor expressed in Xenopus laevis oocytes co-expressing GIRK1/4 assessed as inhibition of GABA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50286226(3-Amino-2-(4-chloro-phenyl)-propane-1-sulfinic aci...)
Affinity DataIC50:  9.00E+4nMAssay Description:Inhibition of Gamma-aminobutyric acid type B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50286226(3-Amino-2-(4-chloro-phenyl)-propane-1-sulfinic aci...)
Affinity DataIC50:  9.00E+4nMAssay Description:Inhibition of Gamma-aminobutyric acid type B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Human)
Beijing Institute of Biotechnology

Curated by ChEMBL
LigandPNGBDBM50286225(3-Amino-2-(4-chloro-phenyl)-propane-1-sulfonic aci...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Gamma-aminobutyric acid type B receptorMore data for this Ligand-Target Pair
In DepthDetails Article