Compile Data Set for Download or QSAR
Report error Found 518 of ic50 for UniProtKB: Q9Y271
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227045(CHEMBL354129)
Affinity DataIC50: 0.0310nMAssay Description:Inhibition of LTC4 induced smooth muscle contraction of guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50023198(CHEMBL21333 | N-(4-oxo-2-(1H-tetrazol-5-yl)-4H-chr...)
Affinity DataIC50: 0.0440nMAssay Description:Inhibition of LTC4 induced smooth muscle contraction of guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227075(CHEMBL171021)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of LTC4 induced smooth muscle contraction of guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227072(CHEMBL169790)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of LTC4 induced smooth muscle contraction of guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227054(CHEMBL354530)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of LTC4 induced smooth muscle contraction of guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227053(CHEMBL170191)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of LTC4 induced smooth muscle contraction of guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50069352((1-{(R)-1-{3-[(E)-2-(7,7-Dimethyl-5,6,7,8-tetrahyd...)
Affinity DataIC50: 0.170nMAssay Description:In vitro inhibition of [3H]LTD4 binding to LTD4 receptor of guinea pig lung membrane with human serum albumin (HSA).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50069356([1-((R)-3-[2-(1-Hydroxy-1-methyl-ethyl)-phenyl]-1-...)
Affinity DataIC50: 0.190nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of guinea pig lung membrane without human serum albumin (HSA).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50069352((1-{(R)-1-{3-[(E)-2-(7,7-Dimethyl-5,6,7,8-tetrahyd...)
Affinity DataIC50: 0.190nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of guinea pig lung membrane without human serum albumin (HSA).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50069356([1-((R)-3-[2-(1-Hydroxy-1-methyl-ethyl)-phenyl]-1-...)
Affinity DataIC50: 0.190nMAssay Description:Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before L...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50068974(CGP-57698 | 2,2-Diethyl-N-[3-(7-fluoro-quinolin-2-...)
Affinity DataIC50: 0.200nMAssay Description:In vitro for antagonistic activity against LTD4 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50069375((R)-2-(1-((1-(3-(2-(5,7-dihydrothieno[3,4-b]pyridi...)
Affinity DataIC50: 0.210nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of guinea pig lung membrane without human serum albumin (HSA).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50069375((R)-2-(1-((1-(3-(2-(5,7-dihydrothieno[3,4-b]pyridi...)
Affinity DataIC50: 0.210nMAssay Description:Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before L...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50104905(CHEMBL3597618)
Affinity DataIC50: 0.220nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50069356([1-((R)-3-[2-(1-Hydroxy-1-methyl-ethyl)-phenyl]-1-...)
Affinity DataIC50: 0.25nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of DMSO differentiated human U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50009073(cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carba...)
Affinity DataIC50: 0.260nMAssay Description:Antagonist activity at human CysLT1 receptorMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50215369(CHEMBL368290)
Affinity DataIC50: 0.300nMAssay Description:In vitro for antagonistic activity against LTD4 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50104904(CHEMBL3597617)
Affinity DataIC50: 0.320nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50069372((1-{(R)-1-{3-[(E)-2-(6,6-Dimethyl-6,7-dihydro-5H-[...)
Affinity DataIC50: 0.340nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of guinea pig lung membrane without human serum albumin (HSA).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50069372((1-{(R)-1-{3-[(E)-2-(6,6-Dimethyl-6,7-dihydro-5H-[...)
Affinity DataIC50: 0.340nMAssay Description:Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before L...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50069350((1-{(R)-1-{3-[(E)-2-(7,7-Dimethyl-6,7-dihydro-5H-[...)
Affinity DataIC50: 0.350nMAssay Description:In vitro inhibition of [3H]LTD4 binding to LTD4 receptor of guinea pig lung membrane with human serum albumin (HSA).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227047(CHEMBL172889)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of LTC4 induced smooth muscle contraction of guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50285678((1-{(R)-1-{3-[(E)-2-(2,3-Dichloro-thieno[3,2-b]pyr...)
Affinity DataIC50: 0.380nMAssay Description:Inhibition of binding of [ H]-LTD4 to DMSO differentiated U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50215411(CHEMBL425675)
Affinity DataIC50: 0.400nMAssay Description:In vitro for antagonistic activity against LTD4 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50069352((1-{(R)-1-{3-[(E)-2-(7,7-Dimethyl-5,6,7,8-tetrahyd...)
Affinity DataIC50: 0.420nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of DMSO differentiated human U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052024(montelukast | CHEMBL787)
Affinity DataIC50: 0.430nMAssay Description:In vitro inhibition of [3H]LTD4 binding to LTD4 receptor of guinea pig lung membrane with human serum albumin (HSA).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50069372((1-{(R)-1-{3-[(E)-2-(6,6-Dimethyl-6,7-dihydro-5H-[...)
Affinity DataIC50: 0.430nMAssay Description:In vitro inhibition of [3H]LTD4 binding to LTD4 receptor of guinea pig lung membrane with human serum albumin (HSA).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50069355((R)-2-(1-((1-(3-(2-(6,7-dihydro-5H-cyclopenta[b]py...)
Affinity DataIC50: 0.440nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of DMSO differentiated human U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50069373(2-(1-(((1R)-3-(2-(2-hydroxypropan-2-yl)phenyl)-1-(...)
Affinity DataIC50: 0.470nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of DMSO differentiated human U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50104883(CHEMBL3597616)
Affinity DataIC50: 0.470nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50285677((1-{(R)-1-{3-[(E)-2-(2,3-Dichloro-thieno[3,2-b]pyr...)
Affinity DataIC50: 0.470nMAssay Description:Inhibition of binding of [ H]-LTD4 to DMSO differentiated U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227136(CHEMBL170100)
Affinity DataIC50: 0.470nMAssay Description:Inhibition of LTC4 induced smooth muscle contraction of guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50052024(montelukast | CHEMBL787)
Affinity DataIC50: 0.5nMAssay Description:Compound were tested for inhibitory activity against Cysteinyl leukotriene D4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50216211(CHEMBL143597)
Affinity DataIC50: 0.5nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of guinea pig lung membrane without human serum albumin (HSA).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50069355((R)-2-(1-((1-(3-(2-(6,7-dihydro-5H-cyclopenta[b]py...)
Affinity DataIC50: 0.5nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of guinea pig lung membrane without human serum albumin (HSA).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50069364((R)-2-(1-((1-(3-(2-(6-butyl-5-methylpyridin-2-yl)v...)
Affinity DataIC50: 0.5nMAssay Description:In vitro inhibition of [3H]LTD4 binding to LTD4 receptor of guinea pig lung membrane with human serum albumin (HSA).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50069355((R)-2-(1-((1-(3-(2-(6,7-dihydro-5H-cyclopenta[b]py...)
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before L...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50215410(CHEMBL369421)
Affinity DataIC50: 0.5nMAssay Description:In vitro for antagonistic activity against LTD4 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50227144(CHEMBL83797)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of LTC4 induced smooth muscle contraction of guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50069373(2-(1-(((1R)-3-(2-(2-hydroxypropan-2-yl)phenyl)-1-(...)
Affinity DataIC50: 0.510nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of guinea pig lung membrane without human serum albumin (HSA).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50069373(2-(1-(((1R)-3-(2-(2-hydroxypropan-2-yl)phenyl)-1-(...)
Affinity DataIC50: 0.510nMAssay Description:Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before L...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50285683((1-{(R)-1-{3-[(E)-2-(2,3-Dichloro-thieno[3,2-b]pyr...)
Affinity DataIC50: 0.550nMAssay Description:Inhibition of binding of [ H]-LTD4 to DMSO differentiated U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50069372((1-{(R)-1-{3-[(E)-2-(6,6-Dimethyl-6,7-dihydro-5H-[...)
Affinity DataIC50: 0.560nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of DMSO differentiated human U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50104872(CHEMBL3597535)
Affinity DataIC50: 0.560nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50069357([1-((R)-3-[2-(1-Hydroxy-1-methyl-ethyl)-phenyl]-1-...)
Affinity DataIC50: 0.580nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of guinea pig lung membrane without human serum albumin (HSA).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50066947(CHEMBL3403186)
Affinity DataIC50: 0.590nMAssay Description:Antagonist activity at human CysLT1 receptor expressed in CHO cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50069375((R)-2-(1-((1-(3-(2-(5,7-dihydrothieno[3,4-b]pyridi...)
Affinity DataIC50: 0.610nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of DMSO differentiated human U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50104864(CHEMBL3597527)
Affinity DataIC50: 0.620nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50069373(2-(1-(((1R)-3-(2-(2-hydroxypropan-2-yl)phenyl)-1-(...)
Affinity DataIC50: 0.630nMAssay Description:In vitro inhibition of [3H]LTD4 binding to LTD4 receptor of guinea pig lung membrane with human serum albumin (HSA).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1/2(Human)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50052024(montelukast | CHEMBL787)
Affinity DataIC50: 0.640nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of guinea pig lung membrane without human serum albumin (HSA).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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