Compile Data Set for Download or QSAR
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TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50069356([1-((R)-3-[2-(1-Hydroxy-1-methyl-ethyl)-phenyl]-1-...)
Affinity DataIC50: 0.190nMAssay Description:Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before L...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50069375((R)-2-(1-((1-(3-(2-(5,7-dihydrothieno[3,4-b]pyridi...)
Affinity DataIC50: 0.210nMAssay Description:Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before L...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50104905(CHEMBL3597618)
Affinity DataIC50: 0.220nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50069356([1-((R)-3-[2-(1-Hydroxy-1-methyl-ethyl)-phenyl]-1-...)
Affinity DataIC50: 0.25nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of DMSO differentiated human U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50009073(cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carba...)
Affinity DataIC50: 0.260nMAssay Description:Antagonist activity at human CysLT1 receptorMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50104904(CHEMBL3597617)
Affinity DataIC50: 0.320nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50069372((1-{(R)-1-{3-[(E)-2-(6,6-Dimethyl-6,7-dihydro-5H-[...)
Affinity DataIC50: 0.340nMAssay Description:Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before L...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50285678((1-{(R)-1-{3-[(E)-2-(2,3-Dichloro-thieno[3,2-b]pyr...)
Affinity DataIC50: 0.380nMAssay Description:Inhibition of binding of [ H]-LTD4 to DMSO differentiated U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50069352((1-{(R)-1-{3-[(E)-2-(7,7-Dimethyl-5,6,7,8-tetrahyd...)
Affinity DataIC50: 0.420nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of DMSO differentiated human U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50069355((R)-2-(1-((1-(3-(2-(6,7-dihydro-5H-cyclopenta[b]py...)
Affinity DataIC50: 0.440nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of DMSO differentiated human U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50069373(2-(1-(((1R)-3-(2-(2-hydroxypropan-2-yl)phenyl)-1-(...)
Affinity DataIC50: 0.470nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of DMSO differentiated human U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50104883(CHEMBL3597616)
Affinity DataIC50: 0.470nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50285677((1-{(R)-1-{3-[(E)-2-(2,3-Dichloro-thieno[3,2-b]pyr...)
Affinity DataIC50: 0.470nMAssay Description:Inhibition of binding of [ H]-LTD4 to DMSO differentiated U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50052024(montelukast | CHEMBL787)
Affinity DataIC50: 0.5nMAssay Description:Compound were tested for inhibitory activity against Cysteinyl leukotriene D4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50069355((R)-2-(1-((1-(3-(2-(6,7-dihydro-5H-cyclopenta[b]py...)
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before L...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50069373(2-(1-(((1R)-3-(2-(2-hydroxypropan-2-yl)phenyl)-1-(...)
Affinity DataIC50: 0.510nMAssay Description:Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before L...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50285683((1-{(R)-1-{3-[(E)-2-(2,3-Dichloro-thieno[3,2-b]pyr...)
Affinity DataIC50: 0.550nMAssay Description:Inhibition of binding of [ H]-LTD4 to DMSO differentiated U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50069372((1-{(R)-1-{3-[(E)-2-(6,6-Dimethyl-6,7-dihydro-5H-[...)
Affinity DataIC50: 0.560nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of DMSO differentiated human U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50104872(CHEMBL3597535)
Affinity DataIC50: 0.560nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50066947(CHEMBL3403186)
Affinity DataIC50: 0.590nMAssay Description:Antagonist activity at human CysLT1 receptor expressed in CHO cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50069375((R)-2-(1-((1-(3-(2-(5,7-dihydrothieno[3,4-b]pyridi...)
Affinity DataIC50: 0.610nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of DMSO differentiated human U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50104864(CHEMBL3597527)
Affinity DataIC50: 0.620nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50285675((1-{(R)-1-{3-[(E)-2-(2,3-Dichloro-thieno[3,2-b]pyr...)
Affinity DataIC50: 0.650nMAssay Description:Inhibition of binding of [ H]-LTD4 to DMSO differentiated U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50285671({1-[(R)-1-{3-[(E)-2-(2,3-Dichloro-thieno[3,2-b]pyr...)
Affinity DataIC50: 0.720nMAssay Description:Inhibition of binding of [ H]-LTD4 to DMSO differentiated U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50285674((1-{(R)-1-{3-[(E)-2-(2,3-Difluoro-thieno[3,2-b]pyr...)
Affinity DataIC50: 0.760nMAssay Description:Inhibition of binding of [ H]-LTD4 to DMSO differentiated U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50052024(montelukast | CHEMBL787)
Affinity DataIC50: 0.780nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of DMSO differentiated human U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50066911(CHEMBL3401689)
Affinity DataIC50: 0.790nMAssay Description:Antagonist activity at human CysLT1 receptor expressed in CHO cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50104910(CHEMBL3597623)
Affinity DataIC50: 0.790nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50104869(CHEMBL3597532)
Affinity DataIC50: 0.800nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50023198(CHEMBL21333 | N-(4-oxo-2-(1H-tetrazol-5-yl)-4H-chr...)
Affinity DataIC50: 0.800nMAssay Description:Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before L...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50069364((R)-2-(1-((1-(3-(2-(6-butyl-5-methylpyridin-2-yl)v...)
Affinity DataIC50: 0.900nMAssay Description:Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before L...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033083(CHEMBL3342953)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human CysLT1 receptor expressed in CHO cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50104839(CHEMBL3597525)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50285670((1-{(R)-1-{3-[(E)-2-(2,3-Dichloro-thieno[3,2-b]pyr...)
Affinity DataIC50: 1.05nMAssay Description:Inhibition of binding of [ H]-LTD4 to DMSO differentiated U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50285672((1-{(R)-1-{3-[2-(2,3-Dichloro-thieno[3,2-b]pyridin...)
Affinity DataIC50: 1.06nMAssay Description:Inhibition of binding of [ H]-LTD4 to DMSO differentiated U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50069357([1-((R)-3-[2-(1-Hydroxy-1-methyl-ethyl)-phenyl]-1-...)
Affinity DataIC50: 1.10nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of DMSO differentiated human U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50104871(CHEMBL3597534)
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50104920(CHEMBL3597633)
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50285673((1-{(R)-1-{3-[(E)-2-(2-Chloro-thieno[3,2-b]pyridin...)
Affinity DataIC50: 1.16nMAssay Description:Inhibition of binding of [ H]-LTD4 to DMSO differentiated U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033060(CHEMBL3342952)
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at human CysLT1 receptor expressed in CHO cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50104836(CHEMBL3597522)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50104911(CHEMBL3597624)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50084814(4-(4-(7-(quinolin-2-ylmethoxy)-2-naphthamido)pheny...)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at CysLT1 receptor in human dU937 cells assessed as inhibition of LTD4-induced increase of calcium level treated 30 mins before L...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50104870(CHEMBL3597533)
Affinity DataIC50: 1.60nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50285676([1-((R)-1-{3-[(E)-2-(2,3-Dichloro-thieno[3,2-b]pyr...)
Affinity DataIC50: 1.63nMAssay Description:Inhibition of binding of [ H]-LTD4 to DMSO differentiated U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50069354([1-((R)-3-[2-(1-Hydroxy-1-methyl-ethyl)-phenyl]-1-...)
Affinity DataIC50: 1.70nMAssay Description:In vitro inhibition of [3H]-LTD4 binding to LTD4 receptor of DMSO differentiated human U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50104921(CHEMBL3597634)
Affinity DataIC50: 1.70nMAssay Description:Antagonist activity at human CysLT1 expressed in CHOK1 cells assessed as inhibition of LTD4-induced calcium mobilization preincubated for 30 mins pri...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50009073(cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carba...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of cysteinyl leukotriene receptor 1 (unknown origin) expressed in HEK293 cell membranes after 45 mins by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50009073(cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carba...)
Affinity DataIC50: 1.90nMAssay Description:Antagonist activity at human CysLT1More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCysteinyl leukotriene receptor 1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50285682((1-{(R)-1-{3-[(E)-2-(3-Chloro-thieno[3,2-b]pyridin...)
Affinity DataIC50: 1.91nMAssay Description:Inhibition of binding of [ H]-LTD4 to DMSO differentiated U937 cell membranesMore data for this Ligand-Target Pair
In DepthDetails Article

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