Compile Data Set for Download or QSAR
Report error Found 769 of ic50 for UniProtKB: Q9R0C9
LigandPNGBDBM50225205(CHEMBL540269)
Affinity DataIC50: 0.00300nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
LigandPNGBDBM50000788([17-(2,3-3H-2-propenyl)]-4, 5a -epoxy-3,14-dihydro...)
Affinity DataIC50: 0.00400nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50017233(LEVO-DROMORAN | CHEMBL592 | LEVORPHANOL)
Affinity DataIC50: 0.00400nMAssay Description:50% Inhibition of stereospecific [3H]-naltrexone (10e-9 M) binding towards opiate receptor in rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2018
Entry Details Article
PubMed
LigandPNGBDBM50000788([17-(2,3-3H-2-propenyl)]-4, 5a -epoxy-3,14-dihydro...)
Affinity DataIC50: 0.00900nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50001707(Tylox | Oxycet | Combunox | Codoxy | Percocet | 10...)
Affinity DataIC50: 0.0130nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
LigandPNGBDBM50225845(CHEMBL293967)
Affinity DataIC50: 0.0150nMAssay Description:The compound was tested for binding affinity against opioid receptor in rat brain membranes, using [3H]dihydromorphine as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2018
Entry Details Article
PubMed
LigandPNGBDBM50225204(CHEMBL606711)
Affinity DataIC50: 0.0200nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
LigandPNGBDBM50000092(Analog of 14-(Arylhydroxyamino)codeinone | 4-methy...)
Affinity DataIC50: 0.0270nMAssay Description:50% Inhibition of stereospecific [3H]-naltrexone (10e-9 M) binding towards opiate receptor in rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2018
Entry Details Article
PubMed
LigandPNGBDBM50000092(Analog of 14-(Arylhydroxyamino)codeinone | 4-methy...)
Affinity DataIC50: 0.0500nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035145(1'-(3-cyclohexyloxypropyl)-3H-spiro[2-benzofuran-1...)
Affinity DataIC50: 0.0700nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035141(1'-(cyclohexylbutyl)-3H-spiro[2-benzofuran-1,4'-pi...)
Affinity DataIC50: 0.0700nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
LigandPNGBDBM50225205(CHEMBL540269)
Affinity DataIC50: 0.0800nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
LigandPNGBDBM50225211(CHEMBL606767)
Affinity DataIC50: 0.0850nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50054124(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Affinity DataIC50: 0.0890nMAssay Description:Evaluated for the binding affinity towards sigma 1 receptor by displacing the radioligand [3H]-SKF- 10047 in whole rat brain membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50054124(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Affinity DataIC50: 0.0890nMAssay Description:Evaluated for the binding affinity towards sigma 1 receptor by displacing the radioligand [3H]-SKF- 10047 in whole rat brain membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035105(Siramesine | Lu 28-179 | 1'-{4-[1-(4-fluorophenyl)...)
Affinity DataIC50: 0.120nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035133(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)
Affinity DataIC50: 0.140nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
LigandPNGBDBM50001707(Tylox | Oxycet | Combunox | Codoxy | Percocet | 10...)
Affinity DataIC50: 0.150nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
LigandPNGBDBM50326670(17-methoxy-4-methyl-(13R,17S)-12-oxa-4-azapentacyc...)
Affinity DataIC50: 0.200nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
LigandPNGBDBM50225206(CHEMBL606643)
Affinity DataIC50: 0.200nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
LigandPNGBDBM50225213(CHEMBL606820)
Affinity DataIC50: 0.200nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035122(1'-(2-phenylpentyl)-3H-spiro[2-benzofuran-1,4'-pip...)
Affinity DataIC50: 0.200nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035144(1'-(2-phenylhexyl)-3H-spiro[2-benzofuran-1,4'-pipe...)
Affinity DataIC50: 0.200nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035129(1'-(2-phenylbutyl)-3H-spiro[2-benzofuran-1,4'-pipe...)
Affinity DataIC50: 0.25nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
LigandPNGBDBM50027473(3-Methyl-1-phenethyl-4-(phenyl-propionyl-amino)-pi...)
Affinity DataIC50: 0.25nMAssay Description:Displacement of [3H]nalotrexone from rat-brain Opioid receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSigma non-opioid intracellular receptor 1(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035097(CHEMBL303336 | 1''-benzylspiro[1,2,3,4-tetrahydron...)
Affinity DataIC50: 0.260nMAssay Description:Binding affinity towards sigma receptor binding site 1 using [3H](+)-pentazocineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035097(CHEMBL303336 | 1''-benzylspiro[1,2,3,4-tetrahydron...)
Affinity DataIC50: 0.260nMAssay Description:Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035134(1'-(3-(cyclohexylthio)propyl)-3H-spiro[2-benzofura...)
Affinity DataIC50: 0.260nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035129(1'-(2-phenylbutyl)-3H-spiro[2-benzofuran-1,4'-pipe...)
Affinity DataIC50: 0.270nMAssay Description:Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
LigandPNGBDBM50013184(CHEMBL343066 | 1H-Indole-2-carboxylic acid [5-(2-f...)
Affinity DataIC50: 0.300nMAssay Description:Displacement of [3H]dihydromorphine (DHM) from rat brain Opioid receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50326659(3,10-dimethoxy-17-methyl-(10S)-17-azatetracyclo[7....)
Affinity DataIC50: 0.300nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
LigandPNGBDBM50225214(CHEMBL606769)
Affinity DataIC50: 0.300nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
LigandPNGBDBM50225848(CHEMBL53563)
Affinity DataIC50: 0.300nMAssay Description:The compound was tested for binding affinity against opioid receptor in rat brain membranes, using [3H]dihydromorphine as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2018
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035142(1-[1-(4-fluorophenyl)-1H-3-indolyl]-4-[6-fluorospi...)
Affinity DataIC50: 0.310nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035135(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)
Affinity DataIC50: 0.340nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035145(1'-(3-cyclohexyloxypropyl)-3H-spiro[2-benzofuran-1...)
Affinity DataIC50: 0.400nMAssay Description:Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
LigandPNGBDBM50354578(BUPRENORPHINE | US9315514, Buprenorphine | US10752...)
Affinity DataIC50: 0.410nMAssay Description:Inhibition of [3H]-Naloxone binding to rat brain membrane without NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2018
Entry Details Article
PubMed
LigandPNGBDBM50224336(CHEMBL1744168)
Affinity DataIC50: 0.410nMAssay Description:Inhibition of [3H]-Naloxone binding to rat brain membrane without NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2018
Entry Details Article
PubMed
LigandPNGBDBM50224339(CHEMBL1744167)
Affinity DataIC50: 0.410nMAssay Description:Inhibition of [3H]-Naloxone binding to rat brain membrane without NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2018
Entry Details Article
PubMed
LigandPNGBDBM50354578(BUPRENORPHINE | US9315514, Buprenorphine | US10752...)
Affinity DataIC50: 0.440nMAssay Description:Inhibition of [3H]naloxone binding to rat brain membrane with 100 mM NaCl.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2018
Entry Details Article
PubMed
LigandPNGBDBM50226933(Naltrexonazine)
Affinity DataIC50: 0.450nMAssay Description:Inhibition of [3H]DAMPGO binding was determined using standard binding assay in rat brain homogenates against opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2018
Entry Details Article
PubMed
LigandPNGBDBM50226933(Naltrexonazine)
Affinity DataIC50: 0.450nMAssay Description:Inhibition of [3H]DAMPGO binding was determined using standard binding assay in rat brain homogenates against opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2018
Entry Details Article
PubMed
LigandPNGBDBM50226933(Naltrexonazine)
Affinity DataIC50: 0.470nMAssay Description:Inhibition of [3H]DAMPGO binding was determined using standard binding assay in rat brain homogenates against opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2018
Entry Details Article
PubMed
LigandPNGBDBM50013209(CHEMBL140365 | 4-Chloro-N-[5-(2-fluoro-phenyl)-1-m...)
Affinity DataIC50: 0.5nMAssay Description:Displacement of [3H]dihydromorphine (DHM) from rat brain Opioid receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50225212(CHEMBL606707)
Affinity DataIC50: 0.5nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
LigandPNGBDBM50225232(CHEMBL606768)
Affinity DataIC50: 0.5nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2018
Entry Details Article
PubMed
LigandPNGBDBM60212(SMR000058767 | NALTREXONE HYDROCHLORIDE | MLS00006...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of [3H]naloxone binding to opioid receptor in presence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2019
Entry Details Article
PubMed
LigandPNGBDBM50224323(CHEMBL1794881)
Affinity DataIC50: 0.510nMAssay Description:Inhibition of [3H]-Naloxone binding to rat brain membrane without NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2018
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035144(1'-(2-phenylhexyl)-3H-spiro[2-benzofuran-1,4'-pipe...)
Affinity DataIC50: 0.530nMAssay Description:Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
LigandPNGBDBM50224340(CHEMBL147150)
Affinity DataIC50: 0.550nMAssay Description:Inhibition of [3H]-Naloxone binding to rat brain membrane without NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2018
Entry Details Article
PubMed
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