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TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50421905(CHEMBL553265)
Affinity DataIC50:  0.251nMAssay Description:In vitro for the binding affinity against sigma receptor by using [3H]DTG as radioligand in guinea pig cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50382166(CHEMBL2023825)
Affinity DataIC50:  0.270nMAssay Description:Displacement of [3H](+)pentazocine from sigma-1 receptor expressed in human Jurkat cell membranes after 2 hrs by liquid scintillation spectroscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50040283(3-Chloro-6-dimethylamino-6-methyl-8-phenyl-5,6,7,8...)
Affinity DataIC50:  0.290nMAssay Description:Binding affinity against sigma receptor from guinea pig brain (minus cerebellum) homogenates, using the novel [3H]-(+/-)-4 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50421907(CHEMBL540274)
Affinity DataIC50:  0.324nMAssay Description:In vitro for the binding affinity against sigma receptor by using [3H]DTG as radioligand in guinea pig cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50036730(3-[4-(4-Chloro-phenyl)-3,6-dihydro-2H-pyridin-1-yl...)
Affinity DataIC50:  0.5nMAssay Description:Binding affinity against sigma receptor in bovine cerebellum using 2.0 nM [3H]-haloperidol in the presence of 25 nM unlabeled spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50054728(1,4-Bis-(3-phenyl-propyl)-piperazine | CHEMBL34640...)
Affinity DataIC50:  0.5nMAssay Description:Binding affinity against sigma receptor using radioligand ([3H](+)-pentazocine) binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50040287((1R,3S)Dimethyl-(2-methyl-4-phenyl-1,2,3,4-tetrahy...)
Affinity DataIC50:  0.510nMAssay Description:Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50040287((1R,3S)Dimethyl-(2-methyl-4-phenyl-1,2,3,4-tetrahy...)
Affinity DataIC50:  0.510nMAssay Description:Binding affinity against sigma receptor from guinea pig brain (minus cerebellum) homogenates, using the novel [3H]-(+/-)-4 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM86029(trans-H2-PAT(+))
Affinity DataIC50:  0.520nMAssay Description:The compound was tested for affinity towards sigma-3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM86029(trans-H2-PAT(+))
Affinity DataIC50:  0.525nMAssay Description:The compound was tested for affinity towards sigma-3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50040282(CHEMBL317029 | CHEMBL545249 | cis-3-Chloro-6-dimet...)
Affinity DataIC50:  0.708nMAssay Description:The compound was tested for affinity towards sigma-3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50040282(CHEMBL317029 | CHEMBL545249 | cis-3-Chloro-6-dimet...)
Affinity DataIC50:  0.710nMAssay Description:The compound was tested for affinity towards sigma-3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50421946(CHEMBL1788383)
Affinity DataIC50:  0.724nMAssay Description:In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50172914((S)-2-(2-Piperidin-1-yl-ethyl)-3-thioxo-2,3,10,10a...)
Affinity DataIC50:  0.900nMAssay Description:Inhibitory concentration against opioid receptor sigma 1 of guinea pig cerebral cortex using [3H]-(+)-pentazocine upon incubation for 150 minutes at ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50282973(4-Fluoro-N-{1-(4-fluoro-naphthalen-1-yl)-4-[4-(5-f...)
Affinity DataIC50: >1nMAssay Description:In vitro binding affinity of the compound towards sigma receptor by the displacement of [3H]-PPP from guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM21395(3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H...)
Affinity DataIC50:  1nMAssay Description:The compound was tested for affinity towards sigma-3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  1nMAssay Description:The compound was tested for affinity towards sigma-3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50421940(CHEMBL62770)
Affinity DataIC50:  1nMAssay Description:In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170657(1''-butyl-3,4-dihydro-2H-spiro[naphthalene-1,4''-p...)
Affinity DataIC50:  1.20nMAssay Description:In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50421930(CHEMBL1788382)
Affinity DataIC50:  1.20nMAssay Description:In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50421906(CHEMBL544281)
Affinity DataIC50:  1.20nMAssay Description:In vitro for the binding affinity against sigma receptor by using [3H]DTG as radioligand in guinea pig cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170660(CHEMBL190883 | CHEMBL521582 | N,N-dipropyl-2-[4-me...)
Affinity DataIC50:  1.30nMAssay Description:In vitro binding affinity at Sigma opioid receptors on guinea pig brain membranes by [3H]3-PPP displacement.More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50421932(CHEMBL1743999)
Affinity DataIC50:  1.30nMAssay Description:In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50421939(CHEMBL1744003)
Affinity DataIC50:  1.40nMAssay Description:In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50040282(CHEMBL317029 | CHEMBL545249 | cis-3-Chloro-6-dimet...)
Affinity DataIC50:  1.40nMAssay Description:Binding affinity against sigma receptor from guinea pig brain (minus cerebellum) homogenates, using the novel [3H]-(+/-)-4 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50421895(CHEMBL555890)
Affinity DataIC50:  1.40nMAssay Description:In vitro for the binding affinity against sigma receptor by using [3H]DTG as radioligand in guinea pig cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50081380(CHEMBL553962 | [1-(4-Methoxy-3-phenethyloxy-benzyl...)
Affinity DataIC50:  1.5nMAssay Description:In vitro binding affinity at Sigma opioid receptors on guinea pig brain membranes by [3H]3-PPP displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50421954(CHEMBL1744015)
Affinity DataIC50:  1.5nMAssay Description:In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50421951(CHEMBL1744002)
Affinity DataIC50:  1.70nMAssay Description:In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50421903(CHEMBL545212)
Affinity DataIC50:  1.70nMAssay Description:In vitro for the binding affinity against sigma receptor by using [3H]DTG as radioligand in guinea pig cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50421913(CHEMBL545682)
Affinity DataIC50:  1.80nMAssay Description:In vitro for the binding affinity against sigma receptor by using [3H]DTG as radioligand in guinea pig cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50081366(CHEMBL540331 | [1-(4-Methoxy-3-phenethyloxy-benzyl...)
Affinity DataIC50:  1.80nMAssay Description:In vitro binding affinity at Sigma opioid receptors on guinea pig brain membranes by [3H]3-PPP displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50421899(CHEMBL545688)
Affinity DataIC50:  1.90nMAssay Description:In vitro for the binding affinity against sigma receptor by using [3H]DTG as radioligand in guinea pig cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50421945(CHEMBL1744017)
Affinity DataIC50:  2nMAssay Description:In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003743((-)-[2-(3,4-Dichloro-phenyl)-ethyl]-methyl-(2-pyrr...)
Affinity DataIC50:  2nMAssay Description:Affinity of compound to Sigma opioid receptor labelled with [3H](+)-3-PPPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50421915(CHEMBL544748)
Affinity DataIC50:  2nMAssay Description:In vitro for the binding affinity against sigma receptor by using [3H]DTG as radioligand in guinea pig cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50282974(CHEMBL58283 | N-{1-Cyclohexyl-4-[4-(5-fluoro-pyrim...)
Affinity DataIC50: >2nMAssay Description:In vitro binding affinity of the compound towards sigma receptor by the displacement of [3H]-PPP from guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50421926(CHEMBL541052)
Affinity DataIC50:  2nMAssay Description:In vitro for the binding affinity against sigma receptor by using [3H]DTG as radioligand in guinea pig cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50081369(CHEMBL128860 | CHEMBL541091 | [1-(4-Methoxy-3-phen...)
Affinity DataIC50:  2.10nMAssay Description:In vitro binding affinity at Sigma opioid receptors on guinea pig brain membranes by [3H]3-PPP displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50421894(CHEMBL555581)
Affinity DataIC50:  2.10nMAssay Description:In vitro for the binding affinity against sigma receptor by using [3H]DTG as radioligand in guinea pig cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50:  2.10nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H]-(+)-pentazocine as radio ligand at pH 7.5 for 150 min at...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50172886((S)-2-[3-(Methyl-phenethyl-amino)-propyl]-10,10a-d...)
Affinity DataIC50:  2.10nMpH: 7.5Assay Description:Inhibitory activity against opioid receptor sigma 1 in guinea pig cerebral cortex using [3H]-(+)-pentazocine as radio ligand at pH 7.5 for 150 min at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50:  2.10nMAssay Description:Inhibitory concentration against opioid receptor sigma 1 of guinea pig cerebral cortex using [3H]-(+)-pentazocine upon incubation for 150 minutes at ...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50421929(CHEMBL544987)
Affinity DataIC50:  2.20nMAssay Description:In vitro for the binding affinity against sigma receptor by using [3H]DTG as radioligand in guinea pig cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50040292(CHEMBL323287 | CHEMBL544309 | trans-Diethyl-(4-phe...)
Affinity DataIC50:  2.20nMAssay Description:The compound was tested for affinity towards sigma-3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM79172(2-[4-[(3Z)-3-[2-(trifluoromethyl)-9-thioxanthenyli...)
Affinity DataIC50:  2.20nMAssay Description:The compound was tested for affinity towards sigma-3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50421904(CHEMBL553561)
Affinity DataIC50:  2.30nMAssay Description:In vitro for the binding affinity against sigma receptor by using [3H]DTG as radioligand in guinea pig cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50421934(CHEMBL1744000)
Affinity DataIC50:  2.30nMAssay Description:In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50172884((S)-2-(1-Benzyl-piperidin-4-yl)-10,10a-dihydro-5H-...)
Affinity DataIC50:  2.40nMpH: 7.5 T: 22°CAssay Description:Inhibitory activity against Opioid receptor sigma 1 in guinea pig cerebral cortex using [3H]-(+)-pentazocine as radio ligand at pH 7.5 for 150 min at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50421914(CHEMBL543810)
Affinity DataIC50:  2.5nMAssay Description:In vitro for the binding affinity against sigma receptor by using [3H]DTG as radioligand in guinea pig cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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