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TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50241089(CHEMBL415049 | AZD1152, 33 | 2-(ethyl(3-(4-(5-(2-(...)
Affinity DataKi:  0.370nMAssay Description:Inhibition of aurora B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50315769(GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...)
Affinity DataKi:  0.380nMAssay Description:Competitive inhibition of Aurora B ATP binding siteMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50315769(GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...)
Affinity DataKi:  0.380nMAssay Description:Competitive inhibition of human Aurora B ATP binding site by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50442149(CHEMBL2441267)
Affinity DataKi:  0.501nMAssay Description:Inhibition of Aurora-B (unknown origin) using 5FAM-PKAtide as substrate after 120 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50277679(N-(4-(4-(4-tert-butylpiperazin-1-yl)-6-(5-methyl-1...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of Aurora-B by time dependent kinetic studyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26277(N-(3,5-difluorophenyl)-2-{3-[(7-{3-[4-(hydroxymeth...)
Affinity DataKi:  1nM ΔG°:  -12.1kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26284(N-(2,3-difluorophenyl)-2-{3-[(7-{3-[(2R)-2-(hydrox...)
Affinity DataKi:  1nM ΔG°:  -12.1kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26285(N-(2,3-difluorophenyl)-2-{3-[(7-{3-[(2S)-2-(hydrox...)
Affinity DataKi: <1nM ΔG°: <-12.1kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26286(N-(2,3-difluorophenyl)-2-{3-[(7-{3-[4-(2-hydroxyet...)
Affinity DataKi: <1nM ΔG°: <-12.1kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26287(N-(2,3-difluorophenyl)-2-[3-({7-[3-(4-hydroxypiper...)
Affinity DataKi: <1nM ΔG°: <-12.1kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26288(N-(2,3-difluorophenyl)-2-{3-[(7-{3-[4-(2-hydroxyet...)
Affinity DataKi: <1nM ΔG°: <-12.1kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26289(N-(3-fluorophenyl)-2-{3-[(7-{3-[(2R)-2-(hydroxymet...)
Affinity DataKi:  1nM ΔG°:  -12.1kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26290(N-(3-fluorophenyl)-2-{3-[(7-{3-[(2-hydroxyethyl)am...)
Affinity DataKi:  1nM ΔG°:  -12.1kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26291(N-(3-fluorophenyl)-2-{3-[(7-{3-[(2-hydroxyethyl)(m...)
Affinity DataKi: <1nM ΔG°: <-12.1kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26292(2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}-6...)
Affinity DataKi:  1nM ΔG°:  -12.1kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26294(CHEMBL214848 | N-(2,3-difluorophenyl)-2-{3-[(7-{3-...)
Affinity DataKi: <1nM ΔG°: <-12.1kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26295(N-(2,3-difluorophenyl)-2-{3-[(7-{3-[(2-hydroxyethy...)
Affinity DataKi: <1nM ΔG°: <-12.1kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26296(CHEMBL216053 | N-(2,3-difluorophenyl)-2-{3-[(7-{3-...)
Affinity DataKi: <1nM ΔG°: <-12.1kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26297(N-(2,3-difluorophenyl)-2-{3-[(7-{3-[ethyl(2-hydrox...)
Affinity DataKi: <1nM ΔG°: <-12.3kcal/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26298(N-(2,3-difluorophenyl)-2-{3-[(7-{3-[(2-hydroxyethy...)
Affinity DataKi: <1nM ΔG°: <-12.3kcal/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26299(N-(2,3-difluorophenyl)-2-{3-[(7-{3-[(2R)-2-(hydrox...)
Affinity DataKi: <1nM ΔG°: <-12.3kcal/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26300(cid_16007391 | 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)a...)
Affinity DataKi: <1nM ΔG°: <-12.3kcal/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26301(N-(3-fluorophenyl)-2-{3-[(7-{3-[(2-hydroxyethyl)(p...)
Affinity DataKi: <1nM ΔG°: <-12.3kcal/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26302(N-(3-fluorophenyl)-2-{3-[(7-{3-[(2R)-2-(hydroxymet...)
Affinity DataKi: <1nM ΔG°: <-12.3kcal/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26303(N-(2,3-difluorophenyl)-2-{4-[(7-{3-[(2R)-2-(hydrox...)
Affinity DataKi: <1nM ΔG°: <-12.1kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26304(N-(2,3-difluorophenyl)-2-{4-[(7-{3-[ethyl(2-hydrox...)
Affinity DataKi: <1nM ΔG°: <-12.1kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26305(N-(3-fluorophenyl)-2-{4-[(7-{3-[(2R)-2-(hydroxymet...)
Affinity DataKi:  1nM ΔG°:  -12.1kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26306(2-{4-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}-6...)
Affinity DataKi:  1nM ΔG°:  -12.1kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26307(N-(3-fluorophenyl)-2-{4-[(7-{3-[(2R)-2-(hydroxymet...)
Affinity DataKi: <1nM ΔG°: <-12.1kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26308(N-(2,3-difluorophenyl)-2-{4-[(7-{3-[(2R)-2-(hydrox...)
Affinity DataKi: <1nM ΔG°: <-12.1kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of Aurora-B by time dependent kinetic studyMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of Aurora B kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKi:  1.80nMAssay Description:Competitive inhibition of Aurora B ATP binding siteMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26274(N-(3-fluorophenyl)-2-{3-[(7-{3-[4-(hydroxymethyl)p...)
Affinity DataKi:  2nM ΔG°:  -11.7kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26276(N-(2,3-difluorophenyl)-2-{3-[(7-{3-[4-(hydroxymeth...)
Affinity DataKi:  2nM ΔG°:  -11.7kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26293(CHEMBL217804 | N-(3-fluorophenyl)-2-{3-[(7-{3-[(2-...)
Affinity DataKi:  2nM ΔG°:  -11.7kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50319623(4-(2,4-Dimethylthiazol-5-yl)-N-(3,4,5-trimethoxyph...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50319622(N,4-Dimethyl-5-(2-(3,4,5-trimethoxyphenylamino)pyr...)
Affinity DataKi:  3nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50004205(MK-0457 | MK-045 | VX-680 | VX-68 | TOZASERTIB | U...)
Affinity DataKi:  3.40nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50619214(CHEMBL5407522)
Affinity DataKi:  3.40nMAssay Description:Inhibition of human N-terminal His-tagged aurora B assessed as inhibition constant incubated for 15 mins using Histone H3 as substrate in presence [g...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50319616(1-(4-(4-(4-(2-Amino-4-methylthiazol-5-yl)pyrimidin...)
Affinity DataKi:  3.80nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50319620(N-(4-(4-(2-(Ethylamino)-4-methylthiazol-5-yl)pyrim...)
Affinity DataKi:  4nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50442153(CHEMBL2441283)
Affinity DataKi:  5nMAssay Description:Inhibition of Aurora-B (unknown origin) using 5FAM-PKAtide as substrate after 120 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50319617(N-Ethyl-4-methyl-5-(2-(4-morpholinophenylamino)pyr...)
Affinity DataKi:  6nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50319621(N-Ethyl-4-methyl-5-(2-(3,4,5-trimethoxyphenylamino...)
Affinity DataKi:  6nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26278(N-(3-chlorophenyl)-2-{3-[(7-{3-[4-(hydroxymethyl)p...)
Affinity DataKi:  8nM ΔG°:  -10.9kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50277586(N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-(piperid...)
Affinity DataKi:  8nMAssay Description:Inhibition of Aurora-BMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM26282(2-{3-[(7-{3-[4-(hydroxymethyl)piperidin-1-yl]propo...)
Affinity DataKi:  9nM ΔG°:  -10.9kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50319619(Aminopyrimidine, 5 | CHEMBL1085626 | 4-(2,4-Dimeth...)
Affinity DataKi:  9nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAurora kinase B(Human)
Xuzhou Medical College

Curated by ChEMBL
LigandPNGBDBM50277583(2-amino-4-methyl-1,3-thiazol-5-yl)-N-[4-(morpholin...)
Affinity DataKi:  9.20nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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