Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 558 for UniProtKB: Q8WW43
LigandPNGBDBM50185404((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-1-...)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50185410((4aS,6S,8aR)-6-(4-chloro-benzenesulfonyl)-6-(2,5-d...)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50185411((4aS,6S,8aR)-6-(4-chloro-benzenesulfonyl)-6-(2,5-d...)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50410179(CHEMBL2096800)
Affinity DataIC50:  0.140nMAssay Description:Inhibitory activity against Gamma-secretase in HeLa cells expressing APP-reporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50185407((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-3-...)
Affinity DataIC50:  0.190nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135575((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)
Affinity DataIC50:  0.200nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50185414((4aS,6S,8aR)-6-(4-chloro-benzenesulfonyl)-6-(2,5-d...)
Affinity DataIC50:  0.240nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50185405((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-3-...)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135589((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)
Affinity DataIC50:  0.300nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50185413((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-6-...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50185408((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-6-...)
Affinity DataIC50:  0.410nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135578(4-{3-[(S)-3-(3,4-Difluoro-phenyl)-2-methyl-propion...)
Affinity DataIC50:  0.490nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50171224(CHEMBL196215 | Cyclic sulfamide)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory concentration against gamma-secretase in whole cell SH-SY5Y assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50185406((4aS,6S,8aR)-6-(4-chloro-benzenesulfonyl)-6-(2,5-d...)
Affinity DataIC50:  0.760nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135579((S)-N-[(S)-5-Benzo[1,3]dioxol-5-yl-1-(2-hydroxy-et...)
Affinity DataIC50:  0.900nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50185412((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-6-...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50171213(CHEMBL194788 | Cyclic sulfamide)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against gamma-secretase in whole cell SH-SY5Y assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50157959(5-Chloro-thiophene-2-sulfonic acid [5-((E)-3-morph...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50185409((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-6-...)
Affinity DataIC50:  1.17nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135584((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)
Affinity DataIC50:  1.20nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50185403((+/-)-(4aS,6R,8aS)-3-tert-butyl-6-(4-chloro-benzen...)
Affinity DataIC50:  1.39nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135586((S)-N-((S)-5-Benzo[1,3]dioxol-5-yl-1-methylcarbamo...)
Affinity DataIC50:  1.80nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135582((S)-N-((S)-5-Benzo[1,3]dioxol-5-yl-2-oxo-2,3-dihyd...)
Affinity DataIC50:  1.80nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129274(CHEMBL3629745)
Affinity DataIC50:  2nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50171219(CHEMBL198301 | Cyclic sulfamide)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration against gamma-secretase in whole cell SH-SY5Y assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129274(CHEMBL3629745)
Affinity DataIC50:  2nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 40 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135591((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)
Affinity DataIC50:  2.20nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50189039(4-(4-(1-(4-chloro-N-(2,5-difluorophenyl)phenylsulf...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of beta amyloid protein 40 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129273(CHEMBL3629744)
Affinity DataIC50:  3nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 40 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129269(CHEMBL3629738 | US9464103, (6aR,7S,10aS)-10a-(4-ch...)
Affinity DataIC50:  3nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129269(CHEMBL3629738 | US9464103, (6aR,7S,10aS)-10a-(4-ch...)
Affinity DataIC50:  3nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50186575(CHEMBL377206 | cis-methyl 4-(3-(4-chlorophenylsulf...)
Affinity DataIC50:  3nMAssay Description:Inhibition of gamma secretase expressed in SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50166702(2-(1-(4-chlorophenylsulfonyl)cyclohexyl)-1,4-diflu...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of gamma-secretase as amyloid peptide production in SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50171215(CHEMBL198302 | Cyclic sulfamide)
Affinity DataIC50:  3.40nMAssay Description:Inhibitory concentration against gamma-secretase in whole cell SH-SY5Y assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135581((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)
Affinity DataIC50:  3.60nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135590((S)-N-[(S)-5-Benzo[1,3]dioxol-5-yl-2-oxo-1-(3-oxo-...)
Affinity DataIC50:  3.70nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50171223(CHEMBL195551 | Cyclic sulfamide)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration against gamma-secretase in whole cell SH-SY5Y assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50593495(CHEMBL5196156)
Affinity DataIC50:  4.5nMAssay Description:Modulation of gamma-secretase (unknown origin) assessed as decrease in total Abeta42 levelsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50135588((S)-3-(3,4-Difluoro-phenyl)-N-[(S)-5-(2,3-dihydro-...)
Affinity DataIC50:  4.70nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036330(CHEMBL3353090)
Affinity DataIC50:  5nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50157959(5-Chloro-thiophene-2-sulfonic acid [5-((E)-3-morph...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28986(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataIC50:  5nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
LigandPNGBDBM50157998(5-Chloro-thiophene-2-sulfonic acid [5-(2-morpholin...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50158012(CHEMBL183351 | N-[13-(5-Chloro-thiophene-2-sulfony...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151297(CHEMBL3771056)
Affinity DataIC50:  5nMAssay Description:Modulation of gamma-secretase activity (unknown origin) assessed as amyloid-beta(1-42) production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50129273(CHEMBL3629744)
Affinity DataIC50:  5nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 558 total ) | Next | Last >>
Jump to: