TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of MEK5 (unknown origin) expressed in baculovirus expression system incubated for 90 mins in presence of ATP by PKlight ATP detection reag...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of GST-tagged MEK5 (unknown origin) expressed in baculovirus expression system incubated for 90 mins by HTS assayMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of MEK5 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataIC50: 4.30nMAssay Description:Inhibition of MEK5 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataIC50: 10.1nMAssay Description:Inhibition of human MEK5 using ERK5 as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of human MEK5 using ERK5 as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataIC50: 40.4nMAssay Description:Inhibition of human MEK5 using ERK5 as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataIC50: 240nMAssay Description:Inhibition of human MEK5 using ERK5 as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Competitive binding affinity to MAP2K5 in human A375 cells after 15 mins in presence of ATP analogueMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataIC50: 870nMAssay Description:Inhibition of N-terminal FLAG-tagged MEK5 (unknown origin) expressed in baculovirus expression system incubated for 5 mins prior to [gamma-33P]ATP ad...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataIC50: 5.50E+3nMAssay Description:IC50 Table 13-20: The protocol calls for test compound of the invention to be incubated with kinase, substrate, cofactors, and radio-isotope-labeled ...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataIC50: 5.50E+3nMAssay Description:IC50 Table 13-20: The protocol calls for test compound of the invention to be incubated with kinase, substrate, cofactors, and radio-isotope-labeled ...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of N-terminus flag-tagged MEK5 expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintillat...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataIC50: 7.68E+3nMAssay Description:Inhibition of human MEK5 using ERK5 as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminus FLAG-tagged MEK5 expressed in baculovirus expression system using [gamma-33P]-ATP measured after 30 mins by scintillation co...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged MEK5 expressed in baculovirus after 5 mins by scintillation counterMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of MAP2K5More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer
Curated by ChEMBL
Newcastle University Centre For Cancer
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human MEK5 using ERK5 as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair