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Found 18 of ic50 for UniProtKB: A0A024R5Y2
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50434072(CHEMBL2381342)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of MEK5 (unknown origin) expressed in baculovirus expression system incubated for 90 mins in presence of ATP by PKlight ATP detection reag...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50434072(CHEMBL2381342)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of GST-tagged MEK5 (unknown origin) expressed in baculovirus expression system incubated for 90 mins by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50434072(CHEMBL2381342)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of MEK5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50559802(CHEMBL4303171)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of MEK5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  10.1nMAssay Description:Inhibition of human MEK5 using ERK5 as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50545573(CHEMBL4635883 | US11530193, Example 54)
Affinity DataIC50:  25nMAssay Description:Inhibition of human MEK5 using ERK5 as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  40.4nMAssay Description:Inhibition of human MEK5 using ERK5 as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50419254(CHEMBL1835063)
Affinity DataIC50:  240nMAssay Description:Inhibition of human MEK5 using ERK5 as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50096279(CHEMBL3577124)
Affinity DataIC50:  800nMAssay Description:Competitive binding affinity to MAP2K5 in human A375 cells after 15 mins in presence of ATP analogueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50432373(CHEMBL2348417)
Affinity DataIC50:  870nMAssay Description:Inhibition of N-terminal FLAG-tagged MEK5 (unknown origin) expressed in baculovirus expression system incubated for 5 mins prior to [gamma-33P]ATP ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM473172((3R,4R)-3-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazol...)
Affinity DataIC50:  5.50E+3nMAssay Description:IC50 Table 13-20: The protocol calls for test compound of the invention to be incubated with kinase, substrate, cofactors, and radio-isotope-labeled ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM473171((3R,4S)-3-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazol...)
Affinity DataIC50:  5.50E+3nMAssay Description:IC50 Table 13-20: The protocol calls for test compound of the invention to be incubated with kinase, substrate, cofactors, and radio-isotope-labeled ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50358430(CHEMBL1614725)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of N-terminus flag-tagged MEK5 expressed in baculovirus infected insect cells using [gamma33P]ATP as substrate after 60 mins by scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50545576(CHEMBL4640712 | US11530193, Example 50)
Affinity DataIC50:  7.68E+3nMAssay Description:Inhibition of human MEK5 using ERK5 as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50386693(CHEMBL2048912)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminus FLAG-tagged MEK5 expressed in baculovirus expression system using [gamma-33P]-ATP measured after 30 mins by scintillation co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50391643(CHEMBL2148052 | CHEMBL2148053)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminal FLAG-tagged MEK5 expressed in baculovirus after 5 mins by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50401152(CHEMBL2205766)
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of MAP2K5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University Centre For Cancer

Curated by ChEMBL
LigandPNGBDBM50545575(CHEMBL4648967 | US11530193, Example 3)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human MEK5 using ERK5 as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed