Compile Data Set for Download or QSAR
Found 81 of ki for UniProtKB: P28335
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50573248(CHEMBL4848305)
Show SMILES Clc1cccc(c1)-c1n[nH]cc1N1CCNCC1
Show InChI InChI=1S/C13H15ClN4/c14-11-3-1-2-10(8-11)13-12(9-16-17-13)18-6-4-15-5-7-18/h1-3,8-9,15H,4-7H2,(H,16,17)
Affinity DataKi:  16nMAssay Description:Binding affinity to 5HT2C receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50130293(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Show SMILES Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl
Show InChI InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)
Affinity DataKi:  18nMAssay Description:Binding affinity to 5-HT2C receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Show SMILES Cc1nc2CCCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12
Show InChI InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3
Affinity DataKi:  21nMAssay Description:Binding affinity to 5-HT2C receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50568908(CHEMBL4861794)
Show SMILES Nc1ccc(cc1)C(=O)CCCN1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C19H24N4O/c20-17-8-6-16(7-9-17)18(24)4-3-11-22-12-14-23(15-13-22)19-5-1-2-10-21-19/h1-2,5-10H,3-4,11-15,20H2
Affinity DataKi:  32nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50568908(CHEMBL4861794)
Show SMILES Nc1ccc(cc1)C(=O)CCCN1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C19H24N4O/c20-17-8-6-16(7-9-17)18(24)4-3-11-22-12-14-23(15-13-22)19-5-1-2-10-21-19/h1-2,5-10H,3-4,11-15,20H2
Affinity DataKi:  35nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50573251(CHEMBL4856702)
Show SMILES Fc1cccc(c1)-c1n[nH]cc1N1CCNCC1
Show InChI InChI=1S/C13H15FN4/c14-11-3-1-2-10(8-11)13-12(9-16-17-13)18-6-4-15-5-7-18/h1-3,8-9,15H,4-7H2,(H,16,17)
Affinity DataKi:  42nMAssay Description:Binding affinity to 5HT2C receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50130293(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Show SMILES Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl
Show InChI InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)
Affinity DataKi:  95nMAssay Description:Displacement of [3H]-LSD from 5HT2C receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation cou...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50130293(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Show SMILES Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl
Show InChI InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)
Affinity DataKi:  95nMAssay Description:Displacement of [3H]-LSD from 5HT2C receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation cou...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50568914(CHEMBL4874069)
Show SMILES O=C(CCCN1CCN(CC1)c1ccccn1)c1ccc2CCCc2c1
Show InChI InChI=1S/C22H27N3O/c26-21(20-10-9-18-5-3-6-19(18)17-20)7-4-12-24-13-15-25(16-14-24)22-8-1-2-11-23-22/h1-2,8-11,17H,3-7,12-16H2
Affinity DataKi:  111nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50568914(CHEMBL4874069)
Show SMILES O=C(CCCN1CCN(CC1)c1ccccn1)c1ccc2CCCc2c1
Show InChI InChI=1S/C22H27N3O/c26-21(20-10-9-18-5-3-6-19(18)17-20)7-4-12-24-13-15-25(16-14-24)22-8-1-2-11-23-22/h1-2,8-11,17H,3-7,12-16H2
Affinity DataKi:  112nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50578333(CHEMBL4862890)
Show SMILES COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2ccc(=O)[nH]c2c1
Affinity DataKi:  122nMAssay Description:Displacement of [3H]-LSD from 5HT2C receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50578333(CHEMBL4862890)
Show SMILES COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2ccc(=O)[nH]c2c1
Affinity DataKi:  123nMAssay Description:Displacement of [3H]-LSD from 5HT2C receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50130293(7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}...)
Show SMILES Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl
Show InChI InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50443101(Cariprazine | RGH-188)
Show SMILES CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cccc(Cl)c2Cl)CC1
Show InChI InChI=1S/C21H32Cl2N4O/c1-25(2)21(28)24-17-8-6-16(7-9-17)10-11-26-12-14-27(15-13-26)19-5-3-4-18(22)20(19)23/h3-5,16-17H,6-15H2,1-2H3,(H,24,28)/t16-,17-
Affinity DataKi:  198nMAssay Description:Displacement of [3H]-LSD from 5HT2C receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation cou...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50443101(Cariprazine | RGH-188)
Show SMILES CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cccc(Cl)c2Cl)CC1
Show InChI InChI=1S/C21H32Cl2N4O/c1-25(2)21(28)24-17-8-6-16(7-9-17)10-11-26-12-14-27(15-13-26)19-5-3-4-18(22)20(19)23/h3-5,16-17H,6-15H2,1-2H3,(H,24,28)/t16-,17-
Affinity DataKi:  200nMAssay Description:Displacement of [3H]-LSD from 5HT2C receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation cou...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50568907(CHEMBL4859988)
Show SMILES CC(=O)Nc1ccc(CCCCN2CCN(CC2)c2ccccn2)cc1
Show InChI InChI=1S/C21H28N4O/c1-18(26)23-20-10-8-19(9-11-20)6-3-5-13-24-14-16-25(17-15-24)21-7-2-4-12-22-21/h2,4,7-12H,3,5-6,13-17H2,1H3,(H,23,26)
Affinity DataKi:  240nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50568907(CHEMBL4859988)
Show SMILES CC(=O)Nc1ccc(CCCCN2CCN(CC2)c2ccccn2)cc1
Show InChI InChI=1S/C21H28N4O/c1-18(26)23-20-10-8-19(9-11-20)6-3-5-13-24-14-16-25(17-15-24)21-7-2-4-12-22-21/h2,4,7-12H,3,5-6,13-17H2,1H3,(H,23,26)
Affinity DataKi:  242nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50568906(CHEMBL4875079)
Show SMILES OC(=O)C(O)=O.CC(=O)Nc1ccc(cc1)C(=O)CCCN1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C21H26N4O2.C2H2O4/c1-17(26)23-19-9-7-18(8-10-19)20(27)5-4-12-24-13-15-25(16-14-24)21-6-2-3-11-22-21;3-1(4)2(5)6/h2-3,6-11H,4-5,12-16H2,1H3,(H,23,26);(H,3,4)(H,5,6)
Affinity DataKi:  244nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50568906(CHEMBL4875079)
Show SMILES OC(=O)C(O)=O.CC(=O)Nc1ccc(cc1)C(=O)CCCN1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C21H26N4O2.C2H2O4/c1-17(26)23-19-9-7-18(8-10-19)20(27)5-4-12-24-13-15-25(16-14-24)21-6-2-3-11-22-21;3-1(4)2(5)6/h2-3,6-11H,4-5,12-16H2,1H3,(H,23,26);(H,3,4)(H,5,6)
Affinity DataKi:  245nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50578335(CHEMBL4863832)
Show SMILES COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1
Affinity DataKi:  302nMAssay Description:Displacement of [3H]-LSD from 5HT2C receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50578335(CHEMBL4863832)
Show SMILES COc1ccc(F)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1
Affinity DataKi:  305nMAssay Description:Displacement of [3H]-LSD from 5HT2C receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50568919(CHEMBL4857665)
Show SMILES Clc1ccc2C(=O)C(CCCCN3CCN(CC3)c3ccccn3)Cc2c1
Show InChI InChI=1S/C22H26ClN3O/c23-19-7-8-20-18(16-19)15-17(22(20)27)5-2-4-10-25-11-13-26(14-12-25)21-6-1-3-9-24-21/h1,3,6-9,16-17H,2,4-5,10-15H2
Affinity DataKi:  363nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50568919(CHEMBL4857665)
Show SMILES Clc1ccc2C(=O)C(CCCCN3CCN(CC3)c3ccccn3)Cc2c1
Show InChI InChI=1S/C22H26ClN3O/c23-19-7-8-20-18(16-19)15-17(22(20)27)5-2-4-10-25-11-13-26(14-12-25)21-6-1-3-9-24-21/h1,3,6-9,16-17H,2,4-5,10-15H2
Affinity DataKi:  367nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50578337(CHEMBL4862770)
Show SMILES COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2CCC(=O)Nc2c1
Show InChI InChI=1S/C24H29ClN2O3/c1-29-23-8-6-18(25)13-21(23)20-12-17(20)15-26-10-2-3-11-30-19-7-4-16-5-9-24(28)27-22(16)14-19/h4,6-8,13-14,17,20,26H,2-3,5,9-12,15H2,1H3,(H,27,28)/t17-,20+/m1/s1
Affinity DataKi:  372nMAssay Description:Displacement of [3H]-LSD from 5HT2C receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50578337(CHEMBL4862770)
Show SMILES COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCCOc1ccc2CCC(=O)Nc2c1
Show InChI InChI=1S/C24H29ClN2O3/c1-29-23-8-6-18(25)13-21(23)20-12-17(20)15-26-10-2-3-11-30-19-7-4-16-5-9-24(28)27-22(16)14-19/h4,6-8,13-14,17,20,26H,2-3,5,9-12,15H2,1H3,(H,27,28)/t17-,20+/m1/s1
Affinity DataKi:  373nMAssay Description:Displacement of [3H]-LSD from 5HT2C receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50573244(CHEMBL4870675)
Show SMILES COc1cccc(c1)-c1n[nH]cc1N1CCNCC1
Show InChI InChI=1S/C14H18N4O/c1-19-12-4-2-3-11(9-12)14-13(10-16-17-14)18-7-5-15-6-8-18/h2-4,9-10,15H,5-8H2,1H3,(H,16,17)
Affinity DataKi:  407nMAssay Description:Binding affinity to 5HT2C receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50570454(CHEMBL4846866)
Show SMILES CN1CCN(Cc2ccc(OCCCCN3CCC(CC3)c3noc4cc(F)ccc34)cc2)CC1
Show InChI InChI=1S/C28H37FN4O2/c1-31-15-17-33(18-16-31)21-22-4-7-25(8-5-22)34-19-3-2-12-32-13-10-23(11-14-32)28-26-9-6-24(29)20-27(26)35-30-28/h4-9,20,23H,2-3,10-19,21H2,1H3
Affinity DataKi:  426nMAssay Description:Binding affinity to 5-HT2C receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50570453(CHEMBL4865907)
Show SMILES CN1CCN(Cc2ccc(OCCCN3CCC(CC3)c3noc4cc(F)ccc34)cc2)CC1
Show InChI InChI=1S/C27H35FN4O2/c1-30-14-16-32(17-15-30)20-21-3-6-24(7-4-21)33-18-2-11-31-12-9-22(10-13-31)27-25-8-5-23(28)19-26(25)34-29-27/h3-8,19,22H,2,9-18,20H2,1H3
Affinity DataKi:  573nMAssay Description:Binding affinity to 5-HT2C receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50578339(CHEMBL4875081)
Show SMILES COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1
Affinity DataKi:  603nMAssay Description:Displacement of [3H]-LSD from 5HT2C receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50578339(CHEMBL4875081)
Show SMILES COc1ccc(Cl)cc1[C@H]1C[C@@H]1CNCCCOc1ccc2ccc(=O)[nH]c2c1
Affinity DataKi:  604nMAssay Description:Displacement of [3H]-LSD from 5HT2C receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50570456(CHEMBL4867978)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(CCN3CCOCC3)cc2)CC1
Show InChI InChI=1S/C27H34FN3O3/c28-23-4-7-25-26(20-23)34-29-27(25)22-9-13-30(14-10-22)11-1-17-33-24-5-2-21(3-6-24)8-12-31-15-18-32-19-16-31/h2-7,20,22H,1,8-19H2
Affinity DataKi:  610nMAssay Description:Binding affinity to 5-HT2C receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50469497(CHEMBL4289498)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCC(=O)c2cc3CCN4c3c(CCC4=O)c2)CC1
Show InChI InChI=1S/C27H28FN3O3/c28-21-4-5-22-24(16-21)34-29-26(22)17-7-11-30(12-8-17)10-1-2-23(32)20-14-18-3-6-25(33)31-13-9-19(15-20)27(18)31/h4-5,14-17H,1-3,6-13H2
Affinity DataKi:  616nMAssay Description:Binding affinity to 5-HT2C receptor (unknown origin)More data for this Ligand-Target Pair
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Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50570439(CHEMBL4861311)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(CCN3CCCCC3)cc2)CC1
Show InChI InChI=1S/C28H36FN3O2/c29-24-7-10-26-27(21-24)34-30-28(26)23-12-18-32(19-13-23)16-4-20-33-25-8-5-22(6-9-25)11-17-31-14-2-1-3-15-31/h5-10,21,23H,1-4,11-20H2
Affinity DataKi:  753nMAssay Description:Binding affinity to 5-HT2C receptor (unknown origin)More data for this Ligand-Target Pair
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Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50579346(CHEMBL4867565)
Show SMILES Fc1cccc(c1)S(=O)(=O)n1ccc2c(nc3ccccc3c12)N1CCNCC1
Show InChI InChI=1S/C21H19FN4O2S/c22-15-4-3-5-16(14-15)29(27,28)26-11-8-18-20(26)17-6-1-2-7-19(17)24-21(18)25-12-9-23-10-13-25/h1-8,11,14,23H,9-10,12-13H2
Affinity DataKi:  830nMAssay Description:Binding affinity to human 5-HT2C receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50568922(CHEMBL4870361)
Show SMILES O=C1CCc2cc(OCCCN3CCN(CC3)c3ccccn3)ccc12
Show InChI InChI=1S/C21H25N3O2/c25-20-8-5-17-16-18(6-7-19(17)20)26-15-3-10-23-11-13-24(14-12-23)21-4-1-2-9-22-21/h1-2,4,6-7,9,16H,3,5,8,10-15H2
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
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Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50568922(CHEMBL4870361)
Show SMILES O=C1CCc2cc(OCCCN3CCN(CC3)c3ccccn3)ccc12
Show InChI InChI=1S/C21H25N3O2/c25-20-8-5-17-16-18(6-7-19(17)20)26-15-3-10-23-11-13-24(14-12-23)21-4-1-2-9-22-21/h1-2,4,6-7,9,16H,3,5,8,10-15H2
Affinity DataKi:  1.01E+3nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
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Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50568921(CHEMBL4871868)
Show SMILES CC1(CCCCN2CCN(CC2)c2ccccn2)Cc2cc(Cl)ccc2C1=O
Show InChI InChI=1S/C23H28ClN3O/c1-23(17-18-16-19(24)7-8-20(18)22(23)28)9-3-5-11-26-12-14-27(15-13-26)21-6-2-4-10-25-21/h2,4,6-8,10,16H,3,5,9,11-15,17H2,1H3
Affinity DataKi:  1.10E+3nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
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Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50568921(CHEMBL4871868)
Show SMILES CC1(CCCCN2CCN(CC2)c2ccccn2)Cc2cc(Cl)ccc2C1=O
Show InChI InChI=1S/C23H28ClN3O/c1-23(17-18-16-19(24)7-8-20(18)22(23)28)9-3-5-11-26-12-14-27(15-13-26)21-6-2-4-10-25-21/h2,4,6-8,10,16H,3,5,9,11-15,17H2,1H3
Affinity DataKi:  1.10E+3nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
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Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50568911(CHEMBL4857597)
Show SMILES O=C1CCc2cc(CCCCN3CCN(CC3)c3ccccn3)ccc2N1
Show InChI InChI=1S/C22H28N4O/c27-22-10-8-19-17-18(7-9-20(19)24-22)5-2-4-12-25-13-15-26(16-14-25)21-6-1-3-11-23-21/h1,3,6-7,9,11,17H,2,4-5,8,10,12-16H2,(H,24,27)
Affinity DataKi:  1.12E+3nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
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Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50568911(CHEMBL4857597)
Show SMILES O=C1CCc2cc(CCCCN3CCN(CC3)c3ccccn3)ccc2N1
Show InChI InChI=1S/C22H28N4O/c27-22-10-8-19-17-18(7-9-20(19)24-22)5-2-4-12-25-13-15-26(16-14-25)21-6-1-3-11-23-21/h1,3,6-7,9,11,17H,2,4-5,8,10,12-16H2,(H,24,27)
Affinity DataKi:  1.13E+3nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
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Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50568912(CHEMBL4865591)
Show SMILES O=C1CCc2cc(OCCCN3CCN(CC3)c3ccccn3)ccc2N1
Show InChI InChI=1S/C21H26N4O2/c26-21-8-5-17-16-18(6-7-19(17)23-21)27-15-3-10-24-11-13-25(14-12-24)20-4-1-2-9-22-20/h1-2,4,6-7,9,16H,3,5,8,10-15H2,(H,23,26)
Affinity DataKi:  1.19E+3nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
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Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50568912(CHEMBL4865591)
Show SMILES O=C1CCc2cc(OCCCN3CCN(CC3)c3ccccn3)ccc2N1
Show InChI InChI=1S/C21H26N4O2/c26-21-8-5-17-16-18(6-7-19(17)23-21)27-15-3-10-24-11-13-25(14-12-24)20-4-1-2-9-22-20/h1-2,4,6-7,9,16H,3,5,8,10-15H2,(H,23,26)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
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Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50036733(1-(4-Fluoro-phenyl)-4-(4-pyridin-2-yl-piperazin-1-...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C19H22FN3O/c20-17-8-6-16(7-9-17)18(24)4-3-11-22-12-14-23(15-13-22)19-5-1-2-10-21-19/h1-2,5-10H,3-4,11-15H2
Affinity DataKi:  1.35E+3nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50568920(CHEMBL4846823)
Show SMILES CC1(CCCN2CCN(CC2)c2ccccn2)Cc2cc(Cl)ccc2C1=O
Show InChI InChI=1S/C22H26ClN3O/c1-22(16-17-15-18(23)6-7-19(17)21(22)27)8-4-10-25-11-13-26(14-12-25)20-5-2-3-9-24-20/h2-3,5-7,9,15H,4,8,10-14,16H2,1H3
Affinity DataKi:  1.45E+3nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
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Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50568920(CHEMBL4846823)
Show SMILES CC1(CCCN2CCN(CC2)c2ccccn2)Cc2cc(Cl)ccc2C1=O
Show InChI InChI=1S/C22H26ClN3O/c1-22(16-17-15-18(23)6-7-19(17)21(22)27)8-4-10-25-11-13-26(14-12-25)20-5-2-3-9-24-20/h2-3,5-7,9,15H,4,8,10-14,16H2,1H3
Affinity DataKi:  1.45E+3nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
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Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50036733(1-(4-Fluoro-phenyl)-4-(4-pyridin-2-yl-piperazin-1-...)
Show SMILES Fc1ccc(cc1)C(=O)CCCN1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C19H22FN3O/c20-17-8-6-16(7-9-17)18(24)4-3-11-22-12-14-23(15-13-22)19-5-1-2-10-21-19/h1-2,5-10H,3-4,11-15H2
Affinity DataKi:  1.54E+3nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50208447(CHEMBL3883955)
Show SMILES Fc1ccc2c(noc2c1)C1CCN(CCCOc2ccc(=O)n(n2)-c2c(F)cccc2F)CC1
Show InChI InChI=1S/C25H23F3N4O3/c26-17-5-6-18-21(15-17)35-30-24(18)16-9-12-31(13-10-16)11-2-14-34-22-7-8-23(33)32(29-22)25-19(27)3-1-4-20(25)28/h1,3-8,15-16H,2,9-14H2
Affinity DataKi:  1.58E+3nMAssay Description:Binding affinity to 5-HT2C receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50568918(CHEMBL4854456)
Show SMILES Clc1cc2CC(CCN3CCN(CC3)c3ccccn3)C(=O)c2cc1Cl
Show InChI InChI=1S/C20H21Cl2N3O/c21-17-12-15-11-14(20(26)16(15)13-18(17)22)4-6-24-7-9-25(10-8-24)19-3-1-2-5-23-19/h1-3,5,12-14H,4,6-11H2
Affinity DataKi:  1.64E+3nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
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Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50568918(CHEMBL4854456)
Show SMILES Clc1cc2CC(CCN3CCN(CC3)c3ccccn3)C(=O)c2cc1Cl
Show InChI InChI=1S/C20H21Cl2N3O/c21-17-12-15-11-14(20(26)16(15)13-18(17)22)4-6-24-7-9-25(10-8-24)19-3-1-2-5-23-19/h1-3,5,12-14H,4,6-11H2
Affinity DataKi:  1.66E+3nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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Target5-hydroxytryptamine receptor 2C(Homo sapiens)
Korea Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50568917(CHEMBL4876297)
Show SMILES Clc1ccc2CC(CCN3CCN(CC3)c3ccccn3)C(=O)c2c1
Show InChI InChI=1S/C20H22ClN3O/c21-17-5-4-15-13-16(20(25)18(15)14-17)6-8-23-9-11-24(12-10-23)19-3-1-2-7-22-19/h1-5,7,14,16H,6,8-13H2
Affinity DataKi:  1.68E+3nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor incubated for 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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