Compile Data Set for Download or QSAR
Found 24 of affinity data for UniProtKB/TrEMBL: P10092
TargetCalcitonin gene-related peptide 2(Homo sapiens)
University of Sheffield

Curated by ChEMBL
LigandPNGBDBM50570408(CHEMBL4873687)
Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccc1CNC(N)=N
Show InChI InChI=1S/C31H35N7O3/c1-30(2,3)28(41)38(17-21-8-5-4-7-20(21)16-35-29(32)33)18-25(39)36-23-11-10-19-14-31(15-22(19)13-23)24-9-6-12-34-26(24)37-27(31)40/h4-13H,14-18H2,1-3H3,(H,36,39)(H4,32,33,35)(H,34,37,40)
Affinity DataIC50: 0.631nMAssay Description:Antagonist activity at human CGRP-2 (8 to 37 residues) expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCalcitonin gene-related peptide 2(Homo sapiens)
University of Sheffield

Curated by ChEMBL
LigandPNGBDBM50570410(CHEMBL4851152)
Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccc1CNC1CC1
Show InChI InChI=1S/C33H37N5O3/c1-32(2,3)31(41)38(19-23-8-5-4-7-22(23)18-35-25-12-13-25)20-28(39)36-26-11-10-21-16-33(17-24(21)15-26)27-9-6-14-34-29(27)37-30(33)40/h4-11,14-15,25,35H,12-13,16-20H2,1-3H3,(H,36,39)(H,34,37,40)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human CGRP-2 (8 to 37 residues) expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCalcitonin gene-related peptide 2(Homo sapiens)
University of Sheffield

Curated by ChEMBL
LigandPNGBDBM50570413(CHEMBL4850259)
Show SMILES CC(N)c1ccccc1CN(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)C(=O)C(C)(C)C
Show InChI InChI=1S/C31H35N5O3/c1-19(32)24-9-6-5-8-21(24)17-36(29(39)30(2,3)4)18-26(37)34-23-12-11-20-15-31(16-22(20)14-23)25-10-7-13-33-27(25)35-28(31)38/h5-14,19H,15-18,32H2,1-4H3,(H,34,37)(H,33,35,38)
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at human CGRP-2 (8 to 37 residues) expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCalcitonin gene-related peptide 2(Homo sapiens)
University of Sheffield

Curated by ChEMBL
LigandPNGBDBM50570411(CHEMBL4877585)
Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccc1CN1CCC1
Show InChI InChI=1S/C33H37N5O3/c1-32(2,3)31(41)38(20-24-9-5-4-8-23(24)19-37-14-7-15-37)21-28(39)35-26-12-11-22-17-33(18-25(22)16-26)27-10-6-13-34-29(27)36-30(33)40/h4-6,8-13,16H,7,14-15,17-21H2,1-3H3,(H,35,39)(H,34,36,40)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human CGRP-2 (8 to 37 residues) expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCalcitonin gene-related peptide 2(Homo sapiens)
University of Sheffield

Curated by ChEMBL
LigandPNGBDBM50570401(CHEMBL4879142)
Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccc1CCN
Show InChI InChI=1S/C31H35N5O3/c1-30(2,3)29(39)36(18-22-8-5-4-7-20(22)12-13-32)19-26(37)34-24-11-10-21-16-31(17-23(21)15-24)25-9-6-14-33-27(25)35-28(31)38/h4-11,14-15H,12-13,16-19,32H2,1-3H3,(H,34,37)(H,33,35,38)
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at human CGRP-2 (8 to 37 residues) expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCalcitonin gene-related peptide 2(Homo sapiens)
University of Sheffield

Curated by ChEMBL
LigandPNGBDBM50570404(CHEMBL4850583)
Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccc1Cn1ccnc1
Show InChI InChI=1S/C33H34N6O3/c1-32(2,3)31(42)39(19-24-8-5-4-7-23(24)18-38-14-13-34-21-38)20-28(40)36-26-11-10-22-16-33(17-25(22)15-26)27-9-6-12-35-29(27)37-30(33)41/h4-15,21H,16-20H2,1-3H3,(H,36,40)(H,35,37,41)
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at human CGRP-2 (8 to 37 residues) expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCalcitonin gene-related peptide 2(Homo sapiens)
University of Sheffield

Curated by ChEMBL
LigandPNGBDBM50570396(CHEMBL4871934)
Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccc1N
Show InChI InChI=1S/C29H31N5O3/c1-28(2,3)27(37)34(16-19-7-4-5-9-23(19)30)17-24(35)32-21-11-10-18-14-29(15-20(18)13-21)22-8-6-12-31-25(22)33-26(29)36/h4-13H,14-17,30H2,1-3H3,(H,32,35)(H,31,33,36)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human CGRP-2 (8 to 37 residues) expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCalcitonin gene-related peptide 2(Homo sapiens)
University of Sheffield

Curated by ChEMBL
LigandPNGBDBM50570409(CHEMBL4857810)
Show SMILES CNCc1ccccc1CN(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)C(=O)C(C)(C)C
Show InChI InChI=1S/C31H35N5O3/c1-30(2,3)29(39)36(18-22-9-6-5-8-21(22)17-32-4)19-26(37)34-24-12-11-20-15-31(16-23(20)14-24)25-10-7-13-33-27(25)35-28(31)38/h5-14,32H,15-19H2,1-4H3,(H,34,37)(H,33,35,38)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human CGRP-2 (8 to 37 residues) expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCalcitonin gene-related peptide 2(Homo sapiens)
University of Sheffield

Curated by ChEMBL
LigandPNGBDBM50570398(CHEMBL4861626)
Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccc1CO
Show InChI InChI=1S/C30H32N4O4/c1-29(2,3)28(38)34(16-20-7-4-5-8-21(20)18-35)17-25(36)32-23-11-10-19-14-30(15-22(19)13-23)24-9-6-12-31-26(24)33-27(30)37/h4-13,35H,14-18H2,1-3H3,(H,32,36)(H,31,33,37)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at human CGRP-2 (8 to 37 residues) expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCalcitonin gene-related peptide 2(Homo sapiens)
University of Sheffield

Curated by ChEMBL
LigandPNGBDBM50570397(CHEMBL4852669)
Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccc1CN
Show InChI InChI=1S/C30H33N5O3/c1-29(2,3)28(38)35(17-21-8-5-4-7-20(21)16-31)18-25(36)33-23-11-10-19-14-30(15-22(19)13-23)24-9-6-12-32-26(24)34-27(30)37/h4-13H,14-18,31H2,1-3H3,(H,33,36)(H,32,34,37)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at human CGRP-2 (8 to 37 residues) expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCalcitonin gene-related peptide 2(Homo sapiens)
University of Sheffield

Curated by ChEMBL
LigandPNGBDBM50570395(CHEMBL4866915)
Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1cccc2[nH]ncc12
Affinity DataIC50: 5nMAssay Description:Antagonist activity at human CGRP-2 (8 to 37 residues) expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCalcitonin gene-related peptide 2(Homo sapiens)
University of Sheffield

Curated by ChEMBL
LigandPNGBDBM50570403(CHEMBL4874651)
Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccc1CN1CCOCC1
Show InChI InChI=1S/C34H39N5O4/c1-33(2,3)32(42)39(21-25-8-5-4-7-24(25)20-38-13-15-43-16-14-38)22-29(40)36-27-11-10-23-18-34(19-26(23)17-27)28-9-6-12-35-30(28)37-31(34)41/h4-12,17H,13-16,18-22H2,1-3H3,(H,36,40)(H,35,37,41)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at human CGRP-2 (8 to 37 residues) expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCalcitonin gene-related peptide 2(Homo sapiens)
University of Sheffield

Curated by ChEMBL
LigandPNGBDBM50570394(CHEMBL4866548)
Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccc1C1CCNC1
Show InChI InChI=1S/C33H37N5O3/c1-32(2,3)31(41)38(19-23-7-4-5-8-26(23)22-12-14-34-18-22)20-28(39)36-25-11-10-21-16-33(17-24(21)15-25)27-9-6-13-35-29(27)37-30(33)40/h4-11,13,15,22,34H,12,14,16-20H2,1-3H3,(H,36,39)(H,35,37,40)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at human CGRP-2 (8 to 37 residues) expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCalcitonin gene-related peptide 2(Homo sapiens)
University of Sheffield

Curated by ChEMBL
LigandPNGBDBM50570406(CHEMBL4862324)
Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccc1C#N
Show InChI InChI=1S/C30H29N5O3/c1-29(2,3)28(38)35(17-21-8-5-4-7-20(21)16-31)18-25(36)33-23-11-10-19-14-30(15-22(19)13-23)24-9-6-12-32-26(24)34-27(30)37/h4-13H,14-15,17-18H2,1-3H3,(H,33,36)(H,32,34,37)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at human CGRP-2 (8 to 37 residues) expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCalcitonin gene-related peptide 2(Homo sapiens)
University of Sheffield

Curated by ChEMBL
LigandPNGBDBM50570400(CHEMBL4876643)
Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccc1C(N)=O
Show InChI InChI=1S/C30H31N5O4/c1-29(2,3)28(39)35(16-19-7-4-5-8-22(19)25(31)37)17-24(36)33-21-11-10-18-14-30(15-20(18)13-21)23-9-6-12-32-26(23)34-27(30)38/h4-13H,14-17H2,1-3H3,(H2,31,37)(H,33,36)(H,32,34,38)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at human CGRP-2 (8 to 37 residues) expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCalcitonin gene-related peptide 2(Homo sapiens)
University of Sheffield

Curated by ChEMBL
LigandPNGBDBM50570392(CHEMBL4870543)
Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccnn1-c1ccccc1
Show InChI InChI=1S/C32H32N6O3/c1-31(2,3)30(41)37(19-25-13-15-34-38(25)24-8-5-4-6-9-24)20-27(39)35-23-12-11-21-17-32(18-22(21)16-23)26-10-7-14-33-28(26)36-29(32)40/h4-16H,17-20H2,1-3H3,(H,35,39)(H,33,36,40)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at human CGRP-2 (8 to 37 residues) expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCalcitonin gene-related peptide 2(Homo sapiens)
University of Sheffield

Curated by ChEMBL
LigandPNGBDBM50570393(CHEMBL4878394)
Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1nccs1
Show InChI InChI=1S/C26H27N5O3S/c1-25(2,3)24(34)31(15-21-27-9-10-35-21)14-20(32)29-18-7-6-16-12-26(13-17(16)11-18)19-5-4-8-28-22(19)30-23(26)33/h4-11H,12-15H2,1-3H3,(H,29,32)(H,28,30,33)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at human CGRP-2 (8 to 37 residues) expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCalcitonin gene-related peptide 2(Homo sapiens)
University of Sheffield

Curated by ChEMBL
LigandPNGBDBM50570390(CHEMBL4851106)
Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccn1
Show InChI InChI=1S/C28H29N5O3/c1-27(2,3)26(36)33(16-21-7-4-5-11-29-21)17-23(34)31-20-10-9-18-14-28(15-19(18)13-20)22-8-6-12-30-24(22)32-25(28)35/h4-13H,14-17H2,1-3H3,(H,31,34)(H,30,32,35)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at human CGRP-2 (8 to 37 residues) expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCalcitonin gene-related peptide 2(Homo sapiens)
University of Sheffield

Curated by ChEMBL
LigandPNGBDBM50570402(CHEMBL4856402)
Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1cccc2CCNCc12
Show InChI InChI=1S/C32H35N5O3/c1-31(2,3)30(40)37(18-22-7-4-6-20-11-13-33-17-25(20)22)19-27(38)35-24-10-9-21-15-32(16-23(21)14-24)26-8-5-12-34-28(26)36-29(32)39/h4-10,12,14,33H,11,13,15-19H2,1-3H3,(H,35,38)(H,34,36,39)
Affinity DataIC50: 126nMAssay Description:Antagonist activity at human CGRP-2 (8 to 37 residues) expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCalcitonin gene-related peptide 2(Homo sapiens)
University of Sheffield

Curated by ChEMBL
LigandPNGBDBM50570412(CHEMBL4853766)
Show SMILES CC(N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)C(=O)C(C)(C)C)c1ccccc1CN
Show InChI InChI=1S/C31H35N5O3/c1-19(24-9-6-5-8-21(24)17-32)36(29(39)30(2,3)4)18-26(37)34-23-12-11-20-15-31(16-22(20)14-23)25-10-7-13-33-27(25)35-28(31)38/h5-14,19H,15-18,32H2,1-4H3,(H,34,37)(H,33,35,38)
Affinity DataIC50: 200nMAssay Description:Antagonist activity at human CGRP-2 (8 to 37 residues) expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCalcitonin gene-related peptide 2(Homo sapiens)
University of Sheffield

Curated by ChEMBL
LigandPNGBDBM50570405(CHEMBL4874859)
Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ccccc1-c1cccnc1
Show InChI InChI=1S/C34H33N5O3/c1-33(2,3)32(42)39(20-24-8-4-5-10-27(24)23-9-6-14-35-19-23)21-29(40)37-26-13-12-22-17-34(18-25(22)16-26)28-11-7-15-36-30(28)38-31(34)41/h4-16,19H,17-18,20-21H2,1-3H3,(H,37,40)(H,36,38,41)
Affinity DataIC50: 398nMAssay Description:Antagonist activity at human CGRP-2 (8 to 37 residues) expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCalcitonin gene-related peptide 2(Homo sapiens)
University of Sheffield

Curated by ChEMBL
LigandPNGBDBM50570407(CHEMBL4865654)
Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1ncccc1CN
Show InChI InChI=1S/C29H32N6O3/c1-28(2,3)27(38)35(16-23-19(15-30)6-4-10-31-23)17-24(36)33-21-9-8-18-13-29(14-20(18)12-21)22-7-5-11-32-25(22)34-26(29)37/h4-12H,13-17,30H2,1-3H3,(H,33,36)(H,32,34,37)
Affinity DataIC50: 501nMAssay Description:Antagonist activity at human CGRP-2 (8 to 37 residues) expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCalcitonin gene-related peptide 2(Homo sapiens)
University of Sheffield

Curated by ChEMBL
LigandPNGBDBM50570399(CHEMBL4846989)
Show SMILES CC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1cccc(CN)c1
Show InChI InChI=1S/C30H33N5O3/c1-29(2,3)28(38)35(17-20-7-4-6-19(12-20)16-31)18-25(36)33-23-10-9-21-14-30(15-22(21)13-23)24-8-5-11-32-26(24)34-27(30)37/h4-13H,14-18,31H2,1-3H3,(H,33,36)(H,32,34,37)
Affinity DataIC50: 794nMAssay Description:Antagonist activity at human CGRP-2 (8 to 37 residues) expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCalcitonin gene-related peptide 2(Homo sapiens)
University of Sheffield

Curated by ChEMBL
LigandPNGBDBM50570391(CHEMBL4876213)
Show SMILES CN1CCCC(CN(CC(=O)Nc2ccc3CC4(Cc3c2)C(=O)Nc2ncccc42)C(=O)C(C)(C)C)C1
Show InChI InChI=1S/C29H37N5O3/c1-28(2,3)27(37)34(17-19-7-6-12-33(4)16-19)18-24(35)31-22-10-9-20-14-29(15-21(20)13-22)23-8-5-11-30-25(23)32-26(29)36/h5,8-11,13,19H,6-7,12,14-18H2,1-4H3,(H,31,35)(H,30,32,36)
Affinity DataIC50: 3.16E+3nMAssay Description:Antagonist activity at human CGRP-2 (8 to 37 residues) expressed in 1321N1 cells assessed as inhibition of forskolin-induced cAMP accumulation preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid