Compile Data Set for Download or QSAR
Found 30 of affinity data for UniProtKB/TrEMBL: P05198
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570964(CHEMBL4857782)
Show SMILES CCc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(c1)C(=O)NC(C)C
Show InChI InChI=1S/C25H26F2N4O3/c1-4-14-9-19(31-25(34)22(32)15-7-17(26)11-18(27)8-15)5-6-20(14)16-10-21(23(28)29-12-16)24(33)30-13(2)3/h5-13,22,32H,4H2,1-3H3,(H2,28,29)(H,30,33)(H,31,34)/t22-/m1/s1
Affinity DataIC50: 9nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570960(CHEMBL4858308)
Show SMILES CCc1cccc(c1)[C@@H](O)C(=O)Nc1ccc(c(C)c1)-c1cnc(N)c(c1)C(=O)NC(C)C
Show InChI InChI=1S/C26H30N4O3/c1-5-17-7-6-8-18(12-17)23(31)26(33)30-20-9-10-21(16(4)11-20)19-13-22(24(27)28-14-19)25(32)29-15(2)3/h6-15,23,31H,5H2,1-4H3,(H2,27,28)(H,29,32)(H,30,33)/t23-/m1/s1
Affinity DataIC50: 18nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570963(CHEMBL4848143)
Show SMILES CC(C)NC(=O)c1cc(cnc1N)-c1ccc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)cc1Cl
Show InChI InChI=1S/C23H21ClF2N4O3/c1-11(2)29-22(32)18-7-13(10-28-21(18)27)17-4-3-16(9-19(17)24)30-23(33)20(31)12-5-14(25)8-15(26)6-12/h3-11,20,31H,1-2H3,(H2,27,28)(H,29,32)(H,30,33)/t20-/m1/s1
Affinity DataIC50: 23nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570956(CHEMBL4869882)
Show SMILES Cc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(c1)C(=O)NC1CC1
Show InChI InChI=1S/C24H22F2N4O3/c1-12-6-18(30-24(33)21(31)13-7-15(25)10-16(26)8-13)4-5-19(12)14-9-20(22(27)28-11-14)23(32)29-17-2-3-17/h4-11,17,21,31H,2-3H2,1H3,(H2,27,28)(H,29,32)(H,30,33)/t21-/m1/s1
Affinity DataIC50: 27nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570941(CHEMBL4862478)
Show SMILES CC(C)NC(=O)c1cc(cnc1N)-c1ccc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)cc1C
Show InChI InChI=1S/C24H24F2N4O3/c1-12(2)29-23(32)20-9-15(11-28-22(20)27)19-5-4-18(6-13(19)3)30-24(33)21(31)14-7-16(25)10-17(26)8-14/h4-12,21,31H,1-3H3,(H2,27,28)(H,29,32)(H,30,33)/t21-/m1/s1
Affinity DataIC50: 33nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570972(CHEMBL4848359)
Show SMILES CNC(=O)c1nc(cnc1N)-c1ccc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)cc1C
Show InChI InChI=1S/C21H19F2N5O3/c1-10-5-14(27-21(31)18(29)11-6-12(22)8-13(23)7-11)3-4-15(10)16-9-26-19(24)17(28-16)20(30)25-2/h3-9,18,29H,1-2H3,(H2,24,26)(H,25,30)(H,27,31)/t18-/m1/s1
Affinity DataIC50: 40nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570958(CHEMBL4853221)
Show SMILES CC(C)NC(=O)c1cc(cnc1N)-c1ccc(NC(=O)[C@H](O)c2cccc(Cl)c2)cc1C
Show InChI InChI=1S/C24H25ClN4O3/c1-13(2)28-23(31)20-11-16(12-27-22(20)26)19-8-7-18(9-14(19)3)29-24(32)21(30)15-5-4-6-17(25)10-15/h4-13,21,30H,1-3H3,(H2,26,27)(H,28,31)(H,29,32)/t21-/m1/s1
Affinity DataIC50: 40nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570966(CHEMBL4861671)
Show SMILES CC(C)NC(=O)c1nc(cnc1N)-c1ccc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)cc1C
Show InChI InChI=1S/C23H23F2N5O3/c1-11(2)28-22(32)19-21(26)27-10-18(30-19)17-5-4-16(6-12(17)3)29-23(33)20(31)13-7-14(24)9-15(25)8-13/h4-11,20,31H,1-3H3,(H2,26,27)(H,28,32)(H,29,33)/t20-/m1/s1
Affinity DataIC50: 42nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570955(CHEMBL4863698)
Show SMILES CCNC(=O)c1cc(cnc1N)-c1ccc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)cc1C
Show InChI InChI=1S/C23H22F2N4O3/c1-3-27-22(31)19-9-14(11-28-21(19)26)18-5-4-17(6-12(18)2)29-23(32)20(30)13-7-15(24)10-16(25)8-13/h4-11,20,30H,3H2,1-2H3,(H2,26,28)(H,27,31)(H,29,32)/t20-/m1/s1
Affinity DataIC50: 45nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570952(CHEMBL4870100)
Show SMILES CC(C)OC(=O)c1cc(cnc1N)-c1ccc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)cc1C
Show InChI InChI=1S/C24H23F2N3O4/c1-12(2)33-24(32)20-9-15(11-28-22(20)27)19-5-4-18(6-13(19)3)29-23(31)21(30)14-7-16(25)10-17(26)8-14/h4-12,21,30H,1-3H3,(H2,27,28)(H,29,31)/t21-/m1/s1
Affinity DataIC50: 49nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570959(CHEMBL4870780)
Show SMILES CC(C)NC(=O)c1cc(cnc1N)-c1ccc(NC(=O)[C@H](O)c2cccc(C)c2)cc1C
Show InChI InChI=1S/C25H28N4O3/c1-14(2)28-24(31)21-12-18(13-27-23(21)26)20-9-8-19(11-16(20)4)29-25(32)22(30)17-7-5-6-15(3)10-17/h5-14,22,30H,1-4H3,(H2,26,27)(H,28,31)(H,29,32)/t22-/m1/s1
Affinity DataIC50: 54nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570953(CHEMBL4875875)
Show SMILES CNC(=O)c1cc(cnc1N)-c1ccc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)cc1C
Show InChI InChI=1S/C22H20F2N4O3/c1-11-5-16(28-22(31)19(29)12-6-14(23)9-15(24)7-12)3-4-17(11)13-8-18(21(30)26-2)20(25)27-10-13/h3-10,19,29H,1-2H3,(H2,25,27)(H,26,30)(H,28,31)/t19-/m1/s1
Affinity DataIC50: 58nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570962(CHEMBL4851480)
Show SMILES CC(C)NC(=O)c1cc(cnc1N)-c1ccc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)cc1F
Show InChI InChI=1S/C23H21F3N4O3/c1-11(2)29-22(32)18-7-13(10-28-21(18)27)17-4-3-16(9-19(17)26)30-23(33)20(31)12-5-14(24)8-15(25)6-12/h3-11,20,31H,1-2H3,(H2,27,28)(H,29,32)(H,30,33)/t20-/m1/s1
Affinity DataIC50: 72nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570957(CHEMBL4876496)
Show SMILES Cc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(c1)C(=O)NC(C)(C)C
Show InChI InChI=1S/C25H26F2N4O3/c1-13-7-18(30-24(34)21(32)14-8-16(26)11-17(27)9-14)5-6-19(13)15-10-20(22(28)29-12-15)23(33)31-25(2,3)4/h5-12,21,32H,1-4H3,(H2,28,29)(H,30,34)(H,31,33)/t21-/m1/s1
Affinity DataIC50: 114nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570968(CHEMBL4854504)
Show SMILES CC(C)NC(=O)c1cncc(c1)-c1ccc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)cc1C
Show InChI InChI=1S/C24H23F2N3O3/c1-13(2)28-23(31)17-7-16(11-27-12-17)21-5-4-20(6-14(21)3)29-24(32)22(30)15-8-18(25)10-19(26)9-15/h4-13,22,30H,1-3H3,(H,28,31)(H,29,32)/t22-/m1/s1
Affinity DataIC50: 181nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570942(CHEMBL4852735)
Show SMILES CC(C)NC(=O)c1cc(cnc1N)-c1ccc(NC(=O)[C@@H](O)c2cc(F)cc(F)c2)cc1C
Show InChI InChI=1S/C24H24F2N4O3/c1-12(2)29-23(32)20-9-15(11-28-22(20)27)19-5-4-18(6-13(19)3)30-24(33)21(31)14-7-16(25)10-17(26)8-14/h4-12,21,31H,1-3H3,(H2,27,28)(H,29,32)(H,30,33)/t21-/m0/s1
Affinity DataIC50: 187nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570943(CHEMBL4870495)
Show SMILES CC(C)NC(=O)c1cc(cnc1N)-c1ccc(NC(=O)[C@H](O)c2ccccc2)cc1C
Show InChI InChI=1S/C24H26N4O3/c1-14(2)27-23(30)20-12-17(13-26-22(20)25)19-10-9-18(11-15(19)3)28-24(31)21(29)16-7-5-4-6-8-16/h4-14,21,29H,1-3H3,(H2,25,26)(H,27,30)(H,28,31)/t21-/m1/s1
Affinity DataIC50: 198nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570944(CHEMBL4866245)
Show SMILES CC(C)NC(=O)c1cc(cnc1N)-c1ccc(NC(=O)Cc2ccccc2)cc1C
Show InChI InChI=1S/C24H26N4O2/c1-15(2)27-24(30)21-13-18(14-26-23(21)25)20-10-9-19(11-16(20)3)28-22(29)12-17-7-5-4-6-8-17/h4-11,13-15H,12H2,1-3H3,(H2,25,26)(H,27,30)(H,28,29)
Affinity DataIC50: 307nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570961(CHEMBL4846663)
Show SMILES CC(C)NC(=O)c1cc(cnc1N)-c1ccc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)cc1
Show InChI InChI=1S/C23H22F2N4O3/c1-12(2)28-22(31)19-9-15(11-27-21(19)26)13-3-5-18(6-4-13)29-23(32)20(30)14-7-16(24)10-17(25)8-14/h3-12,20,30H,1-2H3,(H2,26,27)(H,28,31)(H,29,32)/t20-/m1/s1
Affinity DataIC50: 313nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570965(CHEMBL4870565)
Show SMILES COc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1cnc(N)c(c1)C(=O)NC(C)C
Show InChI InChI=1S/C24H24F2N4O4/c1-12(2)29-23(32)19-8-14(11-28-22(19)27)18-5-4-17(10-20(18)34-3)30-24(33)21(31)13-6-15(25)9-16(26)7-13/h4-12,21,31H,1-3H3,(H2,27,28)(H,29,32)(H,30,33)/t21-/m1/s1
Affinity DataIC50: 366nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570969(CHEMBL4849149)
Show SMILES CC(C)NC(=O)c1cc(cnc1C)-c1ccc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)cc1C
Show InChI InChI=1S/C25H25F2N3O3/c1-13(2)29-24(32)22-10-17(12-28-15(22)4)21-6-5-20(7-14(21)3)30-25(33)23(31)16-8-18(26)11-19(27)9-16/h5-13,23,31H,1-4H3,(H,29,32)(H,30,33)/t23-/m1/s1
Affinity DataIC50: 638nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570948(CHEMBL4868021)
Show SMILES CC(C)NC(=O)c1cc(cnc1N)-c1ccc(NC(=O)[C@](C)(O)c2ccccc2)cc1C
Show InChI InChI=1S/C25H28N4O3/c1-15(2)28-23(30)21-13-17(14-27-22(21)26)20-11-10-19(12-16(20)3)29-24(31)25(4,32)18-8-6-5-7-9-18/h5-15,32H,1-4H3,(H2,26,27)(H,28,30)(H,29,31)/t25-/m1/s1
Affinity DataIC50: 2.13E+3nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570954(CHEMBL4876223)
Show SMILES CN(C)C(=O)c1cc(cnc1N)-c1ccc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)cc1C
Show InChI InChI=1S/C23H22F2N4O3/c1-12-6-17(28-22(31)20(30)13-7-15(24)10-16(25)8-13)4-5-18(12)14-9-19(21(26)27-11-14)23(32)29(2)3/h4-11,20,30H,1-3H3,(H2,26,27)(H,28,31)/t20-/m1/s1
Affinity DataIC50: 2.22E+3nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570946(CHEMBL4853233)
Show SMILES CC(C)NC(=O)c1cc(cnc1N)-c1ccc(NC(=O)Nc2ccccc2)cc1C
Show InChI InChI=1S/C23H25N5O2/c1-14(2)26-22(29)20-12-16(13-25-21(20)24)19-10-9-18(11-15(19)3)28-23(30)27-17-7-5-4-6-8-17/h4-14H,1-3H3,(H2,24,25)(H,26,29)(H2,27,28,30)
Affinity DataIC50: 2.36E+3nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570949(CHEMBL4848921)
Show SMILES CC(C)NC(=O)c1cc(cnc1N)-c1ccc(NC(=O)[C@@](C)(O)c2ccccc2)cc1C
Show InChI InChI=1S/C25H28N4O3/c1-15(2)28-23(30)21-13-17(14-27-22(21)26)20-11-10-19(12-16(20)3)29-24(31)25(4,32)18-8-6-5-7-9-18/h5-15,32H,1-4H3,(H2,26,27)(H,28,30)(H,29,31)/t25-/m0/s1
Affinity DataIC50: 3.02E+3nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570947(CHEMBL4854364)
Show SMILES CO[C@@H](C(=O)Nc1ccc(c(C)c1)-c1cnc(N)c(c1)C(=O)NC(C)C)c1ccccc1
Show InChI InChI=1S/C25H28N4O3/c1-15(2)28-24(30)21-13-18(14-27-23(21)26)20-11-10-19(12-16(20)3)29-25(31)22(32-4)17-8-6-5-7-9-17/h5-15,22H,1-4H3,(H2,26,27)(H,28,30)(H,29,31)/t22-/m1/s1
Affinity DataIC50: 3.34E+3nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570970(CHEMBL4858598)
Show SMILES CNc1ncc(cc1C(=O)NC(C)C)-c1ccc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)cc1C
Show InChI InChI=1S/C25H26F2N4O3/c1-13(2)30-24(33)21-10-16(12-29-23(21)28-4)20-6-5-19(7-14(20)3)31-25(34)22(32)15-8-17(26)11-18(27)9-15/h5-13,22,32H,1-4H3,(H,28,29)(H,30,33)(H,31,34)/t22-/m1/s1
Affinity DataIC50: 4.03E+3nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570967(CHEMBL4878188)
Show SMILES CC(C)NC(=O)c1cc(nnc1N)-c1ccc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)cc1C
Show InChI InChI=1S/C23H23F2N5O3/c1-11(2)27-22(32)18-10-19(29-30-21(18)26)17-5-4-16(6-12(17)3)28-23(33)20(31)13-7-14(24)9-15(25)8-13/h4-11,20,31H,1-3H3,(H2,26,30)(H,27,32)(H,28,33)/t20-/m1/s1
Affinity DataIC50: 7.65E+3nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570971(CHEMBL4853611)
Show SMILES Cc1cc(NC(=O)[C@H](O)c2cc(F)cc(F)c2)ccc1-c1ccc(N)nc1
Show InChI InChI=1S/C20H17F2N3O2/c1-11-6-16(3-4-17(11)12-2-5-18(23)24-10-12)25-20(27)19(26)13-7-14(21)9-15(22)8-13/h2-10,19,26H,1H3,(H2,23,24)(H,25,27)/t19-/m1/s1
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEukaryotic translation initiation factor 2 subunit 1(Homo sapiens)
HiberCell Inc.

Curated by ChEMBL
LigandPNGBDBM50570945(CHEMBL4856844)
Show SMILES CC(C)NC(=O)c1cc(cnc1N)-c1ccc(NC(=O)Oc2ccccc2)cc1C
Show InChI InChI=1S/C23H24N4O3/c1-14(2)26-22(28)20-12-16(13-25-21(20)24)19-10-9-17(11-15(19)3)27-23(29)30-18-7-5-4-6-8-18/h4-14H,1-3H3,(H2,24,25)(H,26,28)(H,27,29)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of eIF2alpha (unknown origin) assessed as eIF2alpha phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed