Compile Data Set for Download or QSAR
Found 24 of affinity data for UniProtKB/TrEMBL: P36776
TargetLon protease homolog, mitochondrial(Homo sapiens)
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50571496(CHEMBL4876525)
Show SMILES CCC[C@@H](NC(=O)c1cnccn1)C(=O)N[C@@H](CCCc1ccccc1)B(O)O
Show InChI InChI=1S/C20H27BN4O4/c1-2-7-16(24-20(27)17-14-22-12-13-23-17)19(26)25-18(21(28)29)11-6-10-15-8-4-3-5-9-15/h3-5,8-9,12-14,16,18,28-29H,2,6-7,10-11H2,1H3,(H,24,27)(H,25,26)/t16-,18+/m1/s1
Affinity DataIC50: 17nMAssay Description:Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLon protease homolog, mitochondrial(Homo sapiens)
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50571500(CHEMBL4856865)
Show SMILES OB(O)[C@H](CCCc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)c1cnccn1
Show InChI InChI=1S/C24H27BN4O4/c30-23(29-22(25(32)33)13-7-12-18-8-3-1-4-9-18)20(16-19-10-5-2-6-11-19)28-24(31)21-17-26-14-15-27-21/h1-6,8-11,14-15,17,20,22,32-33H,7,12-13,16H2,(H,28,31)(H,29,30)/t20-,22+/m1/s1
Affinity DataIC50: 18nMAssay Description:Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetLon protease homolog, mitochondrial(Homo sapiens)
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50571499(CHEMBL4864108)
Show SMILES OB(O)[C@H](CCc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)c1cnccn1
Show InChI InChI=1S/C23H25BN4O4/c29-22(28-21(24(31)32)12-11-17-7-3-1-4-8-17)19(15-18-9-5-2-6-10-18)27-23(30)20-16-25-13-14-26-20/h1-10,13-14,16,19,21,31-32H,11-12,15H2,(H,27,30)(H,28,29)/t19-,21+/m1/s1
Affinity DataIC50: 34nMAssay Description:Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetLon protease homolog, mitochondrial(Homo sapiens)
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50571493(CHEMBL4877126)
Show SMILES CCCC[C@H](NC(=O)[C@@H](CCC)NC(=O)c1cnccn1)B(O)O
Show InChI InChI=1S/C15H25BN4O4/c1-3-5-7-13(16(23)24)20-14(21)11(6-4-2)19-15(22)12-10-17-8-9-18-12/h8-11,13,23-24H,3-7H2,1-2H3,(H,19,22)(H,20,21)/t11-,13+/m1/s1
Affinity DataIC50: 38nMAssay Description:Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetLon protease homolog, mitochondrial(Homo sapiens)
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50571492(CHEMBL4870013)
Show SMILES CCC[C@@H](NC(=O)c1oc(C)nc1C)C(=O)N[C@@H](CCCc1ccccc1)B(O)O
Show InChI InChI=1S/C21H30BN3O5/c1-4-9-17(24-21(27)19-14(2)23-15(3)30-19)20(26)25-18(22(28)29)13-8-12-16-10-6-5-7-11-16/h5-7,10-11,17-18,28-29H,4,8-9,12-13H2,1-3H3,(H,24,27)(H,25,26)/t17-,18+/m1/s1
Affinity DataIC50: 59nMAssay Description:Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetLon protease homolog, mitochondrial(Homo sapiens)
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50571502(CHEMBL4862424)
Show SMILES CC(C)CCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O
Show InChI InChI=1S/C21H29BN4O4/c1-15(2)7-6-10-19(22(29)30)26-20(27)17(13-16-8-4-3-5-9-16)25-21(28)18-14-23-11-12-24-18/h3-5,8-9,11-12,14-15,17,19,29-30H,6-7,10,13H2,1-2H3,(H,25,28)(H,26,27)/t17-,19+/m1/s1
Affinity DataIC50: 65nMAssay Description:Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetLon protease homolog, mitochondrial(Homo sapiens)
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50571501(CHEMBL4870902)
Show SMILES OB(O)[C@H](CCCCCBr)NC(=O)[C@@H](Cc1ccccc1)NC(=O)c1cnccn1
Show InChI InChI=1S/C20H26BBrN4O4/c22-10-6-2-5-9-18(21(29)30)26-19(27)16(13-15-7-3-1-4-8-15)25-20(28)17-14-23-11-12-24-17/h1,3-4,7-8,11-12,14,16,18,29-30H,2,5-6,9-10,13H2,(H,25,28)(H,26,27)/t16-,18+/m1/s1
Affinity DataIC50: 77nMAssay Description:Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetLon protease homolog, mitochondrial(Homo sapiens)
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50571495(CHEMBL4876920)
Show SMILES CCC[C@@H](NC(=O)c1cnccn1)C(=O)N[C@@H](CCc1ccccc1)B(O)O
Show InChI InChI=1S/C19H25BN4O4/c1-2-6-15(23-19(26)16-13-21-11-12-22-16)18(25)24-17(20(27)28)10-9-14-7-4-3-5-8-14/h3-5,7-8,11-13,15,17,27-28H,2,6,9-10H2,1H3,(H,23,26)(H,24,25)/t15-,17+/m1/s1
Affinity DataIC50: 92nMAssay Description:Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetLon protease homolog, mitochondrial(Homo sapiens)
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50571503(CHEMBL4850612)
Show SMILES OB(O)[C@H](CC1CCCCC1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)c1cnccn1
Show InChI InChI=1S/C22H29BN4O4/c28-21(27-20(23(30)31)14-17-9-5-2-6-10-17)18(13-16-7-3-1-4-8-16)26-22(29)19-15-24-11-12-25-19/h1,3-4,7-8,11-12,15,17-18,20,30-31H,2,5-6,9-10,13-14H2,(H,26,29)(H,27,28)/t18-,20+/m1/s1
Affinity DataIC50: 92nMAssay Description:Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetLon protease homolog, mitochondrial(Homo sapiens)
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50571508(CHEMBL4856768)
Show SMILES CCCC[C@@H](NC(=O)c1cnccn1)C(=O)N[C@@H](CC(C)C)B(O)O
Show InChI InChI=1S/C16H27BN4O4/c1-4-5-6-12(20-16(23)13-10-18-7-8-19-13)15(22)21-14(17(24)25)9-11(2)3/h7-8,10-12,14,24-25H,4-6,9H2,1-3H3,(H,20,23)(H,21,22)/t12-,14+/m1/s1
Affinity DataIC50: 93nMAssay Description:Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetLon protease homolog, mitochondrial(Homo sapiens)
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50571498(CHEMBL4847335)
Show SMILES OB(O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)c1cnccn1
Show InChI InChI=1S/C22H23BN4O4/c28-21(27-20(23(30)31)14-17-9-5-2-6-10-17)18(13-16-7-3-1-4-8-16)26-22(29)19-15-24-11-12-25-19/h1-12,15,18,20,30-31H,13-14H2,(H,26,29)(H,27,28)/t18-,20+/m1/s1
Affinity DataIC50: 109nMAssay Description:Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetLon protease homolog, mitochondrial(Homo sapiens)
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50571497(CHEMBL4863384)
Show SMILES CCC[C@@H](NC(=O)c1cnccn1)C(=O)N[C@@H](CC1CCCCC1)B(O)O
Show InChI InChI=1S/C18H29BN4O4/c1-2-6-14(22-18(25)15-12-20-9-10-21-15)17(24)23-16(19(26)27)11-13-7-4-3-5-8-13/h9-10,12-14,16,26-27H,2-8,11H2,1H3,(H,22,25)(H,23,24)/t14-,16+/m1/s1
Affinity DataIC50: 136nMAssay Description:Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetLon protease homolog, mitochondrial(Homo sapiens)
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50571505(CHEMBL4847763)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](CC1CCCCC1)NC(=O)c1cnccn1)B(O)O
Show InChI InChI=1S/C19H31BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h8-9,12-15,17,27-28H,3-7,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17+/m1/s1
Affinity DataIC50: 137nMAssay Description:Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetLon protease homolog, mitochondrial(Homo sapiens)
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50069989((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O
Show InChI InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1
Affinity DataIC50: 183nMAssay Description:Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
TargetLon protease homolog, mitochondrial(Homo sapiens)
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50571509(CHEMBL4861871)
Show SMILES CCC[C@@H](NC(=O)c1cnccn1)C(=O)N[C@@H](CC(C)C)B(O)O
Show InChI InChI=1S/C15H25BN4O4/c1-4-5-11(19-15(22)12-9-17-6-7-18-12)14(21)20-13(16(23)24)8-10(2)3/h6-7,9-11,13,23-24H,4-5,8H2,1-3H3,(H,19,22)(H,20,21)/t11-,13+/m1/s1
Affinity DataIC50: 187nMAssay Description:Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetLon protease homolog, mitochondrial(Homo sapiens)
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50571512(CHEMBL4858320)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O
Show InChI InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17+/m1/s1
Affinity DataIC50: 253nMAssay Description:Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLon protease homolog, mitochondrial(Homo sapiens)
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50571510(CHEMBL4853599)
Show SMILES CC[C@@H](NC(=O)c1cnccn1)C(=O)N[C@@H](CC(C)C)B(O)O
Show InChI InChI=1S/C14H23BN4O4/c1-4-10(18-14(21)11-8-16-5-6-17-11)13(20)19-12(15(22)23)7-9(2)3/h5-6,8-10,12,22-23H,4,7H2,1-3H3,(H,18,21)(H,19,20)/t10-,12+/m1/s1
Affinity DataIC50: 408nMAssay Description:Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetLon protease homolog, mitochondrial(Homo sapiens)
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50571511(CHEMBL4864045)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](C)NC(=O)c1cnccn1)B(O)O
Show InChI InChI=1S/C13H21BN4O4/c1-8(2)6-11(14(21)22)18-12(19)9(3)17-13(20)10-7-15-4-5-16-10/h4-5,7-9,11,21-22H,6H2,1-3H3,(H,17,20)(H,18,19)/t9-,11+/m1/s1
Affinity DataIC50: 433nMAssay Description:Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetLon protease homolog, mitochondrial(Homo sapiens)
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50571507(CHEMBL4859172)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](NC(=O)c1cnccn1)C(C)C)B(O)O
Show InChI InChI=1S/C15H25BN4O4/c1-9(2)7-12(16(23)24)19-15(22)13(10(3)4)20-14(21)11-8-17-5-6-18-11/h5-6,8-10,12-13,23-24H,7H2,1-4H3,(H,19,22)(H,20,21)/t12-,13+/m0/s1
Affinity DataIC50: 546nMAssay Description:Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetLon protease homolog, mitochondrial(Homo sapiens)
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50571494(CHEMBL4850826)
Show SMILES CCC[C@@H](NC(=O)c1cnccn1)C(=O)N[C@@H](Cc1ccccc1)B(O)O
Show InChI InChI=1S/C18H23BN4O4/c1-2-6-14(22-18(25)15-12-20-9-10-21-15)17(24)23-16(19(26)27)11-13-7-4-3-5-8-13/h3-5,7-10,12,14,16,26-27H,2,6,11H2,1H3,(H,22,25)(H,23,24)/t14-,16+/m1/s1
Affinity DataIC50: 556nMAssay Description:Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetLon protease homolog, mitochondrial(Homo sapiens)
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM200228(AB01275474-01 | cid_24871309)
Show SMILES CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O
Show InChI InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17+/m0/s1
Affinity DataIC50: 2.11E+3nMAssay Description:Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
TargetLon protease homolog, mitochondrial(Homo sapiens)
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50571506(CHEMBL4862987)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](NC(=O)c1cnccn1)C(C)(C)C)B(O)O
Show InChI InChI=1S/C16H27BN4O4/c1-10(2)8-12(17(24)25)20-15(23)13(16(3,4)5)21-14(22)11-9-18-6-7-19-11/h6-7,9-10,12-13,24-25H,8H2,1-5H3,(H,20,23)(H,21,22)/t12-,13-/m0/s1
Affinity DataIC50: 2.85E+3nMAssay Description:Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetLon protease homolog, mitochondrial(Homo sapiens)
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50571513(CHEMBL1530)
Show SMILES CC(C)C[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O
Show InChI InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m1/s1
Affinity DataIC50: 2.98E+3nMAssay Description:Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetLon protease homolog, mitochondrial(Homo sapiens)
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50571504(CHEMBL4854436)
Show SMILES CC(C)C[C@H](NC(=O)C(C)(C)NC(=O)c1cnccn1)B(O)O
Show InChI InChI=1S/C14H23BN4O4/c1-9(2)7-11(15(22)23)18-13(21)14(3,4)19-12(20)10-8-16-5-6-17-10/h5-6,8-9,11,22-23H,7H2,1-4H3,(H,18,21)(H,19,20)/t11-/m0/s1
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid