Compile Data Set for Download or QSAR
Found 32 of affinity data for UniProtKB/TrEMBL: Q00993
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571947(CHEMBL4850929)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(CCc34)C3CN(C)C3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C31H31F2N7O4/c1-18(2)39-15-24(30(42)40(31(39)43)21-7-4-19(32)5-8-21)28(41)36-20-6-9-27(25(33)12-20)44-29-23-10-11-38(22-13-37(3)14-22)16-26(23)34-17-35-29/h4-9,12,15,17-18,22H,10-11,13-14,16H2,1-3H3,(H,36,41)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571953(CHEMBL4860541)
Show SMILES CN1CCC(CN2CCc3c(C2)ncnc3Oc2ccc(NC(=O)c3cn(C4CCCC4)c(=O)n(-c4ccc(F)cc4)c3=O)cc2F)CC1
Show InChI InChI=1S/C36H39F2N7O4/c1-42-15-12-23(13-16-42)19-43-17-14-28-31(21-43)39-22-40-34(28)49-32-11-8-25(18-30(32)38)41-33(46)29-20-44(26-4-2-3-5-26)36(48)45(35(29)47)27-9-6-24(37)7-10-27/h6-11,18,20,22-23,26H,2-5,12-17,19,21H2,1H3,(H,41,46)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571952(CHEMBL4858396)
Show SMILES CN1CCC(CN2CCc3c(C2)ncnc3Oc2ccc(NC(=O)c3cn(CC4CC4)c(=O)n(-c4ccc(F)cc4)c3=O)cc2F)CC1
Show InChI InChI=1S/C35H37F2N7O4/c1-41-13-10-23(11-14-41)17-42-15-12-27-30(20-42)38-21-39-33(27)48-31-9-6-25(16-29(31)37)40-32(45)28-19-43(18-22-2-3-22)35(47)44(34(28)46)26-7-4-24(36)5-8-26/h4-9,16,19,21-23H,2-3,10-15,17-18,20H2,1H3,(H,40,45)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571933(CHEMBL4878216)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(Cc34)C(=O)C3CC3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C30H26F2N6O5/c1-16(2)37-13-22(29(41)38(30(37)42)20-8-5-18(31)6-9-20)26(39)35-19-7-10-25(23(32)11-19)43-27-21-12-36(28(40)17-3-4-17)14-24(21)33-15-34-27/h5-11,13,15-17H,3-4,12,14H2,1-2H3,(H,35,39)
Affinity DataIC50: 12nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571944(CHEMBL4856749)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(CCc34)C3CCN(C)CC3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C33H35F2N7O4/c1-20(2)41-17-26(32(44)42(33(41)45)24-7-4-21(34)5-8-24)30(43)38-22-6-9-29(27(35)16-22)46-31-25-12-15-40(18-28(25)36-19-37-31)23-10-13-39(3)14-11-23/h4-9,16-17,19-20,23H,10-15,18H2,1-3H3,(H,38,43)
Affinity DataIC50: 13nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571943(CHEMBL4848465)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(CC5CCN(C)CC5)CCc34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C34H37F2N7O4/c1-21(2)42-18-27(33(45)43(34(42)46)25-7-4-23(35)5-8-25)31(44)39-24-6-9-30(28(36)16-24)47-32-26-12-15-41(19-29(26)37-20-38-32)17-22-10-13-40(3)14-11-22/h4-9,16,18,20-22H,10-15,17,19H2,1-3H3,(H,39,44)
Affinity DataIC50: 15nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571025(CHEMBL4846932)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3cc(NC(=O)N4CCC(CC4)N4CCN(C)CC4)ncn3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C35H40FN9O5/c1-23(2)44-21-29(33(47)45(35(44)49)27-8-4-24(36)5-9-27)32(46)39-25-6-10-28(11-7-25)50-31-20-30(37-22-38-31)40-34(48)43-14-12-26(13-15-43)42-18-16-41(3)17-19-42/h4-11,20-23,26H,12-19H2,1-3H3,(H,39,46)(H,37,38,40,48)
Affinity DataIC50: 15nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571951(CHEMBL4864780)
Show SMILES CN1CCC(CN2CCc3c(C2)ncnc3Oc2ccc(NC(=O)c3cn(CC4CCC4)c(=O)n(-c4ccc(F)cc4)c3=O)cc2F)CC1
Show InChI InChI=1S/C36H39F2N7O4/c1-42-14-11-24(12-15-42)18-43-16-13-28-31(21-43)39-22-40-34(28)49-32-10-7-26(17-30(32)38)41-33(46)29-20-44(19-23-3-2-4-23)36(48)45(35(29)47)27-8-5-25(37)6-9-27/h5-10,17,20,22-24H,2-4,11-16,18-19,21H2,1H3,(H,41,46)
Affinity DataIC50: 16nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571932(CHEMBL4865150)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(Cc34)C(=O)CC3CCN(C)CC3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C34H35F2N7O5/c1-20(2)42-17-26(33(46)43(34(42)47)24-7-4-22(35)5-8-24)31(45)39-23-6-9-29(27(36)15-23)48-32-25-16-41(18-28(25)37-19-38-32)30(44)14-21-10-12-40(3)13-11-21/h4-9,15,17,19-21H,10-14,16,18H2,1-3H3,(H,39,45)
Affinity DataIC50: 17nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571945(CHEMBL4866147)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(CCc34)C3CCN(CC4CC4)CC3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C36H39F2N7O4/c1-22(2)44-19-29(35(47)45(36(44)48)27-8-5-24(37)6-9-27)33(46)41-25-7-10-32(30(38)17-25)49-34-28-13-16-43(20-31(28)39-21-40-34)26-11-14-42(15-12-26)18-23-3-4-23/h5-10,17,19,21-23,26H,3-4,11-16,18,20H2,1-2H3,(H,41,46)
Affinity DataIC50: 20nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571946(CHEMBL4859513)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(CC5CN(C)C5)CCc34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C32H33F2N7O4/c1-19(2)40-16-25(31(43)41(32(40)44)23-7-4-21(33)5-8-23)29(42)37-22-6-9-28(26(34)12-22)45-30-24-10-11-39(15-20-13-38(3)14-20)17-27(24)35-18-36-30/h4-9,12,16,18-20H,10-11,13-15,17H2,1-3H3,(H,37,42)
Affinity DataIC50: 22nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571955(CHEMBL4860402)
Show SMILES CN1CCC(CN2CCc3c(C2)ncnc3Oc2ccc(NC(=O)c3cn(C4CCCC4)c(=O)n(-c4ccc(C)cn4)c3=O)cc2F)CC1
Show InChI InChI=1S/C36H41FN8O4/c1-23-7-10-32(38-18-23)45-35(47)28(20-44(36(45)48)26-5-3-4-6-26)33(46)41-25-8-9-31(29(37)17-25)49-34-27-13-16-43(21-30(27)39-22-40-34)19-24-11-14-42(2)15-12-24/h7-10,17-18,20,22,24,26H,3-6,11-16,19,21H2,1-2H3,(H,41,46)
Affinity DataIC50: 28nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571940(CHEMBL4859147)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(CCc34)C(=O)CC3CCN(C)CC3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C35H37F2N7O5/c1-21(2)43-18-27(34(47)44(35(43)48)25-7-4-23(36)5-8-25)32(46)40-24-6-9-30(28(37)17-24)49-33-26-12-15-42(19-29(26)38-20-39-33)31(45)16-22-10-13-41(3)14-11-22/h4-9,17-18,20-22H,10-16,19H2,1-3H3,(H,40,46)
Affinity DataIC50: 29nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571935(CHEMBL4878071)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(CC5CCN(C)CC5)Cc34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C33H35F2N7O4/c1-20(2)41-17-26(32(44)42(33(41)45)24-7-4-22(34)5-8-24)30(43)38-23-6-9-29(27(35)14-23)46-31-25-16-40(18-28(25)36-19-37-31)15-21-10-12-39(3)13-11-21/h4-9,14,17,19-21H,10-13,15-16,18H2,1-3H3,(H,38,43)
Affinity DataIC50: 32nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571954(CHEMBL4857544)
Show SMILES CN1CCC(CN2CCc3c(C2)ncnc3Oc2ccc(NC(=O)c3cn(CC4CC4)c(=O)n(-c4ccc(C)cn4)c3=O)cc2F)CC1
Show InChI InChI=1S/C35H39FN8O4/c1-22-3-8-31(37-16-22)44-34(46)27(19-43(35(44)47)18-23-4-5-23)32(45)40-25-6-7-30(28(36)15-25)48-33-26-11-14-42(20-29(26)38-21-39-33)17-24-9-12-41(2)13-10-24/h3,6-8,15-16,19,21,23-24H,4-5,9-14,17-18,20H2,1-2H3,(H,40,45)
Affinity DataIC50: 34nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571931(CHEMBL4875387)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(Cc34)C(=O)CN3CCN(C)CC3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C33H34F2N8O5/c1-20(2)42-16-25(32(46)43(33(42)47)23-7-4-21(34)5-8-23)30(45)38-22-6-9-28(26(35)14-22)48-31-24-15-41(17-27(24)36-19-37-31)29(44)18-40-12-10-39(3)11-13-40/h4-9,14,16,19-20H,10-13,15,17-18H2,1-3H3,(H,38,45)
Affinity DataIC50: 42nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571950(CHEMBL4870464)
Show SMILES CC(C)Cn1cc(C(=O)Nc2ccc(Oc3ncnc4CN(CC5CCN(C)CC5)CCc34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C35H39F2N7O4/c1-22(2)17-43-19-28(34(46)44(35(43)47)26-7-4-24(36)5-8-26)32(45)40-25-6-9-31(29(37)16-25)48-33-27-12-15-42(20-30(27)38-21-39-33)18-23-10-13-41(3)14-11-23/h4-9,16,19,21-23H,10-15,17-18,20H2,1-3H3,(H,40,45)
Affinity DataIC50: 46nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571949(CHEMBL4874534)
Show SMILES CN1CCC(CN2CCc3c(C2)ncnc3Oc2ccc(NC(=O)c3cn(CCF)c(=O)n(-c4ccc(F)cc4)c3=O)cc2F)CC1
Show InChI InChI=1S/C33H34F3N7O4/c1-40-12-8-21(9-13-40)17-41-14-10-25-28(19-41)37-20-38-31(25)47-29-7-4-23(16-27(29)36)39-30(44)26-18-42(15-11-34)33(46)43(32(26)45)24-5-2-22(35)3-6-24/h2-7,16,18,20-21H,8-15,17,19H2,1H3,(H,39,44)
Affinity DataIC50: 49nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571942(CHEMBL4851171)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(CC(=O)N5CCC5)CCc34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C32H31F2N7O5/c1-19(2)40-15-24(31(44)41(32(40)45)22-7-4-20(33)5-8-22)29(43)37-21-6-9-27(25(34)14-21)46-30-23-10-13-38(16-26(23)35-18-36-30)17-28(42)39-11-3-12-39/h4-9,14-15,18-19H,3,10-13,16-17H2,1-2H3,(H,37,43)
Affinity DataIC50: 66nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571939(CHEMBL4858522)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(CCc34)C(=O)CCN3CCCC3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C34H35F2N7O5/c1-21(2)42-18-26(33(46)43(34(42)47)24-8-5-22(35)6-9-24)31(45)39-23-7-10-29(27(36)17-23)48-32-25-11-16-41(19-28(25)37-20-38-32)30(44)12-15-40-13-3-4-14-40/h5-10,17-18,20-21H,3-4,11-16,19H2,1-2H3,(H,39,45)
Affinity DataIC50: 74nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571941(CHEMBL4846790)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(CC(=O)N5CCN(C)CC5)CCc34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C34H36F2N8O5/c1-21(2)43-17-26(33(47)44(34(43)48)24-7-4-22(35)5-8-24)31(46)39-23-6-9-29(27(36)16-23)49-32-25-10-11-41(18-28(25)37-20-38-32)19-30(45)42-14-12-40(3)13-15-42/h4-9,16-17,20-21H,10-15,18-19H2,1-3H3,(H,39,46)
Affinity DataIC50: 78nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571925(CHEMBL4852474)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4NC(=O)Cc34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C26H20F2N6O5/c1-13(2)33-11-18(25(37)34(26(33)38)16-6-3-14(27)4-7-16)23(36)31-15-5-8-20(19(28)9-15)39-24-17-10-21(35)32-22(17)29-12-30-24/h3-9,11-13H,10H2,1-2H3,(H,31,36)(H,29,30,32,35)
Affinity DataIC50: 84nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571934(CHEMBL4861291)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(CC5CCOCC5)Cc34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C32H32F2N6O5/c1-19(2)39-16-25(31(42)40(32(39)43)23-6-3-21(33)4-7-23)29(41)37-22-5-8-28(26(34)13-22)45-30-24-15-38(17-27(24)35-18-36-30)14-20-9-11-44-12-10-20/h3-8,13,16,18-20H,9-12,14-15,17H2,1-2H3,(H,37,41)
Affinity DataIC50: 93nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571936(CHEMBL4872556)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(CCc34)C(=O)C3CCC3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C32H30F2N6O5/c1-18(2)39-15-24(31(43)40(32(39)44)22-9-6-20(33)7-10-22)28(41)37-21-8-11-27(25(34)14-21)45-29-23-12-13-38(16-26(23)35-17-36-29)30(42)19-4-3-5-19/h6-11,14-15,17-19H,3-5,12-13,16H2,1-2H3,(H,37,41)
Affinity DataIC50: 100nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571927(CHEMBL4870149)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(C)CCc34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C28H26F2N6O4/c1-16(2)35-13-21(27(38)36(28(35)39)19-7-4-17(29)5-8-19)25(37)33-18-6-9-24(22(30)12-18)40-26-20-10-11-34(3)14-23(20)31-15-32-26/h4-9,12-13,15-16H,10-11,14H2,1-3H3,(H,33,37)
Affinity DataIC50: 110nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571937(CHEMBL4846861)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(CCc34)C(=O)C3CCN(C)CC3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C34H35F2N7O5/c1-20(2)42-17-26(33(46)43(34(42)47)24-7-4-22(35)5-8-24)30(44)39-23-6-9-29(27(36)16-23)48-31-25-12-15-41(18-28(25)37-19-38-31)32(45)21-10-13-40(3)14-11-21/h4-9,16-17,19-21H,10-15,18H2,1-3H3,(H,39,44)
Affinity DataIC50: 120nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571930(CHEMBL4860139)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(Cc34)C(=O)CCN3CCCC3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C33H33F2N7O5/c1-20(2)41-17-25(32(45)42(33(41)46)23-8-5-21(34)6-9-23)30(44)38-22-7-10-28(26(35)15-22)47-31-24-16-40(18-27(24)36-19-37-31)29(43)11-14-39-12-3-4-13-39/h5-10,15,17,19-20H,3-4,11-14,16,18H2,1-2H3,(H,38,44)
Affinity DataIC50: 120nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571938(CHEMBL4875172)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(CCc34)C(=O)CN3CCOCC3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C33H33F2N7O6/c1-20(2)41-16-25(32(45)42(33(41)46)23-6-3-21(34)4-7-23)30(44)38-22-5-8-28(26(35)15-22)48-31-24-9-10-40(17-27(24)36-19-37-31)29(43)18-39-11-13-47-14-12-39/h3-8,15-16,19-20H,9-14,17-18H2,1-2H3,(H,38,44)
Affinity DataIC50: 130nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571928(CHEMBL4869791)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CCN(C)Cc34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C28H26F2N6O4/c1-16(2)35-14-21(27(38)36(28(35)39)19-7-4-17(29)5-8-19)25(37)33-18-6-9-24(22(30)12-18)40-26-20-13-34(3)11-10-23(20)31-15-32-26/h4-9,12,14-16H,10-11,13H2,1-3H3,(H,33,37)
Affinity DataIC50: 150nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571926(CHEMBL4872079)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(C)Cc34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C27H24F2N6O4/c1-15(2)34-12-20(26(37)35(27(34)38)18-7-4-16(28)5-8-18)24(36)32-17-6-9-23(21(29)10-17)39-25-19-11-33(3)13-22(19)30-14-31-25/h4-10,12,14-15H,11,13H2,1-3H3,(H,32,36)
Affinity DataIC50: 220nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571929(CHEMBL4860065)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(Cc34)C(=O)CN3CCOCC3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O
Show InChI InChI=1S/C32H31F2N7O6/c1-19(2)40-15-24(31(44)41(32(40)45)22-6-3-20(33)4-7-22)29(43)37-21-5-8-27(25(34)13-21)47-30-23-14-39(16-26(23)35-18-36-30)28(42)17-38-9-11-46-12-10-38/h3-8,13,15,18-19H,9-12,14,16-17H2,1-2H3,(H,37,43)
Affinity DataIC50: 270nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Mus musculus)
Eisai Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50571948(CHEMBL4870992)
Show SMILES CN1CCC(CN2CCc3c(C2)ncnc3Oc2ccc(NC(=O)c3cn(C4CC4)c(=O)n(-c4ccc(F)cc4)c3=O)cc2F)CC1
Show InChI InChI=1S/C34H35F2N7O4/c1-40-13-10-21(11-14-40)17-41-15-12-26-29(19-41)37-20-38-32(26)47-30-9-4-23(16-28(30)36)39-31(44)27-18-42(24-7-8-24)34(46)43(33(27)45)25-5-2-22(35)3-6-25/h2-6,9,16,18,20-21,24H,7-8,10-15,17,19H2,1H3,(H,39,44)
Affinity DataIC50: 770nMAssay Description:Inhibition of Axl in mouse BaF3 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed