Compile Data Set for Download or QSAR
Found 81 of affinity data for UniProtKB/TrEMBL: P01721
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50078833(4-Methyl-7-(diethylamino)coumarin | 7-(diethylamin...)
Show SMILES CCN(CC)c1ccc2c(C)cc(=O)oc2c1
Show InChI InChI=1S/C14H17NO2/c1-4-15(5-2)11-6-7-12-10(3)8-14(16)17-13(12)9-11/h6-9H,4-5H2,1-3H3
Affinity DataEC50:  6.88E+3nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576187(CHEMBL4860180)
Show SMILES CCN(CC)c1ccc2c(C)c(CCOC(=O)NCC3CCCNC3)c(=O)oc2c1
Show InChI InChI=1S/C23H33N3O4/c1-4-26(5-2)18-8-9-19-16(3)20(22(27)30-21(19)13-18)10-12-29-23(28)25-15-17-7-6-11-24-14-17/h8-9,13,17,24H,4-7,10-12,14-15H2,1-3H3,(H,25,28)
Affinity DataEC50:  8.80E+3nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576188(CHEMBL4855362)
Show SMILES CCN(CC)c1ccc2c(C)c(CCOC(=O)NCc3ccccc3)c(=O)oc2c1
Show InChI InChI=1S/C24H28N2O4/c1-4-26(5-2)19-11-12-20-17(3)21(23(27)30-22(20)15-19)13-14-29-24(28)25-16-18-9-7-6-8-10-18/h6-12,15H,4-5,13-14,16H2,1-3H3,(H,25,28)
Affinity DataEC50:  317nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576189(CHEMBL4867929)
Show SMILES CCN(CC)c1ccc2c(C)c(CCOC(=O)NCc3cccnc3)c(=O)oc2c1
Show InChI InChI=1S/C23H27N3O4/c1-4-26(5-2)18-8-9-19-16(3)20(22(27)30-21(19)13-18)10-12-29-23(28)25-15-17-7-6-11-24-14-17/h6-9,11,13-14H,4-5,10,12,15H2,1-3H3,(H,25,28)
Affinity DataEC50:  944nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576190(CHEMBL4854803)
Show SMILES CCN(CC)c1ccc2c(C)c(CCOC(=O)NCCc3cccnc3)c(=O)oc2c1
Show InChI InChI=1S/C24H29N3O4/c1-4-27(5-2)19-8-9-20-17(3)21(23(28)31-22(20)15-19)11-14-30-24(29)26-13-10-18-7-6-12-25-16-18/h6-9,12,15-16H,4-5,10-11,13-14H2,1-3H3,(H,26,29)
Affinity DataEC50:  3.68E+3nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576191(CHEMBL4875269)
Show SMILES CCN(CC)c1ccc2c(C)c(CCOC(=O)N(C)CCc3cccnc3)c(=O)oc2c1
Show InChI InChI=1S/C25H31N3O4/c1-5-28(6-2)20-9-10-21-18(3)22(24(29)32-23(21)16-20)12-15-31-25(30)27(4)14-11-19-8-7-13-26-17-19/h7-10,13,16-17H,5-6,11-12,14-15H2,1-4H3
Affinity DataEC50: >2.00E+4nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576192(CHEMBL4872061)
Show SMILES CCN(CC)c1ccc2c(C)c(CCOC(=O)NCc3cccc(NC(C)=O)c3)c(=O)oc2c1
Show InChI InChI=1S/C26H31N3O5/c1-5-29(6-2)21-10-11-22-17(3)23(25(31)34-24(22)15-21)12-13-33-26(32)27-16-19-8-7-9-20(14-19)28-18(4)30/h7-11,14-15H,5-6,12-13,16H2,1-4H3,(H,27,32)(H,28,30)
Affinity DataEC50:  194nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576193(CHEMBL4877002)
Show SMILES CCN(CC)c1ccc2c(C)c(CCOC(=O)NCc3cncc(NC(C)=O)c3)c(=O)oc2c1
Show InChI InChI=1S/C25H30N4O5/c1-5-29(6-2)20-7-8-21-16(3)22(24(31)34-23(21)12-20)9-10-33-25(32)27-14-18-11-19(15-26-13-18)28-17(4)30/h7-8,11-13,15H,5-6,9-10,14H2,1-4H3,(H,27,32)(H,28,30)
Affinity DataEC50:  1.17E+3nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576194(CHEMBL4858385)
Show SMILES CCN(CC)c1ccc2c(C)c(CCOC(=O)NCc3cccc(c3)C(N)=O)c(=O)oc2c1
Show InChI InChI=1S/C25H29N3O5/c1-4-28(5-2)19-9-10-20-16(3)21(24(30)33-22(20)14-19)11-12-32-25(31)27-15-17-7-6-8-18(13-17)23(26)29/h6-10,13-14H,4-5,11-12,15H2,1-3H3,(H2,26,29)(H,27,31)
Affinity DataEC50:  228nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576195(CHEMBL4855805)
Show SMILES CCN(CC)c1ccc2c(C)c(CCOC(=O)NCc3cccc(c3)-c3c[nH]cn3)c(=O)oc2c1
Show InChI InChI=1S/C27H30N4O4/c1-4-31(5-2)21-9-10-22-18(3)23(26(32)35-25(22)14-21)11-12-34-27(33)29-15-19-7-6-8-20(13-19)24-16-28-17-30-24/h6-10,13-14,16-17H,4-5,11-12,15H2,1-3H3,(H,28,30)(H,29,33)
Affinity DataEC50:  28nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576196(CHEMBL4849658)
Show SMILES CCN(CC)c1ccc2c(C)c(CCOC(=O)NCc3cccc(c3)-c3ccc[nH]c3=O)c(=O)oc2c1
Show InChI InChI=1S/C29H31N3O5/c1-4-32(5-2)22-11-12-23-19(3)24(28(34)37-26(23)17-22)13-15-36-29(35)31-18-20-8-6-9-21(16-20)25-10-7-14-30-27(25)33/h6-12,14,16-17H,4-5,13,15,18H2,1-3H3,(H,30,33)(H,31,35)
Affinity DataEC50:  26nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576197(CHEMBL4871041)
Show SMILES CCN(CC)c1ccc2c(C)c(CCN3C(=O)NC4(CCN(C4)C(=O)c4c[nH]cn4)C3=O)c(=O)oc2c1
Affinity DataEC50:  729nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576198(CHEMBL4848237)
Show SMILES CCN(CC)c1ccc2c(C)c(CCN3C(=O)NC4(CCN(C4)C(=O)c4ccc[nH]c4=O)C3=O)c(=O)oc2c1
Affinity DataEC50:  3.96E+3nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576199(CHEMBL4851449)
Show SMILES CCN(CC)c1ccc2c(C)c(CCN3C(=O)NC4(CCN(CC4)C(=O)c4c[nH]cn4)C3=O)c(=O)oc2c1
Show InChI InChI=1S/C27H32N6O5/c1-4-31(5-2)18-6-7-19-17(3)20(24(35)38-22(19)14-18)8-11-33-25(36)27(30-26(33)37)9-12-32(13-10-27)23(34)21-15-28-16-29-21/h6-7,14-16H,4-5,8-13H2,1-3H3,(H,28,29)(H,30,37)
Affinity DataEC50:  1.43E+3nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576200(CHEMBL4877901)
Show SMILES CCN(CC)c1ccc2c(C)c(CCN3C(=O)NC4(CCN(CC4)C(=O)c4ccc[nH]c4=O)C3=O)c(=O)oc2c1
Show InChI InChI=1S/C29H33N5O6/c1-4-32(5-2)19-8-9-20-18(3)21(26(37)40-23(20)17-19)10-14-34-27(38)29(31-28(34)39)11-15-33(16-12-29)25(36)22-7-6-13-30-24(22)35/h6-9,13,17H,4-5,10-12,14-16H2,1-3H3,(H,30,35)(H,31,39)
Affinity DataEC50:  2.70E+3nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576201(CHEMBL4846353)
Show SMILES CCN(CC)c1ccc2c(C)c(CCN3C(=O)NC4(CCN(C4)S(=O)(=O)c4ccccc4)C3=O)c(=O)oc2c1
Show InChI InChI=1S/C28H32N4O6S/c1-4-30(5-2)20-11-12-22-19(3)23(25(33)38-24(22)17-20)13-15-32-26(34)28(29-27(32)35)14-16-31(18-28)39(36,37)21-9-7-6-8-10-21/h6-12,17H,4-5,13-16,18H2,1-3H3,(H,29,35)
Affinity DataEC50:  648nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576202(CHEMBL4871026)
Show SMILES CCN(CC)c1ccc2c(C)c(CCN3C(=O)NC4(CCN(C4)S(=O)(=O)c4cccnc4)C3=O)c(=O)oc2c1
Show InChI InChI=1S/C27H31N5O6S/c1-4-30(5-2)19-8-9-21-18(3)22(24(33)38-23(21)15-19)10-13-32-25(34)27(29-26(32)35)11-14-31(17-27)39(36,37)20-7-6-12-28-16-20/h6-9,12,15-16H,4-5,10-11,13-14,17H2,1-3H3,(H,29,35)
Affinity DataEC50:  4.37E+3nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576203(CHEMBL4861156)
Show SMILES CCN(CC)c1ccc2c(C)c(CCN3C(=O)NC4(CCN(C4)c4ncccn4)C3=O)c(=O)oc2c1
Show InChI InChI=1S/C26H30N6O4/c1-4-30(5-2)18-7-8-19-17(3)20(22(33)36-21(19)15-18)9-13-32-23(34)26(29-25(32)35)10-14-31(16-26)24-27-11-6-12-28-24/h6-8,11-12,15H,4-5,9-10,13-14,16H2,1-3H3,(H,29,35)
Affinity DataEC50:  688nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576204(CHEMBL4859449)
Show SMILES CCN(CC)c1ccc2c(C)c(CCN3C(=O)NC4(CCN(C4)c4ncnc5[nH]cnc45)C3=O)c(=O)oc2c1
Affinity DataEC50:  355nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576205(CHEMBL4850480)
Show SMILES CCN(CC)c1ccc2c(C)c(CCN3C(=O)NC4(CCN(CC4)c4ncccn4)C3=O)c(=O)oc2c1
Show InChI InChI=1S/C27H32N6O4/c1-4-31(5-2)19-7-8-20-18(3)21(23(34)37-22(20)17-19)9-14-33-24(35)27(30-26(33)36)10-15-32(16-11-27)25-28-12-6-13-29-25/h6-8,12-13,17H,4-5,9-11,14-16H2,1-3H3,(H,30,36)
Affinity DataEC50:  165nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576206(CHEMBL4856361)
Show SMILES CCN(CC)c1ccc2c(C)c(CCN3C(=O)NC4(CCN(CC4)c4ncnc5[nH]cnc45)C3=O)c(=O)oc2c1
Show InChI InChI=1S/C28H32N8O4/c1-4-34(5-2)18-6-7-19-17(3)20(25(37)40-21(19)14-18)8-11-36-26(38)28(33-27(36)39)9-12-35(13-10-28)24-22-23(30-15-29-22)31-16-32-24/h6-7,14-16H,4-5,8-13H2,1-3H3,(H,33,39)(H,29,30,31,32)
Affinity DataEC50:  46nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576207(CHEMBL4862037)
Show SMILES CCN(CC)c1ccc2c(C)c(CCN3C(=O)NC4(CCN(CC4)c4ncnc5[nH]ncc45)C3=O)c(=O)oc2c1
Show InChI InChI=1S/C28H32N8O4/c1-4-34(5-2)18-6-7-19-17(3)20(25(37)40-22(19)14-18)8-11-36-26(38)28(32-27(36)39)9-12-35(13-10-28)24-21-15-31-33-23(21)29-16-30-24/h6-7,14-16H,4-5,8-13H2,1-3H3,(H,32,39)(H,29,30,31,33)
Affinity DataEC50:  124nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576208(CHEMBL4866739)
Show SMILES CCN(CC)c1ccc2c(C)c(CCN3C(=O)NC4(CCN(CC4)c4nccn5ccnc45)C3=O)c(=O)oc2c1
Show InChI InChI=1S/C29H33N7O4/c1-4-33(5-2)20-6-7-21-19(3)22(26(37)40-23(21)18-20)8-13-36-27(38)29(32-28(36)39)9-14-34(15-10-29)24-25-31-12-17-35(25)16-11-30-24/h6-7,11-12,16-18H,4-5,8-10,13-15H2,1-3H3,(H,32,39)
Affinity DataEC50:  30nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576209(CHEMBL4854105)
Show SMILES CCN(CC)c1ccc2c(C)c(CCN3C(=O)NC4(CCN(CC4)c4nccn5ncnc45)C3=O)c(=O)oc2c1
Show InChI InChI=1S/C28H32N8O4/c1-4-33(5-2)19-6-7-20-18(3)21(25(37)40-22(20)16-19)8-12-35-26(38)28(32-27(35)39)9-13-34(14-10-28)23-24-30-17-31-36(24)15-11-29-23/h6-7,11,15-17H,4-5,8-10,12-14H2,1-3H3,(H,32,39)
Affinity DataEC50:  55nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576210(CHEMBL4859730)
Show SMILES CCN(CC)c1ccc2c(C)c(CCN3CC4(CCN(CC4)c4ncccn4)NC3=O)c(=O)oc2c1
Show InChI InChI=1S/C27H34N6O3/c1-4-31(5-2)20-7-8-21-19(3)22(24(34)36-23(21)17-20)9-14-33-18-27(30-26(33)35)10-15-32(16-11-27)25-28-12-6-13-29-25/h6-8,12-13,17H,4-5,9-11,14-16,18H2,1-3H3,(H,30,35)
Affinity DataEC50:  14nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576211(CHEMBL4870683)
Show SMILES CCN(CC)c1ccc2c(C)c(CCN3CC4(CCN(CC4)c4ncnc5[nH]ncc45)NC3=O)c(=O)oc2c1
Show InChI InChI=1S/C28H34N8O3/c1-4-34(5-2)19-6-7-20-18(3)21(26(37)39-23(20)14-19)8-11-36-16-28(32-27(36)38)9-12-35(13-10-28)25-22-15-31-33-24(22)29-17-30-25/h6-7,14-15,17H,4-5,8-13,16H2,1-3H3,(H,32,38)(H,29,30,31,33)
Affinity DataEC50:  4.70nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576212(CHEMBL4848583)
Show SMILES CCN(CC)c1ccc2c(C)c(CCN3CC4(CCN(CC4)c4nccn5ccnc45)NC3=O)c(=O)oc2c1
Show InChI InChI=1S/C29H35N7O3/c1-4-33(5-2)21-6-7-22-20(3)23(27(37)39-24(22)18-21)8-13-36-19-29(32-28(36)38)9-14-34(15-10-29)25-26-31-12-17-35(26)16-11-30-25/h6-7,11-12,16-18H,4-5,8-10,13-15,19H2,1-3H3,(H,32,38)
Affinity DataEC50:  4.90nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576213(CHEMBL4849620)
Show SMILES CC(Oc1ccc2c(C)cc(=O)oc2c1)c1ccccc1
Show InChI InChI=1S/C18H16O3/c1-12-10-18(19)21-17-11-15(8-9-16(12)17)20-13(2)14-6-4-3-5-7-14/h3-11,13H,1-2H3
Affinity DataEC50:  3.96E+3nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576214(CHEMBL4859852)
Show SMILES CCC(Oc1ccc2c(C)cc(=O)oc2c1)c1ccccc1
Show InChI InChI=1S/C19H18O3/c1-3-17(14-7-5-4-6-8-14)21-15-9-10-16-13(2)11-19(20)22-18(16)12-15/h4-12,17H,3H2,1-2H3
Affinity DataEC50:  1.67E+3nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576215(CHEMBL4847400)
Show SMILES CC(Cc1ccccc1)Oc1ccc2c(C)cc(=O)oc2c1
Show InChI InChI=1S/C19H18O3/c1-13-10-19(20)22-18-12-16(8-9-17(13)18)21-14(2)11-15-6-4-3-5-7-15/h3-10,12,14H,11H2,1-2H3
Affinity DataEC50:  1.38E+3nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576216(CHEMBL4875945)
Show SMILES CC(COc1ccc2c(C)cc(=O)oc2c1)c1ccccc1
Show InChI InChI=1S/C19H18O3/c1-13-10-19(20)22-18-11-16(8-9-17(13)18)21-12-14(2)15-6-4-3-5-7-15/h3-11,14H,12H2,1-2H3
Affinity DataEC50:  444nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576217(CHEMBL4852917)
Show SMILES CC(Oc1ccc2c(C)cc(=O)oc2c1)c1ccccc1F
Show InChI InChI=1S/C18H15FO3/c1-11-9-18(20)22-17-10-13(7-8-14(11)17)21-12(2)15-5-3-4-6-16(15)19/h3-10,12H,1-2H3
Affinity DataEC50:  2.58E+3nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576218(CHEMBL4874211)
Show SMILES C[C@@H](Oc1ccc2c(C)c(CCN3CC4(CCN(CC4)c4nccn5ccnc45)NC3=O)c(=O)oc2c1)c1ccccc1
Show InChI InChI=1S/C33H34N6O4/c1-22-26-9-8-25(42-23(2)24-6-4-3-5-7-24)20-28(26)43-31(40)27(22)10-15-39-21-33(36-32(39)41)11-16-37(17-12-33)29-30-35-14-19-38(30)18-13-34-29/h3-9,13-14,18-20,23H,10-12,15-17,21H2,1-2H3,(H,36,41)/t23-/m1/s1
Affinity DataEC50: <25nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576219(CHEMBL4856046)
Show SMILES C[C@H](Oc1ccc2c(C)c(CCN3CC4(CCN(CC4)c4nccn5ccnc45)NC3=O)c(=O)oc2c1)c1ccccc1
Show InChI InChI=1S/C33H34N6O4/c1-22-26-9-8-25(42-23(2)24-6-4-3-5-7-24)20-28(26)43-31(40)27(22)10-15-39-21-33(36-32(39)41)11-16-37(17-12-33)29-30-35-14-19-38(30)18-13-34-29/h3-9,13-14,18-20,23H,10-12,15-17,21H2,1-2H3,(H,36,41)/t23-/m0/s1
Affinity DataEC50:  5.5nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576220(CHEMBL4866500)
Show SMILES CC(COc1ccc2c(C)c(CCN3CC4(CCN(CC4)c4nccn5ccnc45)NC3=O)c(=O)oc2c1)c1ccccc1
Show InChI InChI=1S/C34H36N6O4/c1-23(25-6-4-3-5-7-25)21-43-26-8-9-27-24(2)28(32(41)44-29(27)20-26)10-15-40-22-34(37-33(40)42)11-16-38(17-12-34)30-31-36-14-19-39(31)18-13-35-30/h3-9,13-14,18-20,23H,10-12,15-17,21-22H2,1-2H3,(H,37,42)
Affinity DataEC50:  8.30nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576220(CHEMBL4866500)
Show SMILES CC(COc1ccc2c(C)c(CCN3CC4(CCN(CC4)c4nccn5ccnc45)NC3=O)c(=O)oc2c1)c1ccccc1
Show InChI InChI=1S/C34H36N6O4/c1-23(25-6-4-3-5-7-25)21-43-26-8-9-27-24(2)28(32(41)44-29(27)20-26)10-15-40-22-34(37-33(40)42)11-16-38(17-12-34)30-31-36-14-19-39(31)18-13-35-30/h3-9,13-14,18-20,23H,10-12,15-17,21-22H2,1-2H3,(H,37,42)
Affinity DataEC50:  3.90nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576221(CHEMBL4848404)
Show SMILES CC(COc1ccc2c(C)c(CN3CC4(CCN(CC4)c4nccn5ccnc45)NC3=O)c(=O)oc2c1)c1ccccc1
Show InChI InChI=1S/C33H34N6O4/c1-22(24-6-4-3-5-7-24)20-42-25-8-9-26-23(2)27(31(40)43-28(26)18-25)19-39-21-33(36-32(39)41)10-14-37(15-11-33)29-30-35-13-17-38(30)16-12-34-29/h3-9,12-13,16-18,22H,10-11,14-15,19-21H2,1-2H3,(H,36,41)
Affinity DataEC50:  187nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576221(CHEMBL4848404)
Show SMILES CC(COc1ccc2c(C)c(CN3CC4(CCN(CC4)c4nccn5ccnc45)NC3=O)c(=O)oc2c1)c1ccccc1
Show InChI InChI=1S/C33H34N6O4/c1-22(24-6-4-3-5-7-24)20-42-25-8-9-26-23(2)27(31(40)43-28(26)18-25)19-39-21-33(36-32(39)41)10-14-37(15-11-33)29-30-35-13-17-38(30)16-12-34-29/h3-9,12-13,16-18,22H,10-11,14-15,19-21H2,1-2H3,(H,36,41)
Affinity DataEC50:  143nMAssay Description:Stabilization of AL patient derived fluorescein-labeled IGLV6-57 T46L/F49Y mutant measured after 24 hrs by proteolysis coupled-fluorescence polarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50078833(4-Methyl-7-(diethylamino)coumarin | 7-(diethylamin...)
Show SMILES CCN(CC)c1ccc2c(C)cc(=O)oc2c1
Show InChI InChI=1S/C14H17NO2/c1-4-15(5-2)11-6-7-12-10(3)8-14(16)17-13(12)9-11/h6-9H,4-5H2,1-3H3
Affinity DataEC50:  3.24E+3nMAssay Description:Stabilization of AL patient derived full length fluorescein-labeled IGLV6-57 expressed in Escherichia coli BL21 (DE3) measured after 24 hrs by proteo...More data for this Ligand-Target Pair
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576222(CHEMBL4854892)
Show SMILES CCN(C)c1ccc2c(C)cc(=O)oc2c1
Show InChI InChI=1S/C13H15NO2/c1-4-14(3)10-5-6-11-9(2)7-13(15)16-12(11)8-10/h5-8H,4H2,1-3H3
Affinity DataEC50:  1.80E+4nMAssay Description:Stabilization of AL patient derived full length fluorescein-labeled IGLV6-57 expressed in Escherichia coli BL21 (DE3) measured after 24 hrs by proteo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576223(CHEMBL4854056)
Show SMILES CCCN(CC)c1ccc2c(C)cc(=O)oc2c1
Show InChI InChI=1S/C15H19NO2/c1-4-8-16(5-2)12-6-7-13-11(3)9-15(17)18-14(13)10-12/h6-7,9-10H,4-5,8H2,1-3H3
Affinity DataEC50:  7.89E+3nMAssay Description:Stabilization of AL patient derived full length fluorescein-labeled IGLV6-57 expressed in Escherichia coli BL21 (DE3) measured after 24 hrs by proteo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576224(CHEMBL4879384)
Show SMILES CCN(C(C)C)c1ccc2c(C)cc(=O)oc2c1
Show InChI InChI=1S/C15H19NO2/c1-5-16(10(2)3)12-6-7-13-11(4)8-15(17)18-14(13)9-12/h6-10H,5H2,1-4H3
Affinity DataEC50:  9.70E+3nMAssay Description:Stabilization of AL patient derived full length fluorescein-labeled IGLV6-57 expressed in Escherichia coli BL21 (DE3) measured after 24 hrs by proteo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576225(CHEMBL4879274)
Show SMILES CCN(CC#C)c1ccc2c(C)cc(=O)oc2c1
Show InChI InChI=1S/C15H15NO2/c1-4-8-16(5-2)12-6-7-13-11(3)9-15(17)18-14(13)10-12/h1,6-7,9-10H,5,8H2,2-3H3
Affinity DataEC50:  2.65E+3nMAssay Description:Stabilization of AL patient derived full length fluorescein-labeled IGLV6-57 expressed in Escherichia coli BL21 (DE3) measured after 24 hrs by proteo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576226(CHEMBL4878847)
Show SMILES Cc1cc(=O)oc2cc(ccc12)N(CC#C)CC#C
Show InChI InChI=1S/C16H13NO2/c1-4-8-17(9-5-2)13-6-7-14-12(3)10-16(18)19-15(14)11-13/h1-2,6-7,10-11H,8-9H2,3H3
Affinity DataEC50:  2.00E+3nMAssay Description:Stabilization of AL patient derived full length fluorescein-labeled IGLV6-57 expressed in Escherichia coli BL21 (DE3) measured after 24 hrs by proteo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576187(CHEMBL4860180)
Show SMILES CCN(CC)c1ccc2c(C)c(CCOC(=O)NCC3CCCNC3)c(=O)oc2c1
Show InChI InChI=1S/C23H33N3O4/c1-4-26(5-2)18-8-9-19-16(3)20(22(27)30-21(19)13-18)10-12-29-23(28)25-15-17-7-6-11-24-14-17/h8-9,13,17,24H,4-7,10-12,14-15H2,1-3H3,(H,25,28)
Affinity DataEC50:  1.69E+3nMAssay Description:Stabilization of AL patient derived full length fluorescein-labeled IGLV6-57 expressed in Escherichia coli BL21 (DE3) measured after 24 hrs by proteo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576188(CHEMBL4855362)
Show SMILES CCN(CC)c1ccc2c(C)c(CCOC(=O)NCc3ccccc3)c(=O)oc2c1
Show InChI InChI=1S/C24H28N2O4/c1-4-26(5-2)19-11-12-20-17(3)21(23(27)30-22(20)15-19)13-14-29-24(28)25-16-18-9-7-6-8-10-18/h6-12,15H,4-5,13-14,16H2,1-3H3,(H,25,28)
Affinity DataEC50:  302nMAssay Description:Stabilization of AL patient derived full length fluorescein-labeled IGLV6-57 expressed in Escherichia coli BL21 (DE3) measured after 24 hrs by proteo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576189(CHEMBL4867929)
Show SMILES CCN(CC)c1ccc2c(C)c(CCOC(=O)NCc3cccnc3)c(=O)oc2c1
Show InChI InChI=1S/C23H27N3O4/c1-4-26(5-2)18-8-9-19-16(3)20(22(27)30-21(19)13-18)10-12-29-23(28)25-15-17-7-6-11-24-14-17/h6-9,11,13-14H,4-5,10,12,15H2,1-3H3,(H,25,28)
Affinity DataEC50:  415nMAssay Description:Stabilization of AL patient derived full length fluorescein-labeled IGLV6-57 expressed in Escherichia coli BL21 (DE3) measured after 24 hrs by proteo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576190(CHEMBL4854803)
Show SMILES CCN(CC)c1ccc2c(C)c(CCOC(=O)NCCc3cccnc3)c(=O)oc2c1
Show InChI InChI=1S/C24H29N3O4/c1-4-27(5-2)19-8-9-20-17(3)21(23(28)31-22(20)15-19)11-14-30-24(29)26-13-10-18-7-6-12-25-16-18/h6-9,12,15-16H,4-5,10-11,13-14H2,1-3H3,(H,26,29)
Affinity DataEC50:  1.11E+3nMAssay Description:Stabilization of AL patient derived full length fluorescein-labeled IGLV6-57 expressed in Escherichia coli BL21 (DE3) measured after 24 hrs by proteo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576191(CHEMBL4875269)
Show SMILES CCN(CC)c1ccc2c(C)c(CCOC(=O)N(C)CCc3cccnc3)c(=O)oc2c1
Show InChI InChI=1S/C25H31N3O4/c1-5-28(6-2)20-9-10-21-18(3)22(24(29)32-23(21)16-20)12-15-31-25(30)27(4)14-11-19-8-7-13-26-17-19/h7-10,13,16-17H,5-6,11-12,14-15H2,1-4H3
Affinity DataEC50:  5.28E+3nMAssay Description:Stabilization of AL patient derived full length fluorescein-labeled IGLV6-57 expressed in Escherichia coli BL21 (DE3) measured after 24 hrs by proteo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetImmunoglobulin lambda variable 6-57(Homo sapiens)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50576192(CHEMBL4872061)
Show SMILES CCN(CC)c1ccc2c(C)c(CCOC(=O)NCc3cccc(NC(C)=O)c3)c(=O)oc2c1
Show InChI InChI=1S/C26H31N3O5/c1-5-29(6-2)21-10-11-22-17(3)23(25(31)34-24(22)15-21)12-13-33-26(32)27-16-19-8-7-9-20(14-19)28-18(4)30/h7-11,14-15H,5-6,12-13,16H2,1-4H3,(H,27,32)(H,28,30)
Affinity DataEC50:  289nMAssay Description:Stabilization of AL patient derived full length fluorescein-labeled IGLV6-57 expressed in Escherichia coli BL21 (DE3) measured after 24 hrs by proteo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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