Compile Data Set for Download or QSAR
Found 74 of affinity data for UniProtKB/TrEMBL: O88634
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578824(CHEMBL4860533)
Show SMILES COc1cc(Cl)c2nc(sc2c1)-c1cc(C)cc2c1ncn(C)c2=O
Show InChI InChI=1S/C18H14ClN3O2S/c1-9-4-11(15-12(5-9)18(23)22(2)8-20-15)17-21-16-13(19)6-10(24-3)7-14(16)25-17/h4-8H,1-3H3
Affinity DataIC50: 84nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578827(CHEMBL4866566)
Show SMILES Cc1cc(-c2nc3CCCCc3s2)c2ncn(C)c(=O)c2c1
Show InChI InChI=1S/C17H17N3OS/c1-10-7-11(15-12(8-10)17(21)20(2)9-18-15)16-19-13-5-3-4-6-14(13)22-16/h7-9H,3-6H2,1-2H3
Affinity DataIC50: 110nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578886(CHEMBL4849569)
Show SMILES CCc1cc(-c2nc3c(Cl)cc(OC)cc3s2)c2ncn(C)c(=O)c2c1
Show InChI InChI=1S/C19H16ClN3O2S/c1-4-10-5-12(16-13(6-10)19(24)23(2)9-21-16)18-22-17-14(20)7-11(25-3)8-15(17)26-18/h5-9H,4H2,1-3H3
Affinity DataIC50: 160nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578829(CHEMBL4855875)
Show SMILES Cc1cc(-c2nc3c(Cl)cc(OCCNS(=O)(=O)c4ccc(cc4)C(F)(F)F)cc3s2)c2ncn(C)c(=O)c2c1
Show InChI InChI=1S/C26H20ClF3N4O4S2/c1-14-9-18(22-19(10-14)25(35)34(2)13-31-22)24-33-23-20(27)11-16(12-21(23)39-24)38-8-7-32-40(36,37)17-5-3-15(4-6-17)26(28,29)30/h3-6,9-13,32H,7-8H2,1-2H3
Affinity DataIC50: 170nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578875(CHEMBL4855377)
Show SMILES Cc1ccc(cc1)S(=O)(=O)NCCOc1cc(Cl)c2nc(sc2c1)-c1cc(C)cc2c1ncn(C)c2=O
Show InChI InChI=1S/C26H23ClN4O4S2/c1-15-4-6-18(7-5-15)37(33,34)29-8-9-35-17-12-21(27)24-22(13-17)36-25(30-24)19-10-16(2)11-20-23(19)28-14-31(3)26(20)32/h4-7,10-14,29H,8-9H2,1-3H3
Affinity DataIC50: 520nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578828(CHEMBL4870185)
Show SMILES CCOCn1cnc2c(cc(C)cc2c1=O)-c1nc2c(Cl)cc(OC)cc2s1
Show InChI InChI=1S/C20H18ClN3O3S/c1-4-27-10-24-9-22-17-13(5-11(2)6-14(17)20(24)25)19-23-18-15(21)7-12(26-3)8-16(18)28-19/h5-9H,4,10H2,1-3H3
Affinity DataIC50: 650nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578820(CHEMBL4857938)
Show SMILES COCc1cnc2c(cc(C)cc2n1)-c1nc2c(Cl)cc(OC)cc2s1
Show InChI InChI=1S/C19H16ClN3O2S/c1-10-4-13(17-15(5-10)22-11(8-21-17)9-24-2)19-23-18-14(20)6-12(25-3)7-16(18)26-19/h4-8H,9H2,1-3H3
Affinity DataIC50: 790nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578826(CHEMBL4871001)
Show SMILES COc1cc(F)c2nc(sc2c1)-c1cc(C)cc2c1ncn(C)c2=O
Show InChI InChI=1S/C18H14FN3O2S/c1-9-4-11(15-12(5-9)18(23)22(2)8-20-15)17-21-16-13(19)6-10(24-3)7-14(16)25-17/h4-8H,1-3H3
Affinity DataIC50: 830nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM364565(6-(Benzofuran-2-yl)-2-(methylthio)imidazo[2,1-b][1...)
Show SMILES CSc1nn2cc(nc2s1)-c1cc2ccccc2o1
Show InChI InChI=1S/C13H9N3OS2/c1-18-13-15-16-7-9(14-12(16)19-13)11-6-8-4-2-3-5-10(8)17-11/h2-7H,1H3
Affinity DataIC50: 940nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578878(CHEMBL4849478)
Show SMILES Cc1cc(-c2nc3c(Cl)cc(OCCNS(=O)(=O)c4ccc(Cl)cc4Cl)cc3s2)c2ncn(C)c(=O)c2c1
Show InChI InChI=1S/C25H19Cl3N4O4S2/c1-13-7-16(22-17(8-13)25(33)32(2)12-29-22)24-31-23-19(28)10-15(11-20(23)37-24)36-6-5-30-38(34,35)21-4-3-14(26)9-18(21)27/h3-4,7-12,30H,5-6H2,1-2H3
Affinity DataIC50: 950nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578823(CHEMBL4866983)
Show SMILES COc1cc(Cl)c2nc(sc2c1)-c1cc(C)cc2c1ccn(C)c2=O
Show InChI InChI=1S/C19H15ClN2O2S/c1-10-6-13(12-4-5-22(2)19(23)14(12)7-10)18-21-17-15(20)8-11(24-3)9-16(17)25-18/h4-9H,1-3H3
Affinity DataIC50: 980nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578850(CHEMBL4867779)
Show SMILES COCn1cnc2c(cc(C)cc2c1=O)-c1nc2c(Cl)cc(OC)cc2s1
Show InChI InChI=1S/C19H16ClN3O3S/c1-10-4-12(16-13(5-10)19(24)23(8-21-16)9-25-2)18-22-17-14(20)6-11(26-3)7-15(17)27-18/h4-8H,9H2,1-3H3
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578876(CHEMBL4871578)
Show SMILES Cc1cc(-c2nc3c(Cl)cc(OCCNS(=O)(=O)c4ccc(Cl)cc4)cc3s2)c2ncn(C)c(=O)c2c1
Show InChI InChI=1S/C25H20Cl2N4O4S2/c1-14-9-18(22-19(10-14)25(32)31(2)13-28-22)24-30-23-20(27)11-16(12-21(23)36-24)35-8-7-29-37(33,34)17-5-3-15(26)4-6-17/h3-6,9-13,29H,7-8H2,1-2H3
Affinity DataIC50: 1.04E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578825(CHEMBL4859532)
Show SMILES Cc1cc(-c2ccc(Cl)cc2Cl)c2ncn(C)c(=O)c2c1
Show InChI InChI=1S/C16H12Cl2N2O/c1-9-5-12(11-4-3-10(17)7-14(11)18)15-13(6-9)16(21)20(2)8-19-15/h3-8H,1-2H3
Affinity DataIC50: 1.22E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578852(CHEMBL4867321)
Show SMILES CCCCc1cc(-c2nc3c(Cl)cc(OC)cc3s2)c2ncn(C)c(=O)c2c1
Show InChI InChI=1S/C21H20ClN3O2S/c1-4-5-6-12-7-14(18-15(8-12)21(26)25(2)11-23-18)20-24-19-16(22)9-13(27-3)10-17(19)28-20/h7-11H,4-6H2,1-3H3
Affinity DataIC50: 1.38E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578861(CHEMBL4849024)
Show SMILES Cc1cc(-c2nc3CCCCc3s2)c2nc[nH]c(=O)c2c1
Show InChI InChI=1S/C16H15N3OS/c1-9-6-10-14(17-8-18-15(10)20)11(7-9)16-19-12-4-2-3-5-13(12)21-16/h6-8H,2-5H2,1H3,(H,17,18,20)
Affinity DataIC50: 1.38E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578821(CHEMBL4871870)
Show SMILES COCc1nc2cc(C)cc(-c3nc4c(Cl)cc(OC)cc4s3)c2[nH]1
Show InChI InChI=1S/C18H16ClN3O2S/c1-9-4-11(16-13(5-9)20-15(21-16)8-23-2)18-22-17-12(19)6-10(24-3)7-14(17)25-18/h4-7H,8H2,1-3H3,(H,20,21)
Affinity DataIC50: 1.63E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM364589(US9862730, Example 41)
Show SMILES Cc1nn2cc(nc2s1)-c1cc2ccccc2o1
Show InChI InChI=1S/C13H9N3OS/c1-8-15-16-7-10(14-13(16)18-8)12-6-9-4-2-3-5-11(9)17-12/h2-7H,1H3
Affinity DataIC50: 1.82E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578822(CHEMBL4847592)
Show SMILES COc1cc(Cl)c2nc(sc2c1)-c1cc(C)cc2C(=O)N(C)CCc12
Show InChI InChI=1S/C19H17ClN2O2S/c1-10-6-13(12-4-5-22(2)19(23)14(12)7-10)18-21-17-15(20)8-11(24-3)9-16(17)25-18/h6-9H,4-5H2,1-3H3
Affinity DataIC50: 1.84E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578847(CHEMBL4858844)
Show SMILES CCn1cnc2c(cc(C)cc2c1=O)-c1nc2c(Cl)cc(OC)cc2s1
Show InChI InChI=1S/C19H16ClN3O2S/c1-4-23-9-21-16-12(5-10(2)6-13(16)19(23)24)18-22-17-14(20)7-11(25-3)8-15(17)26-18/h5-9H,4H2,1-3H3
Affinity DataIC50: 1.85E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578845(CHEMBL4860348)
Show SMILES Cc1cc(-c2nc3c(Cl)cc(OCCNC(=O)OC(C)(C)C)cc3s2)c2ncn(C)c(=O)c2c1
Show InChI InChI=1S/C24H25ClN4O4S/c1-13-8-15(19-16(9-13)22(30)29(5)12-27-19)21-28-20-17(25)10-14(11-18(20)34-21)32-7-6-26-23(31)33-24(2,3)4/h8-12H,6-7H2,1-5H3,(H,26,31)
Affinity DataIC50: 2.07E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578853(CHEMBL4864730)
Show SMILES COc1cc(Cl)c2nc(sc2c1)-c1cc(C)cc2c1nc(C)n(C)c2=O
Show InChI InChI=1S/C19H16ClN3O2S/c1-9-5-12(16-13(6-9)19(24)23(3)10(2)21-16)18-22-17-14(20)7-11(25-4)8-15(17)26-18/h5-8H,1-4H3
Affinity DataIC50: 2.09E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578865(CHEMBL4865655)
Show SMILES COCn1cnc2c(cc(C)cc2c1=O)-c1nc2CCCCc2s1
Show InChI InChI=1S/C18H19N3O2S/c1-11-7-12(17-20-14-5-3-4-6-15(14)24-17)16-13(8-11)18(22)21(9-19-16)10-23-2/h7-9H,3-6,10H2,1-2H3
Affinity DataIC50: 2.32E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578874(CHEMBL4859012)
Show SMILES Cc1cc(-c2nc3c(Cl)cc(OCCNS(=O)(=O)c4ccccc4)cc3s2)c2ncn(C)c(=O)c2c1
Show InChI InChI=1S/C25H21ClN4O4S2/c1-15-10-18(22-19(11-15)25(31)30(2)14-27-22)24-29-23-20(26)12-16(13-21(23)35-24)34-9-8-28-36(32,33)17-6-4-3-5-7-17/h3-7,10-14,28H,8-9H2,1-2H3
Affinity DataIC50: 2.52E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578860(CHEMBL4862300)
Show SMILES Cn1cnc2c(cccc2c1=O)-c1nc2CCCCc2s1
Show InChI InChI=1S/C16H15N3OS/c1-19-9-17-14-10(5-4-6-11(14)16(19)20)15-18-12-7-2-3-8-13(12)21-15/h4-6,9H,2-3,7-8H2,1H3
Affinity DataIC50: 2.61E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578843(CHEMBL4855122)
Show SMILES Cc1cc(-c2nc3c(Cl)cc(Cl)cc3s2)c2ncn(C)c(=O)c2c1
Show InChI InChI=1S/C17H11Cl2N3OS/c1-8-3-10(14-11(4-8)17(23)22(2)7-20-14)16-21-15-12(19)5-9(18)6-13(15)24-16/h3-7H,1-2H3
Affinity DataIC50: 2.62E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578818(CHEMBL4848044)
Show SMILES Cc1cc(-c2nn3ccnc3s2)c2ccn(C)c(=O)c2c1
Show InChI InChI=1S/C15H12N4OS/c1-9-7-11(13-17-19-6-4-16-15(19)21-13)10-3-5-18(2)14(20)12(10)8-9/h3-8H,1-2H3
Affinity DataIC50: 3.00E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578872(CHEMBL4849962)
Show SMILES Cc1cc(-c2nc3c(Cl)cc(OCCN)cc3s2)c2ncn(C)c(=O)c2c1
Show InChI InChI=1S/C19H17ClN4O2S/c1-10-5-12(16-13(6-10)19(25)24(2)9-22-16)18-23-17-14(20)7-11(26-4-3-21)8-15(17)27-18/h5-9H,3-4,21H2,1-2H3
Affinity DataIC50: 3.02E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578815(CHEMBL4855079)
Show SMILES COCc1nc2cc(C)cc(-c3nn4cc(C)nc4s3)c2[nH]1
Show InChI InChI=1S/C15H15N5OS/c1-8-4-10(13-11(5-8)17-12(18-13)7-21-3)14-19-20-6-9(2)16-15(20)22-14/h4-6H,7H2,1-3H3,(H,17,18)
Affinity DataIC50: 3.13E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578819(CHEMBL4867000)
Show SMILES Cc1cn2nc(sc2n1)-c1cc(C)cc2c1ccn(C)c2=O
Show InChI InChI=1S/C16H14N4OS/c1-9-6-12(11-4-5-19(3)15(21)13(11)7-9)14-18-20-8-10(2)17-16(20)22-14/h4-8H,1-3H3
Affinity DataIC50: 3.21E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578864(CHEMBL4849742)
Show SMILES Cc1cc(-c2nc3CCCCc3s2)c2ncn(CC#C)c(=O)c2c1
Show InChI InChI=1S/C19H17N3OS/c1-3-8-22-11-20-17-13(9-12(2)10-14(17)19(22)23)18-21-15-6-4-5-7-16(15)24-18/h1,9-11H,4-8H2,2H3
Affinity DataIC50: 3.37E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578882(CHEMBL4866596)
Show SMILES COCc1cc2cc(C)cc(-c3nn4ccnc4s3)c2o1
Show InChI InChI=1S/C15H13N3O2S/c1-9-5-10-7-11(8-19-2)20-13(10)12(6-9)14-17-18-4-3-16-15(18)21-14/h3-7H,8H2,1-2H3
Affinity DataIC50: 3.44E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578867(CHEMBL4874764)
Show SMILES CCc1cc(-c2nc3CCCCc3s2)c2ncn(C)c(=O)c2c1
Show InChI InChI=1S/C18H19N3OS/c1-3-11-8-12(16-13(9-11)18(22)21(2)10-19-16)17-20-14-6-4-5-7-15(14)23-17/h8-10H,3-7H2,1-2H3
Affinity DataIC50: 3.54E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578839(CHEMBL4873173)
Show SMILES Cc1cc(-c2nccs2)c2ncn(C)c(=O)c2c1
Show InChI InChI=1S/C13H11N3OS/c1-8-5-9(12-14-3-4-18-12)11-10(6-8)13(17)16(2)7-15-11/h3-7H,1-2H3
Affinity DataIC50: 3.64E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578836(CHEMBL4847606)
Show SMILES Cc1cc(-c2cccc(Cl)c2Cl)c2ncn(C)c(=O)c2c1
Show InChI InChI=1S/C16H12Cl2N2O/c1-9-6-11(10-4-3-5-13(17)14(10)18)15-12(7-9)16(21)20(2)8-19-15/h3-8H,1-2H3
Affinity DataIC50: 3.70E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578862(CHEMBL4870259)
Show SMILES CCn1cnc2c(cc(C)cc2c1=O)-c1nc2CCCCc2s1
Show InChI InChI=1S/C18H19N3OS/c1-3-21-10-19-16-12(8-11(2)9-13(16)18(21)22)17-20-14-6-4-5-7-15(14)23-17/h8-10H,3-7H2,1-2H3
Affinity DataIC50: 3.74E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578858(CHEMBL4877231)
Show SMILES COc1cc(F)c2nc(sc2c1)-c1cc(C)cc2c1ncn(CC#C)c2=O
Show InChI InChI=1S/C20H14FN3O2S/c1-4-5-24-10-22-17-13(6-11(2)7-14(17)20(24)25)19-23-18-15(21)8-12(26-3)9-16(18)27-19/h1,6-10H,5H2,2-3H3
Affinity DataIC50: 4.20E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578842(CHEMBL4845780)
Show SMILES Cc1cc(-c2cc3ccccc3o2)c2ncn(C)c(=O)c2c1
Show InChI InChI=1S/C18H14N2O2/c1-11-7-13(16-9-12-5-3-4-6-15(12)22-16)17-14(8-11)18(21)20(2)10-19-17/h3-10H,1-2H3
Affinity DataIC50: 4.26E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578849(CHEMBL4874590)
Show SMILES COc1cc(Cl)c2nc(sc2c1)-c1cc(C)cc2c1ncn(CC#C)c2=O
Show InChI InChI=1S/C20H14ClN3O2S/c1-4-5-24-10-22-17-13(6-11(2)7-14(17)20(24)25)19-23-18-15(21)8-12(26-3)9-16(18)27-19/h1,6-10H,5H2,2-3H3
Affinity DataIC50: 4.26E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578866(CHEMBL4864292)
Show SMILES CCOCn1cnc2c(cc(C)cc2c1=O)-c1nc2CCCCc2s1
Show InChI InChI=1S/C19H21N3O2S/c1-3-24-11-22-10-20-17-13(8-12(2)9-14(17)19(22)23)18-21-15-6-4-5-7-16(15)25-18/h8-10H,3-7,11H2,1-2H3
Affinity DataIC50: 4.77E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578883(CHEMBL4870778)
Show SMILES COCc1cc2cc(C)cc(-c3nn4cc(C)nc4s3)c2o1
Show InChI InChI=1S/C16H15N3O2S/c1-9-4-11-6-12(8-20-3)21-14(11)13(5-9)15-18-19-7-10(2)17-16(19)22-15/h4-7H,8H2,1-3H3
Affinity DataIC50: 4.82E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578855(CHEMBL4870833)
Show SMILES COc1cc(F)c2nc(sc2c1)-c1cccc2c1ncn(C)c2=O
Show InChI InChI=1S/C17H12FN3O2S/c1-21-8-19-14-10(4-3-5-11(14)17(21)22)16-20-15-12(18)6-9(23-2)7-13(15)24-16/h3-8H,1-2H3
Affinity DataIC50: 5.34E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578859(CHEMBL4854301)
Show SMILES COc1cc(F)c2nc(sc2c1)-c1cc(C)cc2c1nc(C)n(C)c2=O
Show InChI InChI=1S/C19H16FN3O2S/c1-9-5-12(16-13(6-9)19(24)23(3)10(2)21-16)18-22-17-14(20)7-11(25-4)8-15(17)26-18/h5-8H,1-4H3
Affinity DataIC50: 5.45E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578834(CHEMBL4852886)
Show SMILES Cc1cc(-c2ccccc2F)c2ncn(C)c(=O)c2c1
Show InChI InChI=1S/C16H13FN2O/c1-10-7-12(11-5-3-4-6-14(11)17)15-13(8-10)16(20)19(2)9-18-15/h3-9H,1-2H3
Affinity DataIC50: 5.48E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578844(CHEMBL4866947)
Show SMILES Cc1cc(-c2nc3c(Cl)cc4OCCOc4c3s2)c2ncn(C)c(=O)c2c1
Show InChI InChI=1S/C19H14ClN3O3S/c1-9-5-10(14-11(6-9)19(24)23(2)8-21-14)18-22-15-12(20)7-13-16(17(15)27-18)26-4-3-25-13/h5-8H,3-4H2,1-2H3
Affinity DataIC50: 5.57E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578870(CHEMBL4863438)
Show SMILES CCCCc1cc(-c2nc3CCCCc3s2)c2ncn(CC)c(=O)c2c1
Show InChI InChI=1S/C21H25N3OS/c1-3-5-8-14-11-15(20-23-17-9-6-7-10-18(17)26-20)19-16(12-14)21(25)24(4-2)13-22-19/h11-13H,3-10H2,1-2H3
Affinity DataIC50: 6.28E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578857(CHEMBL4860078)
Show SMILES COc1cc(F)c2nc(sc2c1)-c1cc(C)cc2c1ncn(C(C)C)c2=O
Show InChI InChI=1S/C20H18FN3O2S/c1-10(2)24-9-22-17-13(5-11(3)6-14(17)20(24)25)19-23-18-15(21)7-12(26-4)8-16(18)27-19/h5-10H,1-4H3
Affinity DataIC50: 6.74E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578846(CHEMBL4858255)
Show SMILES COc1cc(Cl)c2nc(sc2c1)-c1cccc2c1ncn(C)c2=O
Show InChI InChI=1S/C17H12ClN3O2S/c1-21-8-19-14-10(4-3-5-11(14)17(21)22)16-20-15-12(18)6-9(23-2)7-13(15)24-16/h3-8H,1-2H3
Affinity DataIC50: 6.78E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578869(CHEMBL4877639)
Show SMILES CCCCc1cc(-c2nc3CCCCc3s2)c2ncn(C)c(=O)c2c1
Show InChI InChI=1S/C20H23N3OS/c1-3-4-7-13-10-14(18-15(11-13)20(24)23(2)12-21-18)19-22-16-8-5-6-9-17(16)25-19/h10-12H,3-9H2,1-2H3
Affinity DataIC50: 7.04E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProteinase-activated receptor 4(Mus musculus)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50578833(CHEMBL4876067)
Show SMILES COc1ccccc1-c1cc(C)cc2c1ncn(C)c2=O
Show InChI InChI=1S/C17H16N2O2/c1-11-8-13(12-6-4-5-7-15(12)21-3)16-14(9-11)17(20)19(2)10-18-16/h4-10H,1-3H3
Affinity DataIC50: 7.32E+3nMAssay Description:Antagonist activity at PAR4 in ICR mouse platelet-rich plasma assessed as inhibition of PAR4 AP AYPGKF-NH2-induced platelet aggregation by photo-turb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Displayed 1 to 50 (of 74 total ) | Next | Last >>
Jump to: