Compile Data Set for Download or QSAR
Found 4 for UniProtKB: P47809
TargetDual specificity mitogen-activated protein kinase kinase 4(Mus musculus)
Eberhard Karls Universit£t T£bingen

Curated by ChEMBL
LigandPNGBDBM50396483(PLX-4032 | RG 7204 | Ro 5185426 | US10570155, Vemu...)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F
Show InChI InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28)
Affinity DataKd:  8.20nMAssay Description:Binding affinity to GST tagged mouse MKK4 expressed in Escherichia coli expression system measured by Kinomescan assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Mus musculus)
Eberhard Karls Universit£t T£bingen

Curated by ChEMBL
LigandPNGBDBM50568580(CHEMBL4857316)
Show SMILES Fc1c(NS(=O)(=O)Cc2ccccc2)cccc1C(=O)c1c[nH]c2ncc(cc12)-c1cnc(nc1)C1CC1
Show InChI InChI=1S/C28H22FN5O3S/c29-25-21(7-4-8-24(25)34-38(36,37)16-17-5-2-1-3-6-17)26(35)23-15-33-28-22(23)11-19(12-32-28)20-13-30-27(31-14-20)18-9-10-18/h1-8,11-15,18,34H,9-10,16H2,(H,32,33)
Affinity DataKd:  1.10nMAssay Description:Binding affinity to GST tagged mouse MKK4 expressed in Escherichia coli expression system measured by Kinomescan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Mus musculus)
Eberhard Karls Universit£t T£bingen

Curated by ChEMBL
LigandPNGBDBM50568579(CHEMBL4848804)
Show SMILES COc1ncc(cn1)-c1cnc2[nH]cc(C(=O)c3cccc(NS(=O)(=O)Cc4ccccc4)c3F)c2c1
Show InChI InChI=1S/C26H20FN5O4S/c1-36-26-30-12-18(13-31-26)17-10-20-21(14-29-25(20)28-11-17)24(33)19-8-5-9-22(23(19)27)32-37(34,35)15-16-6-3-2-4-7-16/h2-14,32H,15H2,1H3,(H,28,29)
Affinity DataKd:  0.850nMAssay Description:Binding affinity to GST tagged mouse MKK4 expressed in Escherichia coli expression system measured by Kinomescan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Mus musculus)
Eberhard Karls Universit£t T£bingen

Curated by ChEMBL
LigandPNGBDBM50568578(CHEMBL4868537)
Show SMILES Fc1c(NS(=O)(=O)Cc2ccccc2)cccc1C(=O)c1c[nH]c2ncc(cc12)-c1cc2OCCOc2cc1Cl
Show InChI InChI=1S/C29H21ClFN3O5S/c30-23-13-26-25(38-9-10-39-26)12-20(23)18-11-21-22(15-33-29(21)32-14-18)28(35)19-7-4-8-24(27(19)31)34-40(36,37)16-17-5-2-1-3-6-17/h1-8,11-15,34H,9-10,16H2,(H,32,33)
Affinity DataKd:  3.5nMAssay Description:Binding affinity to GST tagged mouse MKK4 expressed in Escherichia coli expression system measured by Kinomescan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed