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TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50289137(6-Fluoro-3-((E)-2-pyridin-3-yl-vinyl)-1H-indole | ...)
Affinity DataKi:  30nMAssay Description:Inhibition of liver TDOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50514041(CHEMBL4452150)
Affinity DataKi:  90nMAssay Description:Mixed uncompetitive inhibition of recombinant human TDO expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using varying concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50514040(CHEMBL4436480)
Affinity DataKi:  120nMAssay Description:Uncompetitive inhibition of recombinant human TDO expressed in Escherichia coli BL21 (DE3) assessed as assessed as inhibition constant using varying ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50514038(CHEMBL4577825)
Affinity DataKi:  130nMAssay Description:Mixed uncompetitive inhibition of recombinant human TDO expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using varying concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50514037(CHEMBL4536439)
Affinity DataKi:  170nMAssay Description:Mixed uncompetitive inhibition of recombinant human TDO expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using varying concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50442991(GNF-Pf-3777 | CHEMBL432537 | US10669273, Compound ...)
Affinity DataKi:  215nMAssay Description:Uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50606592(CHEMBL5219838)
Affinity DataKi:  280nMAssay Description:Binding affinity to human TDO assessed as inhibition constant by Cornhish-Bowden methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50514035(CHEMBL4437046)
Affinity DataKi:  310nMAssay Description:Uncompetitive inhibition of recombinant human TDO expressed in Escherichia coli BL21 (DE3) assessed as assessed as inhibition constant using varying ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM48009(SMR000544298 | 8-fluoranylindolo[2,1-b]quinazoline...)
Affinity DataKi:  336nMAssay Description:Uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50514034(CHEMBL4588805)
Affinity DataKi:  340nMAssay Description:Uncompetitive inhibition of recombinant human TDO expressed in Escherichia coli BL21 (DE3) assessed as assessed as inhibition constant using varying ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50442987(8-Bromotryptanthrin | CHEMBL72165)
Affinity DataKi:  356nMAssay Description:Uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50200540(CHEMBL3972619)
Affinity DataKi:  390nMAssay Description:Binding affinity to human TDO assessed as inhibition constant by Cornhish-Bowden methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50514043(CHEMBL4545004)
Affinity DataKi:  420nMAssay Description:Mixed uncompetitive inhibition of recombinant human TDO expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using varying concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50240612(CHEMBL306946 | Indolo[2,1-b]quinazoline-6,12-dione...)
Affinity DataKi:  581nMAssay Description:Uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50514032(CHEMBL4471831)
Affinity DataKi:  670nMAssay Description:Mixed uncompetitive inhibition of recombinant human TDO expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using varying concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50604731(CHEMBL5204091)
Affinity DataKi:  730nMAssay Description:Competitive inhibition of recombinant human TDO measured by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50442994(CHEMBL312537 | US10669273, Compound 5b)
Affinity DataKi:  834nMAssay Description:Mixed type uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50442995(CHEMBL3086870)
Affinity DataKi:  876nMAssay Description:Mixed type uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50289137(6-Fluoro-3-((E)-2-pyridin-3-yl-vinyl)-1H-indole | ...)
Affinity DataKi:  880nMAssay Description:Competitive inhibition of human recombinant TDO expressed in Escherichia coli BL21 using L-tryptophan as substrate by measuring conversion of N-formy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2013
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50442988(CHEMBL3087009)
Affinity DataKi:  1.00E+3nMAssay Description:Mixed type uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50590775(CHEMBL1990305)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of human TDOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50514036(CHEMBL4468741)
Affinity DataKi:  1.24E+3nMAssay Description:Uncompetitive inhibition of recombinant human TDO expressed in Escherichia coli BL21 (DE3) assessed as assessed as inhibition constant using varying ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50514042(CHEMBL4578338)
Affinity DataKi:  1.56E+3nMAssay Description:Uncompetitive inhibition of recombinant human TDO expressed in Escherichia coli BL21 (DE3) assessed as assessed as inhibition constant using varying ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50514039(CHEMBL4584081)
Affinity DataKi:  2.36E+3nMAssay Description:Uncompetitive inhibition of recombinant human TDO expressed in Escherichia coli BL21 (DE3) assessed as assessed as inhibition constant using varying ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50562501(CHEMBL1970485)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli Rosetta (DE3) pLysS incubated for 20 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataKi:  5.50E+3nMAssay Description:Inhibition of TDO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataKi:  5.60E+3nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli using L-Trp as substrate after 10 to 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataKi:  5.60E+3nMAssay Description:Competitive inhibition of human recombinant TDO expressed in Escherichia coli BL21 using L-tryptophan as substrate by measuring conversion of N-formy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2013
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataKi:  7.47E+3nMAssay Description:Uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50442989(CHEMBL3087010)
Affinity DataKi:  8.41E+3nMAssay Description:Uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50520736(NSC-36398 | CHEMBL483206)
Affinity DataKi:  1.60E+4nMAssay Description:Inhibition of TDO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50514033(CHEMBL4471895)
Affinity DataKi:  1.80E+4nMAssay Description:Uncompetitive inhibition of recombinant human TDO expressed in Escherichia coli BL21 (DE3) assessed as assessed as inhibition constant using varying ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50350281(CHEMBL1812527)
Affinity DataKi:  2.10E+4nMAssay Description:Competitive inhibition of human purified TDO by Henri-Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50126143(Epacadostat | INCB-024360)
Affinity DataKi:  2.17E+4nMAssay Description:Uncompetitive inhibition of recombinant human TDO expressed in Escherichia coli BL21 (DE3) assessed as assessed as inhibition constant using varying ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50126143(Epacadostat | INCB-024360)
Affinity DataKi:  2.17E+4nMAssay Description:Uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50350249(CHEMBL1812547)
Affinity DataKi:  3.24E+4nMAssay Description:Competitive inhibition of human recombinant TDO expressed in Escherichia coli BL21 using L-tryptophan as substrate by measuring conversion of N-formy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2013
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM50442990(CHEMBL1276265)
Affinity DataKi:  4.27E+4nMAssay Description:Mixed type uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
University of Namur (Fundp)

Curated by ChEMBL
LigandPNGBDBM21974((2S)-2-amino-3-(1H-indol-3-yl)propanoic acid | CHE...)
Affinity DataKi:  1.15E+7nMAssay Description:Competitive inhibition of human recombinant TDO expressed in Escherichia coli BL21 using L-tryptophan as substrate by measuring conversion of N-formy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2013
Entry Details Article
PubMed