BindingDB PrimarySearch

Report error Found 261 of ic50 for UniProtKB: Q02485

Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50306490((+)-(S)-3-methyl 5-pentyl 2,6-dimethyl-4-(3-nitrop...)

IC50: 0.420nMAssay Description:Displacement of [3H]nitrendipine from dihydropyridine receptor in rat cardiac membraneMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50029417(CHEMBL277363 | [4-(4-Methoxy-phenyl)-4H-benzo[b]py...)

IC50: 0.420nMAssay Description:Displacement of [3H]nitrendipine from calcium channel receptorMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50306489((-)-(R)-3-methyl 5-pentyl 2,6-dimethyl-4-(3-nitrop...)

IC50: 0.760nMAssay Description:Displacement of [3H]nitrendipine from dihydropyridine receptor in rat cardiac membraneMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50469633(CHEMBL21906)

IC50: 0.780nMAssay Description:Displacement of [3H]nitrendipine from calcium channel receptors (CCRs) from rat cortex homogenateMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50103634(CL-287389 | FK-235 | Nilvadipine | Nivadipine | SK...)

IC50: 1nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channels of rat cerebral cortexMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50101813(CHEBI:31399 | Cilnidipine)

IC50: 1.10nMAssay Description:Inhibition of voltage-dependent L-type calcium channel in rat thoracic aorta ring assessed as effect on high K+ induced contraction by Magnus methodMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50101813(CHEBI:31399 | Cilnidipine)

IC50: 1.10nMAssay Description:Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus methodMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50101813(CHEBI:31399 | Cilnidipine)

IC50: 1.10nMAssay Description:Inhibition of Voltage-dependent L-type calcium channel in rat thoracic aorta ringMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50306490((+)-(S)-3-methyl 5-pentyl 2,6-dimethyl-4-(3-nitrop...)

IC50: 1.48nMAssay Description:Displacement of [3H]nitrendipine from dihydropyridine receptor in rat cerebral cortex membraneMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50229256(CHEMBL73590)

IC50: 1.60nMAssay Description:Affinity to bind dihydropyridine receptor (DHP receptor) by inhibiting the radioligand [3H]nitrendipineMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50101817(Adalat | Adalat Cc | Afeditab Cr | BAY-A-1040 | CH...)

IC50: 1.70nMAssay Description:Inhibition of [3H]nitrendipine binding to calcium channels in the rat brain.More data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50227967(CHEMBL78973)

IC50: 2.10nMAssay Description:Inhibition of [3H]- Nitrendipine binding to L-type calcium channels of rat cerebral cortexMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50101817(Adalat | Adalat Cc | Afeditab Cr | BAY-A-1040 | CH...)

IC50: 2.5nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channels of rat cerebral cortexMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50101817(Adalat | Adalat Cc | Afeditab Cr | BAY-A-1040 | CH...)

IC50: 2.57nMAssay Description:Inhibition of L-type calcium channel in Rattus norvegicus Wistar (rat) thoracic aorta assessed as relaxation of KCl-induced vasoconstriction after 30...More data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50101817(Adalat | Adalat Cc | Afeditab Cr | BAY-A-1040 | CH...)

IC50: 2.60nMAssay Description:Inhibition of L-type calcium channel in Rattus norvegicus Wistar (rat) thoracic aorta assessed as relaxation of KCl-induced vasoconstriction after 30...More data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50101815(CHEBI:7550 | Nicardipine)

IC50: 2.70nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channels of rat cerebral cortexMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50475660(CHEMBL201566)

IC50: 2.80nMAssay Description:Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus methodMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50306489((-)-(R)-3-methyl 5-pentyl 2,6-dimethyl-4-(3-nitrop...)

IC50: 3.62nMAssay Description:Displacement of [3H]nitrendipine from dihydropyridine receptor in rat cerebral cortex membraneMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50475658(CHEMBL201984)

IC50: 3.70nMAssay Description:Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus methodMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50475653(CHEMBL382528)

IC50: 5.80nMAssay Description:Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus methodMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50475650(CHEMBL203041)

IC50: 6.80nMAssay Description:Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus methodMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50479255(CHEMBL453084)

IC50: 7nMAssay Description:Inhibition of voltage-dependent L-type calcium channel in rat thoracic aorta ring assessed as effect on high K+ induced contraction by Magnus methodMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50227968(CHEMBL310953)

IC50: 7.10nMAssay Description:Inhibition of [3H]- Nitrendipine binding to L-type calcium channels of rat cerebral cortexMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50306489((-)-(R)-3-methyl 5-pentyl 2,6-dimethyl-4-(3-nitrop...)

IC50: 8.14nMAssay Description:Displacement of [3H]nitrendipine from dihydropyridine receptor in rat cardiac membraneMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50227969(CHEMBL312176 | CV-4093)

IC50: 8.70nMAssay Description:Inhibition of [3H]- Nitrendipine binding to L-type calcium channels of rat cerebral cortexMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50475663(CHEMBL202464)

IC50: 9nMAssay Description:Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus methodMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50229315(CHEMBL312304)

IC50: 10nMAssay Description:Affinity to bind dihydropyridine receptor (DHP receptor) by inhibiting the radioligand [3H]nitrendipineMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50475664(CHEMBL369934)

IC50: 10nMAssay Description:Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus methodMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50475672(CHEMBL201057)

IC50: 13nMAssay Description:Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus methodMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50475662(CHEMBL201860)

IC50: 14nMAssay Description:Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus methodMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50280077(CHEMBL18988 | sec-Butyl-[4-(2,4-dimethoxy-phenyl)-...)

IC50: 15nMAssay Description:Displacement of [3H]nitrendipine from calcium channel receptorMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50306489((-)-(R)-3-methyl 5-pentyl 2,6-dimethyl-4-(3-nitrop...)

IC50: 17.6nMAssay Description:Displacement of [3H]nitrendipine from dihydropyridine receptor in rat cerebral cortex membraneMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50475669(CHEMBL382072)

IC50: 20nMAssay Description:Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus methodMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50227617(CHEMBL46635)

IC50: 20nMAssay Description:Inhibition of [3H]nitrendipine binding to calcium channels in the rat brain.More data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50475669(CHEMBL382072)

IC50: 20nMAssay Description:Inhibition of voltage-dependent L-type calcium channel in rat thoracic aorta ring assessed as effect on high K+ induced contraction by Magnus methodMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50475656(CHEMBL201306)

IC50: 20nMAssay Description:Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus methodMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50229269(CHEMBL72696)

IC50: 21nMAssay Description:Affinity to bind dihydropyridine receptor (DHP receptor) by inhibiting the radioligand [3H]nitrendipineMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50229269(CHEMBL72696)

IC50: 21nMAssay Description:Affinity to bind dihydropyridine receptor (DHP receptor) by inhibiting the radioligand [3H]nitrendipineMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50227621(CHEMBL46452)

IC50: 26nMAssay Description:Inhibition of [3H]nitrendipine binding to calcium channels in the rat brain.More data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50229288(CHEMBL75494)

IC50: 27nMAssay Description:Affinity to bind dihydropyridine receptor (DHP receptor) by inhibiting the radioligand [3H]nitrendipineMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50227619(CHEMBL44275)

IC50: 28nMAssay Description:Inhibition of [3H]nitrendipine binding to calcium channels in the rat brain.More data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50101817(Adalat | Adalat Cc | Afeditab Cr | BAY-A-1040 | CH...)

IC50: 28nMAssay Description:Inhibition of L-type calcium channel in Rattus norvegicus Wistar (rat) thoracic aorta assessed as relaxation of phenylephrine-induced vasoconstrictio...More data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50101817(Adalat | Adalat Cc | Afeditab Cr | BAY-A-1040 | CH...)

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50475661(CHEMBL204486)

IC50: 31nMAssay Description:Inhibitory activity against L-type calcium channel in SD rat thoracic aorta by Magnus methodMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50227627(CHEMBL295323)

IC50: 31nMAssay Description:Inhibition of [3H]nitrendipine binding to calcium channels in the rat brain.More data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50227615(CHEMBL46590)

IC50: 32nMAssay Description:Inhibition of [3H]nitrendipine binding to calcium channels in the rat brain.More data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50229332(CHEMBL72341)

IC50: 33nMAssay Description:Affinity to bind dihydropyridine receptor (DHP receptor) by inhibiting the radioligand [3H]nitrendipineMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50229310(CHEMBL73583)

IC50: 36nMAssay Description:Affinity to bind dihydropyridine receptor (DHP receptor) by inhibiting the radioligand [3H]nitrendipineMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50229270(CHEMBL306566)

IC50: 37nMAssay Description:Affinity to bind dihydropyridine receptor (DHP receptor) by inhibiting the radioligand [3H]nitrendipineMore data for this Ligand-Target Pair

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Voltage-dependent L-type calcium channel subunit alpha-1S(Rat)
Fourth Military Medical University

Curated by ChEMBL

BDBM50004704((+)-cis-Diltiazem | (2S,3S)-5-(2-(dimethylamino)et...)

IC50: 42nMAssay Description:Displacement of [3H]nitrendipine from calcium channel receptorMore data for this Ligand-Target Pair

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Details PDB

3D Structure (crystal)

Displayed 1 to 50 (of 261 total ) | Next | Last >>

Filter my 261 hits

Targets 2▿
- Voltage-dependent L-type calcium channel subunit alpha-1S 236
- Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S 25
Publications 17▿
- J Med Chem 34: 2248-60 (1991) 93
- Bioorg Med Chem Lett 16: 798-802 (2006) 27
- J Med Chem 31: 1659-64 (1988) 21
- Bioorg Med Chem Lett 18: 4813-6 (2008) 16
- J Nat Prod 77: 1586-93 (2014) 13
- Bioorg Med Chem Lett 20: 805-8 (2010) 6
- J Med Chem 32: 2399-406 (1989) 6
- Bioorg Med Chem Lett 21: 3317-9 (2011) 5
- Bioorg Med Chem Lett 9: 2447-52 (1999) 4
- J Nat Prod 80: 196-200 (2017) 4
- J Med Chem 42: 5266-71 (1999) 3
- J Med Chem 52: 6637-48 (2009) 3
- J Med Chem 35: 4442-9 (1992) 3
- J Med Chem 52: 2352-62 (2009) 3
- Bioorg Med Chem Lett 10: 345-7 (2000) 2
- J Med Chem 31: 454-61 (1988) 1
- Bioorg Med Chem Lett 3: 2099-2104 (1993) 1
Institutions 12▿
- Warner-Lambert 122
- Ajinomoto 43
- Vietnam Academy of Science and Technology 13
- Suntory Institute For Biomedical Research 6
- Fourth Military Medical University 6
- Ajinomoto Pharmaceuticals 5
- Seoul National University 4
- Universita Degli Studi Di Perugia 3
- Universita Degli Studi Di Bologna 3
- National Academy of Sciences of Ukraine 3
- Parke-Davis Neuroscience Research Centre 2
- TBA 1
Affinity: 0.42 to 1.0E+9 nM▿
- IC50 261
- Affinity ≤ nM
Xtal structures: 2
Docked structures: 0
Catalog Cmpds: 14