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TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50299218(Cpd66 | 8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of EphA4 by [gamma33-P]ATP based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of human EPHA4 using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50157880(CHEMBL3787112)
Affinity DataIC50: 9nMAssay Description:Inhibition of EphA4 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50535199(CHEMBL4462106)
Affinity DataIC50: 12nMAssay Description:Antagonist activity against human EphA4 receptor assessed as inhibition of binding of alkaline phosphatase-fused ephrin-A5 to immobilized EphA4 Fc by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50535195(CHEMBL4530593)
Affinity DataIC50: 12nMAssay Description:Antagonist activity against human EphA4 receptor assessed as inhibition of binding of alkaline phosphatase-fused ephrin-A5 to immobilized EphA4 Fc by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 12.5nMAssay Description:Inhibition of human EPHA4 using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50535185(CHEMBL4464968)
Affinity DataIC50: 17nMAssay Description:Antagonist activity against human EphA4 receptor assessed as inhibition of binding of alkaline phosphatase-fused ephrin-A5 to immobilized EphA4 Fc by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50535194(CHEMBL4464855)
Affinity DataIC50: 22nMAssay Description:Antagonist activity against human EphA4 receptor assessed as inhibition of binding of alkaline phosphatase-fused ephrin-A5 to immobilized EphA4 Fc by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50535198(CHEMBL4440005)
Affinity DataIC50: 25nMAssay Description:Antagonist activity against human EphA4 receptor assessed as inhibition of binding of alkaline phosphatase-fused ephrin-A5 to immobilized EphA4 Fc by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50535186(CHEMBL4436732)
Affinity DataIC50: 27nMAssay Description:Antagonist activity against human EphA4 receptor assessed as inhibition of binding of alkaline phosphatase-fused ephrin-A5 to immobilized EphA4 Fc by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50535192(CHEMBL4458170)
Affinity DataIC50: 34nMAssay Description:Antagonist activity against human EphA4 receptor assessed as inhibition of binding of alkaline phosphatase-fused ephrin-A5 to immobilized EphA4 Fc by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50535196(CHEMBL4447628)
Affinity DataIC50: 38nMAssay Description:Antagonist activity against human EphA4 receptor assessed as inhibition of binding of alkaline phosphatase-fused ephrin-A5 to immobilized EphA4 Fc by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50535193(CHEMBL4539149)
Affinity DataIC50: 40nMAssay Description:Antagonist activity against human EphA4 receptor assessed as inhibition of binding of alkaline phosphatase-fused ephrin-A5 to immobilized EphA4 Fc by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50535184(CHEMBL4516686)
Affinity DataIC50: 41nMAssay Description:Antagonist activity against human EphA4 receptor assessed as inhibition of binding of alkaline phosphatase-fused ephrin-A5 to immobilized EphA4 Fc by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50535182(CHEMBL4449863)
Affinity DataIC50: 50nMAssay Description:Antagonist activity against human EphA4 receptor assessed as inhibition of binding of alkaline phosphatase-fused ephrin-A5 to immobilized EphA4 Fc by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50535200(CHEMBL4434643)
Affinity DataIC50: 54nMAssay Description:Antagonist activity against human EphA4 receptor assessed as inhibition of binding of alkaline phosphatase-fused ephrin-A5 to immobilized EphA4 Fc by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataIC50: 70nMAssay Description:Inhibition of EPHA4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50452149(CHEMBL4216073)
Affinity DataIC50: 74nMAssay Description:Inhibition of EphA4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50535181(CHEMBL4436577)
Affinity DataIC50: 83nMAssay Description:Antagonist activity against human EphA4 receptor assessed as inhibition of binding of alkaline phosphatase-fused ephrin-A5 to immobilized EphA4 Fc by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM378885(US10266537, Compound 93)
Affinity DataIC50: 227nMAssay Description:Inhibition of human recombinant EPHA4 (601 to 892 residues) using poly(Glu,Tyr)4:1 as substrate incubated for 40 mins in presence of [gamma33P-ATP] b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50535197(CHEMBL4474623)
Affinity DataIC50: 230nMAssay Description:Antagonist activity against human EphA4 receptor assessed as inhibition of binding of alkaline phosphatase-fused ephrin-A5 to immobilized EphA4 Fc by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50535185(CHEMBL4464968)
Affinity DataIC50: 240nMAssay Description:Inhibition of 0.5 ug/ml ephrinA5-induced human EphA4 tyrosine phosphorylation expressed in HEK293AD cells preincubated for 20 mins followed by ephrin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50535190(CHEMBL4520376)
Affinity DataIC50: 260nMAssay Description:Antagonist activity against human EphA4 receptor assessed as inhibition of binding of alkaline phosphatase-fused ephrin-A5 to immobilized EphA4 Fc by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50535183(CHEMBL4569881)
Affinity DataIC50: 290nMAssay Description:Antagonist activity against human EphA4 receptor assessed as inhibition of binding of alkaline phosphatase-fused ephrin-A5 to immobilized EphA4 Fc by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50535195(CHEMBL4530593)
Affinity DataIC50: 310nMAssay Description:Inhibition of 0.4 ug/ml ephrinA5-induced human EphA4 tyrosine phosphorylation expressed in HEK293AD cells preincubated for 20 mins followed by ephrin...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50535189(CHEMBL4442705)
Affinity DataIC50: 450nMAssay Description:Antagonist activity against human EphA4 receptor assessed as inhibition of binding of alkaline phosphatase-fused ephrin-A5 to immobilized EphA4 Fc by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50535191(CHEMBL4522324)
Affinity DataIC50: 480nMAssay Description:Antagonist activity against human EphA4 receptor assessed as inhibition of binding of alkaline phosphatase-fused ephrin-A5 to immobilized EphA4 Fc by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50535188(CHEMBL4591478)
Affinity DataIC50: 920nMAssay Description:Antagonist activity against human EphA4 receptor assessed as inhibition of binding of alkaline phosphatase-fused ephrin-A5 to immobilized EphA4 Fc by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50535187(CHEMBL4476251)
Affinity DataIC50: 1.20E+3nMAssay Description:Antagonist activity against human EphA4 receptor assessed as inhibition of binding of alkaline phosphatase-fused ephrin-A5 to immobilized EphA4 Fc by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4 [1-949,A922V](Human)
Sanford-Burnham Medical Research Institute

LigandPNGBDBM11985(4-(2,5-dimethyl-1H-pyrrol-1-yl)-2-hydroxybenzoic a...)
Affinity DataIC50: 1.30E+3nMpH: 7.5Assay Description:Protein A-coasted wells (from Pierce Biotechnology) were used to immobilize Eph receptor Fc fusion proteins (from R&D systems)incubated at 1 ug/ml in...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50618607(CHEMBL5425418)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of full length NanoLuc fused EPHA4 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo substrate incubated for 2 hrs in p...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50359971(CHEMBL1927263)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of his-tagged EPHA4-mediated poly(Glu,Tyr) phosphorylation after 75 mins using E4:Y1 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4 [1-949,A922V](Human)
Sanford-Burnham Medical Research Institute

LigandPNGBDBM82187(Salicylic acid derivative, 76D10)
Affinity DataIC50: 2.60E+3nMpH: 7.5Assay Description:Protein A-coasted wells (from Pierce Biotechnology) were used to immobilize Eph receptor Fc fusion proteins (from R&D systems)incubated at 1 ug/ml in...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50428059(CHEMBL2322989)
Affinity DataIC50: 2.70E+3nMAssay Description:Displacement of ephrin-A1-Fc from EphA4 receptor Fc ectodomain (unknown origin) after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50359970(CHEMBL1927262)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of his-tagged EPHA4-mediated poly(Glu,Tyr) phosphorylation after 75 mins using E4:Y1 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50157881(CHEMBL3787614)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of EphA4 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50359969(CHEMBL1927261)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of his-tagged EPHA4-mediated poly(Glu,Tyr) phosphorylation after 75 mins using E4:Y1 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50413752(L-783277 | CHEMBL2012519)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EPHA4 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50535180(CHEMBL4468291)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity against human EphA4 receptor assessed as inhibition of binding of alkaline phosphatase-fused ephrin-A5 to immobilized EphA4 Fc by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM107057(US8592432, 34)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EphA4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4 [1-949,A922V](Human)
Sanford-Burnham Medical Research Institute

LigandPNGBDBM82190(Salicylic acid derivative, compound 2)
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:Protein A-coasted wells (from Pierce Biotechnology) were used to immobilize Eph receptor Fc fusion proteins (from R&D systems)incubated at 1 ug/ml in...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50135286(CHEMBL3745885)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EPHA4 using poly[Glu:Tyr] (4:1) as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EphA4 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50157628(CHEMBL3786167)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EphA4 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50158429(CHEMBL3785500)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EphA4 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50157879(CHEMBL1614712)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EphA4 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50335374(CHEMBL1651522 | CHEMBL1651521 | (3S,9S)-9,16-dihyd...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EPHA4 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50355393(CHEMBL1834657 | US9434697, BGJ398 | US9730931, BGJ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant EPHA4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50363167(CHEMBL1945559)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EphA4 using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 4(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50462709(CHEMBL4245507)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EphA4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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