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TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataKi:  14nMAssay Description:Inhibition of Bcr-AblMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)
Affinity DataKi:  30nMAssay Description:Binding affinity to wild type BCR-ABL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)
Affinity DataKi:  42nMAssay Description:Binding affinity to wild type BCR-ABL T315I mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50399374(CHEMBL2178270)
Affinity DataIC50:  0.330nMAssay Description:Inhibition of wild type Bcr-Abl using Tyr2 peptide as substrate after 2 hrs by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Affinity DataIC50:  0.330nMAssay Description:Inhibition of Bcr-Abl kinase (unknown origin) after 30 mins by HTRF assayMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50399367(CHEMBL2178277)
Affinity DataIC50:  0.360nMAssay Description:Inhibition of wild type Bcr-Abl using Tyr2 peptide as substrate after 2 hrs by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50399373(CHEMBL2178271)
Affinity DataIC50:  0.410nMAssay Description:Inhibition of wild type Bcr-Abl using Tyr2 peptide as substrate after 2 hrs by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50399368(CHEMBL2178276)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of wild type Bcr-Abl using Tyr2 peptide as substrate after 2 hrs by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50399379(CHEMBL2177649)
Affinity DataIC50:  0.450nMAssay Description:Inhibition of wild type Bcr-Abl using Tyr2 peptide as substrate after 2 hrs by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50399376(CHEMBL2178268)
Affinity DataIC50:  0.450nMAssay Description:Inhibition of wild type Bcr-Abl using Tyr2 peptide as substrate after 2 hrs by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50591914(CHEMBL5208315)
Affinity DataIC50:  0.490nMAssay Description:Inhibition of wild type Bcr-Abl (unknown origin) incubated for 1 hr in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of BCR-ABL (unknown origin) by kinase hotspot assayMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50399396(CHEMBL2177632)
Affinity DataIC50:  0.520nMAssay Description:Inhibition of wild type Bcr-Abl using Tyr2 peptide as substrate after 2 hrs by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50433237(CHEMBL2375971)
Affinity DataIC50:  0.520nMAssay Description:Inhibition of Bcr-Abl kinase (unknown origin) after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50399382(CHEMBL2177646)
Affinity DataIC50:  0.520nMAssay Description:Inhibition of wild type Bcr-Abl using Tyr2 peptide as substrate after 2 hrs by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50399380(CHEMBL2177648)
Affinity DataIC50:  0.520nMAssay Description:Inhibition of wild type Bcr-Abl using Tyr2 peptide as substrate after 2 hrs by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50399375(CHEMBL2178269)
Affinity DataIC50:  0.520nMAssay Description:Inhibition of wild type Bcr-Abl using Tyr2 peptide as substrate after 2 hrs by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50399394(CHEMBL2177634)
Affinity DataIC50:  0.540nMAssay Description:Inhibition of wild type Bcr-Abl using Tyr2 peptide as substrate after 2 hrs by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50591905(CHEMBL5206449)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of wild type Bcr-Abl (unknown origin) incubated for 1 hr in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50399383(CHEMBL2177645)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of wild type Bcr-Abl using Tyr2 peptide as substrate after 2 hrs by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50591878(CHEMBL5182032)
Affinity DataIC50:  0.650nMAssay Description:Inhibition of wild type Bcr-Abl (unknown origin) incubated for 1 hr in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50399386(CHEMBL2177642)
Affinity DataIC50:  0.690nMAssay Description:Inhibition of wild type Bcr-Abl using Tyr2 peptide as substrate after 2 hrs by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50399366(CHEMBL2178278)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of wild type Bcr-Abl using Tyr2 peptide as substrate after 2 hrs by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50399381(CHEMBL2177647)
Affinity DataIC50:  0.720nMAssay Description:Inhibition of wild type Bcr-Abl using Tyr2 peptide as substrate after 2 hrs by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50399395(CHEMBL2177633)
Affinity DataIC50:  0.780nMAssay Description:Inhibition of wild type Bcr-Abl using Tyr2 peptide as substrate after 2 hrs by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of wild type Bcr-AblMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50591892(CHEMBL5200499)
Affinity DataIC50:  0.830nMAssay Description:Inhibition of wild type Bcr-Abl (unknown origin) incubated for 1 hr in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50590370(K-0706 | K0706 | Sco-088 | VODOBATINIB | Vodobatin...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of wild type BCR-ABL phosphorylation in mouse BaF3 cells incubated for 4 hrs by immunoblotting analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of Bcr-Abl T315I mutant (unknown origin) using Tyr2 peptide substrate after 2 hrs by FRET-based Z'-lyte assayMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50591875(CHEMBL5179613)
Affinity DataIC50:  0.940nMAssay Description:Inhibition of wild type Bcr-Abl (unknown origin) incubated for 1 hr in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50399365(CHEMBL2178279)
Affinity DataIC50:  0.980nMAssay Description:Inhibition of wild type Bcr-Abl using Tyr2 peptide as substrate after 2 hrs by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50: <1nMAssay Description:Inhibition of BCR-ABL phosphorylation in human K562 cellsMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  1nMAssay Description:Inhibition of wild type Bcr-Abl (unknown origin) using Tyr2 peptide substrate after 2 hrs by FRET-based Z'-lyte assayMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein [1-693](Human)
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: <1nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Affinity DataIC50:  1nMAssay Description:Inhibition of BCR-ABL (unknown origin)More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50: <1nMAssay Description:Inhibition of Bcr-Abl kinaseMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50399392(CHEMBL2177636)
Affinity DataIC50:  1.01nMAssay Description:Inhibition of wild type Bcr-Abl using Tyr2 peptide as substrate after 2 hrs by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50399369(CHEMBL2178275)
Affinity DataIC50:  1.01nMAssay Description:Inhibition of wild type Bcr-Abl using Tyr2 peptide as substrate after 2 hrs by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50399371(CHEMBL2178273)
Affinity DataIC50:  1.03nMAssay Description:Inhibition of wild type Bcr-Abl using Tyr2 peptide as substrate after 2 hrs by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of wild type Bcr-AblMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50399393(CHEMBL2177635)
Affinity DataIC50:  1.18nMAssay Description:Inhibition of wild type Bcr-Abl using Tyr2 peptide as substrate after 2 hrs by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50529313(Flumatinib | HH-GV678 | Hhgv-678)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of BCR-ABL phosphorylation in human K562 cells incubated for 3 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50590368(IY5511 | RADOTINIB | Radotinib)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of BCR-ABL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50323777(CHEMBL1214141 | N-(4-Methyl-3-(1-methyl-7-(6-methy...)
Affinity DataIC50:  1.25nMAssay Description:Inhibition of wild type Bcr-Abl using Tyr2 peptide as substrate after 2 hrs by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50323777(CHEMBL1214141 | N-(4-Methyl-3-(1-methyl-7-(6-methy...)
Affinity DataIC50:  1.25nMAssay Description:Inhibition of wild type Bcr-AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM4552(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of BCR-ABL (unknown origin)More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50399377(CHEMBL2178267)
Affinity DataIC50:  1.42nMAssay Description:Inhibition of wild type Bcr-Abl using Tyr2 peptide as substrate after 2 hrs by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50591888(CHEMBL5187868)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of wild type Bcr-Abl (unknown origin) incubated for 1 hr in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50433236(CHEMBL2375973)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of Bcr-Abl kinase (unknown origin) after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50399372(CHEMBL2178272)
Affinity DataIC50:  1.66nMAssay Description:Inhibition of wild type Bcr-Abl using Tyr2 peptide as substrate after 2 hrs by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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