Compile Data Set for Download or QSAR
Found 6 of ic50 for UniProtKB: P11511
TargetAromatase [1-48](Homo sapiens (Human))
Biomolécules et Cibles Cellulaires Tumorales

LigandPNGBDBM13061(4,4 -(1H-1,2,4-triazol-1-ylmethanediyl)dibenzonitr...)
Show SMILES N#Cc1ccc(cc1)C(c1ccc(cc1)C#N)n1cncn1
Show InChI InChI=1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H
Affinity DataIC50: 18nMAssay Description:The inhibitory activities of the compounds toward aromatase were determined in vitro using human placental microsomes and [1,2,6,7-3H]-androstenedion...More data for this Ligand-Target Pair
TargetAromatase [1-48](Homo sapiens (Human))
Biomolécules et Cibles Cellulaires Tumorales

LigandPNGBDBM85252(2,4-Trans-4'-hydroxy-4-imidazolyl-7-methoxyfla...)
Show SMILES COc1ccc2C(CC(Oc2c1)c1ccc(O)cc1)n1ccnc1
Show InChI InChI=1S/C19H18N2O3/c1-23-15-6-7-16-17(21-9-8-20-12-21)11-18(24-19(16)10-15)13-2-4-14(22)5-3-13/h2-10,12,17-18,22H,11H2,1H3
Affinity DataIC50: 40nMAssay Description:The inhibitory activities of the compounds toward aromatase were determined in vitro using human placental microsomes and [1,2,6,7-3H]-androstenedion...More data for this Ligand-Target Pair
TargetAromatase [1-48](Homo sapiens (Human))
Biomolécules et Cibles Cellulaires Tumorales

LigandPNGBDBM85253(2,4-Trans-4',7-dihydroxy-4-imidazolyl-7-methox...)
Show SMILES Oc1ccc(cc1)C1CC(c2ccc(O)cc2O1)n1ccnc1
Show InChI InChI=1S/C18H16N2O3/c21-13-3-1-12(2-4-13)17-10-16(20-8-7-19-11-20)15-6-5-14(22)9-18(15)23-17/h1-9,11,16-17,21-22H,10H2
Affinity DataIC50: 77nMAssay Description:The inhibitory activities of the compounds toward aromatase were determined in vitro using human placental microsomes and [1,2,6,7-3H]-androstenedion...More data for this Ligand-Target Pair
TargetAromatase [1-48](Homo sapiens (Human))
Biomolécules et Cibles Cellulaires Tumorales

LigandPNGBDBM85249(2,4-Trans-3'-hydroxy-4-imidazolyl-7-methoxyfla...)
Show SMILES COc1ccc2C(CC(Oc2c1)c1cccc(O)c1)n1ccnc1
Show InChI InChI=1S/C19H18N2O3/c1-23-15-5-6-16-17(21-8-7-20-12-21)11-18(24-19(16)10-15)13-3-2-4-14(22)9-13/h2-10,12,17-18,22H,11H2,1H3
Affinity DataIC50: 130nMAssay Description:The inhibitory activities of the compounds toward aromatase were determined in vitro using human placental microsomes and [1,2,6,7-3H]-androstenedion...More data for this Ligand-Target Pair
TargetAromatase [1-48](Homo sapiens (Human))
Biomolécules et Cibles Cellulaires Tumorales

LigandPNGBDBM85251(2,4-Trans-4'-cyano-4-imidazolyl-7-methoxyflava...)
Show SMILES COc1ccc2C(CC(Oc2c1)c1ccc(cc1)C#N)n1ccnc1
Show InChI InChI=1S/C20H17N3O2/c1-24-16-6-7-17-18(23-9-8-22-13-23)11-19(25-20(17)10-16)15-4-2-14(12-21)3-5-15/h2-10,13,18-19H,11H2,1H3
Affinity DataIC50: 133nMAssay Description:The inhibitory activities of the compounds toward aromatase were determined in vitro using human placental microsomes and [1,2,6,7-3H]-androstenedion...More data for this Ligand-Target Pair
TargetAromatase [1-48](Homo sapiens (Human))
Biomolécules et Cibles Cellulaires Tumorales

LigandPNGBDBM85250(2,4-Trans-4'-chloro-4-imidazolyl-7-methoxyflav...)
Show SMILES COc1ccc2C(CC(Oc2c1)c1ccc(Cl)cc1)n1ccnc1
Show InChI InChI=1S/C19H17ClN2O2/c1-23-15-6-7-16-17(22-9-8-21-12-22)11-18(24-19(16)10-15)13-2-4-14(20)5-3-13/h2-10,12,17-18H,11H2,1H3
Affinity DataIC50: 200nMAssay Description:The inhibitory activities of the compounds toward aromatase were determined in vitro using human placental microsomes and [1,2,6,7-3H]-androstenedion...More data for this Ligand-Target Pair