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TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50288098(2-Ethoxy-5-ethyl-benzo[d][1,3]oxazin-4-one | CHEMB...)
Affinity DataKi:  0.0430nM Kon:  0.0000145M-1s-1 Koff:  3.39E+5s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50406288(CHEMBL344066)
Affinity DataKi:  0.0680nM Kon:  0.0000759M-1s-1 Koff:  1.12E+6s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50406293(CHEMBL356120)
Affinity DataKi:  0.0710nM Kon:  0.0000550M-1s-1 Koff:  7.76E+5s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50406217(CHEMBL145002)
Affinity DataKi:  0.100nM Kon:  0.00000617M-1s-1 Koff:  6.46E+4s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50288087(2-Ethoxy-5-methyl-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataKi:  0.126nM Kon:  0.0000117M-1s-1 Koff:  1.02E+5s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50118028(3-Isopropyl-1-methanesulfonyl-4-(2-pyrrolidin-1-yl...)
Affinity DataKi:  0.160nM Kon:  4.90M-1s-1 Koff:  3.05E+4s-1Assay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) using whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50406234(CHEMBL145774)
Affinity DataKi:  0.200nM Kon:  0.0000661M-1s-1 Koff:  3.47E+5s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50406239(CHEMBL357464)
Affinity DataKi:  0.251nM Kon:  0.0000708M-1s-1 Koff:  3.09E+5s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50029703(WIN-63395 | 4-Isopropyl-6-methoxy-1,1-dioxo-2-(1-p...)
Affinity DataKi:  0.270nM Koff:  4.45E+4s-1Assay Description:Apparent binding constant Ki=Kon/KoffMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50282874(4-Isopropyl-1,1-dioxo-2-(1-phenyl-1H-tetrazol-5-yl...)
Affinity DataKi:  0.300nM Koff:  9.40E+4s-1Assay Description:Apparent binding constant Ki=Kon/KoffMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50118029(3-Isopropyl-1-methanesulfonyl-4-(4-piperidin-1-yl-...)
Affinity DataKi:  0.310nM Kon:  0.00000207M-1s-1 Koff:  6.63E+3s-1Assay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) using whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50406240(CHEMBL347760)
Affinity DataKi:  0.398nM Kon:  0.0000182M-1s-1 Koff:  4.57E+4s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50406245(CHEMBL145592)
Affinity DataKi:  0.501nM Kon:  0.00468M-1s-1 Koff:  1.00E+7s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50286327(4,6-Dimethoxy-1,1-dioxo-2-(1-phenyl-1H-tetrazol-5-...)
Affinity DataKi:  0.600nM Koff:  4.90E+4s-1Assay Description:Apparent binding constant Ki=Kon/KoffMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50282873(4-sec-Butyl-1,1-dioxo-2-(1-phenyl-1H-tetrazol-5-yl...)
Affinity DataKi:  0.600nM Koff:  9.40E+4s-1Assay Description:Apparent binding constant Ki=Kon/KoffMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50282868(1,1-Dioxo-2-(1-phenyl-1H-tetrazol-5-ylsulfanylmeth...)
Affinity DataKi:  0.700nM Koff:  1.00E+5s-1Assay Description:Apparent binding constant Ki=Kon/KoffMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50406185(CHEMBL144906)
Affinity DataKi:  1nM Kon:  0.00141M-1s-1 Koff:  1.51E+6s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50291760(5-Ethyl-2-isopropylamino-benzo[d][1,3]oxazin-4-one...)
Affinity DataKi:  1nM Kon:  0.0000661M-1s-1 Koff:  7.08E+4s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50064310(2-Ethoxy-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d...)
Affinity DataKi:  1.40nM Kon:  0.000127M-1s-1 Koff:  9.36E+4s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50406260(CHEMBL143793)
Affinity DataKi:  1.41nM Kon:  0.000355M-1s-1 Koff:  2.51E+5s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50064318(2-Propoxy-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-...)
Affinity DataKi:  1.43nM Kon:  0.000142M-1s-1 Koff:  9.93E+4s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50406221(CHEMBL145729)
Affinity DataKi:  1.58nM Kon:  0.0000112M-1s-1 Koff:  7.08E+3s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50063719(2-Isopropylamino-5-methyl-benzo[d][1,3]oxazin-4-on...)
Affinity DataKi:  1.58nM Kon:  0.0000178M-1s-1 Koff:  1.18E+4s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50118027(4-[1-(2,2-Dimethyl-propyl)-azetidine-3-carbonyl]-3...)
Affinity DataKi:  1.73nM Kon:  0.0000109M-1s-1 Koff:  6.31E+3s-1Assay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) using whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50286330(4,5-Dimethoxy-1,1-dioxo-2-(1-phenyl-1H-tetrazol-5-...)
Affinity DataKi:  2nM Koff:  5.40E+4s-1Assay Description:Apparent binding constant Ki=Kon/KoffMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50282866(4-Ethyl-1,1-dioxo-2-(1-phenyl-1H-tetrazol-5-ylsulf...)
Affinity DataKi:  2nM Koff:  6.30E+4s-1Assay Description:Apparent binding constant Ki=Kon/KoffMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50406198(CHEMBL145035)
Affinity DataKi:  2.51nM Kon:  0.000813M-1s-1 Koff:  3.02E+5s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50064316(2-Ethylsulfanyl-5,6-dimethyl-thieno[2,3-d][1,3]oxa...)
Affinity DataKi:  2.73nM Kon:  0.00358M-1s-1 Koff:  1.31E+6s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50291763(2-Butylamino-5-ethyl-benzo[d][1,3]oxazin-4-one | C...)
Affinity DataKi:  3.98nM Kon:  0.000537M-1s-1 Koff:  1.29E+5s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50064314(5,6-Dimethyl-2-propoxy-thieno[2,3-d][1,3]oxazin-4-...)
Affinity DataKi:  4.02nM Kon:  0.0000628M-1s-1 Koff:  1.56E+4s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50406226(CHEMBL342522)
Affinity DataKi:  5.01nM Kon:  0.0000141M-1s-1 Koff:  2.88E+3s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50064325(2-Ethoxy-5-isopropyl-thieno[2,3-d][1,3]oxazin-4-on...)
Affinity DataKi:  5.61nM Kon:  0.000429M-1s-1 Koff:  7.64E+4s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50064326(2-Methylsulfanyl-5,6,7,8-tetrahydro-benzo[4,5]thie...)
Affinity DataKi:  5.74nM Kon:  0.00156M-1s-1 Koff:  2.72E+5s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50406271(CHEMBL141553)
Affinity DataKi:  6.31nM Kon:  0.00631M-1s-1 Koff:  1.10E+6s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50406290(CHEMBL141707)
Affinity DataKi:  6.31nM Kon:  0.0000436M-1s-1 Koff:  7.59E+3s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50288095(2-Ethoxy-benzo[d][1,3]oxazin-4-one | CHEMBL450273)
Affinity DataKi:  6.31nM Kon:  0.00102M-1s-1 Koff:  1.59E+5s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50291758(5-Methyl-2-propylamino-benzo[d][1,3]oxazin-4-one |...)
Affinity DataKi:  6.31nM Kon:  0.000339M-1s-1 Koff:  5.62E+4s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50406208(CHEMBL146004)
Affinity DataKi:  6.31nM Kon:  0.0000151M-1s-1 Koff:  2.57E+3s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50406216(CHEMBL146003)
Affinity DataKi:  6.31nM Kon:  0.00000871M-1s-1 Koff:  1.32E+3s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50406266(CHEMBL358112)
Affinity DataKi:  7.94nM Kon:  0.0224M-1s-1 Koff:  2.88E+6s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50406313(CHEMBL143792)
Affinity DataKi:  7.94nM Koff:  2.00E+6s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50406319(CHEMBL145492)
Affinity DataKi:  10nM Koff:  6.46E+3s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50406307(CHEMBL146010)
Affinity DataKi:  10nM Kon:  0.00246M-1s-1 Koff:  2.24E+5s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50406257(CHEMBL145252)
Affinity DataKi:  10nM Koff:  3.47E+4s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50064313(2-Ethoxy-5,6-dimethyl-thieno[2,3-d][1,3]oxazin-4-o...)
Affinity DataKi:  10.7nM Kon:  0.000130M-1s-1 Koff:  1.22E+4s-1Assay Description:Steady state inhibition constant for Human Leukocyte Elastase inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50406285(CHEMBL145583)
Affinity DataKi:  12.6nM Kon:  0.0000562M-1s-1 Koff:  4.68E+3s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50406186(CHEMBL142970)
Affinity DataKi:  12.6nM Kon:  0.000562M-1s-1 Koff:  4.90E+4s-1Assay Description:Component deacylation rate constant for interaction with human leukocyte elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50282878(4-Methoxy-1,1-dioxo-2-(1-phenyl-1H-tetrazol-5-ylsu...)
Affinity DataKi:  14nM Koff:  5.60E+3s-1Assay Description:Apparent binding constant Ki=Kon/KoffMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50036479(1,1-Dioxo-2-(1-phenyl-1H-tetrazol-5-ylsulfanylmeth...)
Affinity DataKi:  15nM Koff:  5.60E+3s-1Assay Description:Apparent binding constant Ki=Kon/KoffMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetNeutrophil elastase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50286331(4,7-Dimethoxy-1,1-dioxo-2-(1-phenyl-1H-tetrazol-5-...)
Affinity DataKi:  15nM Koff:  1.10E+3s-1Assay Description:Apparent binding constant Ki=Kon/KoffMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

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