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TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 704925BDBM704925(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-N- (((R)-3-...)
Affinity DataIC50: 0.00600nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 704925BDBM704925(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-N- (((R)-3-...)
Affinity DataIC50: 0.00600nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 704924BDBM704924(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-N- ((4-((((...)
Affinity DataIC50: 0.00700nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 704933BDBM704933(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) | US20240376097...)
Affinity DataIC50: 0.00800nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 704933BDBM704933(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) | US20240376097...)
Affinity DataIC50: 0.00800nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 704914BDBM704914(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-N- ((4-((((...)
Affinity DataIC50: 0.00800nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 705198BDBM705198(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-N- | US2024...)
Affinity DataIC50: 0.00800nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 719007BDBM719007(4-(4-[[4-(4-chlorophenyl)-6,6-dimethyl-2,5-dihydro...)
Affinity DataIC50: 0.0100nMAssay Description:The fluorescence-labeled 23 amino acid peptide BH3 was purchased from CalBiochem (NLWAAQRYGRELRRMSDKFVD). An unbound Fluorescein labeled BH3 peptide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/15/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 704922BDBM704922(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-N- ((4-((((...)
Affinity DataIC50: 0.0110nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 704922BDBM704922(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-N- ((4-((((...)
Affinity DataIC50: 0.0110nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 704912BDBM704912(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4- (2-(4-et...)
Affinity DataIC50: 0.0110nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 704920BDBM704920(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-N- ((4-((((...)
Affinity DataIC50: 0.0120nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 704920BDBM704920(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-N- ((4-((((...)
Affinity DataIC50: 0.0120nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 704917BDBM704917(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-N- ((4-((((...)
Affinity DataIC50: 0.0130nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 704932BDBM704932(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-N-((4-((((...)
Affinity DataIC50: 0.0130nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 704932BDBM704932(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-N-((4-((((...)
Affinity DataIC50: 0.0130nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 704917BDBM704917(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-N- ((4-((((...)
Affinity DataIC50: 0.0130nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 705196BDBM705196(WO2019210828 Example F91b)
Affinity DataIC50: 0.0140nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 704981BDBM704981(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-4-(2-(4-((...)
Affinity DataIC50: 0.0140nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 704981BDBM704981(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-4-(2-(4-((...)
Affinity DataIC50: 0.0140nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 567676BDBM567676(US11420970, Example 1 | US11420968, Example F42)
Affinity DataIC50: 0.0150nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 567773BDBM567773(US11420968, Example F132b)
Affinity DataIC50: 0.0150nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 567773BDBM567773(US11420968, Example F132b)
Affinity DataIC50: 0.0150nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 567800BDBM567800(US11420968, Example F43)
Affinity DataIC50: 0.0150nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 50636459BDBM50636459(CHEMBL5532549)
Affinity DataIC50: 0.0150nMAssay Description:Inhibition of Bcl-2 (unknown origin) using (Ac-GQVGRQLAIIGDK (FITC) INR-amide) as substrate preincubated for 30 mins followed by substrate addition a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 50636459BDBM50636459(CHEMBL5532549)
Affinity DataIC50: 0.0160nMAssay Description:Inhibition of Bcl-2 (unknown origin) using (Ac-GQVGRQLAIIGDK (FITC) INR-amide) as substrate preincubated for 30 mins followed by substrate addition a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 567682BDBM567682(US11420968, Example F48)
Affinity DataIC50: 0.0170nMAssay Description:Inhibition of Bcl-2 (unknown origin) using (Ac-GQVGRQLAIIGDK (FITC) INR-amide) as substrate preincubated for 30 mins followed by substrate addition a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 705100BDBM705100(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-N-((4-((((...)
Affinity DataIC50: 0.0170nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 705051BDBM705051((R)-2-((1H-pyrrolo[2,3-b]pyridin- 5-yl)oxy)-4-(6-(...)
Affinity DataIC50: 0.0170nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 50636456BDBM50636456(Sonrotoclax | Bgb 11417 | Bgb-11417 | BGB-11417 | ...)
Affinity DataIC50: 0.0190nMAssay Description:Inhibition of Bcl-2 (unknown origin) using (Ac-GQVGRQLAIIGDK (FITC) INR-amide) as substrate preincubated for 30 mins followed by substrate addition a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 705197BDBM705197(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-N-((4-((((1...)
Affinity DataIC50: 0.0190nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 704918BDBM704918(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-N- ((4-((((...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 704982BDBM704982(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-N-((4-((((...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 704982BDBM704982(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-N-((4-((((...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 567801BDBM567801(US11420968, Example F64)
Affinity DataIC50: 0.0200nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 567801BDBM567801(US11420968, Example F64)
Affinity DataIC50: 0.0200nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 567744BDBM567744(US11420968, Example F106)
Affinity DataIC50: 0.0210nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 567769BDBM567769(US11420968, Example F130)
Affinity DataIC50: 0.0210nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 567697BDBM567697(US11420968, Example F63)
Affinity DataIC50: 0.0210nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 567744BDBM567744(US11420968, Example F106)
Affinity DataIC50: 0.0210nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 567697BDBM567697(US11420968, Example F63)
Affinity DataIC50: 0.0210nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 567769BDBM567769(US11420968, Example F130)
Affinity DataIC50: 0.0210nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 567661BDBM567661(US11420968, Example F21)
Affinity DataIC50: 0.0220nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 567661BDBM567661(US11420968, Example F21)
Affinity DataIC50: 0.0220nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-xl protein with its ligand in an assay based on fluorescence polarization methodolog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 705148BDBM705148(2-((1H-pyrrolo[2,3-b]pyridin-5-yl) oxy)-4-(6-((R)-...)
Affinity DataIC50: 0.0220nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2 protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance Energy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/20/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 567696BDBM567696(US11420968, Example F62)
Affinity DataIC50: 0.0230nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 567696BDBM567696(US11420968, Example F62)
Affinity DataIC50: 0.0230nMAssay Description:Inhibition of Bcl-2 (unknown origin) using (Ac-GQVGRQLAIIGDK (FITC) INR-amide) as substrate preincubated for 30 mins followed by substrate addition a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 567696BDBM567696(US11420968, Example F62)
Affinity DataIC50: 0.0230nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 567736BDBM567736(US11420968, Example F99)
Affinity DataIC50: 0.0240nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandChemical structure of BindingDB Monomer ID 567736BDBM567736(US11420968, Example F99)
Affinity DataIC50: 0.0240nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
US Patent

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