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Report error Found 392 of affinity data for UniProtKB/TrEMBL: P18054
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50025735((5Z,8Z,11Z,13E)-15-oxoicosa-5,8,11,13-tetraenoic a...)
Affinity DataKi:  87nMAssay Description:Mixed type inhibition of human platelet 12-lipoxygenase assessed as equilibrium inhibitor constant of dissociation from enzyme by measuring 12-HpETE ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50447175(CHEMBL3113165 | US10752581, Compound 35)
Affinity DataKi:  350nMAssay Description:Uncompetitive inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate assessed as 12-HPETE formation by Henri-...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50447176(CHEMBL3113166 | US10752581, Compound 36)
Affinity DataKi:  530nMAssay Description:Uncompetitive inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate assessed as 12-HPETE formation by Henri-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50447176(CHEMBL3113166 | US10752581, Compound 36)
Affinity DataKi:  620nMAssay Description:Competitive inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate assessed as 12-HPETE formation by Henri-Mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50350394(CHEMBL528045)
Affinity DataKi:  700nMAssay Description:Competitive inhibition of human platelet-type N-terminally His6-tagged 12-lipoxygenase assessed as 12-HPETE formation using arachidonic acid by by Mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50447175(CHEMBL3113165 | US10752581, Compound 35)
Affinity DataKi:  720nMAssay Description:Competitive inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate assessed as 12-HPETE formation by Henri-Mi...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50009001(5,6,7-Trihydroxyflavone | 5,6,7-trihydroxy-2-pheny...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of human platelet-type 12-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50221405(CHEMBL391079 | dysidenin)
Affinity DataKi:  9.00E+3nMAssay Description:Inhibition of human 12-hLOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50221404(CHEMBL392270 | neodysidenin)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibition of human 12-hLOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50577453(CHEMBL4869861)
Affinity DataIC50:  50nMAssay Description:Inhibition of wild type human N-terminal His-tagged 12-LOX using arachidonic acid as substrate by UV-Vis spectroscopy analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50009004((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity of the compound against human platelet 12-lipoxygenase was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50009004((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)
Affinity DataIC50:  100nMAssay Description:Compound was tested in vitro for inhibition of 12-LO human plateletMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22372(4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbut...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human platelet-type 12-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50158387(4-[(3-carboxy-4-hydroxy-1-naphthyl)(oxo)acetyl]-1-...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human 12-hLOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50447181(CHEMBL3113197 | US10752581, Compound 67)
Affinity DataIC50:  160nMAssay Description:Inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate by UV-vis spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50447181(CHEMBL3113197 | US10752581, Compound 67)
Affinity DataIC50:  160nMAssay Description:UV-vis cuvette-based assay.More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22372(4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbut...)
Affinity DataIC50:  180nMAssay Description:Inhibition of His-tagged human platelet 12-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50447202(CHEMBL3113193 | US10752581, Compound 63)
Affinity DataIC50:  180nMAssay Description:Inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate by UV-vis spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50447202(CHEMBL3113193 | US10752581, Compound 63)
Affinity DataIC50:  180nMAssay Description:UV-vis cuvette-based assay.More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50221402(CHEMBL238624 | NSC-172033)
Affinity DataIC50:  210nMAssay Description:Inhibition of human 12-hLOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50447180(CHEMBL3113198 | US10752581, Compound 68)
Affinity DataIC50:  220nMAssay Description:Inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate by UV-vis spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50447180(CHEMBL3113198 | US10752581, Compound 68)
Affinity DataIC50:  220nMAssay Description:UV-vis cuvette-based assay.More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50447184(CHEMBL3113169 | US10752581, Compound 39)
Affinity DataIC50:  240nMAssay Description:Inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate by UV-vis spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50447184(CHEMBL3113169 | US10752581, Compound 39)
Affinity DataIC50:  240nMAssay Description:UV-vis cuvette-based assay.More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50447182(CHEMBL3113192 | US10752581, Compound 62)
Affinity DataIC50:  260nMAssay Description:Inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate by UV-vis spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50242010((+)-(5S,8S,9R,10S)-20-methoxypuupehenone | CHEMBL4...)
Affinity DataIC50:  260nMAssay Description:Inhibition of His-tagged human platelet 12-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50447182(CHEMBL3113192 | US10752581, Compound 62)
Affinity DataIC50:  260nMAssay Description:UV-vis cuvette-based assay.More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50242017((+)-(5S,8S,10S)-20-methoxypuupehenol | (+)-(5S,8S,...)
Affinity DataIC50:  280nMAssay Description:Inhibition of His-tagged human platelet 12-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM106776(3‐(3‐chlorophenyl)‐6,7‐dih...)
Affinity DataIC50:  280nMpH: 8.0 T: 23°CAssay Description:All reactions were carried in a volume of 2 mL stirred at 23°C with approximately 2.040 Units of 12-hLOX, 4.200 Units of 15-hLOX-1, and 6.600 Un...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50447220(CHEMBL3113170 | US10752581, Compound 50)
Affinity DataIC50:  330nMAssay Description:UV-vis cuvette-based assay.More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50447213(CHEMBL3113180)
Affinity DataIC50:  330nMAssay Description:Inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate by UV-vis spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50447175(CHEMBL3113165 | US10752581, Compound 35)
Affinity DataIC50:  340nMAssay Description:UV-vis cuvette-based assay.More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50447175(CHEMBL3113165 | US10752581, Compound 35)
Affinity DataIC50:  340nMAssay Description:Inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate by UV-vis spectrophotometric analysisMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50447221(CHEMBL3113168 | US10752581, Compound 38)
Affinity DataIC50:  350nMAssay Description:UV-vis cuvette-based assay.More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50447221(CHEMBL3113168 | US10752581, Compound 38)
Affinity DataIC50:  350nMAssay Description:Inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate by UV-vis spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50447175(CHEMBL3113165 | US10752581, Compound 35)
Affinity DataIC50:  360nMAssay Description:Inhibition of wild type human N-terminal His-tagged 12-LOX using arachidonic acid as substrate by UV-Vis spectroscopy analysisMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50114093(4-chloro-5-[(2R,3S)-4-(2-chloro-4,5-dihydroxypheny...)
Affinity DataIC50:  360nMAssay Description:Inhibitory activity against human platelet 12-lipoxygenase (12-HLO)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50114095(4-[(2R,3S)-4-(4,5-dihydroxy-2-nitrophenyl)-2,3-dim...)
Affinity DataIC50:  360nMAssay Description:Inhibitory activity against human platelet 12-lipoxygenase (12-HLO)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50447203(CHEMBL3113191 | US10752581, Compound 61)
Affinity DataIC50:  390nMAssay Description:Inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate by UV-vis spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50447203(CHEMBL3113191 | US10752581, Compound 61)
Affinity DataIC50:  390nMAssay Description:UV-vis cuvette-based assay.More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50150794(CHEMBL186752 | N-[2-(3-Bromo-4-hydroxy-phenyl)-eth...)
Affinity DataIC50:  400nMAssay Description:Inhibitory effect on human platelet 12-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50042498(CHEMBL333219 | N-{[6-(4-fluorophenoxy)-2H-chromen-...)
Affinity DataIC50:  410nMAssay Description:Inhibitory concentration against human platelet 12-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50135851(2,3,4,5-tetrabromo-6-(3,5-dibromo-2-hydroxy-phenox...)
Affinity DataIC50:  410nMAssay Description:Inhibitory effect on human platelet 12-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50114094(4-bromo-5-[(2R,3S)-4-(2-bromo-4,5-dihydroxyphenyl)...)
Affinity DataIC50:  430nMAssay Description:Inhibitory activity against human platelet 12-lipoxygenase (12-HLO)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Affinity DataIC50:  440nMAssay Description:Inhibition of 12-hLOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50447216(CHEMBL3113176 | US10752581, Compound 46)
Affinity DataIC50:  480nMAssay Description:UV-vis cuvette-based assay.More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50222293(4'-chloro-7,8-dihydroxyisoflavone | CHEMBL241814)
Affinity DataIC50:  480nMAssay Description:Inhibition of 12-hLOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50447216(CHEMBL3113176 | US10752581, Compound 46)
Affinity DataIC50:  480nMAssay Description:Inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate by UV-vis spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50447183(CHEMBL3113178 | US10752581, Compound 48)
Affinity DataIC50:  500nMAssay Description:UV-vis cuvette-based assay.More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50447183(CHEMBL3113178 | US10752581, Compound 48)
Affinity DataIC50:  500nMAssay Description:Inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate by UV-vis spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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