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TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50061669((R)-2-(Benzylamino-methyl)-chroman-7-ol; oxalic ac...)
Affinity DataEC50:  0.0200nMAssay Description:Agonist activity at human dopamine D2L receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50446924(CHEMBL3115575)
Affinity DataEC50:  0.0316nMAssay Description:Agonist activity at human dopamine D2L receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50007422((+)-6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]q...)
Affinity DataEC50:  0.0398nMAssay Description:Agonist activity at D2 long receptor (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50007422((+)-6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]q...)
Affinity DataEC50:  0.0400nMAssay Description:Agonist activity at D2 long receptor (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50446928(CHEMBL3115585)
Affinity DataEC50:  0.0501nMAssay Description:Agonist activity at human dopamine D2L receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50233623(CHEMBL4104013)
Affinity DataEC50:  0.0955nMAssay Description:Agonist activity at human dopamine D2L receptor expressed in F1pIn CHO cells assessed as increase in forskolin-mediated cAMP accumulation incubated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50233623(CHEMBL4104013)
Affinity DataEC50:  0.0960nMAssay Description:Agonist activity at human dopamine D2L receptor expressed in F1pIn CHO cells assessed as increase in forskolin-mediated cAMP accumulation incubated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM185688(UNC10107969 | US9156822, 18)
Affinity DataEC50:  0.100nMpH: 7.4Assay Description:HEK293T cells co-expressing the cAMP biosensor GloSensor-22F (Promega) and hD2 receptors were seeded (10,000 cells/20 ul/well) into white, clear-bott...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50237166(CHEMBL4097330)
Affinity DataEC50:  0.110nMAssay Description:Agonist activity at N-terminal flag-tagged D2S receptor (unknown origin) expressed in HEK293 cells coexpressing renilla luciferase 2-tagged GalphaoB ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50237162(CHEMBL4090208)
Affinity DataEC50:  0.110nMAssay Description:Agonist activity at N-terminal flag-tagged D2S receptor (unknown origin) expressed in HEK293 cells coexpressing renilla luciferase 2-tagged GalphaoA ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50237162(CHEMBL4090208)
Affinity DataEC50:  0.110nMAssay Description:Agonist activity at N-terminal flag-tagged D2S receptor (unknown origin) expressed in HEK293 cells coexpressing renilla luciferase 2-tagged GalphaoB ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50237169(CHEMBL4071185)
Affinity DataEC50:  0.120nMAssay Description:Agonist activity at N-terminal flag-tagged D2S receptor (unknown origin) expressed in HEK293 cells coexpressing renilla luciferase 2-tagged GalphaoB ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50236740(CHEMBL4078348)
Affinity DataEC50:  0.120nMAssay Description:Agonist activity at N-terminal flag-tagged D2S receptor (unknown origin) expressed in HEK293 cells coexpressing renilla luciferase 2-tagged GalphaoA ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50236740(CHEMBL4078348)
Affinity DataEC50:  0.120nMAssay Description:Agonist activity at N-terminal flag-tagged D2S receptor (unknown origin) expressed in HEK293 cells coexpressing renilla luciferase 2-tagged GalphaoB ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50237169(CHEMBL4071185)
Affinity DataEC50:  0.130nMAssay Description:Concentration required for the inhibitory activity against human FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50237166(CHEMBL4097330)
Affinity DataEC50:  0.130nMAssay Description:Agonist activity at N-terminal flag-tagged D2S receptor (unknown origin) expressed in HEK293 cells coexpressing renilla luciferase 2-tagged GalphaoA ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50444830(CHEMBL3099226)
Affinity DataEC50:  0.140nMAssay Description:Agonist activity at human dopamine D2 receptor expressed in CHO cells assessed as increase of forskolin-induced cAMP production after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50446926(CHEMBL3115582)
Affinity DataEC50:  0.158nMAssay Description:Agonist activity at human dopamine D2L receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50237158(CHEMBL4071868)
Affinity DataEC50:  0.160nMAssay Description:Agonist activity at N-terminal flag-tagged D2S receptor (unknown origin) expressed in HEK293 cells coexpressing renilla luciferase 2-tagged GalphaoB ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50237165(CHEMBL4098859)
Affinity DataEC50:  0.170nMAssay Description:Agonist activity at N-terminal flag-tagged D2S receptor (unknown origin) expressed in HEK293 cells coexpressing renilla luciferase 2-tagged GalphaoB ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50273465((+/-)-trans-1-Propyl-1,2,3,4,4a,5,10,10a-octahydro...)
Affinity DataEC50:  0.170nMAssay Description:Agonist activity at human dopamine D2 receptor expressed in CHO cells assessed as increase of forskolin-induced cAMP production after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50443101(Cariprazine | RGH-188)
Affinity DataEC50:  0.180nMAssay Description:Partial agonist activity at human D2 receptor assessed as increase in cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50237158(CHEMBL4071868)
Affinity DataEC50:  0.190nMAssay Description:Concentration required for the inhibitory activity against human FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM185687(UNC10107968 | US9156822, 17)
Affinity DataEC50:  0.200nMpH: 7.4Assay Description:HEK293T cells co-expressing the cAMP biosensor GloSensor-22F (Promega) and hD2 receptors were seeded (10,000 cells/20 ul/well) into white, clear-bott...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50237165(CHEMBL4098859)
Affinity DataEC50:  0.210nMAssay Description:Agonist activity at N-terminal flag-tagged D2S receptor (unknown origin) expressed in HEK293 cells coexpressing renilla luciferase 2-tagged GalphaoA ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50184795(1-(2-methoxyphenyl)-4-((1-phenyl-1H-pyrazol-4-yl)m...)
Affinity DataEC50:  0.220nMAssay Description:Intrinsic activity against dopamine D2(short) receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50595104(CHEMBL5192367)
Affinity DataEC50:  0.230nMAssay Description:Agonist activity at dopamine D2 receptor (unknown origin) assessed as increase in GTPgammaS bindingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50533790(CHEMBL4538230)
Affinity DataEC50:  0.270nMAssay Description:Agonist activity at human D2 dopamine receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50184795(1-(2-methoxyphenyl)-4-((1-phenyl-1H-pyrazol-4-yl)m...)
Affinity DataEC50:  0.280nMAssay Description:Intrinsic activity against dopamine D2(long) receptor assessed as [3H]thymidine uptake in CHO cells by mitogenesis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50237166(CHEMBL4097330)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at N-terminal flag-tagged D2S receptor (unknown origin) expressed in HEK293 cells coexpressing renilla luciferase 2-tagged Galphai1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50164848(CHEMBL3798179)
Affinity DataEC50:  0.300nMAssay Description:Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50395564(CHEMBL160630)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at human D2L receptor expressed in HEK293T cells coexpressing Gi subunit assessed as inhibition of isoproterenol-stimulated cAMP pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50511513(CHEMBL4591021)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at C-terminal RLuc8-fused D2 long receptor (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50021770(CHEMBL3298895)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at human D2L receptor expressed in FlpIn CHO cells assessed as inhibition of forskolin-stimulated cAMP production treated for 30 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50164848(CHEMBL3798179)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at dopamine D2 receptor (unknown origin) by cAMP accumulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50237169(CHEMBL4071185)
Affinity DataEC50:  0.310nMAssay Description:Concentration required for the inhibitory activity against human FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50511513(CHEMBL4591021)
Affinity DataEC50:  0.316nMAssay Description:Agonist activity at C-terminal RLuc8-fused D2 long receptor (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50002173(3-(4-(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)butyl)-...)
Affinity DataEC50:  0.370nMAssay Description:Compound was evaluated for effective concentration in vivo for Dopamine receptor D2 mitogenesis. (95% confidence intervals)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50511516(CHEMBL4555547)
Affinity DataEC50:  0.372nMAssay Description:Agonist activity at D2 long receptor (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50511516(CHEMBL4555547)
Affinity DataEC50:  0.373nMAssay Description:Agonist activity at D2 long receptor (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50237158(CHEMBL4071868)
Affinity DataEC50:  0.390nMAssay Description:Agonist activity at N-terminal flag-tagged D2S receptor (unknown origin) expressed in HEK293 cells coexpressing renilla luciferase 2-tagged Galphai1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50237162(CHEMBL4090208)
Affinity DataEC50:  0.390nMAssay Description:Agonist activity at N-terminal flag-tagged D2S receptor (unknown origin) expressed in HEK293 cells coexpressing renilla luciferase 2-tagged Galphai1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50021796(CHEMBL3299094)
Affinity DataEC50:  0.390nMAssay Description:Partial agonist activity at human D2L receptor expressed in FlpIn CHO cells assessed as induction of ERK1/2 phosphorylation by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50446927(CHEMBL3115579)
Affinity DataEC50:  0.398nMAssay Description:Agonist activity at human dopamine D2L receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50443101(Cariprazine | RGH-188)
Affinity DataEC50:  0.400nMAssay Description:Partial agonist activity at human Gi/o-coupled D2R expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation prein...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50443101(Cariprazine | RGH-188)
Affinity DataEC50:  0.400nMAssay Description:Partial agonist activity at human Gi/o-coupled D2R expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation prein...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50395565(CHEMBL160357)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at D2L receptor in human HTLA cells assessed as beta arrestin recruitment at 6 uM after 18 hrs by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM185697(UNC10108018 | US9156822, 41)
Affinity DataEC50:  0.400nMpH: 7.4Assay Description:HEK293T cells co-expressing the cAMP biosensor GloSensor-22F (Promega) and hD2 receptors were seeded (10,000 cells/20 ul/well) into white, clear-bott...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM185695(UNC10108010 | US9156822, 38)
Affinity DataEC50:  0.400nMpH: 7.4Assay Description:Recruitment of β-arrestin to agonist-stimulated D2 receptors was performed using a previously described Tango-type assay (Barnea et al., Proc. N...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Amsterdam

Curated by ChEMBL
LigandPNGBDBM50524256(CHEMBL4451797)
Affinity DataEC50:  0.400nMAssay Description:Partial agonist activity at human D2L receptor expressed in HEK293T cells co-expressing Galpahi1/Gbeta1/GFP2-Ggamma2 assessed as Galphai1 dissociatio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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