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TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50053813((1-{1-Benzyl-2-oxo-2-[3-(3,4,4a,8a-tetrahydro-1H-i...)
Affinity DataKi:  0.220nMAssay Description:Inhibition of the cysteine protease human Calpain 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50053865((3-Methyl-1-{1-[3-(3,4,4a,8a-tetrahydro-1H-isoquin...)
Affinity DataKi:  0.310nMAssay Description:Inhibition of the cysteine protease human Calpain 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50053851((3-Methyl-1-{1-[3-(3,4,4a,8a-tetrahydro-2H-quinoli...)
Affinity DataKi:  0.370nMAssay Description:Inhibition of the cysteine protease human Calpain 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50053800((1-{1-Benzyl-2-oxo-2-[3-(3,4,4a,8a-tetrahydro-2H-q...)
Affinity DataKi:  0.380nMAssay Description:Inhibition of the cysteine protease human Calpain 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50065404((R)-N-((S)-5-Benzenesulfonylamino-1-formyl-pentyl)...)
Affinity DataKi:  2nMAssay Description:Inhibitory activity against recombinant human Calpain-I receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50290289((S)-2-[(S)-2-((S)-2-Acetylamino-4-methyl-pentanoyl...)
Affinity DataKi:  3.40nMAssay Description:Equilibrium dissociation constant of the compound for the inhibition of human Mu-calpain was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50065398((R)-3-Benzyloxy-N-[(S)-1-(4-benzyloxy-benzyl)-2-ox...)
Affinity DataKi:  4nMAssay Description:Inhibitory activity against recombinant human Calpain-I receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50065401((S)-N-((S)-1-Benzyl-2-oxo-ethyl)-3-benzylsulfanyl-...)
Affinity DataKi:  6nMAssay Description:Inhibitory activity against recombinant human Calpain-I receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50112833(CHEMBL280587 | N-(1-Benzyl-2-carbamoyl-2-oxo-ethyl...)
Affinity DataKi:  6nMAssay Description:Inhibition of calpain, using human mu-calpain isolated from erythrocytes and Suc-Leu-Tyr-AMC as the fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50084655(CHEMBL92708 | Calpeptin | Z-Leu-Nle-CHO | [(S)-1-(...)
Affinity DataKi:  7nMAssay Description:The binding affinity against calpain.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50258392(CHEMBL4092996)
Affinity DataKi:  8nMAssay Description:Inhibition of human erythrocytes calpain-1 using Suc-Leu-Tyr-AMC as substrate by kinetic fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50080227(CHEMBL305715 | N-((S)-1-Benzyl-2-{2-[5-(3-cyano-ph...)
Affinity DataKi:  8nMAssay Description:Inhibitory activity against recombinant human calpain IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50065407((R)-N-((S)-1-Benzyl-2-oxo-ethyl)-3-benzyloxy-2-met...)
Affinity DataKi:  8nMAssay Description:Inhibitory activity against recombinant human Calpain-I receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50014577(CHEMBL286722 | MDL-2170 | Z-Val-Phe-H | [(S)-1-((S...)
Affinity DataKi:  8nMAssay Description:Inhibitory activity against recombinant human Calpain-I receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50128678(CHEMBL310855 | N-(1-Carbamoyl-2-phenyl-ethyl)-2-(2...)
Affinity DataKi:  8.40nMAssay Description:Inhibitory activity against human Calpain 1 isolated from erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain small subunit 1/1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50042397(3-(2-Benzyloxycarbonylamino-4-methyl-pentanoylamin...)
Affinity DataKi:  8.5nMAssay Description:Inhibitory activity of alpha-keto esters towards calpain 1 at pH 8.0.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50065396((R)-N-((S)-1-Benzyl-2-oxo-ethyl)-3-benzyloxy-2-eth...)
Affinity DataKi:  9nMAssay Description:Inhibitory activity against recombinant human Calpain-I receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50065412((R)-N-((S)-1-Benzyl-2-oxo-ethyl)-3-benzyloxy-2-(th...)
Affinity DataKi:  9nMAssay Description:Inhibitory activity against recombinant human Calpain-I receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50065399((R)-N-((S)-1-Benzyl-2-oxo-ethyl)-3-benzyloxy-2-met...)
Affinity DataKi:  9nMAssay Description:Inhibitory activity against recombinant human Calpain-I receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50065411((R)-N-((S)-1-Benzyl-2-oxo-ethyl)-2-methanesulfonyl...)
Affinity DataKi:  9nMAssay Description:Inhibitory activity against recombinant human Calpain-I receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50092301(1-(Benzo[b]thiophene-2-carbonyl)-piperidine-4-carb...)
Affinity DataKi:  9nMAssay Description:Inhibition of Suc-Leu-Tyr-AMC binding to human mu-calpain from erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50276901(CHEMBL4167219)
Affinity DataKi:  9nMAssay Description:Inhibition of human erythrocytes mu-calpain using SucLeu-Tyr-AMC as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50258354(CHEMBL4094671)
Affinity DataKi:  10nMAssay Description:Inhibition of human erythrocytes calpain-1 using Suc-Leu-Tyr-AMC as substrate by kinetic fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50065405((R)-N-((S)-1-Benzyl-2-oxo-ethyl)-3-(1H-indol-3-yl)...)
Affinity DataKi:  10nMAssay Description:Inhibitory activity against recombinant human Calpain-I receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50073850((S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyr...)
Affinity DataKi:  10nMAssay Description:Tested for inhibitory activity against calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50080220((S)-3-((R)-3-Benzyloxy-2-methanesulfonylamino-prop...)
Affinity DataKi:  10nMAssay Description:Inhibitory activity against recombinant human calpain IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50065403((R)-N-((S)-1-Benzyl-2-oxo-ethyl)-2-methanesulfonyl...)
Affinity DataKi:  11nMAssay Description:Inhibitory activity against recombinant human Calpain-I receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50065408((S)-N-((S)-1-Benzyl-2-oxo-ethyl)-2-methanesulfonyl...)
Affinity DataKi:  11nMAssay Description:Inhibitory activity against recombinant human Calpain-I receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50065400((R)-N-((S)-1-Benzyl-2-oxo-ethyl)-2-methanesulfonyl...)
Affinity DataKi:  11nMAssay Description:Inhibitory activity against recombinant human Calpain-I receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50128679(CHEMBL77784 | N-(1-Carbamoyl-pentyl)-2-[2-(4-dimet...)
Affinity DataKi:  13.3nMAssay Description:Inhibitory activity against human Calpain 1 isolated from erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50080217(CHEMBL80867 | N-{(S)-1-Benzyl-2-oxo-2-[2-(5-pyridi...)
Affinity DataKi:  14nMAssay Description:Inhibitory activity against recombinant human calpain IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50080225(CHEMBL311512 | N-[(S)-2-(2-{5-[3-(Acetylamino-meth...)
Affinity DataKi:  14nMAssay Description:Inhibitory activity against recombinant human calpain IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50073850((S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyr...)
Affinity DataKi:  15nMAssay Description:Inhibition of calpain, using human mu-calpain isolated from erythrocytes and Suc-Leu-Tyr-AMC as the fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50080231(CHEMBL312549 | N-((S)-1-Benzyl-2-{2-[5-(3-formyl-p...)
Affinity DataKi:  15nMAssay Description:Inhibitory activity against recombinant human calpain IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50128680(CHEMBL80903 | N-(1-Benzyl-2-oxo-ethyl)-2-(2-naphth...)
Affinity DataKi:  15nMAssay Description:Inhibitory activity against human Calpain 1 isolated from erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50073850((S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyr...)
Affinity DataKi:  15nMAssay Description:Inhibition of Suc-Leu-Tyr-AMC binding to human mu-calpain from erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50112845(CHEMBL280654 | N-(1-Benzyl-2-oxo-ethyl)-2-(2-napht...)
Affinity DataKi:  15nMAssay Description:Inhibition of calpain, using human mu-calpain isolated from erythrocytes and Suc-Leu-Tyr-AMC as the fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50073850((S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyr...)
Affinity DataKi:  15.5nMAssay Description:Inhibitory activity against human Calpain 1 isolated from erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50258312(CHEMBL4095528)
Affinity DataKi:  18nMAssay Description:Inhibition of human erythrocyte calpain 1 using Suc-Leu-Tyr-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50258312(CHEMBL4095528)
Affinity DataKi:  18nMAssay Description:Inhibition of Calpain I (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50258312(CHEMBL4095528)
Affinity DataKi:  18nMAssay Description:Inhibition of human erythrocytes calpain-1 using Suc-Leu-Tyr-AMC as substrate by kinetic fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50128681(CHEMBL80933 | N-(1-Carbamoyl-2-phenyl-ethyl)-2-[2-...)
Affinity DataKi:  18.3nMAssay Description:Inhibitory activity against human Calpain 1 isolated from erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50053822(CHEMBL132586 | Calpain XII | {3-Methyl-1-[1-(pyrid...)
Affinity DataKi:  19nMAssay Description:Inhibition of the cysteine protease human Calpain 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50258394(CHEMBL4068214)
Affinity DataKi:  20nMAssay Description:Inhibition of human erythrocytes calpain-1 using Suc-Leu-Tyr-AMC as substrate by kinetic fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50080222(4-Methyl-pentanoic acid {(S)-1-benzyl-2-oxo-2-[2-(...)
Affinity DataKi:  21nMAssay Description:Inhibitory activity against recombinant human Calpain 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50258320(CHEMBL4077634)
Affinity DataKi:  21nMAssay Description:Inhibition of human erythrocytes calpain-1 using Suc-Leu-Tyr-AMC as substrate by kinetic fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50080213(CHEMBL311256 | N-((S)-1-Benzyl-2-{2-[5-(3-morpholi...)
Affinity DataKi:  21nMAssay Description:Inhibitory activity against recombinant human Calpain 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50065413((R)-2-Benzenesulfonylamino-N-((S)-1-benzyl-2-oxo-e...)
Affinity DataKi:  22nMAssay Description:Inhibitory activity against recombinant human Calpain-I receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50522682(CHEMBL4462518)
Affinity DataKi:  26nMAssay Description:Inhibition of Cal1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Human)
Georgia Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50080223(CHEMBL310826 | N-{(S)-1-Benzyl-2-oxo-2-[2-(5-pyrid...)
Affinity DataKi:  26nMAssay Description:Inhibitory activity against recombinant human calpain IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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