Compile Data Set for Download or QSAR
Found 729 of ic50 for UniProtKB: P35408
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM190273(US9180116, 21C)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1CC(F)(F)C(=O)N1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C21H27F2NO4/c1-2-3-4-5-18(25)11-10-17-14-21(22,23)20(28)24(17)13-12-15-6-8-16(9-7-15)19(26)27/h6-11,17-18,25H,2-5,12-14H2,1H3,(H,26,27)/b11-10+/t17-,18-/m0/s1
Affinity DataKi:  0.0820nM IC50: 0.220nMpH: 6.0Assay Description:Assay Volume and Format:200 μl in 96-well plateCell membrane homogenates (20 μg protein) are incubated for 120 min at 22 C. with 0.5 nM [3...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM190282(US9180116, 33C)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(s1)C(O)=O
Show InChI InChI=1S/C20H27F2NO4S/c1-2-3-4-6-15(24)9-8-14-13-20(21,22)19(27)23(14)12-5-7-16-10-11-17(28-16)18(25)26/h8-11,14-15,24H,2-7,12-13H2,1H3,(H,25,26)/b9-8+/t14-,15-/m0/s1
Affinity DataKi:  0.100nM IC50: 0.280nMpH: 6.0Assay Description:Assay Volume and Format:200 μl in 96-well plateCell membrane homogenates (20 μg protein) are incubated for 120 min at 22 C. with 0.5 nM [3...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM50140261(CHEMBL3753860)
Show SMILES Cc1ccc(cc1C(=O)Nc1c(C)cc(cc1C)C(O)=O)-c1cccc(CO)c1
Show InChI InChI=1S/C24H23NO4/c1-14-7-8-19(18-6-4-5-17(11-18)13-26)12-21(14)23(27)25-22-15(2)9-20(24(28)29)10-16(22)3/h4-12,26H,13H2,1-3H3,(H,25,27)(H,28,29)
Affinity DataIC50: 0.280nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assa...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM190272(US9180116, 12D)
Show SMILES CCC#CC[C@H](C)[C@H](O)\C=C\[C@H]1CC(F)(F)C(=O)N1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H27F2NO4/c1-3-4-5-6-16(2)20(27)12-11-19-15-23(24,25)22(30)26(19)14-13-17-7-9-18(10-8-17)21(28)29/h7-12,16,19-20,27H,3,6,13-15H2,1-2H3,(H,28,29)/b12-11+/t16-,19-,20+/m0/s1
Affinity DataKi:  0.120nM IC50: 0.320nMpH: 6.0Assay Description:Assay Volume and Format:200 μl in 96-well plateCell membrane homogenates (20 μg protein) are incubated for 120 min at 22 C. with 0.5 nM [3...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM50101822((Z)-7-[(1R,2R,3R)-3-Hydroxy-2-((E)-(R)-3-hydroxy-o...)
Show SMILES CCCCC[C@@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16-,17-,19-/m1/s1
Affinity DataKi:  0.140nM IC50: 0.380nMpH: 6.0Assay Description:Assay Volume and Format:200 μl in 96-well plateCell membrane homogenates (20 μg protein) are incubated for 120 min at 22 C. with 0.5 nM [3...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM50520104(CHEMBL4535971)
Show SMILES C\C=C\c1nnn(Cc2ccc(cc2)C(F)(F)F)c1C(=O)N[C@@H](C)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H21F3N4O3/c1-3-4-19-20(21(31)27-14(2)16-7-9-17(10-8-16)22(32)33)30(29-28-19)13-15-5-11-18(12-6-15)23(24,25)26/h3-12,14H,13H2,1-2H3,(H,27,31)(H,32,33)/b4-3+/t14-/m0/s1
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human EP4 transfected in human HEK293 cells co transfected with SmBit-beta-arrestin. assessed as reduction in PGE2 induced-beta-arresti...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM190270(US9180116, 9C)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1CC(F)(F)C(=O)N1CCCCCCC(O)=O
Show InChI InChI=1S/C19H31F2NO4/c1-2-3-6-9-16(23)12-11-15-14-19(20,21)18(26)22(15)13-8-5-4-7-10-17(24)25/h11-12,15-16,23H,2-10,13-14H2,1H3,(H,24,25)/b12-11+/t15-,16-/m0/s1
Affinity DataKi:  0.210nM IC50: 0.570nMpH: 6.0Assay Description:Assay Volume and Format:200 μl in 96-well plateCell membrane homogenates (20 μg protein) are incubated for 120 min at 22 C. with 0.5 nM [3...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM578769(US11479550, Example 11-15(2) | US11479550, Example...)
Show SMILES COCCNC(=O)c1ccc2c(C)cn([C@H](C)C(=O)Nc3cc(ccc3CCCC(O)=O)C#N)c2c1
Show InChI InChI=1S/C27H30N4O5/c1-17-16-31(24-14-21(9-10-22(17)24)27(35)29-11-12-36-3)18(2)26(34)30-23-13-19(15-28)7-8-20(23)5-4-6-25(32)33/h7-10,13-14,16,18H,4-6,11-12H2,1-3H3,(H,29,35)(H,30,34)(H,32,33)/t18-/m1/s1
Affinity DataIC50: 0.570nMAssay Description:CHO cells expressing human EP4 receptor subtypes were prepared according to the methods of Nishigaki et al. (Non-Patent Literature 4), and used for e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM50140264(CHEMBL3753835)
Show SMILES Cc1ccc(nc1C(=O)Nc1c(C)cc(cc1C)C(O)=O)-c1cccc(CO)c1
Show InChI InChI=1S/C23H22N2O4/c1-13-7-8-19(17-6-4-5-16(11-17)12-26)24-21(13)22(27)25-20-14(2)9-18(23(28)29)10-15(20)3/h4-11,26H,12H2,1-3H3,(H,25,27)(H,28,29)
Affinity DataIC50: 0.670nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assa...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM50140253(CHEMBL3752948)
Show SMILES Cc1cc(cc(C)c1NC(=O)c1nc(ccc1C(F)(F)F)-c1cccc(CO)c1)C(O)=O
Show InChI InChI=1S/C23H19F3N2O4/c1-12-8-16(22(31)32)9-13(2)19(12)28-21(30)20-17(23(24,25)26)6-7-18(27-20)15-5-3-4-14(10-15)11-29/h3-10,29H,11H2,1-2H3,(H,28,30)(H,31,32)
Affinity DataIC50: 0.670nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assa...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM578749(US11479550, Example 3-9(2))
Show SMILES COCCNC(=O)c1ccc2c(C)cn([C@H](C)C(=O)Nc3cc(Cn4cc(C)cn4)ccc3CCCC(O)=O)c2c1
Show InChI InChI=1S/C31H37N5O5/c1-20-16-33-35(17-20)19-23-8-9-24(6-5-7-29(37)38)27(14-23)34-30(39)22(3)36-18-21(2)26-11-10-25(15-28(26)36)31(40)32-12-13-41-4/h8-11,14-18,22H,5-7,12-13,19H2,1-4H3,(H,32,40)(H,34,39)(H,37,38)/t22-/m1/s1
Affinity DataIC50: 0.700nMAssay Description:CHO cells expressing human EP4 receptor subtypes were prepared according to the methods of Nishigaki et al. (Non-Patent Literature 4), and used for e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM35847((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
Affinity DataIC50: 0.700nMAssay Description:Inhibitory activity against human EP4 receptor expressed in HEK293 ebna cellsMore data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM50140262(CHEMBL3753567)
Show SMILES Cc1cc(cc(C)c1NC(=O)c1cc(ccc1F)-c1cccc(CO)c1)C(O)=O
Show InChI InChI=1S/C23H20FNO4/c1-13-8-18(23(28)29)9-14(2)21(13)25-22(27)19-11-17(6-7-20(19)24)16-5-3-4-15(10-16)12-26/h3-11,26H,12H2,1-2H3,(H,25,27)(H,28,29)
Affinity DataIC50: 0.730nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assa...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM190275(US9180116, 28C | US9180116, 28H)
Show SMILES C[C@@H](CCCc1ccccc1)[C@H](O)\C=C\[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(s1)C(O)=O
Show InChI InChI=1S/C26H31F2NO4S/c1-18(7-5-10-19-8-3-2-4-9-19)22(30)14-12-20-17-26(27,28)25(33)29(20)16-6-11-21-13-15-23(34-21)24(31)32/h2-4,8-9,12-15,18,20,22,30H,5-7,10-11,16-17H2,1H3,(H,31,32)/b14-12+/t18-,20-,22+/m0/s1
Affinity DataKi:  0.280nM IC50: 0.740nMpH: 6.0Assay Description:Assay Volume and Format:200 μl in 96-well plateCell membrane homogenates (20 μg protein) are incubated for 120 min at 22 C. with 0.5 nM [3...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM578774(4-[2-({2-[3-methyl-6-(methylcarbamoyl)-1H-indol-1-...)
Show SMILES CNC(=O)c1ccc2c(C)cn(C(C)C(=O)Nc3cc(Oc4ccccc4)ccc3CCCC(O)=O)c2c1
Show InChI InChI=1S/C30H31N3O5/c1-19-18-33(27-16-22(30(37)31-3)13-15-25(19)27)20(2)29(36)32-26-17-24(38-23-9-5-4-6-10-23)14-12-21(26)8-7-11-28(34)35/h4-6,9-10,12-18,20H,7-8,11H2,1-3H3,(H,31,37)(H,32,36)(H,34,35)
Affinity DataIC50: 0.790nMAssay Description:CHO cells expressing human EP4 receptor subtypes were prepared according to the methods of Nishigaki et al. (Non-Patent Literature 4), and used for e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM578746(US11479550, Example 3-3(2))
Show SMILES CCNC(=O)c1ccc2c(C)cn([C@H](C)C(=O)Nc3cc(Cn4cc(C)cn4)ccc3CCCC(O)=O)c2c1
Show InChI InChI=1S/C30H35N5O4/c1-5-31-30(39)24-11-12-25-20(3)17-35(27(25)14-24)21(4)29(38)33-26-13-22(18-34-16-19(2)15-32-34)9-10-23(26)7-6-8-28(36)37/h9-17,21H,5-8,18H2,1-4H3,(H,31,39)(H,33,38)(H,36,37)/t21-/m1/s1
Affinity DataIC50: 0.900nMAssay Description:CHO cells expressing human EP4 receptor subtypes were prepared according to the methods of Nishigaki et al. (Non-Patent Literature 4), and used for e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM50334131((S)-4-(1-(1-(4-chlorobenzyl)indoline-7-carboxamido...)
Show SMILES C[C@H](NC(=O)c1cccc2CCN(Cc3ccc(Cl)cc3)c12)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H23ClN2O3/c1-16(18-7-9-20(10-8-18)25(30)31)27-24(29)22-4-2-3-19-13-14-28(23(19)22)15-17-5-11-21(26)12-6-17/h2-12,16H,13-15H2,1H3,(H,27,29)(H,30,31)/t16-/m0/s1
Affinity DataIC50: 0.920nMAssay Description:Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillat...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM50499955(CHEMBL3741430)
Show SMILES Cc1cc(cc(C)c1NC(=O)c1cc(cc2ccccc12)-c1cccc(CO)c1)C(O)=O
Show InChI InChI=1S/C27H23NO4/c1-16-10-22(27(31)32)11-17(2)25(16)28-26(30)24-14-21(13-20-7-3-4-9-23(20)24)19-8-5-6-18(12-19)15-29/h3-14,29H,15H2,1-2H3,(H,28,30)(H,31,32)
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM50334130((S)-4-(1-(1-(3,4-dichlorobenzyl)indoline-7-carboxa...)
Show SMILES C[C@H](NC(=O)c1cccc2CCN(Cc3ccc(Cl)c(Cl)c3)c12)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H22Cl2N2O3/c1-15(17-6-8-19(9-7-17)25(31)32)28-24(30)20-4-2-3-18-11-12-29(23(18)20)14-16-5-10-21(26)22(27)13-16/h2-10,13,15H,11-12,14H2,1H3,(H,28,30)(H,31,32)/t15-/m0/s1
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillat...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM50319838((S)-4-(1-(5-chloro-1-(4-(trifluoromethyl)benzyl)-1...)
Show SMILES C[C@H](NC(=O)c1cc(Cl)cc2ccn(Cc3ccc(cc3)C(F)(F)F)c12)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H20ClF3N2O3/c1-15(17-4-6-18(7-5-17)25(34)35)31-24(33)22-13-21(27)12-19-10-11-32(23(19)22)14-16-2-8-20(9-3-16)26(28,29)30/h2-13,15H,14H2,1H3,(H,31,33)(H,34,35)/t15-/m0/s1
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillat...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM190267(US9180116, 1F)
Show SMILES CC#CC[C@H](C)[C@H](O)\C=C\[C@H]1CC(F)(F)C(=O)N1CCCCCCC(O)=O
Show InChI InChI=1S/C20H29F2NO4/c1-3-4-9-15(2)17(24)12-11-16-14-20(21,22)19(27)23(16)13-8-6-5-7-10-18(25)26/h11-12,15-17,24H,5-10,13-14H2,1-2H3,(H,25,26)/b12-11+/t15-,16-,17+/m0/s1
Affinity DataKi:  0.440nM IC50: 1.20nMpH: 6.0Assay Description:Assay Volume and Format:200 μl in 96-well plateCell membrane homogenates (20 μg protein) are incubated for 120 min at 22 C. with 0.5 nM [3...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM50333748(CHEMBL1644003 | N,N,5,7-tetramethyl-3-(4-(2-(3-tos...)
Show SMILES CN(C)C(=O)c1sc2c(C)cc(C)cc2c1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C29H31N3O4S2/c1-18-6-12-23(13-7-18)38(35,36)31-29(34)30-15-14-21-8-10-22(11-9-21)25-24-17-19(2)16-20(3)26(24)37-27(25)28(33)32(4)5/h6-13,16-17H,14-15H2,1-5H3,(H2,30,31,34)
Affinity DataIC50: 1.20nMAssay Description:Antagonist activity at human EP4 receptor in HEK293 cells by cell-based functional assayMore data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM285498(4-[4-Cyano-2-({[(1R,2R)-6′-(methylcarbamoyl)...)
Show SMILES CNC(=O)c1ccc2CC[C@]3(C[C@H]3C(=O)Nc3cc(ccc3CCCC(O)=O)C#N)c2c1
Show InChI InChI=1S/C25H25N3O4/c1-27-23(31)18-8-7-16-9-10-25(19(16)12-18)13-20(25)24(32)28-21-11-15(14-26)5-6-17(21)3-2-4-22(29)30/h5-8,11-12,20H,2-4,9-10,13H2,1H3,(H,27,31)(H,28,32)(H,29,30)/t20-,25-/m0/s1
Affinity DataIC50: 1.20nMT: 2°CAssay Description:EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM578743(US11479550, Example 2-6(2))
Show SMILES CNC(=O)c1ccc2c(C)cn([C@H](C)C(=O)Nc3cc(Cn4ccc(C)n4)ccc3CCCC(O)=O)c2c1
Show InChI InChI=1S/C29H33N5O4/c1-18-16-34(26-15-23(29(38)30-4)10-11-24(18)26)20(3)28(37)31-25-14-21(17-33-13-12-19(2)32-33)8-9-22(25)6-5-7-27(35)36/h8-16,20H,5-7,17H2,1-4H3,(H,30,38)(H,31,37)(H,35,36)/t20-/m1/s1
Affinity DataIC50: 1.20nMAssay Description:CHO cells expressing human EP4 receptor subtypes were prepared according to the methods of Nishigaki et al. (Non-Patent Literature 4), and used for e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM190268(US9180116, 2C)
Show SMILES CCC#CC[C@H](C)[C@H](O)\C=C\[C@H]1CC(F)(F)C(=O)N1CCCCCCC(O)=O
Show InChI InChI=1S/C21H31F2NO4/c1-3-4-7-10-16(2)18(25)13-12-17-15-21(22,23)20(28)24(17)14-9-6-5-8-11-19(26)27/h12-13,16-18,25H,3,5-6,8-11,14-15H2,1-2H3,(H,26,27)/b13-12+/t16-,17-,18+/m0/s1
Affinity DataKi:  0.490nM IC50: 1.30nMpH: 6.0Assay Description:Assay Volume and Format:200 μl in 96-well plateCell membrane homogenates (20 μg protein) are incubated for 120 min at 22 C. with 0.5 nM [3...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM50520069(CHEMBL4457944)
Show SMILES C[C@H](NC(=O)c1c(nnn1CCOc1cccc(c1)C(F)(F)F)-c1ccccc1)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C27H23F3N4O4/c1-17(18-10-12-20(13-11-18)26(36)37)31-25(35)24-23(19-6-3-2-4-7-19)32-33-34(24)14-15-38-22-9-5-8-21(16-22)27(28,29)30/h2-13,16-17H,14-15H2,1H3,(H,31,35)(H,36,37)/t17-/m0/s1
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at human EP4 expressed in CHO cells coexpressing G16-alpha assessed as intracellular calcium flux preincubated for 15 mins follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM578764(US11479550, Example 11-1(2))
Show SMILES CCNC(=O)c1ccc2c(C)cn([C@H](C)C(=O)Nc3cc(ccc3CCCC(O)=O)C#N)c2c1
Show InChI InChI=1S/C26H28N4O4/c1-4-28-26(34)20-10-11-21-16(2)15-30(23(21)13-20)17(3)25(33)29-22-12-18(14-27)8-9-19(22)6-5-7-24(31)32/h8-13,15,17H,4-7H2,1-3H3,(H,28,34)(H,29,33)(H,31,32)/t17-/m1/s1
Affinity DataIC50: 1.30nMAssay Description:CHO cells expressing human EP4 receptor subtypes were prepared according to the methods of Nishigaki et al. (Non-Patent Literature 4), and used for e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM50319836(4-(1-(5-chloro-1-(4-(trifluoromethyl)benzyl)-1H-in...)
Show SMILES OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1cc(Cl)cc2ccn(Cc3ccc(cc3)C(F)(F)F)c12
Show InChI InChI=1S/C27H20ClF3N2O3/c28-21-13-18-9-12-33(15-16-1-5-20(6-2-16)27(29,30)31)23(18)22(14-21)24(34)32-26(10-11-26)19-7-3-17(4-8-19)25(35)36/h1-9,12-14H,10-11,15H2,(H,32,34)(H,35,36)
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillat...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM50319837(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
Show SMILES OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1cccc2ccn(Cc3ccc(cc3)C(F)(F)F)c12
Show InChI InChI=1S/C27H21F3N2O3/c28-27(29,30)21-8-4-17(5-9-21)16-32-15-12-18-2-1-3-22(23(18)32)24(33)31-26(13-14-26)20-10-6-19(7-11-20)25(34)35/h1-12,15H,13-14,16H2,(H,31,33)(H,34,35)
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillat...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM285464(4-{4-Cyano-2-[({2′R, 4S)-6-[(1-methyl 1H-pyr...)
Show SMILES Cn1cc(NC(=O)c2ccc3OCC[C@]4(C[C@H]4C(=O)Nc4cc(ccc4CCCC(O)=O)C#N)c3c2)cn1
Show InChI InChI=1S/C28H27N5O5/c1-33-16-20(15-30-33)31-26(36)19-7-8-24-21(12-19)28(9-10-38-24)13-22(28)27(37)32-23-11-17(14-29)5-6-18(23)3-2-4-25(34)35/h5-8,11-12,15-16,22H,2-4,9-10,13H2,1H3,(H,31,36)(H,32,37)(H,34,35)/t22-,28-/m0/s1
Affinity DataIC50: 1.30nMT: 2°CAssay Description:EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM50334136((S)-4-(1-(1-(biphenyl-4-ylmethyl)indoline-7-carbox...)
Show SMILES C[C@H](NC(=O)c1cccc2CCN(Cc3ccc(cc3)-c3ccccc3)c12)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C31H28N2O3/c1-21(23-14-16-27(17-15-23)31(35)36)32-30(34)28-9-5-8-26-18-19-33(29(26)28)20-22-10-12-25(13-11-22)24-6-3-2-4-7-24/h2-17,21H,18-20H2,1H3,(H,32,34)(H,35,36)/t21-/m0/s1
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillat...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM578751(US11479550, Example 3-20(2))
Show SMILES C[C@H](C(=O)Nc1cc(Cn2cc(C)cn2)ccc1CCCC(O)=O)n1cc(C)c2ccc(cc12)C(=O)NCC1CC1
Show InChI InChI=1S/C32H37N5O4/c1-20-15-34-36(17-20)19-24-9-10-25(5-4-6-30(38)39)28(13-24)35-31(40)22(3)37-18-21(2)27-12-11-26(14-29(27)37)32(41)33-16-23-7-8-23/h9-15,17-18,22-23H,4-8,16,19H2,1-3H3,(H,33,41)(H,35,40)(H,38,39)/t22-/m1/s1
Affinity DataIC50: 1.40nMAssay Description:CHO cells expressing human EP4 receptor subtypes were prepared according to the methods of Nishigaki et al. (Non-Patent Literature 4), and used for e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM50125405((R)-5-((E)-(S)-3-Hydroxy-4-phenyl-but-1-enyl)-1-[6...)
Show SMILES O[C@@H](Cc1ccccc1)\C=C\[C@H]1CCC(=O)N1CCCCCCc1nnn[nH]1
Show InChI InChI=1S/C21H29N5O2/c27-19(16-17-8-4-3-5-9-17)13-11-18-12-14-21(28)26(18)15-7-2-1-6-10-20-22-24-25-23-20/h3-5,8-9,11,13,18-19,27H,1-2,6-7,10,12,14-16H2,(H,22,23,24,25)/b13-11+/t18-,19+/m0/s1
Affinity DataIC50: 1.40nMAssay Description:EP4 agonist potency utilizing a stable clone of pSV40-EP4 transfected into HEK293 cells expressing EP4 receptorMore data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM50319840((S)-4-(1-(1-(3-chloro-5-(trifluoromethoxy)benzyl)-...)
Show SMILES C[C@H](NC(=O)c1cccc2ccn(Cc3cc(Cl)cc(OC(F)(F)F)c3)c12)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H20ClF3N2O4/c1-15(17-5-7-19(8-6-17)25(34)35)31-24(33)22-4-2-3-18-9-10-32(23(18)22)14-16-11-20(27)13-21(12-16)36-26(28,29)30/h2-13,15H,14H2,1H3,(H,31,33)(H,34,35)/t15-/m0/s1
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillat...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM578756(US11479550, Example 7-3(2))
Show SMILES CNC(=O)c1ccc2c(C)cn([C@H](C)C(=O)Nc3cc(Cn4cnc(n4)C(F)(F)F)ccc3CCCC(O)=O)c2c1
Show InChI InChI=1S/C28H29F3N6O4/c1-16-13-37(23-12-20(26(41)32-3)9-10-21(16)23)17(2)25(40)34-22-11-18(7-8-19(22)5-4-6-24(38)39)14-36-15-33-27(35-36)28(29,30)31/h7-13,15,17H,4-6,14H2,1-3H3,(H,32,41)(H,34,40)(H,38,39)/t17-/m1/s1
Affinity DataIC50: 1.5nMAssay Description:CHO cells expressing human EP4 receptor subtypes were prepared according to the methods of Nishigaki et al. (Non-Patent Literature 4), and used for e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM50319843((S)-4-(1-(5-chloro-1-(3-chlorobenzyl)-1H-indole-7-...)
Show SMILES C[C@H](NC(=O)c1cc(Cl)cc2ccn(Cc3cccc(Cl)c3)c12)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H20Cl2N2O3/c1-15(17-5-7-18(8-6-17)25(31)32)28-24(30)22-13-21(27)12-19-9-10-29(23(19)22)14-16-3-2-4-20(26)11-16/h2-13,15H,14H2,1H3,(H,28,30)(H,31,32)/t15-/m0/s1
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillat...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM50335985(CHEMBL1669013 | N-(1-(4-(4,9-diethoxy-1-oxo-1H-ben...)
Show SMILES CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CC2(CC2)NC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1C
Show InChI InChI=1S/C35H37N3O6S/c1-5-43-31-26-9-7-8-10-27(26)32(44-6-2)30-28(31)21-38(33(30)39)29-16-13-24(19-23(29)4)20-35(17-18-35)36-34(40)37-45(41,42)25-14-11-22(3)12-15-25/h7-16,19H,5-6,17-18,20-21H2,1-4H3,(H2,36,37,40)
Affinity DataIC50: 1.5nMAssay Description:Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM453713(2-(9-Ethyl-8-fluoro-6-methyl-9H-carbazol-3-yl)-1-(...)
Show SMILES CCn1c2ccc(cc2c2cc(C)cc(F)c12)-c1nc2cc(ccc2n1CCOC)C(O)=O
Show InChI InChI=1S/C26H24FN3O3/c1-4-29-22-7-5-16(13-18(22)19-11-15(2)12-20(27)24(19)29)25-28-21-14-17(26(31)32)6-8-23(21)30(25)9-10-33-3/h5-8,11-14H,4,9-10H2,1-3H3,(H,31,32)
Affinity DataIC50: 1.5nMAssay Description:5. 1 Detection PrincipleBinding of prostaglandin D2 to the human PGD receptor induces activation of membrane-bound adenylate cyclases and leads to th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM285502(US10077247, Example 20-2)
Show SMILES COCCNC(=O)c1cc2c(OCC[C@]22C[C@H]2C(=O)Nc2cc(ccc2CCCC(O)=O)C#N)cc1F
Show InChI InChI=1S/C27H28FN3O6/c1-36-10-8-30-25(34)18-12-19-23(13-21(18)28)37-9-7-27(19)14-20(27)26(35)31-22-11-16(15-29)5-6-17(22)3-2-4-24(32)33/h5-6,11-13,20H,2-4,7-10,14H2,1H3,(H,30,34)(H,31,35)(H,32,33)/t20-,27-/m0/s1
Affinity DataIC50: 1.60nMT: 2°CAssay Description:EP4 Antagonistic Activity Measurement Experiment Using Prostanoid Receptor Subtype Expressing CellsCHO cells expressing rat EP4 receptor subtypes wer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM578766(US11479550, Example 11-7(2))
Show SMILES C[C@H](C(=O)Nc1cc(ccc1CCCC(O)=O)C#N)n1cc(C)c2ccc(cc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C28H32N4O4/c1-17-16-32(24-14-21(11-12-22(17)24)27(36)31-28(3,4)5)18(2)26(35)30-23-13-19(15-29)9-10-20(23)7-6-8-25(33)34/h9-14,16,18H,6-8H2,1-5H3,(H,30,35)(H,31,36)(H,33,34)/t18-/m1/s1
Affinity DataIC50: 1.60nMAssay Description:CHO cells expressing human EP4 receptor subtypes were prepared according to the methods of Nishigaki et al. (Non-Patent Literature 4), and used for e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM50163381(CHEMBL3793002)
Show SMILES Cc1ccc(nc1C(=O)Nc1c(C)cc(cc1C)C(O)=O)N1CCC(F)(F)CC1
Show InChI InChI=1S/C21H23F2N3O3/c1-12-4-5-16(26-8-6-21(22,23)7-9-26)24-18(12)19(27)25-17-13(2)10-15(20(28)29)11-14(17)3/h4-5,10-11H,6-9H2,1-3H3,(H,25,27)(H,28,29)
Affinity DataIC50: 1.60nMAssay Description:Antagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM50308134(4-[({[2,5-Dichloro-4-(3-chlorobenzyl)-3-thienyl]ca...)
Show SMILES OC(=O)c1ccc(CNC(=O)c2c(Cl)sc(Cl)c2Cc2cccc(Cl)c2)cc1
Show InChI InChI=1S/C20H14Cl3NO3S/c21-14-3-1-2-12(8-14)9-15-16(18(23)28-17(15)22)19(25)24-10-11-4-6-13(7-5-11)20(26)27/h1-8H,9-10H2,(H,24,25)(H,26,27)
Affinity DataIC50: 1.60nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximi...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM578773(US11479550, Example 12-1(2))
Show SMILES CNC(=O)c1ccc2c(C)cn([C@H](C)C(=O)Nc3cc(Cn4cc(C)cn4)ccc3CCCC(O)=O)c2c1
Show InChI InChI=1S/C29H33N5O4/c1-18-14-31-33(15-18)17-21-8-9-22(6-5-7-27(35)36)25(12-21)32-28(37)20(3)34-16-19(2)24-11-10-23(13-26(24)34)29(38)30-4/h8-16,20H,5-7,17H2,1-4H3,(H,30,38)(H,32,37)(H,35,36)/t20-/m1/s1
Affinity DataIC50: 1.60nMAssay Description:CHO cells expressing human EP4 receptor subtypes were prepared according to the methods of Nishigaki et al. (Non-Patent Literature 4), and used for e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM50140254(CHEMBL3753372)
Show SMILES Cc1ccc(C(O)=O)c(C)c1NC(=O)c1nc(ccc1C)-c1cccc(Cl)c1
Show InChI InChI=1S/C22H19ClN2O3/c1-12-7-9-17(22(27)28)14(3)19(12)25-21(26)20-13(2)8-10-18(24-20)15-5-4-6-16(23)11-15/h4-11H,1-3H3,(H,25,26)(H,27,28)
Affinity DataIC50: 1.60nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assa...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM578748(US11479550, Example 3-7(2))
Show SMILES CC(C)NC(=O)c1ccc2c(C)cn([C@H](C)C(=O)Nc3cc(Cn4cc(C)cn4)ccc3CCCC(O)=O)c2c1
Show InChI InChI=1S/C31H37N5O4/c1-19(2)33-31(40)25-11-12-26-21(4)17-36(28(26)14-25)22(5)30(39)34-27-13-23(18-35-16-20(3)15-32-35)9-10-24(27)7-6-8-29(37)38/h9-17,19,22H,6-8,18H2,1-5H3,(H,33,40)(H,34,39)(H,37,38)/t22-/m1/s1
Affinity DataIC50: 1.70nMAssay Description:CHO cells expressing human EP4 receptor subtypes were prepared according to the methods of Nishigaki et al. (Non-Patent Literature 4), and used for e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM50319837(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
Show SMILES OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1cccc2ccn(Cc3ccc(cc3)C(F)(F)F)c12
Show InChI InChI=1S/C27H21F3N2O3/c28-27(29,30)21-8-4-17(5-9-21)16-32-15-12-18-2-1-3-22(23(18)32)24(33)31-26(13-14-26)20-10-6-19(7-11-20)25(34)35/h1-12,15H,13-14,16H2,(H,31,33)(H,34,35)
Affinity DataIC50: 1.80nMAssay Description:Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillat...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM50308133(4-[(1R)-1-({[2,5-Dichloro-4-(3-chlorobenzyl)-3-thi...)
Show SMILES C[C@@H](NC(=O)c1c(Cl)sc(Cl)c1Cc1cccc(Cl)c1)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C21H16Cl3NO3S/c1-11(13-5-7-14(8-6-13)21(27)28)25-20(26)17-16(18(23)29-19(17)24)10-12-3-2-4-15(22)9-12/h2-9,11H,10H2,1H3,(H,25,26)(H,27,28)/t11-/m1/s1
Affinity DataIC50: 1.80nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillation proximi...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM578745(US11479550, Example 2-27(4))
Show SMILES CNC(=O)c1ccc2c(C)cn([C@H](C)C(=O)Nc3cc(Cn4nc(C)cc4C(F)(F)F)ccc3CCCC(O)=O)c2c1
Show InChI InChI=1S/C30H32F3N5O4/c1-17-15-37(25-14-22(29(42)34-4)10-11-23(17)25)19(3)28(41)35-24-13-20(8-9-21(24)6-5-7-27(39)40)16-38-26(30(31,32)33)12-18(2)36-38/h8-15,19H,5-7,16H2,1-4H3,(H,34,42)(H,35,41)(H,39,40)/t19-/m1/s1
Affinity DataIC50: 1.80nMAssay Description:CHO cells expressing human EP4 receptor subtypes were prepared according to the methods of Nishigaki et al. (Non-Patent Literature 4), and used for e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM50140263(CHEMBL3753286)
Show SMILES Cc1ccc(C(O)=O)c(C)c1NC(=O)c1nc(ccc1C(F)(F)F)-c1cccc(CO)c1
Show InChI InChI=1S/C23H19F3N2O4/c1-12-6-7-16(22(31)32)13(2)19(12)28-21(30)20-17(23(24,25)26)8-9-18(27-20)15-5-3-4-14(10-15)11-29/h3-10,29H,11H2,1-2H3,(H,28,30)(H,31,32)
Affinity DataIC50: 1.90nMAssay Description:Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assa...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Cayman Chemical Company Inc

US Patent
LigandPNGBDBM578769(US11479550, Example 11-15(2) | US11479550, Example...)
Show SMILES COCCNC(=O)c1ccc2c(C)cn([C@H](C)C(=O)Nc3cc(ccc3CCCC(O)=O)C#N)c2c1
Show InChI InChI=1S/C27H30N4O5/c1-17-16-31(24-14-21(9-10-22(17)24)27(35)29-11-12-36-3)18(2)26(34)30-23-13-19(15-28)7-8-20(23)5-4-6-25(32)33/h7-10,13-14,16,18H,4-6,11-12H2,1-3H3,(H,29,35)(H,30,34)(H,32,33)/t18-/m1/s1
Affinity DataIC50: 1.90nMAssay Description:CHO cells expressing human EP4 receptor subtypes were prepared according to the methods of Nishigaki et al. (Non-Patent Literature 4), and used for e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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