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Report error Found 971 of affinity data for UniProtKB/TrEMBL: P39900
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92441(RXP470, 1 | RXP470, Compound 4)
Affinity DataKi:  0.190nM ΔG°:  -55.5kJ/molepH: 6.8 T: 25°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM50265078((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
Affinity DataKi:  0.190nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM50592891(CHEMBL5191016)
Affinity DataKi:  0.190nMAssay Description:Inhibition of human MMP-12 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92441(RXP470, 1 | RXP470, Compound 4)
Affinity DataKi:  0.200nM ΔG°:  -55.4kJ/molepH: 6.8 T: 25°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM50265078((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
Affinity DataKi:  0.240nMpH: 6.8Assay Description:Inhibition of human MMP12 catalytic domain (98 to 266) at pH 6.8 by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM50265078((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
Affinity DataKi:  0.260nMAssay Description:Binding affinity to human MMP12 catalytic domain (98 to 266) by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM50505154(CHEMBL4581500)
Affinity DataKi:  0.260nMAssay Description:Inhibition of human MMP12More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM50426080(CHEMBL2316257)
Affinity DataKi:  0.280nMAssay Description:Inhibition of human MMP12More data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM50426080(CHEMBL2316257)
Affinity DataKi:  0.280nMAssay Description:Binding affinity to human MMP12 catalytic domain (98 to 266) by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM120258(US8691753, 95 bis)
Affinity DataKi:  0.300nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM50505152(CHEMBL4435285)
Affinity DataKi:  0.900nMAssay Description:Inhibition of human MMP12More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM50434226(CHEMBL2385483)
Affinity DataKi:  1nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM50505151(CHEMBL4520279)
Affinity DataKi:  1nMAssay Description:Inhibition of human MMP12 by photoaffinity probe based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM50555050(CHEMBL4764575)
Affinity DataKi:  1nMAssay Description:Inhibition of human recombinant MMP12 using Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM120222(US8691753, 71)
Affinity DataKi:  1.05nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM50555052(CHEMBL4751015)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human recombinant MMP12 using Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM50555051(CHEMBL4739996)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human recombinant MMP12 using Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM120212(US8691753, 61 | US8691753, 72)
Affinity DataKi:  1.63nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM120242(US8691753, 91)
Affinity DataKi:  1.84nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)
Affinity DataKi:  1.90nM ΔG°:  -49.8kJ/molepH: 6.8 T: 25°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)
Affinity DataKi:  1.92nM ΔG°:  -49.8kJ/molepH: 6.8 T: 25°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM120246(US8691753, 95 | US8691753, 96)
Affinity DataKi:  1.92nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM50434222(CHEMBL2385487)
Affinity DataKi:  2nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM50294120(2-(biphenyl-4-ylsulfonamido)-N-hydroxyacetamide | ...)
Affinity DataKi:  2nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM120217(US8691753, 66)
Affinity DataKi:  2.20nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM120191(US8691753, 39)
Affinity DataKi:  2.20nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92446(Inhibitor, 16)
Affinity DataKi:  2.5nM ΔG°:  -49.1kJ/molepH: 6.8 T: 25°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM120252(US8691753, 101)
Affinity DataKi:  2.56nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM120243(US8691753, 92)
Affinity DataKi:  2.58nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92449(Inhibitor, 19)
Affinity DataKi:  2.90nM ΔG°:  -48.7kJ/molepH: 6.8 T: 25°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM120254(US8691753, 103)
Affinity DataKi:  2.90nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92448(Inhibitor, 18)
Affinity DataKi:  3.30nM ΔG°:  -48.4kJ/molepH: 6.8 T: 25°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM120215(US8691753, 64)
Affinity DataKi:  3.30nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92447(Inhibitor, 17)
Affinity DataKi:  3.30nM ΔG°:  -48.4kJ/molepH: 6.8 T: 25°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM120168(US8691753, 16)
Affinity DataKi:  3.40nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM120219(US8691753, 68)
Affinity DataKi:  3.5nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92445(Inhibitor, 10 | US8691753, 105)
Affinity DataKi:  3.60nM ΔG°:  -48.2kJ/molepH: 6.8 T: 25°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92445(Inhibitor, 10 | US8691753, 105)
Affinity DataKi:  3.65nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)
Affinity DataKi:  3.70nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM120256(US8691753, 106)
Affinity DataKi:  4.30nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
Affinity DataKi:  4.30nMAssay Description:Inhibition of MMP12 by fluorimetric assayMore data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM120221(US8691753, 70)
Affinity DataKi:  4.70nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM50433864(CHEMBL2380403)
Affinity DataKi:  4.80nMAssay Description:Inhibition of MMP12 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM50592895(CHEMBL5187653)
Affinity DataKi:  5nMAssay Description:Inhibition of MMP-12 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM50434213(CHEMBL2385489)
Affinity DataKi:  5nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM50434224(CHEMBL2385485)
Affinity DataKi:  5nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM120213(US8691753, 62)
Affinity DataKi:  5.20nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM120250(US8691753, 99)
Affinity DataKi:  5.40nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM120173(US8691753, 21)
Affinity DataKi:  5.40nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM50434221(CHEMBL2385490)
Affinity DataKi:  6nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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