Compile Data Set for Download or QSAR
Found 196 of ic50 for UniProtKB: Q8TF76
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human haspin using Histone H3 as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human haspin using Histone H3 as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human haspin using Histone H3 as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM50246769(CHEMBL4064608)
Show SMILES C1CC(CCO1)c1c[nH]c2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c12
Show InChI InChI=1S/C21H31N5O2/c1-3-17(26-7-11-28-12-8-26)4-2-16(1)25-21-19-18(15-5-9-27-10-6-15)13-22-20(19)23-14-24-21/h13-17H,1-12H2,(H2,22,23,24,25)/t16-,17-
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant N-terminal His6-tagged human haspin (471 end residues) expressed in baculovirus infected Sf21 insect cellsMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
Affinity DataIC50: 7.60nMAssay Description:Inhibition of human haspin using Histone H3 as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350270(US10208056, Compound 105)
Show SMILES CCn1c(C(N)=O)c(Cl)c2c1-c1ccncc1OC21CCCCC1
Show InChI InChI=1S/C18H20ClN3O2/c1-2-22-15-11-6-9-21-10-12(11)24-18(7-4-3-5-8-18)13(15)14(19)16(22)17(20)23/h6,9-10H,2-5,7-8H2,1H3,(H2,20,23)
Affinity DataIC50: 8.82nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350269(US10208056, Compound 104)
Show SMILES CCn1c(C(N)=O)c(Cl)c2c1-c1ccncc1OC21CCOCC1
Show InChI InChI=1S/C17H18ClN3O3/c1-2-21-14-10-3-6-20-9-11(10)24-17(4-7-23-8-5-17)12(14)13(18)15(21)16(19)22/h3,6,9H,2,4-5,7-8H2,1H3,(H2,19,22)
Affinity DataIC50: 8.91nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350253(US10208056, Compound 80)
Show SMILES CCn1c(cc2c1-c1ccncc1OC21CCCCC1)C(N)=O
Show InChI InChI=1S/C18H21N3O2/c1-2-21-14(17(19)22)10-13-16(21)12-6-9-20-11-15(12)23-18(13)7-4-3-5-8-18/h6,9-11H,2-5,7-8H2,1H3,(H2,19,22)
Affinity DataIC50: 9.56nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350256(US10208056, Compound 83)
Show SMILES Cn1c(cc2c1-c1ccncc1OC21CCCCC1)C(N)=O
Show InChI InChI=1S/C17H19N3O2/c1-20-13(16(18)21)9-12-15(20)11-5-8-19-10-14(11)22-17(12)6-3-2-4-7-17/h5,8-10H,2-4,6-7H2,1H3,(H2,18,21)
Affinity DataIC50: 9.80nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM50442760(CHEMBL2443044)
Show SMILES CN1CCC(CC1)NC(=O)c1cc(on1)-c1c(O)cc(O)cc1Oc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C22H22N4O7/c1-25-8-6-13(7-9-25)23-22(29)17-12-20(33-24-17)21-18(28)10-15(27)11-19(21)32-16-4-2-14(3-5-16)26(30)31/h2-5,10-13,27-28H,6-9H2,1H3,(H,23,29)
Affinity DataIC50: 10nMAssay Description:Inhibition of haspin (V473 to K798) (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM50442759(CHEMBL2443138)
Show SMILES CN(C)c1ccc(Oc2cc(O)cc(O)c2-c2cc(no2)C(=O)NC2CCN(C)CC2)cc1
Show InChI InChI=1S/C24H28N4O5/c1-27(2)16-4-6-18(7-5-16)32-21-13-17(29)12-20(30)23(21)22-14-19(26-33-22)24(31)25-15-8-10-28(3)11-9-15/h4-7,12-15,29-30H,8-11H2,1-3H3,(H,25,31)
Affinity DataIC50: 10nMAssay Description:Inhibition of haspin (V473 to K798) (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM50442758(CHEMBL2443139)
Show SMILES CC(C)Nc1ccc(Oc2cc(O)cc(O)c2-c2cc(no2)C(=O)NC2CCN(C)CC2)cc1
Show InChI InChI=1S/C25H30N4O5/c1-15(2)26-16-4-6-19(7-5-16)33-22-13-18(30)12-21(31)24(22)23-14-20(28-34-23)25(32)27-17-8-10-29(3)11-9-17/h4-7,12-15,17,26,30-31H,8-11H2,1-3H3,(H,27,32)
Affinity DataIC50: 10nMAssay Description:Inhibition of haspin (V473 to K798) (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM50442757(CHEMBL2443026)
Show SMILES CN(C)c1ccc(Oc2cc(O)cc(O)c2-c2cc(no2)C(=O)NC2CCN(CC2)C2CCC3(CC2)OCCO3)cc1
Show InChI InChI=1S/C31H38N4O7/c1-34(2)21-3-5-24(6-4-21)41-27-18-23(36)17-26(37)29(27)28-19-25(33-42-28)30(38)32-20-9-13-35(14-10-20)22-7-11-31(12-8-22)39-15-16-40-31/h3-6,17-20,22,36-37H,7-16H2,1-2H3,(H,32,38)
Affinity DataIC50: 10nMAssay Description:Inhibition of haspin (V473 to K798) (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM50466167(CHEMBL4278808)
Show SMILES Oc1ccc(c(F)c1)-c1nc2ccc3[nH]ncc3c2c2CCCCc12
Show InChI InChI=1S/C20H16FN3O/c21-16-9-11(25)5-6-14(16)20-13-4-2-1-3-12(13)19-15-10-22-24-17(15)7-8-18(19)23-20/h5-10,25H,1-4H2,(H,22,24)
Affinity DataIC50: 12nMAssay Description:Inhibition of Haspin (unknown origin) after 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350255(US10208056, Compound 82)
Show SMILES CCn1c(cc2c1-c1ccncc1OC21CCOCC1)C(N)=O
Show InChI InChI=1S/C17H19N3O3/c1-2-20-13(16(18)21)9-12-15(20)11-3-6-19-10-14(11)23-17(12)4-7-22-8-5-17/h3,6,9-10H,2,4-5,7-8H2,1H3,(H2,18,21)
Affinity DataIC50: 12.8nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM50542441(CHEMBL4642838)
Show SMILES Oc1ccc2C(=O)\C(Oc2c1)=C\c1c[nH]c2ncccc12
Show InChI InChI=1S/C16H10N2O3/c19-10-3-4-12-13(7-10)21-14(15(12)20)6-9-8-18-16-11(9)2-1-5-17-16/h1-8,19H,(H,17,18)/b14-6-
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant Haspin (470 to 798 residues) expressed in bacteria using Histone H3 and ARTKQTARKSTGGKAPRKQLA as substrate in presenc...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350183(US10208056, Compound 15)
Show SMILES NC(=O)c1cc2c([nH]1)-c1ccncc1OC21CCC1
Show InChI InChI=1S/C14H13N3O2/c15-13(18)10-6-9-12(17-10)8-2-5-16-7-11(8)19-14(9)3-1-4-14/h2,5-7,17H,1,3-4H2,(H2,15,18)
Affinity DataIC50: 15.9nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350264(US10208056, Compound 91)
Show SMILES CCn1c(cc2c1-c1ccncc1OC21CCNCC1)C(N)=O
Show InChI InChI=1S/C17H20N4O2/c1-2-21-13(16(18)22)9-12-15(21)11-3-6-20-10-14(11)23-17(12)4-7-19-8-5-17/h3,6,9-10,19H,2,4-5,7-8H2,1H3,(H2,18,22)
Affinity DataIC50: 16.5nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350266(US10208056, Compound 94)
Show SMILES CCn1c(C(N)=O)c(C2CC2)c2c1-c1ccncc1OC2(C)C
Show InChI InChI=1S/C18H21N3O2/c1-4-21-15-11-7-8-20-9-12(11)23-18(2,3)14(15)13(10-5-6-10)16(21)17(19)22/h7-10H,4-6H2,1-3H3,(H2,19,22)
Affinity DataIC50: 17.5nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350220(US10208056, Compound 52)
Show SMILES CC1(C)Oc2cnccc2-c2c1cc(C(N)=O)n2CCF
Show InChI InChI=1S/C15H16FN3O2/c1-15(2)10-7-11(14(17)20)19(6-4-16)13(10)9-3-5-18-8-12(9)21-15/h3,5,7-8H,4,6H2,1-2H3,(H2,17,20)
Affinity DataIC50: 22.4nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350249(US10208056, Compound 76)
Show SMILES NC(=O)c1cc2c(-c3ccncc3OC22CCC2)n1CCF
Show InChI InChI=1S/C16H16FN3O2/c17-5-7-20-12(15(18)21)8-11-14(20)10-2-6-19-9-13(10)22-16(11)3-1-4-16/h2,6,8-9H,1,3-5,7H2,(H2,18,21)
Affinity DataIC50: 24.2nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350265(US10208056, Compound 92)
Show SMILES NC(=O)c1cc2c(-c3ccncc3OC22CCOCC2)n1CCF
Show InChI InChI=1S/C17H18FN3O3/c18-4-6-21-13(16(19)22)9-12-15(21)11-1-5-20-10-14(11)24-17(12)2-7-23-8-3-17/h1,5,9-10H,2-4,6-8H2,(H2,19,22)
Affinity DataIC50: 25.6nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350239(US10208056, Compound 66)
Show SMILES CCn1c(cc2c1-c1ccncc1OC21CCC1)C(N)=O
Show InChI InChI=1S/C16H17N3O2/c1-2-19-12(15(17)20)8-11-14(19)10-4-7-18-9-13(10)21-16(11)5-3-6-16/h4,7-9H,2-3,5-6H2,1H3,(H2,17,20)
Affinity DataIC50: 26.2nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350196(US10208056, Compound 28)
Show SMILES CC1(C)Oc2cnccc2-c2[nH]c(C(N)=O)c(Cl)c12
Show InChI InChI=1S/C13H12ClN3O2/c1-13(2)8-9(14)11(12(15)18)17-10(8)6-3-4-16-5-7(6)19-13/h3-5,17H,1-2H3,(H2,15,18)
Affinity DataIC50: 26.6nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350240(US10208056, Compound 67)
Show SMILES Cn1c(cc2c1-c1ccncc1OC21CCC1)C(N)=O
Show InChI InChI=1S/C15H15N3O2/c1-18-11(14(16)19)7-10-13(18)9-3-6-17-8-12(9)20-15(10)4-2-5-15/h3,6-8H,2,4-5H2,1H3,(H2,16,19)
Affinity DataIC50: 27.6nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350202(US10208056, Compound 34)
Show SMILES CC1(C)Oc2cncc(Cl)c2-c2[nH]c(cc12)C(N)=O
Show InChI InChI=1S/C13H12ClN3O2/c1-13(2)6-3-8(12(15)18)17-11(6)10-7(14)4-16-5-9(10)19-13/h3-5,17H,1-2H3,(H2,15,18)
Affinity DataIC50: 31.8nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM50364776(CHEMBL1952141 | CHEMBL1952329)
Show SMILES CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1
Show InChI InChI=1S/C20H22F3N5O/c1-27-9-7-14(8-10-27)12-24-18-5-6-19-25-13-17(28(19)26-18)15-3-2-4-16(11-15)29-20(21,22)23/h2-6,11,13-14H,7-10,12H2,1H3,(H,24,26)
Affinity DataIC50: 34nMAssay Description:Inhibition of haspinMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350259(US10208056, Compound 86)
Show SMILES CC1(C)Oc2cnccc2-c2[nH]c(C(N)=O)c(C3CC3)c12
Show InChI InChI=1S/C16H17N3O2/c1-16(2)12-11(8-3-4-8)14(15(17)20)19-13(12)9-5-6-18-7-10(9)21-16/h5-8,19H,3-4H2,1-2H3,(H2,17,20)
Affinity DataIC50: 34.5nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM50466158(CHEMBL4290247)
Show SMILES Fc1ccc(CC(=O)Nc2cncc(c2)-c2cc(cs2)-c2cccnc2)cc1
Show InChI InChI=1S/C22H16FN3OS/c23-19-5-3-15(4-6-19)8-22(27)26-20-9-17(12-25-13-20)21-10-18(14-28-21)16-2-1-7-24-11-16/h1-7,9-14H,8H2,(H,26,27)
Affinity DataIC50: 36nMAssay Description:Inhibition of recombinant human Haspin expressed in Baculovirus expression system by Adapta assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350211(US10208056, Compound 43)
Show SMILES CCn1c(cc2c1-c1ccncc1OC2(C)C)C(N)=O
Show InChI InChI=1S/C15H17N3O2/c1-4-18-11(14(16)19)7-10-13(18)9-5-6-17-8-12(9)20-15(10,2)3/h5-8H,4H2,1-3H3,(H2,16,19)
Affinity DataIC50: 36.8nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350169(US10208056, Compound 1)
Show SMILES CC1(C)Oc2cnccc2-c2[nH]c(cc12)C(N)=O
Show InChI InChI=1S/C13H13N3O2/c1-13(2)8-5-9(12(14)17)16-11(8)7-3-4-15-6-10(7)18-13/h3-6,16H,1-2H3,(H2,14,17)
Affinity DataIC50: 38.1nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350252(US10208056, Compound 79)
Show SMILES CCn1c(cc2c1-c1ccncc1OC21CCN(CC(F)(F)F)CC1)C(N)=O
Show InChI InChI=1S/C19H21F3N4O2/c1-2-26-14(17(23)27)9-13-16(26)12-3-6-24-10-15(12)28-18(13)4-7-25(8-5-18)11-19(20,21)22/h3,6,9-10H,2,4-5,7-8,11H2,1H3,(H2,23,27)
Affinity DataIC50: 38.6nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350257(US10208056, Compound 84)
Show SMILES NC(=O)c1cc2c(-c3ccncc3OC22CCCCC2)n1CCF
Show InChI InChI=1S/C18H20FN3O2/c19-7-9-22-14(17(20)23)10-13-16(22)12-4-8-21-11-15(12)24-18(13)5-2-1-3-6-18/h4,8,10-11H,1-3,5-7,9H2,(H2,20,23)
Affinity DataIC50: 42.1nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350224(US10208056, Compound 54)
Show SMILES CC(C)C1(C)Oc2cnccc2-c2[nH]c(cc12)C(N)=O
Affinity DataIC50: 52.9nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350180(US10208056, Compound 12)
Show SMILES NC(=O)c1cc2c([nH]1)-c1ccncc1OC21CCNCC1
Show InChI InChI=1S/C15H16N4O2/c16-14(20)11-7-10-13(19-11)9-1-4-18-8-12(9)21-15(10)2-5-17-6-3-15/h1,4,7-8,17,19H,2-3,5-6H2,(H2,16,20)
Affinity DataIC50: 53.3nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350181(US10208056, Compound 13)
Show SMILES NC(=O)c1cc2c([nH]1)-c1ccncc1OC21CCCCC1
Show InChI InChI=1S/C16H17N3O2/c17-15(20)12-8-11-14(19-12)10-4-7-18-9-13(10)21-16(11)5-2-1-3-6-16/h4,7-9,19H,1-3,5-6H2,(H2,17,20)
Affinity DataIC50: 53.6nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350199(US10208056, Compound 31)
Show SMILES CC1(C)Oc2cnccc2-c2[nH]c(C(N)=O)c(c12)-c1ccccc1
Show InChI InChI=1S/C19H17N3O2/c1-19(2)15-14(11-6-4-3-5-7-11)17(18(20)23)22-16(15)12-8-9-21-10-13(12)24-19/h3-10,22H,1-2H3,(H2,20,23)
Affinity DataIC50: 73.2nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM50469211(CHEMBL4283503)
Show SMILES O=C(Nc1cncc(c1)-c1cc(cs1)-c1cccnc1)C1CC1
Show InChI InChI=1S/C18H15N3OS/c22-18(12-3-4-12)21-16-6-14(9-20-10-16)17-7-15(11-23-17)13-2-1-5-19-8-13/h1-2,5-12H,3-4H2,(H,21,22)
Affinity DataIC50: 76nMAssay Description:Inhibition of human GST-tagged haspin expressed in baculovirus expression system in presence of 100 uM ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM50542439(CHEMBL4637707)
Show SMILES Oc1ccc2C(=O)\C(CCc2c1)=C\c1c[nH]c2ncccc12
Show InChI InChI=1S/C18H14N2O2/c21-14-5-6-15-11(9-14)3-4-12(17(15)22)8-13-10-20-18-16(13)2-1-7-19-18/h1-2,5-10,21H,3-4H2,(H,19,20)/b12-8+
Affinity DataIC50: 77nMAssay Description:Inhibition of human recombinant Haspin (470 to 798 residues) expressed in bacteria using Histone H3 and ARTKQTARKSTGGKAPRKQLA as substrate in presenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350214(US10208056, Compound 46)
Show SMILES NC(=O)c1cc2c([nH]1)-c1ccncc1OC21CCN(CCc2ccccc2)CC1
Show InChI InChI=1S/C23H24N4O2/c24-22(28)19-14-18-21(26-19)17-6-10-25-15-20(17)29-23(18)8-12-27(13-9-23)11-7-16-4-2-1-3-5-16/h1-6,10,14-15,26H,7-9,11-13H2,(H2,24,28)
Affinity DataIC50: 81.3nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350190(US10208056, Compound 22)
Show SMILES Cn1c(cc2c1-c1ccncc1OC2(C)C)C(N)=O
Show InChI InChI=1S/C14H15N3O2/c1-14(2)9-6-10(13(15)18)17(3)12(9)8-4-5-16-7-11(8)19-14/h4-7H,1-3H3,(H2,15,18)
Affinity DataIC50: 87.4nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350197(US10208056, Compound 29)
Show SMILES CC1(C)Oc2cnccc2-c2[nH]c(C(O)=O)c(Br)c12
Show InChI InChI=1S/C13H11BrN2O3/c1-13(2)8-9(14)11(12(17)18)16-10(8)6-3-4-15-5-7(6)19-13/h3-5,16H,1-2H3,(H,17,18)
Affinity DataIC50: 89.3nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350201(US10208056, Compound 33)
Show SMILES CC1(C)Oc2cnccc2-c2[nH]c(C(N)=O)c(C=C)c12
Show InChI InChI=1S/C15H15N3O2/c1-4-8-11-12(18-13(8)14(16)19)9-5-6-17-7-10(9)20-15(11,2)3/h4-7,18H,1H2,2-3H3,(H2,16,19)
Affinity DataIC50: 90.6nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350262(US10208056, Compound 89)
Show SMILES CCn1c(cc2[C@@H](Oc3cnccc3-c12)C1CCCCC1)C(N)=O
Show InChI InChI=1S/C19H23N3O2/c1-2-22-15(19(20)23)10-14-17(22)13-8-9-21-11-16(13)24-18(14)12-6-4-3-5-7-12/h8-12,18H,2-7H2,1H3,(H2,20,23)/t18-/m0/s1
Affinity DataIC50: 95.2nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM50379521(CHEMBL2012574)
Show SMILES COc1ccc2c(c1)n(CCCCN)c1c(nccc21)C(F)(F)F
Show InChI InChI=1S/C17H18F3N3O/c1-24-11-4-5-12-13-6-8-22-16(17(18,19)20)15(13)23(14(12)10-11)9-3-2-7-21/h4-6,8,10H,2-3,7,9,21H2,1H3
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant N-terminal MBP-tagged haspin kinase expressed in Escherichia coli DE3 after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350261(US10208056, Compound 88)
Show SMILES CCn1c(C(N)=O)c(c2c1-c1ccncc1OC2(C)C)-c1cccc(OC)c1
Show InChI InChI=1S/C22H23N3O3/c1-5-25-19-15-9-10-24-12-16(15)28-22(2,3)18(19)17(20(25)21(23)26)13-7-6-8-14(11-13)27-4/h6-12H,5H2,1-4H3,(H2,23,26)
Affinity DataIC50: 106nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM50560888(CHEMBL4749646)
Show SMILES CC(C)c1ccn2ncnc(N[C@H]3CC[C@H](CC3)N3CCN(CC3)C(=O)CCC(=O)N3CCC(CCN4CCN(CC4)c4ccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c5c4)CC3)c12
Show InChI InChI=1S/C47H63N11O6/c1-31(2)36-16-20-57-43(36)44(48-30-49-57)50-33-3-5-34(6-4-33)53-25-27-56(28-26-53)42(61)12-11-41(60)55-18-14-32(15-19-55)13-17-52-21-23-54(24-22-52)35-7-8-37-38(29-35)47(64)58(46(37)63)39-9-10-40(59)51-45(39)62/h7-8,16,20,29-34,39H,3-6,9-15,17-19,21-28H2,1-2H3,(H,48,49,50)(H,51,59,62)/t33-,34+,39?
Affinity DataIC50: 110nMAssay Description:Inhibition of GSG2 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350260(US10208056, Compound 87)
Show SMILES COCCn1c(cc2c1-c1ccncc1OC21CCOCC1)C(N)=O
Show InChI InChI=1S/C18H21N3O4/c1-23-9-6-21-14(17(19)22)10-13-16(21)12-2-5-20-11-15(12)25-18(13)3-7-24-8-4-18/h2,5,10-11H,3-4,6-9H2,1H3,(H2,19,22)
Affinity DataIC50: 136nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350254(US10208056, Compound 81)
Show SMILES Cn1c(cc2c1-c1ccncc1OC21CCOCC1)C(N)=O
Show InChI InChI=1S/C16H17N3O3/c1-19-12(15(17)20)8-11-14(19)10-2-5-18-9-13(10)22-16(11)3-6-21-7-4-16/h2,5,8-9H,3-4,6-7H2,1H3,(H2,17,20)
Affinity DataIC50: 138nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Gachon University

Curated by ChEMBL
LigandPNGBDBM350225(US10208056, Compound 55)
Show SMILES CC1(C)Oc2cnccc2-c2[nH]c(C(N)=O)c(c12)C1=CCOCC1
Show InChI InChI=1S/C18H19N3O3/c1-18(2)14-13(10-4-7-23-8-5-10)16(17(19)22)21-15(14)11-3-6-20-9-12(11)24-18/h3-4,6,9,21H,5,7-8H2,1-2H3,(H2,19,22)
Affinity DataIC50: 146nMAssay Description:The kinase assay relies on ADP-GloKM biochemical kinase assay (Promega). This is a luminescent kinase assay that measures ADP formed from a kinase re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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