Compile Data Set for Download or QSAR
Report error Found 630 of ec50 for UniProtKB: Q8NER1
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50305285BDBM50305285([(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydrox...)
Affinity DataEC50:  0.00500nMAssay Description:Agonist activity at human TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50366620BDBM50366620(RESINIFERATOXIN)
Affinity DataEC50:  0.0190nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50366620BDBM50366620(RESINIFERATOXIN)
Affinity DataEC50:  0.0190nMAssay Description:Agonist activity at human TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50305283BDBM50305283([(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydrox...)
Affinity DataEC50:  0.150nMAssay Description:Agonist activity at human TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50473857BDBM50473857(CHEMBL124602)
Affinity DataEC50:  0.398nMAssay Description:Concentration necessary to induce a relative half-maximal response measured by the entry of [Ca2+] into human embryonic kidney HEK293 cells overexpre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 20460BDBM20460(N-Vannilyloleoylamide | (Z)-N-[(4-hydroxy-3-methox...)
Affinity DataEC50:  0.501nMAssay Description:Concentration necessary to induce a relative half-maximal response measured by the entry of [Ca2+] into human embryonic kidney HEK293 cells overexpre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50473843BDBM50473843(CHEMBL121808)
Affinity DataEC50:  0.501nMAssay Description:Concentration necessary to induce a relative half-maximal response measured by the entry of [Ca2+] into human embryonic kidney HEK293 cells overexpre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50473844BDBM50473844(CHEMBL123254)
Affinity DataEC50:  0.501nMAssay Description:Concentration necessary to induce a relative half-maximal response measured by the entry of [Ca2+] into human embryonic kidney HEK293 cells overexpre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50305281BDBM50305281([(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydrox...)
Affinity DataEC50:  0.650nMAssay Description:Agonist activity at human TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50366620BDBM50366620(RESINIFERATOXIN)
Affinity DataEC50:  0.920nMAssay Description:Agonist activity at human TRPV1 expressed in CHO cells assessed as 45Ca2+ uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50366620BDBM50366620(RESINIFERATOXIN)
Affinity DataEC50:  0.920nMAssay Description:Agonist activity at human TRPV1 expressed in CHO cells assessed as stimulation of Ca2+ uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50305282BDBM50305282([(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydrox...)
Affinity DataEC50:  0.980nMAssay Description:Agonist activity at human TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50444876BDBM50444876(CHEMBL3099608)
Affinity DataEC50:  0.990nMAssay Description:Agonist activity at human TRPV1 expressed in CHO cells assessed as 45Ca2+ uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196343BDBM50196343(2-((3-(4-hydroxy-3-methoxybenzyl)thioureido)methyl...)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at human TRPV1 expressed in CHO cells assessed as 45Ca2+ uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50473859BDBM50473859(CHEMBL124002)
Affinity DataEC50:  1.30nMAssay Description:Concentration necessary to induce a relative half-maximal response measured by the entry of [Ca2+] into human embryonic kidney HEK293 cells overexpre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50473845BDBM50473845(CHEMBL122864)
Affinity DataEC50:  1.30nMAssay Description:Concentration necessary to induce a relative half-maximal response measured by the entry of [Ca2+] into human embryonic kidney HEK293 cells overexpre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196616BDBM50196616((E)-3-(4-hydroxy-3-methoxy-phenyl)-acrylic acid (3...)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50473848BDBM50473848(CHEMBL333489)
Affinity DataEC50:  1.60nMAssay Description:Concentration necessary to induce a relative half-maximal response measured by the entry of [Ca2+] into human embryonic kidney HEK293 cells overexpre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50595685BDBM50595685(CHEMBL5173171)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at human TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium accumulation measured at 180 sec by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196621BDBM50196621(4-hydroxy-3-iodo-5-methoxy-benzoic acid (3aR,3bR,4...)
Affinity DataEC50:  1.90nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50366620BDBM50366620(RESINIFERATOXIN)
Affinity DataEC50:  1.90nMAssay Description:Induced [Ca2+] influx in Vanilloid receptor subtype 1 expressing HEK 293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50473855BDBM50473855(CHEMBL313885)
Affinity DataEC50:  2nMAssay Description:Concentration necessary to induce a relative half-maximal response measured by the entry of [Ca2+] into human embryonic kidney HEK293 cells overexpre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50473841BDBM50473841(CHEMBL124415)
Affinity DataEC50:  2nMAssay Description:Concentration necessary to induce a relative half-maximal response measured by the entry of [Ca2+] into human embryonic kidney HEK293 cells overexpre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50415874BDBM50415874(CHEMBL1095331)
Affinity DataEC50:  2nMAssay Description:Antagonist activity at human TRPV1 expressed in tetracycline-stimulated HEK293 cells assessed as inhibition of capsaicin-induced intracellular calciu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50622249BDBM50622249(CHEMBL5428602)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 20334BDBM20334(1-isoquinolin-5-yl-3-{[4-(trifluoromethyl)phenyl]m...)
Affinity DataEC50:  2.10nMpH: 7.4 T: 2°CAssay Description:The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2008
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50398494BDBM50398494(CHEMBL2177429)
Affinity DataEC50:  2.20nMAssay Description:Antagonist activity at recombinant human TRPV1 expressed in CHO cells assessed as as inhibition of capsaicin-induced calcium uptake incubated for 5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50473853BDBM50473853(CHEMBL332105)
Affinity DataEC50:  2.5nMAssay Description:Concentration necessary to induce a relative half-maximal response measured by the entry of [Ca2+] into human embryonic kidney HEK293 cells overexpre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 20461BDBM20461(Zostrix | (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl...)
Affinity DataEC50:  2.51nMAssay Description:Agonist activity at human TRPV1 expressed in tetracycline-stimulated HEK293 cells assessed as increase in intracellular calcium levels by fluorimetri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50415875BDBM50415875(CHEMBL1097704)
Affinity DataEC50:  2.51nMAssay Description:Antagonist activity at human TRPV1 expressed in tetracycline-stimulated HEK293 cells assessed as inhibition of capsaicin-induced intracellular calciu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50415876BDBM50415876(CHEMBL1096703)
Affinity DataEC50:  2.51nMAssay Description:Antagonist activity at human TRPV1 expressed in tetracycline-stimulated HEK293 cells assessed as inhibition of capsaicin-induced intracellular calciu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50566158BDBM50566158(CHEMBL4789932)
Affinity DataEC50:  2.80nMAssay Description:Agonist activity at human TRPV1 expressed in CHO cells assessed as stimulation of calcium uptake by 45Ca2+ uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 20351BDBM20351(3-{[4-(azepan-1-yl)-3-fluorophenyl]methyl}-1-isoqu...)
Affinity DataEC50:  2.80nMpH: 7.4 T: 2°CAssay Description:The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2008
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50566165BDBM50566165(CHEMBL4789599)
Affinity DataEC50:  3.10nMAssay Description:Agonist activity at human TRPV1 expressed in CHO cells assessed as stimulation of calcium uptake by 45Ca2+ uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50473865BDBM50473865(CHEMBL122849)
Affinity DataEC50:  3.20nMAssay Description:Concentration necessary to induce a relative half-maximal response measured by the entry of [Ca2+] into human embryonic kidney HEK293 cells overexpre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50473847BDBM50473847(CHEMBL121925)
Affinity DataEC50:  3.20nMAssay Description:Concentration necessary to induce a relative half-maximal response measured by the entry of [Ca2+] into human embryonic kidney HEK293 cells overexpre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50473864BDBM50473864(CHEMBL126095)
Affinity DataEC50:  3.20nMAssay Description:Concentration necessary to induce a relative half-maximal response measured by the entry of [Ca2+] into human embryonic kidney HEK293 cells overexpre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 20338BDBM20338(3-{[4-(azepan-1-yl)phenyl]methyl}-1-isoquinolin-5-...)
Affinity DataEC50:  3.30nMpH: 7.4 T: 2°CAssay Description:The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2008
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 20344BDBM20344(3-({4-[(1R,5S)-8-azabicyclo[3.2.1]octan-8-yl]pheny...)
Affinity DataEC50:  3.30nMpH: 7.4 T: 2°CAssay Description:The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2008
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 20345BDBM20345(3-{[4-(azepan-1-yl)phenyl]methyl}-1-(3-methylisoqu...)
Affinity DataEC50:  3.80nMpH: 7.4 T: 2°CAssay Description:The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2008
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 20461BDBM20461(Zostrix | (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl...)
Affinity DataEC50:  3.90nMAssay Description:Agonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50473842BDBM50473842(CHEMBL124163)
Affinity DataEC50:  4nMAssay Description:Concentration necessary to induce a relative half-maximal response measured by the entry of [Ca2+] into human embryonic kidney HEK293 cells overexpre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 20334BDBM20334(1-isoquinolin-5-yl-3-{[4-(trifluoromethyl)phenyl]m...)
Affinity DataEC50:  4nMpH: 7.4 T: 2°CAssay Description:The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2008
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 20334BDBM20334(1-isoquinolin-5-yl-3-{[4-(trifluoromethyl)phenyl]m...)
Affinity DataEC50:  4nMpH: 7.4 T: 2°CAssay Description:The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196617BDBM50196617(3-(4-hydroxy-3-methoxy-phenyl)-propionic acid (3aR...)
Affinity DataEC50:  4.60nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 20350BDBM20350(3-{[4-(azepan-1-yl)-3-(trifluoromethyl)phenyl]meth...)
Affinity DataEC50:  4.60nMpH: 7.4 T: 2°CAssay Description:The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2008
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 20339BDBM20339(3-{[4-(azocan-1-yl)phenyl]methyl}-1-isoquinolin-5-...)
Affinity DataEC50:  4.70nMpH: 7.4 T: 2°CAssay Description:The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2008
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50196615BDBM50196615(phenyl-acetic acid (3aR,3bR,4R,5aR,8aR,8bS,11aR)-3...)
Affinity DataEC50:  4.70nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 20458BDBM20458(A-778317 | 1-[(1R)-5-tert-butyl-2,3-dihydro-1H-ind...)
Affinity DataKi:  7nM ΔG°:  -11.1kcal/mole EC50:  5nMpH: 7.4 T: 2°CAssay Description:The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2008
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50473856BDBM50473856(CHEMBL126172)
Affinity DataEC50:  5nMAssay Description:Concentration necessary to induce a relative half-maximal response measured by the entry of [Ca2+] into human embryonic kidney HEK293 cells overexpre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
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