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TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM155343(US9006249, Example 49-2 | US9603819, Example 49-2)
Affinity DataIC50:  0.0300nMpH: 7.4 T: 2°CAssay Description:See A fluorescence lifetime-based assay for protease inhibitor profiling on human kallikrein 7 Doering K, Meder G, Hinnenberger M, Woelcke J, Mayr L ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM155343(US9006249, Example 49-2 | US9603819, Example 49-2)
Affinity DataIC50:  0.0300nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM309469((2R,4S)-5-(3′-Chloro-biphenyl-4-yl)-4-[(3-hy...)
Affinity DataIC50:  0.0400nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM153121(US8993631, 29-2 | US9006249, Example 49-1)
Affinity DataIC50:  0.0400nMpH: 7.4 T: 2°CAssay Description:See A fluorescence lifetime-based assay for protease inhibitor profiling on human kallikrein 7 Doering K, Meder G, Hinnenberger M, Woelcke J, Mayr L ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50175518((3R,7S)-7-((R)-2-Mercapto-3-phenyl-propionylamino)...)
Affinity DataIC50:  0.0800nMAssay Description:Inhibitory concentration against neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM138390(US8877786, Example 3-1)
Affinity DataIC50:  0.0900nMpH: 7.4 T: 2°CAssay Description:The in vitro inhibition of recombinant human neutral endopeptidase (NEP, EC 3.424.11) can be determined as follows:Recombinant human neutral endopept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM186570(US9163040, 2)
Affinity DataIC50:  0.110nMpH: 7.4 T: 2°CAssay Description:Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 pM) is pre-incubated wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50073120((4S,6S,9aS)-6-((S)-2-Mercapto-3-phenyl-propionylam...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM138395(US8877786, Example 3-12)
Affinity DataIC50:  0.200nMpH: 7.4 T: 2°CAssay Description:The in vitro inhibition of recombinant human neutral endopeptidase (NEP, EC 3.424.11) can be determined as follows:Recombinant human neutral endopept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM138396(US8877786, Example 3-13)
Affinity DataIC50:  0.200nMpH: 7.4 T: 2°CAssay Description:The in vitro inhibition of recombinant human neutral endopeptidase (NEP, EC 3.424.11) can be determined as follows:Recombinant human neutral endopept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM155344(US9006249, Example 49-3 | US9603819, Example 49-3)
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:See A fluorescence lifetime-based assay for protease inhibitor profiling on human kallikrein 7 Doering K, Meder G, Hinnenberger M, Woelcke J, Mayr L ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM138391(US8877786, Example 3-2)
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:The in vitro inhibition of recombinant human neutral endopeptidase (NEP, EC 3.424.11) can be determined as follows:Recombinant human neutral endopept...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM155344(US9006249, Example 49-3 | US9603819, Example 49-3)
Affinity DataIC50:  0.300nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM153128(US8993631, 36)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50344195((S)-2-(1-((S)-1-carboxy-2-(5-(4-chlorophenyl)oxazo...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50344193((S)-2-(1-((S)-1-carboxy-2-(5-phenyloxazol-2-yl)eth...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50354041(CHEMBL1829584)
Affinity DataIC50:  0.360nMAssay Description:Inhibition of neutral endopeptidase in human fibroblasts homogenates using glutaryl-Ala-Ala-Phe-4-methoxy-2-naphtylamide as substrate after 1 hrs by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM130359(US8822534, Example 5-39 | US8993631, 5-8)
Affinity DataIC50:  0.380nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50354042(CHEMBL1829585)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of neutral endopeptidase in human fibroblasts homogenates using glutaryl-Ala-Ala-Phe-4-methoxy-2-naphtylamide as substrate after 1 hrs by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50291559(CHEMBL268473 | {2-Benzo[1,3]dioxol-5-yl-1-[(S)-2-b...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50344191((S)-2-(1-((S)-1-carboxy-2-(5-phenyloxazol-2-yl)eth...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50403254(CHEMBL51389)
Affinity DataIC50:  0.600nMAssay Description:Tested in vitro for inhibition of neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50085452((S)-2-[((S)-6-Amino-2-methanesulfonylamino-hexanoy...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50503883(CHEMBL4443691)
Affinity DataIC50:  0.631nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50503875(CHEMBL4435800)
Affinity DataIC50:  0.631nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50287299((2S,4S)-5-Biphenyl-4-yl-4-(4-carboxymethyl-thiazol...)
Affinity DataIC50:  0.690nMAssay Description:In vitro inhibition of Neutral EndopeptidaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50291555(CHEMBL276690 | {2-Benzo[1,3]dioxol-4-yl-1-[(S)-2-b...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50291558(CHEMBL276872 | {1-[(S)-2-Biphenyl-4-yl-1-(1H-tetra...)
Affinity DataIC50:  0.740nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50509659(CHEMBL4443138)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50400808(CHEMBL2204326)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50064106(CGS-26303 | CHEMBL290698 | {[(R)-2-Biphenyl-4-yl-1...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50056252((6S,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50:  0.900nMAssay Description:Inhibitory concentration required to inhibit neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50056252((6S,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50064106(CGS-26303 | CHEMBL290698 | {[(R)-2-Biphenyl-4-yl-1...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50503895(CHEMBL4465325)
Affinity DataIC50:  1nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50403250(CHEMBL51780)
Affinity DataIC50:  1nMAssay Description:Tested in vitro for inhibition of neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM153108(US8993631, 16-5 | US9006249, Example 3-32 | US9603...)
Affinity DataIC50:  1nMAssay Description:The activity of a compound according to the present invention can be assessed by the following in vitro & in vivo methods and/or by the following in ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human NEP-mediated amyloid beta hydrolysisMore data for this Ligand-Target Pair
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50503881(CHEMBL4469350)
Affinity DataIC50:  1nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50503884(CHEMBL4547120)
Affinity DataIC50:  1nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50503886(CHEMBL4456519)
Affinity DataIC50:  1nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM153108(US8993631, 16-5 | US9006249, Example 3-32 | US9603...)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:See A fluorescence lifetime-based assay for protease inhibitor profiling on human kallikrein 7 Doering K, Meder G, Hinnenberger M, Woelcke J, Mayr L ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50403253(CHEMBL301751)
Affinity DataIC50:  1.20nMAssay Description:Tested in vitro for inhibition of neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50041071((2-Mercaptomethyl-3-phenyl-butyrylamino)-acetic ac...)
Affinity DataIC50:  1.30nMAssay Description:In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50002022((2-Benzyl-3-hydroxycarbamoyl-propionylamino)-aceti...)
Affinity DataIC50:  1.40nMAssay Description:Inhibitory potency against neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50291557(CHEMBL268761 | {1-[(S)-2-Biphenyl-4-yl-1-(1H-tetra...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM130365(US8822534, Example 11-1 | US8822534, Example 12-1 ...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50509652(CHEMBL4557208)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50403257(CHEMBL51438)
Affinity DataIC50:  1.70nMAssay Description:Tested in vitro for inhibition of neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50344197((S)-2-(1-((S)-1-carboxy-2-(3-phenyl-1,2,4-oxadiazo...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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