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TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451503(CHEMBL12513)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50062599(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | EN3...)
Affinity DataIC50:  0.950nMAssay Description:Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/gluta...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451505(CHEMBL274422)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50591726(CHEMBL450325)
Affinity DataIC50:  2.60nMAssay Description:Displacement of [3H]L-689560 from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50492253(CHEMBL2398522)
Affinity DataIC50:  4.20nMAssay Description:Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/gluta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451498(CHEMBL536107)
Affinity DataIC50:  4.20nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50591725(CHEMBL61720)
Affinity DataIC50:  4.40nMAssay Description:Displacement of [3H]L-689560 from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50069465(CHEMBL343863 | Thiophene-2-carboxylic acid (7-brom...)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]MDL from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50069459(CHEMBL413125 | Thiophene-3-carboxylic acid (7-brom...)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]MDL from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50069483(CHEMBL356281 | N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrah...)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]MDL from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50492252(CHEMBL55568)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/gluta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM393276(5-(3,4- difluorobenzenesulfon- amidomethyl)-6- met...)
Affinity DataIC50:  16.2nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2A (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
PDB3D3D Structure (crystal)

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451509(CHEMBL268920)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM393246(5-(3-chloro-4- fluorobenzenesulfon- amidomethyl)-6...)
Affinity DataIC50:  19.6nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2A (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50344263((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...)
Affinity DataIC50:  29nMAssay Description:Antagonist activity at NR2A transfected in oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM86494(EAA-090 | Perzinfotel | WAY-126090)
Affinity DataIC50:  30nMAssay Description:Binding affinity to NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM393274(5-(3- chlorobenzenesulfon- midomethyl)-6- methyl-N...)
Affinity DataIC50:  39.5nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2A (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451518(CHEMBL12256)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50329477((S)-N-(3-(4-(3-aminopropylamino)butylamino)propyl)...)
Affinity DataIC50:  47nMAssay Description:Antagonist activity at NR1-1a/NR2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current at -60mV ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451513(CHEMBL273686)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451506(CHEMBL543489)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2A heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451515(CHEMBL12301)
Affinity DataIC50:  60nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2A heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM393080(5-(3-chloro-4- fluorobenzenesulfon- amidomethyl)-N...)
Affinity DataIC50:  61nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2A (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
In DepthDetails US Patent
PDB3D3D Structure (crystal)

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM17657((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Affinity DataIC50:  70nMAssay Description:Binding affinity to NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50476423(CHEMBL228435)
Affinity DataIC50:  72nMAssay Description:Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50476427(CHEMBL228436)
Affinity DataIC50:  78nMAssay Description:Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM393273(5-(3-chloro-4- fluorobenzenesulfon- amidomethyl)-6...)
Affinity DataIC50:  87.8nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2A (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50492255(CHEMBL2009741)
Affinity DataIC50:  89nMAssay Description:Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/gluta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM50591726(CHEMBL450325)
Affinity DataIC50:  90nMAssay Description:Displacement of [3H]NMDA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451507(CHEMBL543252)
Affinity DataIC50:  90nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2A heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50329480((S)-N-(20-amino-2,7-dioxo-1-phenyl-3,8,12,17-tetra...)
Affinity DataIC50:  106nMAssay Description:Antagonist activity at NR1-1a/NR2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current at -60mV ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM393097(6-(3-chloro-4- fluorobenzenesulfon- amidomethyl)-N...)
Affinity DataIC50:  108nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2A (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM393074(5-(3-chloro-4- fluorobenzenesulfon- amidomethyl)-N...)
Affinity DataIC50:  108nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2A (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451512(CHEMBL268714)
Affinity DataIC50:  110nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2A heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50476430(CHEMBL388315)
Affinity DataIC50:  111nMAssay Description:Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50476424(CHEMBL228380)
Affinity DataIC50:  117nMAssay Description:Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50476432(CHEMBL228437)
Affinity DataIC50:  127nMAssay Description:Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM393275(5-(4- fluorobenzenesulfon- amidomethyl)-6- methyl-...)
Affinity DataIC50:  137nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2A (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50064176(CHEMBL27673 | CHEMBL500996 | METHOCTRAMINE | N,N''...)
Affinity DataIC50:  138nMAssay Description:Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/gluta...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50476433(CHEMBL228486)
Affinity DataIC50:  145nMAssay Description:Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM393277(5-(3-chloro-4- fluorobenzenesulfon- amidomethyl)-N...)
Affinity DataIC50:  169nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2A (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451520(CHEMBL276670)
Affinity DataIC50:  170nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2A heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM393194(5-(3-chloro-4- fluorobenzenesulfon- amidomethyl)-N...)
Affinity DataIC50:  180nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2A (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM393059(5-(3-chloro-4- fluorobenzenesulfon- amidomethyl)-N...)
Affinity DataIC50:  187nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2A (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50476425(CHEMBL228325)
Affinity DataIC50:  198nMAssay Description:Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451517(CHEMBL536106)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2A heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50476422(CHEMBL390304)
Affinity DataIC50:  203nMAssay Description:Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 2A(Human)
Central South University

Curated by ChEMBL
LigandPNGBDBM393066(5-(3-chloro-4- fluorobenzenesulfon- amidomethyl)-N...)
Affinity DataIC50:  204nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2A (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50476431(CHEMBL390521)
Affinity DataIC50:  211nMAssay Description:Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50476426(CHEMBL390305)
Affinity DataIC50:  215nMAssay Description:Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

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