Affinity DataIC50: 0.0250nMAssay Description:Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125I]DOI as radioligand. To define nonspecific binding, 1...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0250nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125]DOI as radioligand. To define nonspecific binding, 10...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0400nMAssay Description:Compounds of the present application bind to the 5-HT2 receptor subtypes in the following assays: Compounds of the invention are tested on 5-HT2A and...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0690nMAssay Description:R-SAT assays were performed as described previously (Weiner et al., 2001), with the following modifications. In brief, NIH-3T3 cells were grown to 80...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0820nMpH: 7.4Assay Description:Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125I]DOI as radioligand. To define nonspecific binding, 1...More data for this Ligand-Target Pair
Affinity DataIC50: 0.240nMAssay Description:The experiment was carried out at Cerep Contract Laboratories (Cat. ref. #471).Compound (I) was also tested in an in vivo set up demonstrating centra...More data for this Ligand-Target Pair
Affinity DataIC50: 0.25nMAssay Description:The experiment was carried out at Cerep Contract Laboratories (Cat. ref. #471).Compound (I) was also tested in an in vivo set up demonstrating centra...More data for this Ligand-Target Pair
Affinity DataIC50: 0.260nMAssay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
Affinity DataIC50: 0.260nMAssay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
Affinity DataIC50: 0.260nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125]DOI as radioligand. To define nonspecific binding, 10...More data for this Ligand-Target Pair
Affinity DataIC50: 0.260nMAssay Description:Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125I]DOI as radioligand. To define nonspecific binding, 1...More data for this Ligand-Target Pair
Affinity DataIC50: 0.270nMAssay Description:Displacement of [3H]Ketanserin from recombinant human 5-HT2A receptor extracted from CHO cell membrane incubated for 60 mins by radioligand binding a...More data for this Ligand-Target Pair
Affinity DataIC50: 0.316nMAssay Description:Compound was evaluated for its inverse agonist activity against 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.330nMAssay Description:The experiment was carried out at Cerep Contract Laboratories (Cat. ref. #471).Compound (I) was also tested in an in vivo set up demonstrating centra...More data for this Ligand-Target Pair
Affinity DataIC50: 0.340nMAssay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
Affinity DataIC50: 0.350nMAssay Description:Displacement of [3H]ketanserin from human recombinant 5HT2A receptor expressed in HEK293 cells measured after 60 mins by scintillation counting metho...More data for this Ligand-Target Pair
Affinity DataIC50: 0.350nMAssay Description:Displacement of [3H]ketanserin from human recombinant 5-HT2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.370nMAssay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
Affinity DataIC50: 0.370nMAssay Description:The experiment was carried out at Cerep Contract Laboratories (Cat. ref. #471).Compound (I) was also tested in an in vivo set up demonstrating centra...More data for this Ligand-Target Pair
Affinity DataIC50: 0.390nMAssay Description:Antagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium fl...More data for this Ligand-Target Pair
Affinity DataIC50: 0.420nMAssay Description:Inhibitory concentration against 5-hydroxytryptamine 2 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.430nMAssay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
Affinity DataIC50: 0.430nMAssay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
Affinity DataIC50: 0.450nMAssay Description:For total binding, a total volume of 50 ul of appropriately diluted membranes (diluted in assay buffer containing 50 mM Tris HCl (pH 7.4), 10 mM MgCl...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Displacement of [3H]ketanserin from human recombinant 5HT2A receptor expressed in avCHO-K1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.510nMpH: 7.4Assay Description:Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125I]DOI as radioligand. To define nonspecific binding, 1...More data for this Ligand-Target Pair
Affinity DataIC50: 0.520nMAssay Description:Displacement of [3H]ketanserin from human recombinant 5-HT2A receptor in HEK293 cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 0.540nMAssay Description:Antagonist activity at 5-HT2A receptor (unknown origin) expressed in CHO-K1 cells assessed as reduction in intracellular Ca2+ mobilization incubated ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.540nMAssay Description:Antagonist activity at 5HT2A receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.540nMAssay Description:CHO-K1/5-HT2A cells in the logarithmic growth phase were seeded into a 384-well plate at a density of 10000 cells per well, and cultured in a 37° C.,...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium fl...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.610nMAssay Description:The experiment was carried out at Cerep Contract Laboratories (Cat. ref. #471).Compound (I) was also tested in an in vivo set up demonstrating centra...More data for this Ligand-Target Pair
Affinity DataIC50: 0.610nMAssay Description:Inhibitory concentration against 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.630nMAssay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
Affinity DataIC50: 0.640nMAssay Description:Displacement of [3H]ketanserin human recombinant 5-HT2A receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Displacement of [3H]ketanserin from human recombinant 5HT2A receptor expressed in avCHO-K1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.708nMAssay Description:Antagonist activity at human 5HT2A receptor expressed in CHOK1 cells assessed as inhibition of 5-HT induced inositol phosphate production incubated f...More data for this Ligand-Target Pair
Affinity DataIC50: 0.720nMAssay Description:Antagonist activity at human 5HT2A receptor expressed in CHOK1 cells assessed as inhibition of 5-HT induced inositol phosphate production incubated f...More data for this Ligand-Target Pair
Affinity DataIC50: 0.790nMAssay Description:5-HT2A Receptor: Experimental buffer: 50 mM Tris-HCl pH 7.4, 4 mM CaCl2); washing liquor: 50 mM Tris-HCl pH 7.4, stored at 4° C.; 0.5% PEI solution: ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.790nMAssay Description:The experiment was carried out at Cerep Contract Laboratories (Cat. ref. #471).Compound (I) was also tested in an in vivo set up demonstrating centra...More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.810nMAssay Description:Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated...More data for this Ligand-Target Pair
Affinity DataIC50: 0.813nMAssay Description:Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated...More data for this Ligand-Target Pair
Affinity DataIC50: 0.820nMAssay Description:Displacement of [3H] ketanserin from human recombinant 5-HT2A receptor measured after 60 mins by scintillation counter methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.830nMAssay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
Affinity DataIC50: 0.870nMAssay Description:Antagonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of serotonin hydrochloride-induced calcium fl...More data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
Affinity DataIC50: 0.910nMAssay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
Affinity DataIC50: 0.960nMAssay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
