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Report error Found 3251 of affinity data for UniProtKB/TrEMBL: P51681
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50134046((4-{(4-Bromo-phenyl)-[(E)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM160935(US10167299, Maraviroc | US9107954, maraviroc)
Affinity DataKi:  0.240nMAssay Description:Afterwards, the pharmacological profile of bivalent ligand 1 at the chemokine receptor CCR5 was characterized similarly. The competitive radioligand ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50134054((4-{(4-Bromo-phenyl)-[(E)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50124943((4-{(4-Bromo-phenyl)-[(Z)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of [125I]RANTES binding to CCR5 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50124953((4-{(4-Bromo-phenyl)-[(Z)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of [125I]RANTES binding to CCR5 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50134070((4-{(4-Bromo-phenyl)-[(E)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50123438((3,5-Dichloro-pyridin-4-yl)-(4-methyl-4-{(S)-3-met...)
Affinity DataKi:  0.700nMAssay Description:Ability to inhibit [125I]-labeled RANTES binding to the CCR5 receptor expressed in membrane preparations from CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50124957((4-{(4-Bromo-phenyl)-[(Z)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of [125I]RANTES binding to CCR5 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50123438((3,5-Dichloro-pyridin-4-yl)-(4-methyl-4-{(S)-3-met...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50124957((4-{(4-Bromo-phenyl)-[(Z)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50398339(CHEMBL2178569)
Affinity DataKi:  1nMAssay Description:Binding affinity to CCR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50104954((2,6-Dimethyl-phenyl)-(4-methyl-4-{(S)-3-methyl-4-...)
Affinity DataKi:  1nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50104942((4-Fluoro-naphthalen-1-yl)-{4-[4-(4-methoxy-benzen...)
Affinity DataKi:  1nMAssay Description:Inhibition of RANTES binding to C-C chemokine receptor type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50134072((4-{(4-Bromo-phenyl)-[(E)-methoxyimino]-methyl}-4'...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50145684((4,6-Dimethyl-pyrimidin-5-yl)-(4-methyl-4-{(S)-3-m...)
Affinity DataKi:  1.10nMAssay Description:Antagonistic activity of the compound against C-C chemokine receptor type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50104940(CHEMBL323172 | {4-[(4-Bromo-phenyl)-methoxyimino-m...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of RANTES binding to C-C chemokine receptor type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50134044((4-{(4-Bromo-phenyl)-[(E)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50104933(CHEMBL105821 | {4-[(4-Bromo-phenyl)-ethoxyimino-me...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of RANTES binding to C-C chemokine receptor type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)
Affinity DataKi:  1.10nMAssay Description:Antagonist at CCR5 (unknown origin) assessed as inhibitory constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50124946((4-{(4-Bromo-phenyl)-[(Z)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of [125I]RANTES binding to CCR5 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50124946((4-{(4-Bromo-phenyl)-[(Z)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50124956((4-{(4-Bromo-phenyl)-[(E)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of [125I]RANTES binding to CCR5 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50124956((4-{(4-Bromo-phenyl)-[(E)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)
Affinity DataKi:  1.40nMAssay Description:Inhibitory activity of the compound against specific binding of [125I]-MIP-1 alpha to human CCR5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50145681((4,6-Dimethyl-pyrimidin-5-yl)-(4-methyl-4-{(S)-3-m...)
Affinity DataKi:  1.40nMAssay Description:Antagonistic activity of the compound against C-C chemokine receptor type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50145686((4-{(S)-4-[(S)-2-Cyclopropyl-1-(4-trifluoromethyl-...)
Affinity DataKi:  1.60nMAssay Description:Antagonistic activity of the compound against C-C chemokine receptor type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50115528((Z)-(4-((4-bromophenyl)(ethoxyimino)methyl)-4'-met...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of RANTES binding to C-C chemokine receptor type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50104946((2,4-Dimethyl-pyridin-3-yl)-(4-methyl-4-{(S)-3-met...)
Affinity DataKi:  2nMAssay Description:Ability to inhibit [125I]-labeled RANTES binding to the CCR5 receptor expressed in membrane preparations from CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50124958((4-{(4-Bromo-phenyl)-[(E)-propoxyimino]-methyl}-4'...)
Affinity DataKi:  2nMAssay Description:Inhibition of [125I]RANTES binding to CCR5 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50124958((4-{(4-Bromo-phenyl)-[(E)-propoxyimino]-methyl}-4'...)
Affinity DataKi:  2nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50104935((4-{(4-Bromo-phenyl)-[(E)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  2nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50104929((4-{(4-Bromo-phenyl)-[(E)-methoxyimino]-methyl}-4'...)
Affinity DataKi:  2nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50104929((4-{(4-Bromo-phenyl)-[(E)-methoxyimino]-methyl}-4'...)
Affinity DataKi:  2nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50104935((4-{(4-Bromo-phenyl)-[(E)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  2nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50398340(CHEMBL2178576)
Affinity DataKi:  2nMAssay Description:Binding affinity to CCR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50104930((Z)-{4-[(4-Bromo-phenyl)-methoxyimino-methyl]-[1,4...)
Affinity DataKi:  2nMAssay Description:Inhibition of RANTES binding to C-C chemokine receptor type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50104931((4-{(4-Bromo-phenyl)-[(E)-ethoxyimino]-methyl}-4''...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50124951((4-{(4-Bromo-phenyl)-[(E)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50104931((4-{(4-Bromo-phenyl)-[(E)-ethoxyimino]-methyl}-4''...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of RANTES binding to C-C chemokine receptor type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50145685((4,6-Dimethyl-pyrimidin-5-yl)-(4-{(S)-4-[(R)-2-met...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of [125I]RANTES binding to CCR5 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50124951((4-{(4-Bromo-phenyl)-[(E)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of [125I]RANTES binding to CCR5 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50124948((4-{(4-Bromo-phenyl)-[(Z)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of [125I]RANTES binding to CCR5 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50134052((4-{(4-Bromo-phenyl)-[(E)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50134047((4-{(4-Bromo-phenyl)-[(E)-ethoxyimino]-methyl}-4'-...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50104946((2,4-Dimethyl-pyridin-3-yl)-(4-methyl-4-{(S)-3-met...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50104946((2,4-Dimethyl-pyridin-3-yl)-(4-methyl-4-{(S)-3-met...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity at C-C chemokine receptor type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50145685((4,6-Dimethyl-pyrimidin-5-yl)-(4-{(S)-4-[(R)-2-met...)
Affinity DataKi:  2.5nMAssay Description:Antagonistic activity of the compound against C-C chemokine receptor type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50123436((3,5-Dichloro-1-oxy-pyridin-4-yl)-(4-methyl-4-{(S)...)
Affinity DataKi:  2.70nMAssay Description:Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50123436((3,5-Dichloro-1-oxy-pyridin-4-yl)-(4-methyl-4-{(S)...)
Affinity DataKi:  2.70nMAssay Description:Ability to inhibit [125I]-labeled RANTES binding to the CCR5 receptor expressed in membrane preparations from CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Human)
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50123435((4,6-Dimethyl-pyrimidin-5-yl)-(4-methyl-4-{(S)-3-m...)
Affinity DataKi:  2.80nMAssay Description:Antagonistic activity of the compound against C-C chemokine receptor type 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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