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TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50029051((-)-arterenol | (-)-noradrenaline | (-)-norepineph...)
Affinity DataEC50:  12nMAssay Description:In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50156310(4-(3-(3-benzenesulfonylfuroxan-4-yloxy)propyl)phen...)
Affinity DataEC50:  12nMAssay Description:Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50156304(3-benzenesulfonyl-4-ethoxy-furazan 2-oxide | 4-eth...)
Affinity DataEC50:  12nMAssay Description:Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50186605(4-(3-(3-benzenesulfonylfuroxan-4-yloxy)propyl)-2,6...)
Affinity DataEC50:  22nMAssay Description:Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50156303(2-(3-benzenesulfonylfuroxan-4-yloxymethyl)-2,5,7,8...)
Affinity DataEC50:  44nMAssay Description:Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50027031((2-Chloro-phenyl)-(4,5-dihydro-1H-imidazol-2-ylmet...)
Affinity DataEC50:  50nMAssay Description:Agonist activity against alpha-1 adrenergic receptor from rat vas deferensMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50027035(3-[(4,5-Dihydro-1H-imidazol-2-ylmethyl)-amino]-phe...)
Affinity DataEC50:  61nMAssay Description:Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50156308(4-(3-(3-benzenesulfonylfuroxan-4-yloxy)propyl)-2,6...)
Affinity DataEC50:  110nMAssay Description:Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50186606(3-(4-hydroxyphenyl)prop-1,2-diyl dinitrate | CHEMB...)
Affinity DataEC50:  130nMAssay Description:Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036910(4-(1-Naphthalen-1-yl-ethyl)-1H-imidazole | CHEMBL3...)
Affinity DataEC50:  153nMAssay Description:50% Molar effective concentration for agonistic activity against Alpha-1 adrenergic receptor in rat aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50067212(CHEBI:8093 | Cyclomydril | Duo-Medihaler | Phenyle...)
Affinity DataEC50:  155nMAssay Description:In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50186612(1,2-bis-nitrooxy-propane | CHEMBL206527)
Affinity DataEC50:  240nMAssay Description:Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50036913((+-)-4-(alpha,2,3-trimethylbenzyl)imidazole | 4-[1...)
Affinity DataEC50:  281nMAssay Description:50% Molar effective concentration afainst Alpha-1 adrenergic receptor in rat aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50027036((4,5-Dihydro-1H-imidazol-2-ylmethyl)-methyl-p-toly...)
Affinity DataEC50:  300nMAssay Description:Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50027032((4,5-Dihydro-1H-imidazol-2-ylmethyl)-p-tolyl-amine...)
Affinity DataEC50:  340nMAssay Description:Agonist activity against alpha-1 adrenergic receptor from rat vas deferensMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50156310(4-(3-(3-benzenesulfonylfuroxan-4-yloxy)propyl)phen...)
Affinity DataEC50:  360nMAssay Description:Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50186604(4-((N-(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propyl...)
Affinity DataEC50:  410nMAssay Description:Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131411(4-(4-Chloro-benzyl)-2-methyl-2H-phthalazin-1-one |...)
Affinity DataEC50:  430nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50186605(4-(3-(3-benzenesulfonylfuroxan-4-yloxy)propyl)-2,6...)
Affinity DataEC50:  500nMAssay Description:Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50186608(3-((4-hydroxy-3,5-dimethoxy)phenyl)prop-1,2-diyl d...)
Affinity DataEC50:  640nMAssay Description:Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50156303(2-(3-benzenesulfonylfuroxan-4-yloxymethyl)-2,5,7,8...)
Affinity DataEC50:  670nMAssay Description:Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM56339(4-(4-chlorobenzyl)-1(2H)-phthalazinone | 4-(4-chlo...)
Affinity DataEC50:  790nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131402(4-(benzo[d][1,3]dioxol-5-ylmethyl)-2-methylphthala...)
Affinity DataEC50:  930nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50183669(4-(4-(methylthio)benzyl)-2-methylphthalazin-1(2H)-...)
Affinity DataEC50:  930nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM31046(3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity against alpha-1 adrenergic receptor from rat vas deferensMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50156307(3-(4-hydroxyphenyl)propyl nitrate | 4-(3-Nitrooxy-...)
Affinity DataEC50:  1.00E+3nMAssay Description:Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50470944(CHEMBL336161)
Affinity DataEC50:  1.02E+3nMAssay Description:In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50156305(2,5,7,8-Tetramethyl-2-(3-nitrooxy-propoxymethyl)-c...)
Affinity DataEC50:  1.20E+3nMAssay Description:Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50183666(4-(2,4-dichlorobenzyl)-2-methylphthalazin-1(2H)-on...)
Affinity DataEC50:  1.20E+3nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50183687(4-(4-chlorobenzyl)-2-ethylphthalazin-1(2H)-one | C...)
Affinity DataEC50:  1.30E+3nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50183690(4-(2-chlorobenzyl)-2-methylphthalazin-1(2H)-one | ...)
Affinity DataEC50:  1.40E+3nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50186603(4-((N-((6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)...)
Affinity DataEC50:  1.50E+3nMAssay Description:Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50027037((4,5-Dihydro-1H-imidazol-2-ylmethyl)-ethyl-p-tolyl...)
Affinity DataEC50:  1.60E+3nMAssay Description:Agonist activity against alpha-1 adrenergic receptor from rat vas deferensMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50118702(2-Amino-1-(2,5-dimethoxy-phenyl)-ethanol | CHEMBL1...)
Affinity DataEC50:  1.86E+3nMAssay Description:Agonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aortaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50118702(2-Amino-1-(2,5-dimethoxy-phenyl)-ethanol | CHEMBL1...)
Affinity DataEC50:  1.90E+3nMAssay Description:Effective concentration of the compound was determined in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50183678(4-(2-chlorobenzyl)phthalazin-1(2H)-one | CHEMBL378...)
Affinity DataEC50:  1.90E+3nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131408(4-(3,4-Dimethoxy-benzyl)-2-methyl-2H-phthalazin-1-...)
Affinity DataEC50:  2.20E+3nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50118703(CHEMBL109783 | N-[5-(4,5-Dihydro-1H-imidazol-2-yl)...)
Affinity DataEC50:  2.57E+3nMAssay Description:Agonist activity at alpha1D adrenoreceptor in Rattus norvegicus (rat) aortaMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50118703(CHEMBL109783 | N-[5-(4,5-Dihydro-1H-imidazol-2-yl)...)
Affinity DataEC50:  2.57E+3nMAssay Description:In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50118703(CHEMBL109783 | N-[5-(4,5-Dihydro-1H-imidazol-2-yl)...)
Affinity DataEC50:  2.60E+3nMAssay Description:Effective concentration of the compound was determined in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50183665(4-(4-chlorobenzyl)-2-allylphthalazin-1(2H)-one | C...)
Affinity DataEC50:  2.60E+3nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131414(4-(benzo[d][1,3]dioxol-5-ylmethyl)phthalazin-1(2H)...)
Affinity DataEC50:  2.90E+3nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM35234(DL-[7-3H]norepinephrine | NOREPINEPHRINE | Noradre...)
Affinity DataEC50:  3.00E+3nMAssay Description:Displacement of [3H]WB4101 from alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50019061((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...)
Affinity DataEC50:  3.00E+3nMAssay Description:Displacement of [3H]WB4101 from alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50186607(4-dimethylaminomethyl-2-oxy-furazan-3-carboxylic a...)
Affinity DataEC50:  3.10E+3nMAssay Description:Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50186610(3-((4-hydroxy-3,5-di-tert-butyl)phenyl)prop-1,2-di...)
Affinity DataEC50:  3.30E+3nMAssay Description:Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50131410(4-(3,4-Dimethoxy-benzyl)-2H-phthalazin-1-one | 4-(...)
Affinity DataEC50:  3.70E+3nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50186611(3-(4-hydroxy-3,5-dimethoxyphenyl)propyl nitrate | ...)
Affinity DataEC50:  4.30E+3nMAssay Description:Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic stripsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50183683(4-(naphthalen-1-ylmethyl)phthalazin-1(2H)-one | CH...)
Affinity DataEC50:  4.40E+3nMAssay Description:Vasorelaxation of phenylephrine-stimulated Wistar rat aorta contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50156308(4-(3-(3-benzenesulfonylfuroxan-4-yloxy)propyl)-2,6...)
Affinity DataEC50:  4.80E+3nMAssay Description:Vasodilator activity assessed as ability to relax phenylephrine-induced contraction of Wistar rat aortic strips in presence of 1 uM ODQMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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