TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 0.00692nMAssay Description:Binding affinity at Alpha-1 adrenergic receptor sites on rat cerebral cortical membranes by [3H]prazosin displacement.More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 0.162nMAssay Description:Displacement of [3H]prazosin binding to Alpha-1 adrenergic receptor sites on rat cerebral cortical membranes at 100 nM concentrationMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 0.180nMAssay Description:Ability to inhibit binding of [3H]PRAZ to alpha-1 adrenergic receptor in rat brainMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 0.25nMAssay Description:Displacement of [3H]-prazosin from rat alpha1 adrenoceptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 0.360nMAssay Description:Inhibition of [3H]prazosin binding to alpha-1 adrenergic receptor from rat cortical membranesMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 0.450nMAssay Description:Ability to inhibit binding of [3H]PRAZ to alpha-1 adrenergic receptor in rat brainMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 0.513nMAssay Description:Binding affinity at Alpha-1 adrenergic receptor sites on rat cerebral cortical membranes by [3H]prazosin displacement.More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 0.580nMAssay Description:Inhibition of specific [3H]prazosin binding (0.2 nM) to rat brain membranes alpha1 adrenoceptor.More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparationMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 0.690nMAssay Description:Ability to bind at alpha-1 adrenergic receptor by displacing [3H]WB-4101More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 0.692nMAssay Description:Displacement of [3H]prazosin binding to Alpha-1 adrenergic receptor sites on rat cerebral cortical membranes at 100 nM concentrationMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 0.876nMAssay Description:Binding affinity against alpha-1 adrenergic receptor in rat cerebral cortex tissue using [3H]WB-4101 as radioligandMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Ability to bind at alpha-1 adrenergic receptor by displacing [3H]WB-4101More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Ability to bind at alpha-1 adrenergic receptor by displacing [3H]WB-4101More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Binding affinity against alpha-1 adrenergic receptor in rat cerebral cortex tissue using [3H]WB-4101 as radioligandMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Ability to inhibit binding of [3H]PRAZ to alpha-1 adrenergic receptor in rat brainMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Compound is evaluated for its ability to compete with [3H]prazosin for binding to Alpha-1 adrenergic receptor sites on rat cerebral cortical membrane...More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Binding affinity against alpha-1 adrenergic receptor in rat cerebral cortex tissue using [3H]WB-4101 as radioligandMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Displacement of [3H]prazosin from Alpha-1 adrenergic receptor of whole rat brain membranesMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Binding affinity against alpha-1 adrenergic receptor in rat cerebral cortex tissue using [3H]WB-4101 as radioligandMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 2.60nMAssay Description:Displacement of [3H]prazosin from alpha-1 adrenoceptors in whole rat brain membranesMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Displacement of [3H]prazosin from Alpha-1 adrenergic receptor of whole rat brain membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Antagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoreceptors on isolated thoracic aorta from ratMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Displacement of [3H]prazosin binding to Alpha-1 adrenergic receptor sites on rat cerebral cortical membranes at 100 nM concentrationMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Displacement of [3H]prazosin from Alpha-1 adrenergic receptor of whole rat brain membranesMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Binding affinity at Alpha-1 adrenergic receptor sites on rat cerebral cortical membranes by [3H]prazosin displacement.More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 4.40nMAssay Description:Displacement of [3H]prazosin binding to Alpha-1 adrenergic receptor sites on rat cerebral cortical membranes at 100 nM concentrationMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 4.5nMAssay Description:Displacement of [3H]prazosin binding to Alpha-1 adrenergic receptor sites on rat cerebral cortical membranes at 100 nM concentrationMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Antagonist affinity [non competitive (irreversible)] at alpha-1D-adrenoreceptors on isolated thoracic aorta from ratMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 5.20nMAssay Description:Concentration of compound for 50% displacement of [3H]WB-4101 from Alpha-1 adrenergic receptor of rat brainMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 5.30nMAssay Description:Inhibition of [3H]prazosin binding to alpha-1 adrenergic receptor from rat cortical membranesMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 5.40nMAssay Description:Binding affinity at Alpha-1 adrenergic receptor sites on rat cerebral cortical membranes by [3H]prazosin displacement.More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 5.5nMAssay Description:Inhibition of [3H]prazosin binding to alpha-1 adrenergic receptor from rat cortical membranesMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of [3H]WB-4101 binding to rat cortical Alpha-1 adrenergic receptor in vitroMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 7.20nMAssay Description:Binding affinity against alpha-1 adrenergic receptor in rat cerebral cortex tissue using [3H]WB-4101 as radioligandMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 7.60nMAssay Description:Compound is evaluated for its ability to compete with [3H]prazosin for binding to Alpha-1 adrenergic receptor sites on rat cerebral cortical membrane...More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 7.80nMAssay Description:Ability to inhibit [3H]WB-4101 binding to rat cortical alpha-1-adrenergic receptorMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 7.80nMAssay Description:The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 7.90nMAssay Description:The concentration required to inhibit [3H]prazosin binding to Alpha-1 adrenergic receptor in rat brain membranes was measured (in vitro)More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:In vitro affinity for cortical alpha-1 adrenergic receptor labelled with [3H]WB-4101More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
National Institute On Aging/Grc
Curated by ChEMBL
National Institute On Aging/Grc
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of Angiotensin I converting enzymeMore data for this Ligand-Target Pair