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Report error Found 350 of affinity data for UniProtKB/TrEMBL: P04035
LigandPNGBDBM50004774((S)-2-Methyl-butyric acid (1S,3R,7S,8S,8aR)-8-[2-(...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of human HMGCoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM18372((3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethan...)
Affinity DataKi:  0.900nMAssay Description:Inhibitory constant against HMG-CoA reductaseMore data for this Ligand-Target Pair
LigandPNGBDBM50139181((1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotet...)
Affinity DataKi:  2.60nMAssay Description:Inhibitory constant against HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50279858((3R,5R)-7-(2-Benzyloxy-4,6-dichloro-phenyl)-3,5-di...)
Affinity DataKi:  3nMAssay Description:The inhibitory activity of the compound against purified recombinant human HMG-CoA reductase was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM22164((3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylca...)
Affinity DataKi:  6.20nMAssay Description:Inhibition of HMG-CoA Reductase (unknown origin)More data for this Ligand-Target Pair
LigandPNGBDBM50279859((S)-4-{[2-(2-Benzyloxy-4,6-dichloro-phenyl)-ethyl]...)
Affinity DataKi:  16nMAssay Description:The inhibitory activity of the compound against purified recombinant human HMG-CoA reductase was evaluatedMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50160720(3-hydroxy-3-methylglutaric acid | 3-hydroxy-3-meth...)
Affinity DataKi:  23.5nMAssay Description:Inhibitory constant against HMG-CoA reductaseMore data for this Ligand-Target Pair
LigandPNGBDBM50321104(CHEMBL1163804 | DFGYVAE)
Affinity DataKi:  51nMAssay Description:Competitive inhibition of HMG-CoA reductase by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50321100(CHEMBL1164546 | GF(4-fluro)PTGG)
Affinity DataKi:  260nMAssay Description:Competitive inhibition of HMG-CoA reductase by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50139181((1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotet...)
Affinity DataKi:  6.80E+4nMAssay Description:Inhibitory constant against HMG-CoA reductase with alpha asaroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM18372((3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethan...)
Affinity DataKi:  7.10E+4nMAssay Description:Inhibitory constant against HMG-CoA reductase with alpha asaroneMore data for this Ligand-Target Pair
LigandPNGBDBM50013216((racemic)Sodium salt of7-[4-(4-Fluoro-phenyl)-1,2-...)
Affinity DataIC50:  0.00200nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50007261(CHEMBL102091 | Sodium; 7-[4-(4-fluoro-phenyl)-2-is...)
Affinity DataIC50: <0.0100nMAssay Description:In vitro inhibition of HMG-CoA reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50013210(CHEMBL162642 | Sodium salt of 7-[4-(4-Fluoro-pheny...)
Affinity DataIC50:  0.0140nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50013217(CHEMBL159951 | Sodium salt of7-[1-Cyclohexyl-4-(4-...)
Affinity DataIC50:  0.0180nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50004774((S)-2-Methyl-butyric acid (1S,3R,7S,8S,8aR)-8-[2-(...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50013212(CHEMBL160102 | Sodium salt of7-[4-(4-Fluoro-phenyl...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50013219(CHEMBL2375155 | Sodium salt of7-[1-Cyclohexyl-4-(4...)
Affinity DataIC50:  0.106nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50215692(CHEMBL400874 | sodium (3R,5R)-7-(5-((4-cyanobenzyl...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50013221(CHEMBL163277 | Sodium salt of7-[4-(4-Fluoro-phenyl...)
Affinity DataIC50:  0.270nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50215693(CHEMBL437774 | sodium (3R,5R)-7-(5-((4-carboxyphen...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50215676(CHEMBL228955 | sodium (3R,5R)-7-(3-(4-fluorophenyl...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of HMGCoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50215688(CHEMBL399773 | sodium (3R,5R)-7-(5-((3-(dimethylca...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50215689(CHEMBL250317 | sodium (3R,5R)-7-(5-((4-carbamoylph...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50215700(CHEMBL400973 | sodium (3R,5R)-7-(3-(4-fluorophenyl...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50007272(CHEMBL102168 | Sodium; 6-[4'-fluoro-5-(4-fluoro-ph...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of the incorporation of sodium [14C]acetate into cholesterol in HEP G2 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50013220(CHEMBL161829 | Sodium salt of7-[4-(4-Fluoro-phenyl...)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of hepatic cells (HEP G2, a human hepatoma cell line)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50215704(CHEMBL398551 | sodium (3R,5R)-7-(5-(((1,5-dimethyl...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50215699(CHEMBL400747 | sodium (3R,5R)-7-(3,4-bis(4-fluorop...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50215707(CHEMBL250749 | sodium (3R,5R)-7-(5-((4-(methoxymet...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50215708(CHEMBL249724 | sodium (3R,5R)-7-(5-((4-methoxybenz...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50215690(CHEMBL399313 | sodium (3R,5R)-7-(5-(benzylcarbamoy...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50215684(CHEMBL398240 | sodium (3R,5R)-7-(3-(4-fluorophenyl...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50139181((1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotet...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of HMG-CoA reductase (unknown origin) using [14C]-HMG-CoA as substrate after 5 mins in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM155376(US9006282, Example 2, Compound 4 | US9102656, Exam...)
Affinity DataIC50:  1nMAssay Description:The following procedure was followed using a HMG-CoA Reductase assay kit obtained from Sigma-Aldrich (catalogue number CS1090). The assay is based on...More data for this Ligand-Target Pair
In DepthDetails US Patent

LigandPNGBDBM155374(US9006282, Example 2, Compound 2 | US9102656, Exam...)
Affinity DataIC50: <1nMAssay Description:The following procedure was followed using a HMG-CoA Reductase assay kit obtained from Sigma-Aldrich (catalogue number CS1090). The assay is based on...More data for this Ligand-Target Pair
In DepthDetails US Patent

LigandPNGBDBM50014820((E)-6-{2-[2-Cyclohexyl-4-(4-fluoro-phenyl)-6-isopr...)
Affinity DataIC50:  1nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of human HEP G2 cells, determined by decreased incorporation of sodium [14C]-acetate into choles...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM155380(US9006282, Example 2, Compound 8 | US9102656, Exam...)
Affinity DataIC50:  1nMAssay Description:The following procedure was followed using a HMG-CoA Reductase assay kit obtained from Sigma-Aldrich (catalogue number CS1090). The assay is based on...More data for this Ligand-Target Pair
In DepthDetails US Patent

LigandPNGBDBM50014828((E)-6-{2-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-py...)
Affinity DataIC50:  1nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of human HEP G2 cells, determined by decreased incorporation of sodium [14C]-acetate into choles...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50215694(CHEMBL249906 | sodium (3R,5R)-7-(5-((3-carbamoylbe...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50215698(CHEMBL251499 | sodium (3R,5R)-7-(5-((4-(dimethylca...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50215683(CHEMBL403127 | sodium (3R,5R)-7-(5-((4-(dimethylca...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50215691(CHEMBL398239 | sodium (3R,5R)-7-(3-(4-fluorophenyl...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50215666((3R,5R)-7-(3,4-bis(4-fluorophenyl)-1-isopropyl-5-(...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of HMGCoA reductaseMore data for this Ligand-Target Pair
LigandPNGBDBM50007303(6-(4'-Fluoro-3,5-diisopropyl-biphenyl-2-yloxymethy...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of the incorporation of sodium [14C]acetate into cholesterol in HEP G2 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM18374(CHEMBL394937 | Pyrrole-based compound, 30 | sodium...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50215706(CHEMBL399315 | sodium (3R,5R)-7-(5-((3-methoxybenz...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50215672(CHEMBL228528 | sodium (3R,5R)-7-(5-(3-fluorophenyl...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of HMGCoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50004774((S)-2-Methyl-butyric acid (1S,3R,7S,8S,8aR)-8-[2-(...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human HMGCoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM155379(US9006282, Example 2, Compound 7 | US9102656, Exam...)
Affinity DataIC50:  2nMAssay Description:The following procedure was followed using a HMG-CoA Reductase assay kit obtained from Sigma-Aldrich (catalogue number CS1090). The assay is based on...More data for this Ligand-Target Pair
In DepthDetails US Patent

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