Compile Data Set for Download or QSAR
Report error Found 15 of kd for UniProtKB: O95271
LigandPNGBDBM50593627(CHEMBL5199558)
Affinity DataKd: <2nMAssay Description:Binding affinity to recombinant human TNKS1 (1091 to 1327 residues) assessed as dissociation constant by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
LigandPNGBDBM50409631(CHEMBL5279214)
Affinity DataKd:  6nMAssay Description:Binding affinity to recombinant human TNKS1 (1091 to 1327 residues) assessed as dissociation constant by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
LigandPNGBDBM50409628(CHEMBL5276381)
Affinity DataKd:  6nMAssay Description:Binding affinity to recombinant human TNKS1 (1091 to 1327 residues) assessed as dissociation constant by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
LigandPNGBDBM50318567(2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiop...)
Affinity DataKd:  8nMAssay Description:Binding affinity to human recombinant TNSK1 expressed in Escherichia coli by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50084621(BMN 673 | Talazoparib)
Affinity DataKd:  14nMAssay Description:Binding affinity to TNKS1 (unknown origin) assessed as dissociation constant incubated for 30 mins by streptavidin pulldown based Western blot analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50618275(CHEMBL5424788)
Affinity DataKd:  15nMAssay Description:Binding affinity to TNKS1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
LigandPNGBDBM50084621(BMN 673 | Talazoparib)
Affinity DataKd:  53nMAssay Description:Binding affinity to PARP5a (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50380590(CHEMBL1898239)
Affinity DataKd:  79nMAssay Description:Binding affinity to biotinylated Avi-tagged TNKS1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50318567(2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiop...)
Affinity DataKd:  100nMAssay Description:Binding affinity to TNKS1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50462627(CHEMBL1958308)
Affinity DataKd:  520nMAssay Description:Binding affinity to recombinant human N-terminal GSt-tagged TNKS1 (1000 to 1328 residues) expressed in baculovirus infected Sf9 cells by surface plas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
LigandPNGBDBM50462626(CHEMBL4127893)
Affinity DataKd:  5.26E+3nMAssay Description:Binding affinity to recombinant human N-terminal GSt-tagged TNKS1 (1000 to 1328 residues) expressed in baculovirus infected Sf9 cells by surface plas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
LigandPNGBDBM124951(US8765972, 4)
Affinity DataKd: >1.00E+4nMAssay Description:Displacement of fluorescent probe from human recombinant His-tagged TNKS1 catalytic domain (1091-1325 residues) by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM124950(US8765972, 3)
Affinity DataKd: >1.00E+4nMAssay Description:Displacement of fluorescent probe from human recombinant His-tagged TNKS1 catalytic domain (1091-1325 residues) by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM50446130(AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to PARP5a (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM209932(Veliparib | 2-[(2R)-2-methylpyrrolidin-2-yl]-1H-be...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to PARP5a (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed