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TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50276884(CHEMBL42707)
Affinity DataIC50: <0.00200nMAssay Description:Displacement of [3H]17beta-estradiol from ER in human MCF7 cells after 18 hrs by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  0.0100nMAssay Description:In vitro inhibition of estrogen-stimulated MCF-7 cell proliferationMore data for this Ligand-Target Pair
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50523039(CHEMBL4591338)
Affinity DataIC50:  0.0100nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by FITC/Hoechst 33342 staining based immunofluorescence imaging analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50532101(CHEMBL4439408)
Affinity DataIC50:  0.0240nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50532101(CHEMBL4439408)
Affinity DataIC50:  0.0240nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM368199((S)-2-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)...)
Affinity DataIC50:  0.0300nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...More data for this Ligand-Target Pair
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM368199((S)-2-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)...)
Affinity DataIC50:  0.0300nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by FITC/Hoechst staining based immunofluorescence imaging analysisMore data for this Ligand-Target Pair
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM368199((S)-2-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)...)
Affinity DataIC50:  0.0300nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by FITC/Hoechst 33342 staining based immunofluorescence imaging analysisMore data for this Ligand-Target Pair
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50523049(CHEMBL4441471)
Affinity DataIC50:  0.0300nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by FITC/Hoechst 33342 staining based immunofluorescence imaging analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50542086(CHEMBL4649161)
Affinity DataIC50:  0.0310nMAssay Description:Induction of ERalpha degradation in human T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM361453(2,2-difluoro-3- ((1R,3R)-1-(6- fluoro-3-(2- ((3- f...)
Affinity DataIC50:  0.0340nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM300953(N-(4-((6S,8R)-7-(2,2-difluoropropyl)-8-methyl-6,7,...)
Affinity DataIC50:  0.0398nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ER-alpha level incubated for 18 to 24 hrs by Alexa fluor 488/Hoechst sta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50525253(CHEMBL4518283)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of ERalpha in human MCF7 cells after 36 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM361490(N-(2-(3- ((1R,3R)-2- (2,2- difluoroethyl)- 3-methy...)
Affinity DataIC50:  0.0420nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50532103(CHEMBL4464224)
Affinity DataIC50:  0.0450nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM361518(2,2-difluoro-3- ((1R,3R)-1-(5- fluoro-2-(2- ((3- f...)
Affinity DataIC50:  0.0450nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50276893(CHEMBL1193539)
Affinity DataIC50:  0.0460nMAssay Description:Displacement of [3H]17beta-estradiol from ER in human MCF7 cells after 18 hrs by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM300973(2-fluoro-6- ((6S,8R)-1- fluoro-8- methyl-7- (2,2,2...)
Affinity DataIC50:  0.0480nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50523050(CHEMBL4455953)
Affinity DataIC50:  0.0500nMAssay Description:Degradation of ER alpha in human MCF7 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50572808(Gdc-9545 | Giredestrant | RO-7197597 | RO7197597)
Affinity DataIC50:  0.0500nMAssay Description:Antagonist activity at estrogen receptor in human T47D cells incubated for 18 hrs by ultra high sensitivity luminescence reporter gene assayMore data for this Ligand-Target Pair
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50523050(CHEMBL4455953)
Affinity DataIC50:  0.0500nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by FITC/Hoechst 33342 staining based immunofluorescence imaging analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEstrogen receptor beta(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM19443(2-(4-hydroxyphenyl)-3-{4-[2-(piperidin-1-yl)ethoxy...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of 17-beta-estradiol (10e-11 M) mediated MCF-7 cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM300961(1-(3-Fluoropropyl)-N-(4-((6R,8R)-8-methyl-7-(2,2,2...)
Affinity DataIC50:  0.0500nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM300973(2-fluoro-6- ((6S,8R)-1- fluoro-8- methyl-7- (2,2,2...)
Affinity DataIC50:  0.0501nMAssay Description:Induction of ERalpha degradation in human MCF7 cells incubated for 18 to 22 hrs by immuno-fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50532105(CHEMBL4449709)
Affinity DataIC50:  0.0510nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50542086(CHEMBL4649161)
Affinity DataIC50:  0.0530nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by FITC/Hoechst staining based immunofluorescence imaging analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM300933(N-(3,5-difluoro-4-((6S,8R)-8-methyl-7-(2,2,2-trifl...)
Affinity DataIC50:  0.0550nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50532102(CHEMBL4437985)
Affinity DataIC50:  0.0550nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM361473(3-((1R,3R)-1- (3,5-difluoro- 2-(2-((3- fluoropropy...)
Affinity DataIC50:  0.0580nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM361420(Preparation of 3-fluoro-N-(2-((5-methoxy-4-((1R,3R...)
Affinity DataIC50:  0.0590nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50532098(CHEMBL4464058)
Affinity DataIC50:  0.0590nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50572809(CHEMBL4866043)
Affinity DataIC50:  0.0600nMAssay Description:Antagonist activity at estrogen receptor in human T47D cells incubated for 18 hrs by ultra high sensitivity luminescence reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50121317(1,1-bis(4,4'-hydroxyphenyl)-2-phenylbut-1-ene | 4,...)
Affinity DataIC50:  0.0600nMAssay Description:Binding affinity to GST-tagged human ER alpha ligand-binding domain by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50169743((13S,17S)-13-Methyl-7-[9-(4,4,5,5,5-pentafluoro-pe...)
Affinity DataIC50:  0.0600nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as inhibition of insulin-mediated cell proliferation after 6 days by Hoechst 33258 dye-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM300956((6S,8R)-7-(2,2-difluoroethyl)-6-(4-((1-(3-fluoropr...)
Affinity DataIC50:  0.0620nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM300953(N-(4-((6S,8R)-7-(2,2-difluoropropyl)-8-methyl-6,7,...)
Affinity DataIC50:  0.0630nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM300962(1-(3-fluoropropyl)-N-(3-methoxy-4-((6S,8R)-8-methy...)
Affinity DataIC50:  0.0631nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ER-alpha level incubated for 18 to 24 hrs by Alexa fluor 488/Hoechst sta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50169743((13S,17S)-13-Methyl-7-[9-(4,4,5,5,5-pentafluoro-pe...)
Affinity DataIC50:  0.0631nMAssay Description:Antagonist activity at ERalpha receptor in human MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM300962(1-(3-fluoropropyl)-N-(3-methoxy-4-((6S,8R)-8-methy...)
Affinity DataIC50:  0.0650nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50542087(CHEMBL4635493 | US11672785, Goodacre Compound 107 ...)
Affinity DataIC50:  0.0650nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by FITC/Hoechst staining based immunofluorescence imaging analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM361495(3-((1R,3R)-1- (6-fluoro-3-(2- ((3- fluoropropyl) a...)
Affinity DataIC50:  0.0650nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50572829(CHEMBL4856969)
Affinity DataIC50:  0.0700nMAssay Description:Antagonist activity at estrogen receptor in human T47D cells incubated for 18 hrs by ultra high sensitivity luminescence reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50523040(CHEMBL4463541)
Affinity DataIC50:  0.0700nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by FITC/Hoechst 33342 staining based immunofluorescence imaging analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM361519(3-((1R,3R)-1- (3-chloro-5- fluoro-2-(2- ((3- fluor...)
Affinity DataIC50:  0.0700nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM368199((S)-2-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)...)
Affinity DataIC50:  0.0700nMAssay Description:MCF-7 cells were adjusted to a concentration of 40,000 cells per mL in RPMI containing 10% FBS and 20 mM HEPES. 16 microliters of the cell suspension...More data for this Ligand-Target Pair
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM361472(3-((1R,3R)-1- (3,5-difluoro- 2-(2-((3- fluoropropy...)
Affinity DataIC50:  0.0710nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM300983(N-(4-((6S,8R)- 7-(2,2- difluoroethyl)- 8-methyl- 6...)
Affinity DataIC50:  0.0750nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM50532106(CHEMBL4539802)
Affinity DataIC50:  0.0760nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM361470(3-((1R,3R)-1- (2,6-difluoro- 3-(2-((3- fluoropropy...)
Affinity DataIC50:  0.0760nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetEstrogen receptor(Human)
Jain University

Curated by ChEMBL
LigandPNGBDBM300929(3-((6S,8R)-6-(2,6-difluoro-4-((1-(3-fluoropropyl)a...)
Affinity DataIC50:  0.0770nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

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