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Report error Found 31 of ec50 for UniProtKB: Q00959
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50583031(CHEMBL5081078)
Affinity DataEC50:  53nMAssay Description:Agonist activity at rat GluN1/GluN2A NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode volt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50583019(CHEMBL5081008)
Affinity DataEC50:  93nMAssay Description:Agonist activity at rat GluN1/GluN2A NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode volt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50583020(CHEMBL5087374)
Affinity DataEC50:  130nMAssay Description:Agonist activity at rat GluN1/GluN2A NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode volt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50583021(CHEMBL5091289)
Affinity DataEC50:  180nMAssay Description:Agonist activity at rat GluN1/GluN2A NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode volt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50583022(CHEMBL5085583)
Affinity DataEC50:  220nMAssay Description:Agonist activity at rat GluN1/GluN2A NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode volt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50583023(CHEMBL5081203)
Affinity DataEC50:  260nMAssay Description:Agonist activity at rat GluN1/GluN2A NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode volt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50220152(2-(Amino-carboxy-methyl)-cyclopropanecarboxylic ac...)
Affinity DataEC50:  262nMAssay Description:Agonist activity at rat recombinant wild type GluN1/GluN2A receptor expressed in Xenopus laevis oocytes by two electrode voltage clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50432711(CHEMBL2348224)
Affinity DataEC50:  277nMAssay Description:Agonist activity at rat recombinant wild type GluN1/GluN2A receptor expressed in Xenopus laevis oocytes by two electrode voltage clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM20180((1S,2R,5S,10S,11S,14R,15R)-14-[(2R,5S)-5-hydroxy-6...)
Affinity DataEC50:  650nMAssay Description:Positive allosteric modulation of recombinant rat GluN1/GluN2A receptor expressed in Xenopus laevis oocytes assessed as increase in glycine/L-glutama...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM18133(2-aminoacetic acid | [14C]Glycine | CHEMBL773 | Gl...)
Affinity DataEC50:  990nMAssay Description:Agonist activity at rat GluN1/GluN2A NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode volt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM23167((2R)-2-amino-3-hydroxypropanoic acid | CHEMBL28512...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at rat GluN1/GluN2A NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode volt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50432710(CHEMBL2348221)
Affinity DataEC50:  1.18E+3nMAssay Description:Agonist activity at rat recombinant wild type GluN1/GluN2A receptor expressed in Xenopus laevis oocytes by two electrode voltage clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  1.80E+3nMAssay Description:Agonist activity at rat NR1/NR2A receptor expressed in BHK21 cells assessed as change in intracellular calcium levels by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50583024(CHEMBL5087170)
Affinity DataEC50:  3.10E+3nMAssay Description:Agonist activity at rat GluN1/GluN2A NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode volt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50583025(CHEMBL5093773)
Affinity DataEC50:  4.30E+3nMAssay Description:Agonist activity at rat GluN1/GluN2A NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode volt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50583026(CHEMBL5072895)
Affinity DataEC50:  4.80E+3nMAssay Description:Agonist activity at rat GluN1/GluN2A NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode volt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50583027(CHEMBL5076681)
Affinity DataEC50:  4.90E+3nMAssay Description:Agonist activity at rat GluN1/GluN2A NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode volt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50583028(CHEMBL5087550)
Affinity DataEC50:  6.60E+3nMAssay Description:Agonist activity at rat GluN1/GluN2A NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode volt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50531767(CHEMBL4530995)
Affinity DataEC50:  7.50E+3nMAssay Description:Positive allosteric modulation of rat GluN1/GluN2A expressed in Xenopus laevis oocytes assessed as potentiation of L-glutamate/glycine-induced curren...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50461796(CHEMBL4224777)
Affinity DataEC50:  8.90E+3nMAssay Description:Positive allosteric modulation of recombinant rat GluN1alpha/GluN2A receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50583029(CHEMBL5081696)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at rat GluN1/GluN2A NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode volt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50583030(CHEMBL5083882)
Affinity DataEC50:  2.30E+4nMAssay Description:Agonist activity at rat GluN1/GluN2A NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode volt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50531769(CHEMBL4467653)
Affinity DataEC50:  2.67E+4nMAssay Description:Positive allosteric modulation of rat GluN1/GluN2A expressed in Xenopus laevis oocytes assessed as potentiation of L-glutamate/glycine-induced curren...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50503152(CHEMBL4452216)
Affinity DataEC50:  2.80E+4nMAssay Description:Positive allosteric modulation of rat GluN1/GluN2A expressed in Xenopus laevis oocytes assessed as potentiation of L-glutamate/glycine-induced curren...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50432708(CHEMBL2348223)
Affinity DataEC50:  2.88E+4nMAssay Description:Agonist activity at rat recombinant wild type GluN1/GluN2A receptor expressed in Xenopus laevis oocytes by two electrode voltage clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50531768(CHEMBL4531020)
Affinity DataEC50:  3.94E+4nMAssay Description:Positive allosteric modulation of rat GluN1/GluN2A expressed in Xenopus laevis oocytes assessed as potentiation of L-glutamate/glycine-induced curren...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50432709(CHEMBL2348222)
Affinity DataEC50:  4.63E+4nMAssay Description:Agonist activity at rat recombinant wild type GluN1/GluN2A receptor expressed in Xenopus laevis oocytes by two electrode voltage clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50318264((+)-2-Amino-3-(4-hydroxy-1,2,5-oxadiazol-3-yl)prop...)
Affinity DataEC50:  4.70E+4nMAssay Description:Agonist activity at rat NR1/NR2A receptor expressed in BHK21 cells assessed as change in intracellular calcium levels by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50318264((+)-2-Amino-3-(4-hydroxy-1,2,5-oxadiazol-3-yl)prop...)
Affinity DataEC50:  4.70E+4nMAssay Description:Agonist activity at rat NR1/NR2A receptor expressed in BHK21 cells assessed as change in intracellular calcium levels by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50252359((R,S)-2-amino-2-(1-hydroxy-1H-pyrazol-5-yl)acetic ...)
Affinity DataEC50:  8.20E+4nMAssay Description:Agonist activity at rat recombinant wild type GluN1/GluN2A receptor expressed in Xenopus laevis oocytes by two electrode voltage clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50531770(CHEMBL4572997)
Affinity DataEC50:  1.14E+5nMAssay Description:Positive allosteric modulation of rat GluN1/GluN2A expressed in Xenopus laevis oocytes assessed as potentiation of L-glutamate/glycine-induced curren...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed