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TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519)
Affinity DataKi:  18nMAssay Description:Inhibition of recombinant human full length N-terminal His6-tagged CDK5/N-terminal GST-tagged p25 expressed in baculovirus infected Sf21 insect cells...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50395894(CHEMBL2163771)
Affinity DataKi:  70nMAssay Description:Inhibition of CDK5/p25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50395892(CHEMBL2163772)
Affinity DataKi:  110nMAssay Description:Inhibition of CDK5/p25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50525155(CHEMBL4561424)
Affinity DataKi:  160nMAssay Description:Inhibition of recombinant full length N-terminal GST tagged human CDK5/p25 expressed in baculovirus infected sf9 cells using histone H1 as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50133557(1-[2-(2,6-Dichloro-benzyl)-thiazol-4-yl]-3-morphol...)
Affinity DataKi:  500nMAssay Description:Inhibition of Tau Protein Kinase II (TPK II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50525156(CHEMBL4476248)
Affinity DataKi:  800nMAssay Description:Inhibition of recombinant full length N-terminal GST tagged human CDK5/p25 expressed in baculovirus infected sf9 cells using histone H1 as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50525162(CHEMBL4434651)
Affinity DataKi:  880nMAssay Description:Inhibition of recombinant full length N-terminal GST tagged human CDK5/p25 expressed in baculovirus infected sf9 cells using histone H1 as substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50525160(CHEMBL4522230)
Affinity DataKi:  990nMAssay Description:Inhibition of recombinant full length N-terminal GST tagged human CDK5/p25 expressed in baculovirus infected sf9 cells using histone H1 as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50525157(CHEMBL4460155)
Affinity DataKi:  1.01E+3nMAssay Description:Inhibition of recombinant full length N-terminal GST tagged human CDK5/p25 expressed in baculovirus infected sf9 cells using histone H1 as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50525158(CHEMBL4515564)
Affinity DataKi:  1.23E+3nMAssay Description:Inhibition of recombinant full length N-terminal GST tagged human CDK5/p25 expressed in baculovirus infected sf9 cells using histone H1 as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50525159(CHEMBL4471293)
Affinity DataKi:  1.26E+3nMAssay Description:Inhibition of recombinant full length N-terminal GST tagged human CDK5/p25 expressed in baculovirus infected sf9 cells using histone H1 as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50463479(CHEMBL4249925)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of CDK5/p35 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50525161(CHEMBL4557901)
Affinity DataKi:  1.44E+3nMAssay Description:Inhibition of recombinant full length N-terminal GST tagged human CDK5/p25 expressed in baculovirus infected sf9 cells using histone H1 as substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50525154(CHEMBL4581547)
Affinity DataKi:  1.72E+3nMAssay Description:Inhibition of recombinant full length N-terminal GST tagged human CDK5/p25 expressed in baculovirus infected sf9 cells using histone H1 as substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50463483(CHEMBL4245242)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of CDK5/p35 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50463484(CHEMBL4248525)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of CDK5/p35 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50525163(CHEMBL4566271)
Affinity DataKi:  2.03E+3nMAssay Description:Inhibition of recombinant full length N-terminal GST tagged human CDK5/p25 expressed in baculovirus infected sf9 cells using histone H1 as substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50395887(CHEMBL2163770)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition of CDK5/p25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50395888(CHEMBL2163769)
Affinity DataKi:  2.53E+4nMAssay Description:Inhibition of CDK5/p25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50395890(CHEMBL2163774)
Affinity DataKi:  2.61E+4nMAssay Description:Inhibition of CDK5/p25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM7453(1-aza-9-oxafluorene deriv. 7b | 4-methoxy-3-phenyl...)
Affinity DataKi:  2.17E+5nMAssay Description:Inhibition of CDK5/p25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50331612(CHEMBL1290072 | N-(4-methoxybenzyl)benzofuro[2,3-b...)
Affinity DataKi: >1.00E+6nMAssay Description:Inhibition of human CDK5/p25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50395893(CHEMBL1165662)
Affinity DataKi: >1.00E+6nMAssay Description:Inhibition of CDK5/p25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50395891(CHEMBL2163773)
Affinity DataKi: >1.00E+6nMAssay Description:Inhibition of CDK5/p25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50395889(CHEMBL2163768)
Affinity DataKi: >1.00E+6nMAssay Description:Inhibition of CDK5/p25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50585766(CHEMBL5080866)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of Nano-Luc fused human full length CDK5/P35 transfected in HEK293 cells incubated for 1 hr by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50585763(CHEMBL5075328)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of full length N-terminal GST fused human CDK5(1 to 292 residues)/ p25 (99 to 307 residues) expressed in baculovirus expression system usi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM6878(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3n ...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50585759(CHEMBL5081712)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of full length N-terminal GST fused human CDK5(1 to 292 residues)/ p25 (99 to 307 residues) expressed in baculovirus expression system usi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50585770(CHEMBL5080351)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of full length N-terminal GST fused human CDK5(1 to 292 residues)/ p25 (99 to 307 residues) expressed in baculovirus expression system usi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50585768(CHEMBL5074832)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of full length N-terminal GST fused human CDK5(1 to 292 residues)/ p25 (99 to 307 residues) expressed in baculovirus expression system usi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50585762(CHEMBL5077138)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of full length N-terminal GST fused human CDK5(1 to 292 residues)/ p25 (99 to 307 residues) expressed in baculovirus expression system usi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM601933(4-((6'-hydroxy-8'-oxo-7',8'-dihydro-6'H- spiro[cyc...)
Affinity DataIC50:  0.680nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetCyclin-dependent kinase 5 activator 1(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601933(4-((6'-hydroxy-8'-oxo-7',8'-dihydro-6'H- spiro[cyc...)
Affinity DataIC50:  0.680nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM601933(4-((6'-hydroxy-8'-oxo-7',8'-dihydro-6'H- spiro[cyc...)
Affinity DataIC50:  0.800nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50585785(CHEMBL5077028)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of full length N-terminal GST fused human CDK5(1 to 292 residues)/ p25 (99 to 307 residues) expressed in baculovirus expression system usi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50585774(CHEMBL5086375)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of full length N-terminal GST fused human CDK5(1 to 292 residues)/ p25 (99 to 307 residues) expressed in baculovirus expression system usi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50585780(CHEMBL5090019)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of full length N-terminal GST fused human CDK5(1 to 292 residues)/ p25 (99 to 307 residues) expressed in baculovirus expression system usi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50585761(CHEMBL5078762)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of full length N-terminal GST fused human CDK5(1 to 292 residues)/ p25 (99 to 307 residues) expressed in baculovirus expression system usi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50585775(CHEMBL5091792)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of full length N-terminal GST fused human CDK5(1 to 292 residues)/ p25 (99 to 307 residues) expressed in baculovirus expression system usi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50585779(CHEMBL5088595)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of full length N-terminal GST fused human CDK5(1 to 292 residues)/ p25 (99 to 307 residues) expressed in baculovirus expression system usi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50585782(CHEMBL5080361)
Affinity DataIC50:  1nMAssay Description:Inhibition of full length N-terminal GST fused human CDK5(1 to 292 residues)/ p25 (99 to 307 residues) expressed in baculovirus expression system usi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK5/p35 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant CDK5/p25 (unknown origin) expressed in baculovirus infected Sf9 insect cells using biotinylated histone H1 as substrate aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM601953(2'-((4-(piperazine-1- carbonyl)phenyl)amino)-7',8'...)
Affinity DataIC50:  1nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetCyclin-dependent kinase 5 activator 1(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601953(2'-((4-(piperazine-1- carbonyl)phenyl)amino)-7',8'...)
Affinity DataIC50:  1nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50585756(CHEMBL5092400)
Affinity DataIC50:  1nMAssay Description:Inhibition of full length N-terminal GST fused human CDK5(1 to 292 residues)/ p25 (99 to 307 residues) expressed in baculovirus expression system usi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50585772(CHEMBL5080566)
Affinity DataIC50:  1nMAssay Description:Inhibition of Nano-Luc fused human full length CDK5/P35 transfected in HEK293 cells incubated for 1 hr by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50585760(CHEMBL5077125)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of full length N-terminal GST fused human CDK5(1 to 292 residues)/ p25 (99 to 307 residues) expressed in baculovirus expression system usi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50059889((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of CDK5/P25 (unknown origin)-mediated phosphorylation of peptide substrate incubated for 15 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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