Affinity DataEC50: 0.617nMAssay Description:Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateMore data for this Ligand-Target Pair
Affinity DataEC50: 1.20nMAssay Description:Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateMore data for this Ligand-Target Pair
Affinity DataEC50: 1.20nMAssay Description:Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine m...More data for this Ligand-Target Pair
Affinity DataEC50: 1.5nMAssay Description:Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 min...More data for this Ligand-Target Pair
Affinity DataEC50: 1.60nMAssay Description:Alpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPMore data for this Ligand-Target Pair
Affinity DataEC50: 1.60nMAssay Description:Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine m...More data for this Ligand-Target Pair
Affinity DataEC50: 2.10nMAssay Description:Agonist activity at recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane incubated for 30 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.30nMAssay Description:Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateMore data for this Ligand-Target Pair
Affinity DataEC50: 2.80nMAssay Description:Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic/Mu-type opioid receptor(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataEC50: 3nMAssay Description:Inhibition of MOR/alpha2A adrenergic receptor heterodimer expressed in HEK293 cells assessed as stimulation of ERK1/2 phosphorylationMore data for this Ligand-Target Pair
Affinity DataEC50: 3.30nMAssay Description:Agonist potency at Alpha-2A stably expressed in CHO cells.More data for this Ligand-Target Pair
Affinity DataEC50: 4.10nMAssay Description:Effective concentration at Alpha-2A adrenergic receptor from CHO-C10 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 6.30nMAssay Description:Agonist potency at Alpha-2A stably expressed in CHO cells.More data for this Ligand-Target Pair
Affinity DataEC50: 6.30nMAssay Description:Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...More data for this Ligand-Target Pair
Affinity DataEC50: 8.10nMAssay Description:Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine m...More data for this Ligand-Target Pair
Affinity DataEC50: 8.30nMAssay Description:Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryMore data for this Ligand-Target Pair
Affinity DataEC50: 8.5nMAssay Description:Displacement of [3H]MK912 from human recombinant adrenergic alpha2A receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 8.70nMAssay Description:Effective concentration at Alpha-2A adrenergic receptor from CHO-C10 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 11nMAssay Description:Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateMore data for this Ligand-Target Pair
Affinity DataEC50: 11nMAssay Description:Alpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPMore data for this Ligand-Target Pair
Affinity DataEC50: 12nMAssay Description:Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...More data for this Ligand-Target Pair
Affinity DataEC50: 14nMAssay Description:Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 min...More data for this Ligand-Target Pair
Affinity DataEC50: 15nMAssay Description:Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 min...More data for this Ligand-Target Pair
Affinity DataEC50: 19nMAssay Description:Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...More data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:Agonist potency at Alpha-2A stably expressed in CHO cells.More data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:Agonist potency at Alpha-2A stably expressed in CHO cells.More data for this Ligand-Target Pair
Affinity DataEC50: 27nMAssay Description:Agonist activity at human cloned adrenergic alpha-2A receptor expressed in CHOK1 cells by beta-lactamase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 28nMAssay Description:Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 min...More data for this Ligand-Target Pair
Affinity DataEC50: 30nMAssay Description:Agonist activity at human adrenoceptor alpha2A expressed in CHOK1 cells assessed as stimulation of agonist-induced [35S]GTPgammaS binding by scintill...More data for this Ligand-Target Pair
Affinity DataEC50: 30nMAssay Description:Agonist activity at recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane incubated for 30 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 30nMAssay Description:Agonist activity at recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane incubated for 30 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 32nMAssay Description:Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...More data for this Ligand-Target Pair
Affinity DataEC50: 35nMAssay Description:Alpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPMore data for this Ligand-Target Pair
Affinity DataEC50: 37nMAssay Description:Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 min...More data for this Ligand-Target Pair
Affinity DataEC50: 38nMAssay Description:Agonistic activity towards human Alpha-2A adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine m...More data for this Ligand-Target Pair
Affinity DataEC50: 39nMAssay Description:Agonist activity at human alpha2A adrenoceptor expressed in CHO-K1 cells after 30 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 40nMAssay Description:Agonist potency at Alpha-2A adrenergic receptor assayed in CHO cells expressing human alpha 2aMore data for this Ligand-Target Pair
Affinity DataEC50: 42nMAssay Description:Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryMore data for this Ligand-Target Pair
Affinity DataEC50: 63nMAssay Description:Agonist activity at human adrenoceptor aplha 2A expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...More data for this Ligand-Target Pair
Affinity DataEC50: 63nMAssay Description:Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationMore data for this Ligand-Target Pair
Affinity DataEC50: 63nMAssay Description:Agonist activity at human alpha2a-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 63nMAssay Description:Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryMore data for this Ligand-Target Pair
Affinity DataEC50: 71nMAssay Description:Alpha-2A adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPMore data for this Ligand-Target Pair
Affinity DataEC50: 73nMAssay Description:Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 min...More data for this Ligand-Target Pair
Affinity DataEC50: 74nMAssay Description:Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataEC50: 74nMAssay Description:Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryMore data for this Ligand-Target Pair
Affinity DataEC50: 76nMAssay Description:Agonist activity at human adrenergic alpha-2A receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryMore data for this Ligand-Target Pair
Affinity DataEC50: 76nMAssay Description:Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryMore data for this Ligand-Target Pair
Affinity DataEC50: 79nMAssay Description:Agonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as stimulation of extracellular acidificationMore data for this Ligand-Target Pair
Affinity DataEC50: 82nMAssay Description:Agonist activity at human recombinant alpha2A adrenergic receptor expressed in CHO cells assessed as induction of [35S]GTPgammaS binding after 60 min...More data for this Ligand-Target Pair