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Found 24 of ic50 for UniProtKB: P01116
TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550333(4-((2S,5R,M)-4-Acryloyl-2,5-dimethylpiperazin-1-yl...)
Affinity DataIC50:  13nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550345((M)-4-(4-Acryloyl-cis-3,5-dimethylpiperazin-1-yl)-...)
Affinity DataIC50:  14nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550344((M)-4-(4-Acryloyl-cis-3,5-dimethylpiperazin-1-yl)-...)
Affinity DataIC50:  16nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550332(4-((2S,5R,M)-4-Acryloyl-2,5-dimethylpiperazin-1-yl...)
Affinity DataIC50:  27nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550338(4-((2S,5R)-4-Acryloyl-2,5-dimethylpiperazin-1-yl)-...)
Affinity DataIC50:  30nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550350(4-(4-Acryloyl-cis-3,5-dimethylpiperazin-1-yl)-6-ch...)
Affinity DataIC50:  34nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550336(4-((2S,5R,M)-4-Acryloyl-2,5-dimethylpiperazin-1-yl...)
Affinity DataIC50:  38nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550331(4-((2S,5R,M)-4-Acryloyl-2,5-dimethylpiperazin-1-yl...)
Affinity DataIC50:  40nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550349(4-(4-Acryloyl-cis-3,5-dimethylpiperazin-1-yl)-6-ch...)
Affinity DataIC50:  42nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550337(4-((2S,5R)-4-Acryloyl-2,5-dimethylpiperazin-1-yl)-...)
Affinity DataIC50:  49nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550343((M)-4-(4-Acryloyl-cis-3,5-dimethylpiperazin-1-yl)-...)
Affinity DataIC50:  53nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550339(4-((2S,5R)-4-Acryloyl-2,5-dimethylpiperazin-1-yl)-...)
Affinity DataIC50:  54nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550348((M)-4-(4-Acryloyl-cis-3,5-dimethylpiperazin-1-yl)-...)
Affinity DataIC50:  69nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550335(4-((2S,5R,M)-4-Acryloyl-2,5-dimethylpiperazin-1-yl...)
Affinity DataIC50:  79nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550351(4-(4-Acryloyl-cis-3,5-dimethylpiperazin-1-yl)-7-(2...)
Affinity DataIC50:  92nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550347((M)-4-(4-Acryloyl-cis-3,5-dimethylpiperazin-1-yl)-...)
Affinity DataIC50:  117nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550338(4-((2S,5R)-4-Acryloyl-2,5-dimethylpiperazin-1-yl)-...)
Affinity DataIC50:  136nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM544164(1-(4,6- Diisopropylpyrimidin- 5-yl)-4-[(2S,5R)- 2,...)
Affinity DataIC50:  160nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550353(4-(4-Acryloyl-cis-3,5-dimethylpiperazin-1-yl)-1-(4...)
Affinity DataIC50:  173nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550334(4-((2S,5R,M)-4-Acryloyl-2,5-dimethylpiperazin-1-yl...)
Affinity DataIC50:  206nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550342(4-((2S,5R)-4-Acryloyl-2,5-dimethylpiperazin-1-yl)-...)
Affinity DataIC50:  214nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550354(4-(4-Acryloyl-cis-3,5-dimethylpiperazin-1-yl)-7-(2...)
Affinity DataIC50:  396nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550346((M)-4-(4-Acryloyl-cis-3,5-dimethylpiperazin-1-yl)-...)
Affinity DataIC50:  512nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550352(4-(4-Acryloyl-cis-3,5-dimethylpiperazin-1-yl)-1-(4...)
Affinity DataIC50:  560nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent