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TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50095105(4-{2-[4-(Benzo[1,3]dioxole-5-sulfonyl)-phenyl]-[1,...)
Affinity DataKi:  0.0100nMAssay Description:Antagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50095105(4-{2-[4-(Benzo[1,3]dioxole-5-sulfonyl)-phenyl]-[1,...)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50095105(4-{2-[4-(Benzo[1,3]dioxole-5-sulfonyl)-phenyl]-[1,...)
Affinity DataKi:  0.0100nMAssay Description:Antagonistic activity of the compound against Muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50066861(BA-679-BR | Spiriva | Tiotropium Bromide | Tiotrop...)
Affinity DataKi:  0.0200nMAssay Description:Binding affinity to human M2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50296345((1R,2R,4S,5R,7S)-7-(2-hydroxy-2,2-di-thiophen-2-yl...)
Affinity DataKi:  0.0215nMAssay Description:Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 24 hrs by filter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM81768(BENZYLIC ACID | CAS_6581-06-2 | NSC_5311391 | Quin...)
Affinity DataKi:  0.0270nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50110523(1-{1-[4-(Benzo[1,3]dioxole-5-sulfonyl)-phenyl]-eth...)
Affinity DataKi:  0.0300nMAssay Description:Binding affinity against human cloned Muscarinic acetylcholine receptor M2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50110539(1-{1-[4-(Benzo[1,3]dioxole-5-sulfonyl)-phenyl]-eth...)
Affinity DataKi:  0.0300nMAssay Description:Binding affinity against human cloned Muscarinic acetylcholine receptor M2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50095111(4-{(4R,5R)-2-[4-(Benzo[1,3]dioxole-5-sulfonyl)-phe...)
Affinity DataKi:  0.0300nMAssay Description:Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50451113(CHEMBL2114068)
Affinity DataKi:  0.0300nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM81768(BENZYLIC ACID | CAS_6581-06-2 | NSC_5311391 | Quin...)
Affinity DataKi:  0.0300nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50095097(4-{2-[4-(Benzo[1,3]dioxole-5-sulfonyl)-phenyl]-[1,...)
Affinity DataKi:  0.0310nMAssay Description:Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50110534(1-Cyclohexyl-4-{1-[4-(4-methoxy-benzenesulfonyl)-p...)
Affinity DataKi:  0.0400nMAssay Description:Binding affinity against human cloned Muscarinic acetylcholine receptor M2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM81768(BENZYLIC ACID | CAS_6581-06-2 | NSC_5311391 | Quin...)
Affinity DataKi:  0.0400nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50010096(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Affinity DataKi:  0.0450nMAssay Description:Binding affinity for muscarinic acetylcholine receptor M2 by measuring displacement of [3H]-QNB from guinea pig heartMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50010096(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Affinity DataKi:  0.0450nMAssay Description:Ability of compound to displace (-)-[3H]3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in the heart from Guinea Pig.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50010096(CHEMBL12980 | Hydroxy-diphenyl-acetic acid 1-aza-b...)
Affinity DataKi:  0.0510nMAssay Description:Ability of compound to displace (-)-[3H]3-Quinuclidinyl benzilate (-)-[3H]-QNB from Muscarinic acetylcholine receptors in cerebral cortex from Guinea...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50011851(2,2-Diphenyl-propionic acid 6-methyl-6-aza-bicyclo...)
Affinity DataKi:  0.0540nMAssay Description:Inhibition of [3H]QNB binding against muscarinic acetylcholine receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50355612(CHEMBL1910848)
Affinity DataKi:  0.0560nMAssay Description:Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50451114(CHEMBL2115128)
Affinity DataKi:  0.0570nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50296336((3R)-3-{[(2S)-2-Cyclopentyl-2-hydroxy-2-(2-thienyl...)
Affinity DataKi:  0.0600nMAssay Description:Binding affinity to muscarinic M2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50296345((1R,2R,4S,5R,7S)-7-(2-hydroxy-2,2-di-thiophen-2-yl...)
Affinity DataKi:  0.0610nMAssay Description:Displacement of [3H]-NMS from human recombinant M2 receptor expressed in CHO cells after 2 hrs by filter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50241132(3-Hydroxy-2-phenyl-propionic acid 9-methyl-3-oxa-9...)
Affinity DataKi:  0.0631nMAssay Description:Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting ...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50525130(CHEMBL4540949)
Affinity DataKi:  0.0631nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50525115(CHEMBL4582879)
Affinity DataKi:  0.0631nMAssay Description:Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 0.2 nM [3H]-NMS after 3 hrs by microbeta2 scin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50525115(CHEMBL4582879)
Affinity DataKi:  0.0631nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50092959(4-{1-[4-(4-Methoxy-benzenesulfonyl)-phenyl]-vinyl}...)
Affinity DataKi:  0.0700nMAssay Description:Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50095112(4-{2-[4-(Benzo[1,3]dioxole-5-sulfonyl)-phenyl]-[1,...)
Affinity DataKi:  0.0730nMAssay Description:Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50083651((S)-3-Hydroxy-2-(2-tetradecanoylamino-acetylamino)...)
Affinity DataKi:  0.0759nMAssay Description:Ability to displace [3H]QNB from HM1 receptor binding to acetylcholine was evaluated by ligand inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50083651((S)-3-Hydroxy-2-(2-tetradecanoylamino-acetylamino)...)
Affinity DataKi:  0.0760nMAssay Description:Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM85817(NNC 11-1585)
Affinity DataKi:  0.0790nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50525115(CHEMBL4582879)
Affinity DataKi:  0.0794nMAssay Description:Competitive displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells using 2 nM [3H]-NMS after 3 hrs by microbeta2 scinti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50525132(CHEMBL4451383)
Affinity DataKi:  0.0794nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50525124(CHEMBL4569639)
Affinity DataKi:  0.0794nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50525110(CHEMBL4455570)
Affinity DataKi:  0.0794nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50525122(CHEMBL4589047)
Affinity DataKi:  0.0794nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells after 3 hrs by microbeta2 scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50568858(CHEMBL4856113)
Affinity DataKi:  0.0794nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50296329((3R)-3-{[Hydroxy(di-2-thienyl)acetyl]oxy}-1-(2-phe...)
Affinity DataKi:  0.0800nMAssay Description:Binding affinity to muscarinic M2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50296331((3R)-3-{[Hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phe...)
Affinity DataKi:  0.0800nMAssay Description:Binding affinity to muscarinic M2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50568832(CHEMBL4597498)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50381654(CHEMBL2023764)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50110543(CHEMBL167396 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50296345((1R,2R,4S,5R,7S)-7-(2-hydroxy-2,2-di-thiophen-2-yl...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to muscarinic M2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50110551(CHEMBL352291 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50110557(CHEMBL352380 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50110555(CHEMBL164935 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50568851(CHEMBL4864727)
Affinity DataKi:  0.102nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50568856(CHEMBL4859378)
Affinity DataKi:  0.105nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cell membranes assessed as inhibition constant by radioligand competition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50265995(CHEMBL4097258)
Affinity DataKi:  0.107nMAssay Description:Displacement of [3H]UNSW-MK259 from human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells after 3 hrs by liquid scintillation counting ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50092959(4-{1-[4-(4-Methoxy-benzenesulfonyl)-phenyl]-vinyl}...)
Affinity DataKi:  0.110nMAssay Description:Binding affinity to muscarinic M2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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