Compile Data Set for Download or QSAR
Found 3 of kd for UniProtKB: Q9NR97
TargetToll-like receptor 8(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50543138(CHEMBL4646526)
Show SMILES [O-]C(=O)C(F)(F)F.CC[N+]1=C(\C=C\C=C\C=C2\N(CCCCCC(=O)NC34CCC(COc5ncc(cc5C)-c5ccnc6[nH]ncc56)(CC3)CC4)c3ccc(cc3C2(C)C)S(O)(=O)=O)C(C)(C)c2cc(ccc12)S(O)(=O)=O
Show InChI InChI=1S/C54H63N7O8S2.C2HF3O2/c1-7-60-44-19-17-38(70(63,64)65)31-42(44)51(3,4)46(60)14-10-8-11-15-47-52(5,6)43-32-39(71(66,67)68)18-20-45(43)61(47)29-13-9-12-16-48(62)58-54-25-22-53(23-26-54,24-27-54)35-69-50-36(2)30-37(33-56-50)40-21-28-55-49-41(40)34-57-59-49;3-2(4,5)1(6)7/h8,10-11,14-15,17-21,28,30-34H,7,9,12-13,16,22-27,29,35H2,1-6H3,(H3-,55,57,58,59,62,63,64,65,66,67,68);(H,6,7)
Affinity DataKd:  65nMAssay Description:Binding affinity to human TLR8 extracellular domain (27 to 827 residues) expressed in Drosophila S2 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetToll-like receptor 8(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50514141(CHEMBL4543348)
Show SMILES [O-][N+](=O)c1c(I)cccc1Oc1ccc(cc1)-c1nnco1
Show InChI InChI=1S/C14H8IN3O4/c15-11-2-1-3-12(13(11)18(19)20)22-10-6-4-9(5-7-10)14-17-16-8-21-14/h1-8H
Affinity DataKd:  86nMAssay Description:Binding affinity to human TLR8 (27 to 827 residues) expressed in HEK293 cells in presence of R848 by ITC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetToll-like receptor 8(Homo sapiens (Human))
Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50514792(CHEMBL4519240)
Show SMILES CSc1nnc(CCCO)n1-c1cc(C)c(C)c(C)c1
Show InChI InChI=1S/C15H21N3OS/c1-10-8-13(9-11(2)12(10)3)18-14(6-5-7-19)16-17-15(18)20-4/h8-9,19H,5-7H2,1-4H3
Affinity DataKd:  225nMAssay Description:Binding affinity to human TLR8 ectodomain by isothermal titration calorimetryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB