Compile Data Set for Download or QSAR
maximum 50k data
Found 165 of ec50 data for complexid = 160,163,50000022,50000075,50000151
LigandPNGBDBM50126036(6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...)
Affinity DataEC50:  0.100nMAssay Description:Inhibition of farnesylation in NIH-3T3H-ras cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126036(6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...)
Affinity DataEC50:  0.100nMAssay Description:Reduced farnesylation in H-Ras NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126034(4-[1-Hydroxy-3-(3'-methoxy-5-pentanoyl-biphenyl-2-...)
Affinity DataEC50: <0.100nMAssay Description:Inhibition of farnesylation in NIH-3T3H-ras cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076811(CHEMBL10877 | Lithium; (S)-2-({5-[5-(4-chloro-phen...)
Affinity DataEC50:  0.100nMAssay Description:EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076790(CHEMBL10902 | Lithium; (S)-2-{[2'-methyl-5-(5-pyri...)
Affinity DataEC50:  0.300nMAssay Description:EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076802(CHEMBL10912 | Lithium; (S)-2-{[2'-methyl-5-(5-pyri...)
Affinity DataEC50: >0.300nMAssay Description:EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076808(CHEMBL10762 | Lithium; (S)-2-{[2'-methyl-5-(5-pyri...)
Affinity DataEC50: >0.300nMAssay Description:EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135353(5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...)
Affinity DataEC50:  0.5nMAssay Description:In vitro inhibitory activity against Factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126320(1-{[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-m...)
Affinity DataEC50:  0.5nMAssay Description:In vitro inhibition of geranylgeranyltransferase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135353(5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...)
Affinity DataEC50:  0.5nMAssay Description:In vitro effective concentration of the compound against farnesyltransferase (FT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076794(CHEMBL276602 | Lithium; (S)-2-({5-[5-(4-isopropyl-...)
Affinity DataEC50:  0.780nMAssay Description:EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135372(6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)
Affinity DataEC50:  0.810nMAssay Description:In vitro effective concentration of the compound against farnesyltransferase (FT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50130378(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataEC50:  0.900nMAssay Description:Inhibition of hDJ2 protein farnesylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076795(CHEMBL11210 | Lithium; (S)-2-({5-[5-(4-dimethylami...)
Affinity DataEC50:  0.900nMAssay Description:EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126322(4-Cyano-5-naphthalen-1-yl-3,6-dihydro-2H-pyridine-...)
Affinity DataEC50: >1nMAssay Description:In vitro inhibition of geranylgeranyltransferase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126044(5-[(4-Cyano-phenyl)-hydroxy-(3-methyl-3H-imidazol-...)
Affinity DataEC50: <1nMAssay Description:Inhibition of farnesylation in NIH-3T3H-ras cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126025(4-[3-(4-Cyano-phenyl)-1-hydroxy-1-(3-methyl-3H-imi...)
Affinity DataEC50: <1nMAssay Description:Inhibition of farnesylation in NIH-3T3H-ras cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076813(CHEMBL10687 | Lithium; (S)-2-({5-[5-(2-methoxy-phe...)
Affinity DataEC50: >1nMAssay Description:EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126027(4-[3-(4-Ethynyl-phenyl)-1-hydroxy-1-(3-methyl-3H-i...)
Affinity DataEC50: <1nMAssay Description:Inhibition of human GGTase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide of C-terminal of human K-RasMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076800(CHEMBL430307 | Lithium; (S)-2-({5-[5-(4-acetyl-phe...)
Affinity DataEC50: >1nMAssay Description:EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076797(CHEMBL10955 | Lithium; (S)-2-{[2'-methyl-5-(5-phen...)
Affinity DataEC50: >1nMAssay Description:EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076806(CHEMBL273265 | Lithium; (S)-2-({5-[5-(4-methoxy-ph...)
Affinity DataEC50: >1nMAssay Description:EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076807(CHEMBL273721 | Lithium; (S)-2-({5-[5-(3-methoxy-ph...)
Affinity DataEC50: >1nMAssay Description:EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076803(CHEMBL10970 | Lithium; (S)-2-({5-[5-(2-fluoro-phen...)
Affinity DataEC50: >1nMAssay Description:EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076809(CHEMBL417606 | Lithium; (S)-2-({5-[5-(4-formyl-phe...)
Affinity DataEC50: >1nMAssay Description:EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126040(6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...)
Affinity DataEC50:  1.20nMAssay Description:Inhibition of farnesylation in NIH-3T3H-ras cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076810(CHEMBL428001 | Lithium; (S)-4-methylsulfanyl-2-({2...)
Affinity DataEC50:  1.20nMAssay Description:EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135379(6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)
Affinity DataEC50:  1.20nMAssay Description:In vitro effective concentration of the compound against farnesyltransferase (FT); Not activeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153785(4-((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)-2-...)
Affinity DataEC50:  1.20nMAssay Description:Inhibition of H-Ras transformed NIH-3T3-cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153168(6-({[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-am...)
Affinity DataEC50:  1.34nMAssay Description:Reduced farnesylation in H-Ras NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126026(3-Benzo[1,3]dioxol-5-yl-4-[3-(4-cyano-phenyl)-3-hy...)
Affinity DataEC50:  1.40nMAssay Description:Inhibition of farnesylation in NIH-3T3H-ras cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50130372(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataEC50:  1.5nMAssay Description:Inhibition of hDJ2 protein farnesylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076798(CHEMBL273697 | Lithium; (S)-2-({5-[5-(4-fluoro-phe...)
Affinity DataEC50:  1.5nMAssay Description:EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153170(6-({[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-me...)
Affinity DataEC50:  1.57nMAssay Description:Reduced farnesylation in H-Ras NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126335(6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...)
Affinity DataEC50:  1.60nMAssay Description:Inhibition of H-Ras transformed NIH-3T3-cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153797(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)
Affinity DataEC50:  1.60nMAssay Description:Inhibition of H-Ras transformed NIH-3T3-cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126335(6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...)
Affinity DataEC50:  1.60nMAssay Description:Inhibition of Ras farnesylation in H-Ras transformed NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153169(3-Benzo[1,3]dioxol-5-yl-4-[3-(4-cyano-benzyl)-3H-i...)
Affinity DataEC50:  1.65nMAssay Description:Reduced farnesylation in H-Ras NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50076791(CHEMBL10990 | Lithium; (S)-4-methylsulfanyl-2-{[2'...)
Affinity DataEC50:  1.80nMAssay Description:EC50 is measured as inhibition of ras processing in a whole cell assay for farnesyltransferase (FTase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135367(5-Benzo[1,3]dioxol-5-yl-6-[(4-cyano-phenyl)-(3-met...)
Affinity DataEC50:  2.10nMAssay Description:In vitro effective concentration of the compound against farnesyltransferase (FT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135378(5-(3-Bromo-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-3...)
Affinity DataEC50:  2.10nMAssay Description:In vitro effective concentration of the compound against farnesyltransferase (FT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126041(6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...)
Affinity DataEC50:  2.70nMAssay Description:Inhibition of farnesylation in NIH-3T3H-ras cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126041(6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...)
Affinity DataEC50:  2.70nMAssay Description:Inhibition of human FTase-catalyzed incorporation of [3H]-FPP into recombinant Ras CVIMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126041(6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...)
Affinity DataEC50:  2.74nMAssay Description:Reduced farnesylation in H-Ras NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135364(5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...)
Affinity DataEC50:  2.90nMAssay Description:In vitro effective concentration of the compound against farnesyltransferase (FT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50130365(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataEC50:  3.10nMAssay Description:Inhibition of hDJ2 protein farnesylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126039(4-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-(4-pe...)
Affinity DataEC50:  3.80nMAssay Description:Inhibition of farnesylation in NIH-3T3H-ras cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135377(6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)
Affinity DataEC50:  3.90nMAssay Description:In vitro effective concentration of the compound against farnesyltransferase (FT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126028(3',5'-Dichloro-6-[3-(4-cyano-phenyl)-3-hydroxy-3-(...)
Affinity DataEC50:  3.90nMAssay Description:Inhibition of farnesylation in NIH-3T3H-ras cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135361(6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)
Affinity DataEC50:  3.90nMAssay Description:In vitro effective concentration of the compound against farnesyltransferase (FT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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