Compile Data Set for Download or QSAR
Found 308 Enz. Inhib. hit(s) with all data for entry = 10239
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521949(N-[3-[6-(difluoromethoxy)-2- methyl-3-oxo-4H-1,4- ...)
Show SMILES CC1Sc2cc(-c3n[nH]cc3NC(=O)c3cnn4cccnc34)c(OC(F)F)cc2NC1=O
Affinity DataKi:  0.0300nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521947(N-[3-[6-(difluoromethoxy)-2- methyl-3,4-dihydro-2H...)
Show SMILES CC1CNc2cc(OC(F)F)c(cc2S1)-c1n[nH]cc1NC(=O)c1cnn2cccnc12
Affinity DataKi:  0.0300nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521924(N-[3-[6-(difluoromethoxy)-3- oxo-4H-1,4-benzothiaz...)
Show SMILES FC(F)Oc1cc2NC(=O)CSc2cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C19H13F2N7O3S/c20-19(21)31-13-5-11-14(32-8-15(29)25-11)4-9(13)16-12(7-23-27-16)26-18(30)10-6-24-28-3-1-2-22-17(10)28/h1-7,19H,8H2,(H,23,27)(H,25,29)(H,26,30)
Affinity DataKi:  0.0400nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521924(N-[3-[6-(difluoromethoxy)-3- oxo-4H-1,4-benzothiaz...)
Show SMILES FC(F)Oc1cc2NC(=O)CSc2cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C19H13F2N7O3S/c20-19(21)31-13-5-11-14(32-8-15(29)25-11)4-9(13)16-12(7-23-27-16)26-18(30)10-6-24-28-3-1-2-22-17(10)28/h1-7,19H,8H2,(H,23,27)(H,25,29)(H,26,30)
Affinity DataKi:  0.0500nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521931(N-[5-[6-(difluoromethoxy)- 1H-indazol-5-yl]-1H-pyr...)
Show SMILES Nc1cc(OC(F)F)c(cc1C=N)-c1n[nH]cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C18H14F2N8O2/c19-18(20)30-14-5-12(22)9(6-21)4-10(14)15-13(8-24-27-15)26-17(29)11-7-25-28-3-1-2-23-16(11)28/h1-8,18,21H,22H2,(H,24,27)(H,26,29)
Affinity DataKi:  0.0500nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521947(N-[3-[6-(difluoromethoxy)-2- methyl-3,4-dihydro-2H...)
Show SMILES CC1CNc2cc(OC(F)F)c(cc2S1)-c1n[nH]cc1NC(=O)c1cnn2cccnc12
Affinity DataKi:  0.0500nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM522020(N-[3-[6-(difluoromethoxy)- 2,2-dimethyl-3,4-dihydr...)
Show SMILES CC1(C)CNc2cc(OC(F)F)c(cc2S1)-c1n[nH]cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C21H19F2N7O2S/c1-21(2)10-25-13-7-15(32-20(22)23)11(6-16(13)33-21)17-14(9-26-29-17)28-19(31)12-8-27-30-5-3-4-24-18(12)30/h3-9,20,25H,10H2,1-2H3,(H,26,29)(H,28,31)
Affinity DataKi:  0.0500nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521947(N-[3-[6-(difluoromethoxy)-2- methyl-3,4-dihydro-2H...)
Show SMILES CC1CNc2cc(OC(F)F)c(cc2S1)-c1n[nH]cc1NC(=O)c1cnn2cccnc12
Affinity DataKi:  0.0500nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521949(N-[3-[6-(difluoromethoxy)-2- methyl-3-oxo-4H-1,4- ...)
Show SMILES CC1Sc2cc(-c3n[nH]cc3NC(=O)c3cnn4cccnc34)c(OC(F)F)cc2NC1=O
Affinity DataKi:  0.0500nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521949(N-[3-[6-(difluoromethoxy)-2- methyl-3-oxo-4H-1,4- ...)
Show SMILES CC1Sc2cc(-c3n[nH]cc3NC(=O)c3cnn4cccnc34)c(OC(F)F)cc2NC1=O
Affinity DataKi:  0.0500nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521922(N-[3-[6-(difluoromethoxy)- 3,4-dihydro-2H-1,4- ben...)
Show SMILES FC(F)Oc1cc2NCCSc2cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C19H15F2N7O2S/c20-19(21)30-14-7-12-15(31-5-3-22-12)6-10(14)16-13(9-24-27-16)26-18(29)11-8-25-28-4-1-2-23-17(11)28/h1-2,4,6-9,19,22H,3,5H2,(H,24,27)(H,26,29)
Affinity DataKi:  0.0600nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521935(N-[3-[5-(difluoromethoxy)-2- methyl-benzothiophen-...)
Show SMILES Cc1cc2cc(OC(F)F)c(cc2s1)-c1n[nH]cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C20H14F2N6O2S/c1-10-5-11-6-15(30-20(21)22)12(7-16(11)31-10)17-14(9-24-27-17)26-19(29)13-8-25-28-4-2-3-23-18(13)28/h2-9,20H,1H3,(H,24,27)(H,26,29)
Affinity DataKi:  0.0600nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521949(N-[3-[6-(difluoromethoxy)-2- methyl-3-oxo-4H-1,4- ...)
Show SMILES CC1Sc2cc(-c3n[nH]cc3NC(=O)c3cnn4cccnc34)c(OC(F)F)cc2NC1=O
Affinity DataKi:  0.0600nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521950(N-[3-[6-(difluoromethoxy)-3- oxo-4H-1,4-benzoxazin...)
Show SMILES FC(F)Oc1cc2NC(=O)COc2cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C19H13F2N7O4/c20-19(21)32-13-5-11-14(31-8-15(29)25-11)4-9(13)16-12(7-23-27-16)26-18(30)10-6-24-28-3-1-2-22-17(10)28/h1-7,19H,8H2,(H,23,27)(H,25,29)(H,26,30)
Affinity DataKi:  0.0600nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM522062(N-[3-[5-(difluoromethoxy)- 1,2-benzothiazol-6-yl]-...)
Show SMILES FC(F)Oc1cc2cnsc2cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C18H11F2N7O2S/c19-18(20)29-13-4-9-6-24-30-14(9)5-10(13)15-12(8-22-26-15)25-17(28)11-7-23-27-3-1-2-21-16(11)27/h1-8,18H,(H,22,26)(H,25,28)
Affinity DataKi:  0.0600nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521949(N-[3-[6-(difluoromethoxy)-2- methyl-3-oxo-4H-1,4- ...)
Show SMILES CC1Sc2cc(-c3n[nH]cc3NC(=O)c3cnn4cccnc34)c(OC(F)F)cc2NC1=O
Affinity DataKi:  0.0600nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM522037(N-[3-[6-(difluoromethoxy)- 3,4-dihydro-2H-1,4- ben...)
Show SMILES Cn1nnnc1Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc2SCCNc2cc1OC(F)F
Show InChI InChI=1S/C22H19F2N11O2S/c1-33-18(29-31-32-33)11-34-10-15(28-21(36)13-9-27-35-5-2-3-26-20(13)35)19(30-34)12-7-17-14(25-4-6-38-17)8-16(12)37-22(23)24/h2-3,5,7-10,22,25H,4,6,11H2,1H3,(H,28,36)
Affinity DataKi:  0.0600nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM522050(N-[1-(cyanomethyl)-3-[6- (difluoromethoxy)-3,4- di...)
Show SMILES FC(F)Oc1cc2NCCSc2cc1-c1nn(CC#N)cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C21H16F2N8O2S/c22-21(23)33-16-9-14-17(34-7-4-25-14)8-12(16)18-15(11-30(29-18)6-2-24)28-20(32)13-10-27-31-5-1-3-26-19(13)31/h1,3,5,8-11,21,25H,4,6-7H2,(H,28,32)
Affinity DataKi:  0.0600nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM522051(N-[3-[6-(difluoromethoxy)- 3,4-dihydro-2H-1,4- ben...)
Show SMILES FC(F)Oc1cc2NCCSc2cc1-c1nn(cc1NC(=O)c1cnn2cccnc12)C1CCOC1=O
Show InChI InChI=1S/C23H19F2N7O4S/c24-23(25)36-17-9-14-18(37-7-4-26-14)8-12(17)19-15(11-32(30-19)16-2-6-35-22(16)34)29-21(33)13-10-28-31-5-1-3-27-20(13)31/h1,3,5,8-11,16,23,26H,2,4,6-7H2,(H,29,33)
Affinity DataKi:  0.0600nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521951(N-[3-[6-(difluoromethoxy)-3- methyl-3,4-dihydro-2H...)
Show SMILES CC1CSc2cc(-c3n[nH]cc3NC(=O)c3cnn4cccnc34)c(OC(F)F)cc2N1
Affinity DataKi:  0.0600nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521931(N-[5-[6-(difluoromethoxy)- 1H-indazol-5-yl]-1H-pyr...)
Show SMILES Nc1cc(OC(F)F)c(cc1C=N)-c1n[nH]cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C18H14F2N8O2/c19-18(20)30-14-5-12(22)9(6-21)4-10(14)15-13(8-24-27-15)26-17(29)11-7-25-28-3-1-2-23-16(11)28/h1-8,18,21H,22H2,(H,24,27)(H,26,29)
Affinity DataKi:  0.0700nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521947(N-[3-[6-(difluoromethoxy)-2- methyl-3,4-dihydro-2H...)
Show SMILES CC1CNc2cc(OC(F)F)c(cc2S1)-c1n[nH]cc1NC(=O)c1cnn2cccnc12
Affinity DataKi:  0.0700nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM522000(N-[3-[6-(difluoromethoxy)-3- oxo-4H-1,4-benzothiaz...)
Show SMILES Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc2SCC(=O)Nc2cc1OC(F)F
Show InChI InChI=1S/C20H15F2N7O3S/c1-28-8-13(26-19(31)11-7-24-29-4-2-3-23-18(11)29)17(27-28)10-5-15-12(25-16(30)9-33-15)6-14(10)32-20(21)22/h2-8,20H,9H2,1H3,(H,25,30)(H,26,31)
Affinity DataKi:  0.0700nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM522007(N-[3-[6-(difluoromethoxy)-2- methyl-3-oxo-4H-1,4- ...)
Show SMILES CC1Sc2cc(-c3nn(C)cc3NC(=O)c3cnn4cccnc34)c(OC(F)F)cc2NC1=O
Show InChI InChI=1S/C21H17F2N7O3S/c1-10-19(31)26-13-7-15(33-21(22)23)11(6-16(13)34-10)17-14(9-29(2)28-17)27-20(32)12-8-25-30-5-3-4-24-18(12)30/h3-10,21H,1-2H3,(H,26,31)(H,27,32)
Affinity DataKi:  0.0700nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521947(N-[3-[6-(difluoromethoxy)-2- methyl-3,4-dihydro-2H...)
Show SMILES CC1CNc2cc(OC(F)F)c(cc2S1)-c1n[nH]cc1NC(=O)c1cnn2cccnc12
Affinity DataKi:  0.0700nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521947(N-[3-[6-(difluoromethoxy)-2- methyl-3,4-dihydro-2H...)
Show SMILES CC1CNc2cc(OC(F)F)c(cc2S1)-c1n[nH]cc1NC(=O)c1cnn2cccnc12
Affinity DataKi:  0.0700nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521949(N-[3-[6-(difluoromethoxy)-2- methyl-3-oxo-4H-1,4- ...)
Show SMILES CC1Sc2cc(-c3n[nH]cc3NC(=O)c3cnn4cccnc34)c(OC(F)F)cc2NC1=O
Affinity DataKi:  0.0700nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM522000(N-[3-[6-(difluoromethoxy)-3- oxo-4H-1,4-benzothiaz...)
Show SMILES Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc2SCC(=O)Nc2cc1OC(F)F
Show InChI InChI=1S/C20H15F2N7O3S/c1-28-8-13(26-19(31)11-7-24-29-4-2-3-23-18(11)29)17(27-28)10-5-15-12(25-16(30)9-33-15)6-14(10)32-20(21)22/h2-8,20H,9H2,1H3,(H,25,30)(H,26,31)
Affinity DataKi:  0.0700nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521921(N-[3-[6-(difluoromethoxy)- 3,4-dihydro-2H-1,4- ben...)
Show SMILES FC(F)Oc1cc2NCCOc2cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C19H15F2N7O3/c20-19(21)31-14-7-12-15(30-5-3-22-12)6-10(14)16-13(9-24-27-16)26-18(29)11-8-25-28-4-1-2-23-17(11)28/h1-2,4,6-9,19,22H,3,5H2,(H,24,27)(H,26,29)
Affinity DataKi:  0.0800nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521936(N-[3-[6- (difluoromethoxy)indan-5-yl]- 1H-pyrazol-...)
Show SMILES FC(F)Oc1cc2CCCc2cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C20H16F2N6O2/c21-20(22)30-16-8-12-4-1-3-11(12)7-13(16)17-15(10-24-27-17)26-19(29)14-9-25-28-6-2-5-23-18(14)28/h2,5-10,20H,1,3-4H2,(H,24,27)(H,26,29)
Affinity DataKi:  0.0800nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521951(N-[3-[6-(difluoromethoxy)-3- methyl-3,4-dihydro-2H...)
Show SMILES CC1CSc2cc(-c3n[nH]cc3NC(=O)c3cnn4cccnc34)c(OC(F)F)cc2N1
Affinity DataKi:  0.0800nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM522063(N-[3-[6-(difluoromethoxy)- 1,2-benzothiazol-5-yl]-...)
Show SMILES FC(F)Oc1cc2sncc2cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C18H11F2N7O2S/c19-18(20)29-13-5-14-9(6-24-30-14)4-10(13)15-12(8-22-26-15)25-17(28)11-7-23-27-3-1-2-21-16(11)27/h1-8,18H,(H,22,26)(H,25,28)
Affinity DataKi:  0.0800nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM522020(N-[3-[6-(difluoromethoxy)- 2,2-dimethyl-3,4-dihydr...)
Show SMILES CC1(C)CNc2cc(OC(F)F)c(cc2S1)-c1n[nH]cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C21H19F2N7O2S/c1-21(2)10-25-13-7-15(32-20(22)23)11(6-16(13)33-21)17-14(9-26-29-17)28-19(31)12-8-27-30-5-3-4-24-18(12)30/h3-9,20,25H,10H2,1-2H3,(H,26,29)(H,28,31)
Affinity DataKi:  0.0800nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM522041(N-[3-[6-(difluoromethoxy)- 3,4-dihydro-2H-1,4- ben...)
Show SMILES Cn1cc(Cn2cc(NC(=O)c3cnn4cccnc34)c(n2)-c2cc3SCCNc3cc2OC(F)F)nn1
Show InChI InChI=1S/C23H20F2N10O2S/c1-33-10-13(30-32-33)11-34-12-17(29-22(36)15-9-28-35-5-2-3-27-21(15)35)20(31-34)14-7-19-16(26-4-6-38-19)8-18(14)37-23(24)25/h2-3,5,7-10,12,23,26H,4,6,11H2,1H3,(H,29,36)
Affinity DataKi:  0.0800nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM522047(N-[3-[6-(difluoromethoxy)-3- oxo-4H-1,4-benzoxazin...)
Show SMILES Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc2OCC(=O)Nc2cc1OC(F)F
Show InChI InChI=1S/C20H15F2N7O4/c1-28-8-13(26-19(31)11-7-24-29-4-2-3-23-18(11)29)17(27-28)10-5-15-12(25-16(30)9-32-15)6-14(10)33-20(21)22/h2-8,20H,9H2,1H3,(H,25,30)(H,26,31)
Affinity DataKi:  0.0800nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521998(N-[3-[6-(difluoromethoxy)- 3,4-dihydro-2H-1,4- ben...)
Show SMILES Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc2SCCNc2cc1OC(F)F
Show InChI InChI=1S/C20H17F2N7O2S/c1-28-10-14(26-19(30)12-9-25-29-5-2-3-24-18(12)29)17(27-28)11-7-16-13(23-4-6-32-16)8-15(11)31-20(21)22/h2-3,5,7-10,20,23H,4,6H2,1H3,(H,26,30)
Affinity DataKi:  0.0800nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521922(N-[3-[6-(difluoromethoxy)- 3,4-dihydro-2H-1,4- ben...)
Show SMILES FC(F)Oc1cc2NCCSc2cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C19H15F2N7O2S/c20-19(21)30-14-7-12-15(31-5-3-22-12)6-10(14)16-13(9-24-27-16)26-18(29)11-8-25-28-4-1-2-23-17(11)28/h1-2,4,6-9,19,22H,3,5H2,(H,24,27)(H,26,29)
Affinity DataKi:  0.0900nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521926(N-[3-[5-(difluoromethoxy)- 2,3-dihydrobenzofuran-6...)
Show SMILES FC(F)Oc1cc2CCOc2cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C19H14F2N6O3/c20-19(21)30-15-6-10-2-5-29-14(10)7-11(15)16-13(9-23-26-16)25-18(28)12-8-24-27-4-1-3-22-17(12)27/h1,3-4,6-9,19H,2,5H2,(H,23,26)(H,25,28)
Affinity DataKi:  0.0900nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521950(N-[3-[6-(difluoromethoxy)-3- oxo-4H-1,4-benzoxazin...)
Show SMILES FC(F)Oc1cc2NC(=O)COc2cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C19H13F2N7O4/c20-19(21)32-13-5-11-14(31-8-15(29)25-11)4-9(13)16-12(7-23-27-16)26-18(30)10-6-24-28-3-1-2-22-17(10)28/h1-7,19H,8H2,(H,23,27)(H,25,29)(H,26,30)
Affinity DataKi:  0.0900nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM522007(N-[3-[6-(difluoromethoxy)-2- methyl-3-oxo-4H-1,4- ...)
Show SMILES CC1Sc2cc(-c3nn(C)cc3NC(=O)c3cnn4cccnc34)c(OC(F)F)cc2NC1=O
Show InChI InChI=1S/C21H17F2N7O3S/c1-10-19(31)26-13-7-15(33-21(22)23)11(6-16(13)34-10)17-14(9-29(2)28-17)27-20(32)12-8-25-30-5-3-4-24-18(12)30/h3-10,21H,1-2H3,(H,26,31)(H,27,32)
Affinity DataKi:  0.0900nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM522051(N-[3-[6-(difluoromethoxy)- 3,4-dihydro-2H-1,4- ben...)
Show SMILES FC(F)Oc1cc2NCCSc2cc1-c1nn(cc1NC(=O)c1cnn2cccnc12)C1CCOC1=O
Show InChI InChI=1S/C23H19F2N7O4S/c24-23(25)36-17-9-14-18(37-7-4-26-14)8-12(17)19-15(11-32(30-19)16-2-6-35-22(16)34)29-21(33)13-10-28-31-5-1-3-27-20(13)31/h1,3,5,8-11,16,23,26H,2,4,6-7H2,(H,29,33)
Affinity DataKi:  0.0900nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM522047(N-[3-[6-(difluoromethoxy)-3- oxo-4H-1,4-benzoxazin...)
Show SMILES Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc2OCC(=O)Nc2cc1OC(F)F
Show InChI InChI=1S/C20H15F2N7O4/c1-28-8-13(26-19(31)11-7-24-29-4-2-3-23-18(11)29)17(27-28)10-5-15-12(25-16(30)9-32-15)6-14(10)33-20(21)22/h2-8,20H,9H2,1H3,(H,25,30)(H,26,31)
Affinity DataKi:  0.0900nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM522050(N-[1-(cyanomethyl)-3-[6- (difluoromethoxy)-3,4- di...)
Show SMILES FC(F)Oc1cc2NCCSc2cc1-c1nn(CC#N)cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C21H16F2N8O2S/c22-21(23)33-16-9-14-17(34-7-4-25-14)8-12(16)18-15(11-30(29-18)6-2-24)28-20(32)13-10-27-31-5-1-3-26-19(13)31/h1,3,5,8-11,21,25H,4,6-7H2,(H,28,32)
Affinity DataKi:  0.0900nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM522051(N-[3-[6-(difluoromethoxy)- 3,4-dihydro-2H-1,4- ben...)
Show SMILES FC(F)Oc1cc2NCCSc2cc1-c1nn(cc1NC(=O)c1cnn2cccnc12)C1CCOC1=O
Show InChI InChI=1S/C23H19F2N7O4S/c24-23(25)36-17-9-14-18(37-7-4-26-14)8-12(17)19-15(11-32(30-19)16-2-6-35-22(16)34)29-21(33)13-10-28-31-5-1-3-27-20(13)31/h1,3,5,8-11,16,23,26H,2,4,6-7H2,(H,29,33)
Affinity DataKi:  0.0900nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM522038(N-[3-[6-(difluoromethoxy)- 3,4-dihydro-2H-1,4- ben...)
Show SMILES Cn1nnc(Cn2cc(NC(=O)c3cnn4cccnc34)c(n2)-c2cc3SCCNc3cc2OC(F)F)n1
Show InChI InChI=1S/C22H19F2N11O2S/c1-33-30-18(29-32-33)11-34-10-15(28-21(36)13-9-27-35-5-2-3-26-20(13)35)19(31-34)12-7-17-14(25-4-6-38-17)8-16(12)37-22(23)24/h2-3,5,7-10,22,25H,4,6,11H2,1H3,(H,28,36)
Affinity DataKi:  0.0900nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521921(N-[3-[6-(difluoromethoxy)- 3,4-dihydro-2H-1,4- ben...)
Show SMILES FC(F)Oc1cc2NCCOc2cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C19H15F2N7O3/c20-19(21)31-14-7-12-15(30-5-3-22-12)6-10(14)16-13(9-24-27-16)26-18(29)11-8-25-28-4-1-2-23-17(11)28/h1-2,4,6-9,19,22H,3,5H2,(H,24,27)(H,26,29)
Affinity DataKi:  0.100nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521960(N-[3-[6-(difluoromethoxy)- 3,4-dihydro-2H-1,4- ben...)
Show SMILES FC(F)Oc1cc2NCCSc2cc1-c1nn(CC(=O)N2CCC=CC2)cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C26H24F2N8O3S/c27-26(28)39-20-12-18-21(40-10-6-29-18)11-16(20)23-19(14-35(33-23)15-22(37)34-7-2-1-3-8-34)32-25(38)17-13-31-36-9-4-5-30-24(17)36/h1-2,4-5,9,11-14,26,29H,3,6-8,10,15H2,(H,32,38)
Affinity DataKi:  0.100nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521961(N-[3-[6-(difluoromethoxy)- 3,4-dihydro-2H-1,4- ben...)
Show SMILES FC(F)Oc1cc2NCCSc2cc1-c1nn(CC(=O)N2CCCCC2)cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C26H26F2N8O3S/c27-26(28)39-20-12-18-21(40-10-6-29-18)11-16(20)23-19(14-35(33-23)15-22(37)34-7-2-1-3-8-34)32-25(38)17-13-31-36-9-4-5-30-24(17)36/h4-5,9,11-14,26,29H,1-3,6-8,10,15H2,(H,32,38)
Affinity DataKi:  0.100nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM521988(N-[3-[6-(difluoromethoxy)- 3,4-dihydro-2H-1,4- ben...)
Show SMILES FC(F)Oc1cc2NCCSc2cc1-c1nn(CCN[C@@H]2CCOC2)cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C25H26F2N8O3S/c26-25(27)38-20-11-18-21(39-9-5-29-18)10-16(20)22-19(13-34(33-22)7-4-28-15-2-8-37-14-15)32-24(36)17-12-31-35-6-1-3-30-23(17)35/h1,3,6,10-13,15,25,28-29H,2,4-5,7-9,14H2,(H,32,36)/t15-/m1/s1
Affinity DataKi:  0.100nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech, Inc.

US Patent
LigandPNGBDBM522062(N-[3-[5-(difluoromethoxy)- 1,2-benzothiazol-6-yl]-...)
Show SMILES FC(F)Oc1cc2cnsc2cc1-c1n[nH]cc1NC(=O)c1cnn2cccnc12
Show InChI InChI=1S/C18H11F2N7O2S/c19-18(20)29-13-4-9-6-24-30-14(9)5-10(13)15-12(8-22-26-15)25-17(28)11-7-23-27-3-1-2-21-16(11)27/h1-8,18H,(H,22,26)(H,25,28)
Affinity DataKi:  0.100nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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