Compile Data Set for Download or QSAR
Found 69 Enz. Inhib. hit(s) with all data for entry = 10540
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548267((R)-7'-isopropyl-2'-((R)-3-methylmorpholino)-7'H-s...)
Show SMILES CC(C)[C@H]1n2nc(cc2C(=O)NC11CC1)N1CCOC[C@H]1C
Show InChI InChI=1S/C16H24N4O2/c1-10(2)14-16(4-5-16)17-15(21)12-8-13(18-20(12)14)19-6-7-22-9-11(19)3/h8,10-11,14H,4-7,9H2,1-3H3,(H,17,21)/t11-,14-/m1/s1
Affinity DataIC50: 24nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548263((R)-7'-cyclopropyl-7'-methyl-2'-((R)-3-methylmorph...)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)NC3(CC3)[C@@](C)(C3CC3)n2n1
Show InChI InChI=1S/C17H24N4O2/c1-11-10-23-8-7-20(11)14-9-13-15(22)18-17(5-6-17)16(2,12-3-4-12)21(13)19-14/h9,11-12H,3-8,10H2,1-2H3,(H,18,22)/t11-,16-/m1/s1
Affinity DataIC50: 27nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548261((R)-7-cyclopropyl-7-ethyl-2-((R)-3-methylmorpholin...)
Show SMILES CC[C@]1(CNC(=O)c2cc(nn12)N1CCOC[C@H]1C)C1CC1
Show InChI InChI=1S/C16H24N4O2/c1-3-16(12-4-5-12)10-17-15(21)13-8-14(18-20(13)16)19-6-7-22-9-11(19)2/h8,11-12H,3-7,9-10H2,1-2H3,(H,17,21)/t11-,16+/m1/s1
Affinity DataIC50: 32nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548269((R)-2-((R)-3-methylmorpholino)-6-(trifluoromethyl)...)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)N[C@H](Cn2n1)C(F)(F)F
Show InChI InChI=1S/C12H15F3N4O2/c1-7-6-21-3-2-18(7)10-4-8-11(20)16-9(12(13,14)15)5-19(8)17-10/h4,7,9H,2-3,5-6H2,1H3,(H,16,20)/t7-,9-/m1/s1
Affinity DataIC50: 37nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548257((R)-7-cyclopropyl-7-methyl-2-((R)-3-methylmorpholi...)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)NC[C@@](C)(C3CC3)n2n1
Show InChI InChI=1S/C15H22N4O2/c1-10-8-21-6-5-18(10)13-7-12-14(20)16-9-15(2,11-3-4-11)19(12)17-13/h7,10-11H,3-6,8-9H2,1-2H3,(H,16,20)/t10-,15+/m1/s1
Affinity DataIC50: 41nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
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TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548239((R)-7-(tert-butyl)-2-((R)-3-methylmorpholino)-6,7-...)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)NC[C@H](n2n1)C(C)(C)C
Show InChI InChI=1S/C15H24N4O2/c1-10-9-21-6-5-18(10)13-7-11-14(20)16-8-12(15(2,3)4)19(11)17-13/h7,10,12H,5-6,8-9H2,1-4H3,(H,16,20)/t10-,12+/m1/s1
Affinity DataIC50: 43nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548275(WO2022093820, Compound 41)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)N[C@@H]3[C@@H](CCC3(C)C)n2n1
Show InChI InChI=1S/C16H24N4O2/c1-10-9-22-7-6-19(10)13-8-12-15(21)17-14-11(20(12)18-13)4-5-16(14,2)3/h8,10-11,14H,4-7,9H2,1-3H3,(H,17,21)/t10-,11-,14-/m1/s1
Affinity DataIC50: 51nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548249((S)-2-((R)-3-methylmorpholino)-7-(perfluoroethyl)-...)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)NC[C@H](n2n1)C(F)(F)C(F)(F)F
Show InChI InChI=1S/C13H15F5N4O2/c1-7-6-24-3-2-21(7)10-4-8-11(23)19-5-9(22(8)20-10)12(14,15)13(16,17)18/h4,7,9H,2-3,5-6H2,1H3,(H,19,23)/t7-,9+/m1/s1
Affinity DataIC50: 52nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548245(WO2022093820, Compound 11)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)NC[C@H](n2n1)C1(C)CC1
Show InChI InChI=1S/C15H22N4O2/c1-10-9-21-6-5-18(10)13-7-11-14(20)16-8-12(19(11)17-13)15(2)3-4-15/h7,10,12H,3-6,8-9H2,1-2H3,(H,16,20)/t10-,12+/m1/s1
Affinity DataIC50: 56nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548235((R)-7-isopropyl-2-((R)-3-methylmorpholino)-6,7-dih...)
Show SMILES CC(C)[C@@H]1CNC(=O)c2cc(nn12)N1CCOC[C@H]1C
Show InChI InChI=1S/C14H22N4O2/c1-9(2)12-7-15-14(19)11-6-13(16-18(11)12)17-4-5-20-8-10(17)3/h6,9-10,12H,4-5,7-8H2,1-3H3,(H,15,19)/t10-,12+/m1/s1
Affinity DataIC50: 78nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548243((5aS,8aR)-2-((R)-3-methylmorpholino)-5,5a,6,7,8,8a...)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)N[C@H]3CCC[C@H]3n2n1
Show InChI InChI=1S/C14H20N4O2/c1-9-8-20-6-5-17(9)13-7-12-14(19)15-10-3-2-4-11(10)18(12)16-13/h7,9-11H,2-6,8H2,1H3,(H,15,19)/t9-,10+,11-/m1/s1
Affinity DataIC50: 83nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548265((R)-7'-cyclopropyl-2'-((R)-3-methylmorpholino)-7'H...)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)NC3(CC3)[C@@H](C3CC3)n2n1
Show InChI InChI=1S/C16H22N4O2/c1-10-9-22-7-6-19(10)13-8-12-15(21)17-16(4-5-16)14(11-2-3-11)20(12)18-13/h8,10-11,14H,2-7,9H2,1H3,(H,17,21)/t10-,14-/m1/s1
Affinity DataIC50: 84nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548259((R)-7-isopropyl-7-methyl-2-((R)-3-methylmorpholino...)
Show SMILES CC(C)[C@]1(C)CNC(=O)c2cc(nn12)N1CCOC[C@H]1C
Show InChI InChI=1S/C15H24N4O2/c1-10(2)15(4)9-16-14(20)12-7-13(17-19(12)15)18-5-6-21-8-11(18)3/h7,10-11H,5-6,8-9H2,1-4H3,(H,16,20)/t11-,15+/m1/s1
Affinity DataIC50: 90nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548251((S)-2-((R)-3-methylmorpholino)-7-(trifluoromethyl)...)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)NC[C@H](n2n1)C(F)(F)F
Show InChI InChI=1S/C12H15F3N4O2/c1-7-6-21-3-2-18(7)10-4-8-11(20)16-5-9(12(13,14)15)19(8)17-10/h4,7,9H,2-3,5-6H2,1H3,(H,16,20)/t7-,9+/m1/s1
Affinity DataIC50: 93nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548280(WO2022093820, Compound 48)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)NC[C@H](n2n1)C1(CC1)c1ccccc1
Show InChI InChI=1S/C20H24N4O2/c1-14-13-26-10-9-23(14)18-11-16-19(25)21-12-17(24(16)22-18)20(7-8-20)15-5-3-2-4-6-15/h2-6,11,14,17H,7-10,12-13H2,1H3,(H,21,25)/t14-,17+/m1/s1
Affinity DataIC50: 100nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548297(WO2022093820, Compound 65)
Show SMILES CC[C@H](C)C[C@@H]1CNC(=O)c2cc(nn12)N1CCOC[C@H]1C
Show InChI InChI=1S/C16H26N4O2/c1-4-11(2)7-13-9-17-16(21)14-8-15(18-20(13)14)19-5-6-22-10-12(19)3/h8,11-13H,4-7,9-10H2,1-3H3,(H,17,21)/t11-,12+,13+/m0/s1
Affinity DataIC50: 109nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548288(WO2022093820, Compound 56)
Show SMILES C[C@H](C1CNC(=O)c2cc(nn12)N1CCOC[C@H]1C)c1ccccc1
Show InChI InChI=1S/C19H24N4O2/c1-13-12-25-9-8-22(13)18-10-16-19(24)20-11-17(23(16)21-18)14(2)15-6-4-3-5-7-15/h3-7,10,13-14,17H,8-9,11-12H2,1-2H3,(H,20,24)/t13-,14+,17?/m1/s1
Affinity DataIC50: 119nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548253((6S,7R)-7-cyclopropyl-6-methyl-2-((R)-3-methylmorp...)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)N[C@@H](C)[C@@H](C3CC3)n2n1
Show InChI InChI=1S/C15H22N4O2/c1-9-8-21-6-5-18(9)13-7-12-15(20)16-10(2)14(11-3-4-11)19(12)17-13/h7,9-11,14H,3-6,8H2,1-2H3,(H,16,20)/t9-,10+,14+/m1/s1
Affinity DataIC50: 170nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548295(WO2022093820, Compound 63 | WO2022093820, Compound...)
Show SMILES CC[C@@H](C)C[C@@H]1CNC(=O)c2cc(nn12)N1CCOC[C@H]1C
Show InChI InChI=1S/C16H26N4O2/c1-4-11(2)7-13-9-17-16(21)14-8-15(18-20(13)14)19-5-6-22-10-12(19)3/h8,11-13H,4-7,9-10H2,1-3H3,(H,17,21)/t11-,12-,13-/m1/s1
Affinity DataIC50: 171nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548247((S)-7-(2-hydroxypropan-2-yl)-2-((R)-3-methylmorpho...)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)NC[C@H](n2n1)C(C)(C)O
Show InChI InChI=1S/C14H22N4O3/c1-9-8-21-5-4-17(9)12-6-10-13(19)15-7-11(14(2,3)20)18(10)16-12/h6,9,11,20H,4-5,7-8H2,1-3H3,(H,15,19)/t9-,11+/m1/s1
Affinity DataIC50: 174nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548237((R)-7-cyclobutyl-2-((R)-3-methylmorpholino)-6,7-di...)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)NC[C@@H](C3CCC3)n2n1
Show InChI InChI=1S/C15H22N4O2/c1-10-9-21-6-5-18(10)14-7-12-15(20)16-8-13(19(12)17-14)11-3-2-4-11/h7,10-11,13H,2-6,8-9H2,1H3,(H,16,20)/t10-,13+/m1/s1
Affinity DataIC50: 237nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548277(WO2022093820, Compound 45)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)NC[C@](C)(C3CCC3)n2n1
Show InChI InChI=1S/C16H24N4O2/c1-11-9-22-7-6-19(11)14-8-13-15(21)17-10-16(2,20(13)18-14)12-4-3-5-12/h8,11-12H,3-7,9-10H2,1-2H3,(H,17,21)/t11-,16-/m1/s1
Affinity DataIC50: 260nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548241((R)-7-cyclopentyl-2-((R)-3-methylmorpholino)-6,7-d...)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)NC[C@@H](C3CCCC3)n2n1
Show InChI InChI=1S/C16H24N4O2/c1-11-10-22-7-6-19(11)15-8-13-16(21)17-9-14(20(13)18-15)12-4-2-3-5-12/h8,11-12,14H,2-7,9-10H2,1H3,(H,17,21)/t11-,14+/m1/s1
Affinity DataIC50: 346nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548290(WO2022093820, Compound 58)
Show SMILES C[C@H]([C@@H]1CNC(=O)c2cc(nn12)N1CCOC[C@H]1C)c1ccccc1
Show InChI InChI=1S/C19H24N4O2/c1-13-12-25-9-8-22(13)18-10-16-19(24)20-11-17(23(16)21-18)14(2)15-6-4-3-5-7-15/h3-7,10,13-14,17H,8-9,11-12H2,1-2H3,(H,20,24)/t13-,14+,17+/m1/s1
Affinity DataIC50: 388nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548292(WO2022093820, Compound 60)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)NC[C@H](CC(F)(F)F)n2n1
Show InChI InChI=1S/C13H17F3N4O2/c1-8-7-22-3-2-19(8)11-4-10-12(21)17-6-9(20(10)18-11)5-13(14,15)16/h4,8-9H,2-3,5-7H2,1H3,(H,17,21)/t8-,9+/m1/s1
Affinity DataIC50: 429nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548271((6S,7R)-6,7-dicyclopropyl-2-((R)-3-methylmorpholin...)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)N[C@@H](C3CC3)[C@@H](C3CC3)n2n1
Show InChI InChI=1S/C17H24N4O2/c1-10-9-23-7-6-20(10)14-8-13-17(22)18-15(11-2-3-11)16(12-4-5-12)21(13)19-14/h8,10-12,15-16H,2-7,9H2,1H3,(H,18,22)/t10-,15+,16-/m1/s1
Affinity DataIC50: 480nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548302(WO2022093820, Compound 70)
Show SMILES C[C@H](CO)C1CNC(=O)c2cc(nn12)N1CCOC[C@H]1C
Show InChI InChI=1S/C14H22N4O3/c1-9(7-19)12-6-15-14(20)11-5-13(16-18(11)12)17-3-4-21-8-10(17)2/h5,9-10,12,19H,3-4,6-8H2,1-2H3,(H,15,20)/t9-,10-,12?/m1/s1
Affinity DataIC50: 532nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
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In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548286(WO2022093820, Compound 54)
Show SMILES COC[C@@]1(CNC(=O)c2cc(nn12)N1CCOC[C@H]1C)C(C)C
Show InChI InChI=1S/C16H26N4O3/c1-11(2)16(10-22-4)9-17-15(21)13-7-14(18-20(13)16)19-5-6-23-8-12(19)3/h7,11-12H,5-6,8-10H2,1-4H3,(H,17,21)/t12-,16+/m1/s1
Affinity DataIC50: 563nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548283(WO2022093820, Compound 51)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)N[C@@H](CC(F)(F)F)Cn2n1
Show InChI InChI=1S/C13H17F3N4O2/c1-8-7-22-3-2-19(8)11-4-10-12(21)17-9(5-13(14,15)16)6-20(10)18-11/h4,8-9H,2-3,5-7H2,1H3,(H,17,21)/t8-,9+/m1/s1
Affinity DataIC50: 682nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548294(WO2022093820, Compound 62)
Show SMILES CC(C)C[C@H]1CNC(=O)c2cc(nn12)N1CCOC[C@H]1C
Show InChI InChI=1S/C15H24N4O2/c1-10(2)6-12-8-16-15(20)13-7-14(17-19(12)13)18-4-5-21-9-11(18)3/h7,10-12H,4-6,8-9H2,1-3H3,(H,16,20)/t11-,12+/m1/s1
Affinity DataIC50: 739nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548279(WO2022093820, Compound 47)
Show SMILES CC[C@H]1CNC(=O)c2cc(nn12)N1CCOC[C@H]1C
Show InChI InChI=1S/C13H20N4O2/c1-3-10-7-14-13(18)11-6-12(15-17(10)11)16-4-5-19-8-9(16)2/h6,9-10H,3-5,7-8H2,1-2H3,(H,14,18)/t9-,10+/m1/s1
Affinity DataIC50: 747nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548301(WO2022093820, Compound 69)
Show SMILES C[C@@H](CO)C1CNC(=O)c2cc(nn12)N1CCOC[C@H]1C
Show InChI InChI=1S/C14H22N4O3/c1-9(7-19)12-6-15-14(20)11-5-13(16-18(11)12)17-3-4-21-8-10(17)2/h5,9-10,12,19H,3-4,6-8H2,1-2H3,(H,15,20)/t9-,10+,12?/m0/s1
Affinity DataIC50: 784nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548282(WO2022093820, Compound 50)
Show SMILES CC(C)C1(CO)CNC(=O)c2cc(nn12)N1CCOC[C@H]1C
Show InChI InChI=1S/C15H24N4O3/c1-10(2)15(9-20)8-16-14(21)12-6-13(17-19(12)15)18-4-5-22-7-11(18)3/h6,10-11,20H,4-5,7-9H2,1-3H3,(H,16,21)/t11-,15?/m1/s1
Affinity DataIC50: 847nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548303(WO2022093820, Compound 71)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)NCC(C)(C)n2n1
Show InChI InChI=1S/C13H20N4O2/c1-9-7-19-5-4-16(9)11-6-10-12(18)14-8-13(2,3)17(10)15-11/h6,9H,4-5,7-8H2,1-3H3,(H,14,18)/t9-/m1/s1
Affinity DataIC50: 919nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548255((6R,7R)-7-cyclopropyl-6- methyl-2-((R)-3-methylmor...)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)N[C@H](C)[C@@H](C3CC3)n2n1
Show InChI InChI=1S/C15H22N4O2/c1-9-8-21-6-5-18(9)13-7-12-15(20)16-10(2)14(11-3-4-11)19(12)17-13/h7,9-11,14H,3-6,8H2,1-2H3,(H,16,20)/t9-,10-,14+/m1/s1
Affinity DataIC50: 923nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548262((S)-7-cyclopropyl-7-ethyl-2-((R)-3-methylmorpholin...)
Show SMILES CC[C@@]1(CNC(=O)c2cc(nn12)N1CCOC[C@H]1C)C1CC1
Show InChI InChI=1S/C16H24N4O2/c1-3-16(12-4-5-12)10-17-15(21)13-8-14(18-20(13)16)19-6-7-22-9-11(19)2/h8,11-12H,3-7,9-10H2,1-2H3,(H,17,21)/t11-,16-/m1/s1
Affinity DataIC50: 1.30E+3nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548258((S)-7-cyclopropyl-7-methyl-2-((R)-3-methylmorpholi...)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)NC[C@](C)(C3CC3)n2n1
Show InChI InChI=1S/C15H22N4O2/c1-10-8-21-6-5-18(10)13-7-12-14(20)16-9-15(2,11-3-4-11)19(12)17-13/h7,10-11H,3-6,8-9H2,1-2H3,(H,16,20)/t10-,15-/m1/s1
Affinity DataIC50: 1.34E+3nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548273((R)-7-cyclopropyl-6,6-dimethyl-2-((R)-3-methylmorp...)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)NC(C)(C)[C@@H](C3CC3)n2n1
Show InChI InChI=1S/C16H24N4O2/c1-10-9-22-7-6-19(10)13-8-12-15(21)17-16(2,3)14(11-4-5-11)20(12)18-13/h8,10-11,14H,4-7,9H2,1-3H3,(H,17,21)/t10-,14-/m1/s1
Affinity DataIC50: 1.45E+3nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548244((5aR,8aS)-2-((R)-3-methylmorpholino)-5,5a,6,7,8,8a...)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)N[C@@H]3CCC[C@@H]3n2n1
Show InChI InChI=1S/C14H20N4O2/c1-9-8-20-6-5-17(9)13-7-12-14(19)15-10-3-2-4-11(10)18(12)16-13/h7,9-11H,2-6,8H2,1H3,(H,15,19)/t9-,10-,11+/m1/s1
Affinity DataIC50: 1.49E+3nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548264((S)-7'-cyclopropyl-7'-methyl-2'-((R)-3-methylmorph...)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)NC3(CC3)[C@](C)(C3CC3)n2n1
Show InChI InChI=1S/C17H24N4O2/c1-11-10-23-8-7-20(11)14-9-13-15(22)18-17(5-6-17)16(2,12-3-4-12)21(13)19-14/h9,11-12H,3-8,10H2,1-2H3,(H,18,22)/t11-,16+/m1/s1
Affinity DataIC50: 1.75E+3nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548260((S)-7-isopropyl-7-methyl-2-((R)-3-methylmorpholino...)
Show SMILES CC(C)[C@@]1(C)CNC(=O)c2cc(nn12)N1CCOC[C@H]1C
Show InChI InChI=1S/C15H24N4O2/c1-10(2)15(4)9-16-14(20)12-7-13(17-19(12)15)18-5-6-21-8-11(18)3/h7,10-11H,5-6,8-9H2,1-4H3,(H,16,20)/t11-,15-/m1/s1
Affinity DataIC50: 2.17E+3nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548246(WO2022093820, Compound 12)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)NC[C@@H](n2n1)C1(C)CC1
Show InChI InChI=1S/C15H22N4O2/c1-10-9-21-6-5-18(10)13-7-11-14(20)16-8-12(19(11)17-13)15(2)3-4-15/h7,10,12H,3-6,8-9H2,1-2H3,(H,16,20)/t10-,12-/m1/s1
Affinity DataIC50: 3.35E+3nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548266((S)-7'-cyclopropyl-2'-((R)-3-methylmorpholino)-7'H...)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)NC3(CC3)[C@H](C3CC3)n2n1
Show InChI InChI=1S/C16H22N4O2/c1-10-9-22-7-6-19(10)13-8-12-15(21)17-16(4-5-16)14(11-2-3-11)20(12)18-13/h8,10-11,14H,2-7,9H2,1H3,(H,17,21)/t10-,14+/m1/s1
Affinity DataIC50: 3.65E+3nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548276(WO2022093820, Compound 44)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)NC[C@@](C)(C3CCC3)n2n1
Show InChI InChI=1S/C16H24N4O2/c1-11-9-22-7-6-19(11)14-8-13-15(21)17-10-16(2,20(13)18-14)12-4-3-5-12/h8,11-12H,3-7,9-10H2,1-2H3,(H,17,21)/t11-,16+/m1/s1
Affinity DataIC50: 4.00E+3nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548270((S)-2-((R)-3-methylmorpholino)-6-(trifluoromethyl)...)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)N[C@@H](Cn2n1)C(F)(F)F
Show InChI InChI=1S/C12H15F3N4O2/c1-7-6-21-3-2-18(7)10-4-8-11(20)16-9(12(13,14)15)5-19(8)17-10/h4,7,9H,2-3,5-6H2,1H3,(H,16,20)/t7-,9+/m1/s1
Affinity DataIC50: 4.62E+3nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548256((6S,7S)-7- cyclopropyl-6-methyl-2-((R)-3-methylmor...)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)N[C@@H](C)[C@H](C3CC3)n2n1
Show InChI InChI=1S/C15H22N4O2/c1-9-8-21-6-5-18(9)13-7-12-15(20)16-10(2)14(11-3-4-11)19(12)17-13/h7,9-11,14H,3-6,8H2,1-2H3,(H,16,20)/t9-,10+,14-/m1/s1
Affinity DataIC50: 4.90E+3nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548274((S)-7-cyclopropyl-6,6-dimethyl-2-((R)-3-methylmorp...)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)NC(C)(C)[C@H](C3CC3)n2n1
Show InChI InChI=1S/C16H24N4O2/c1-10-9-22-7-6-19(10)13-8-12-15(21)17-16(2,3)14(11-4-5-11)20(12)18-13/h8,10-11,14H,4-7,9H2,1-3H3,(H,17,21)/t10-,14+/m1/s1
Affinity DataIC50: 6.05E+3nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548254((6R,7S)-7-cyclopropyl-6-methyl-2-((R)-3- methylmor...)
Show SMILES C[C@@H]1COCCN1c1cc2C(=O)N[C@H](C)[C@H](C3CC3)n2n1
Show InChI InChI=1S/C15H22N4O2/c1-9-8-21-6-5-18(9)13-7-12-15(20)16-10(2)14(11-3-4-11)19(12)17-13/h7,9-11,14H,3-6,8H2,1-2H3,(H,16,20)/t9-,10-,14-/m1/s1
Affinity DataIC50: 1.26E+4nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548278(WO2022093820, Compound 46)
Show SMILES CC[C@@H]1CNC(=O)c2cc(nn12)N1CCOC[C@H]1C
Show InChI InChI=1S/C13H20N4O2/c1-3-10-7-14-13(18)11-6-12(15-17(10)11)16-4-5-19-8-9(16)2/h6,9-10H,3-5,7-8H2,1-2H3,(H,14,18)/t9-,10-/m1/s1
Affinity DataIC50: 1.28E+4nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
GENENTECH, INC.

WIPO
LigandPNGBDBM548293(WO2022093820, Compound 61)
Show SMILES CC(C)C[C@@H]1CNC(=O)c2cc(nn12)N1CCOC[C@H]1C
Show InChI InChI=1S/C15H24N4O2/c1-10(2)6-12-8-16-15(20)13-7-14(17-19(12)13)18-4-5-21-9-11(18)3/h7,10-12H,4-6,8-9H2,1-3H3,(H,16,20)/t11-,12-/m1/s1
Affinity DataIC50: 1.28E+4nMAssay Description: [0194] Experimental compound in DMSO was dispensed to a 384-well microplate via acoustic dispenser at 50 nl per well. At 2.5 Ál per well, an enzyme ...More data for this Ligand-Target Pair
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In DepthDetails PubMed
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