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Report error Found 100 Enz. Inhib. hit(s) with all data for entry = 50005650
TargetSodium- and chloride-dependent GABA transporter 1(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039251((R)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-enyl)pi...)
Affinity DataIC50:  70nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetSodium- and chloride-dependent GABA transporter 1(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50020891((R)-1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carbo...)
Affinity DataIC50:  130nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 1(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50003618(1-{2-[Bis-(4-trifluoromethyl-phenyl)-methoxy]-ethy...)
Affinity DataIC50:  260nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 1(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50003627(1-(2-Trityloxy-ethyl)-piperidine-3-carboxylic acid...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 1(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039239(1-[2-(9-Phenyl-9H-fluoren-9-yloxy)-ethyl]-piperidi...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 1(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039243(1-[2-(9-Phenyl-9H-xanthen-9-yloxy)-ethyl]-piperidi...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 3(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039246((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibitory activity against human sodium and chloride dependent GABA transporter 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM24183(4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic a...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 1(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM24183(4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic a...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSodium- and chloride-dependent GABA transporter 1(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50020883((R)-Piperidine-3-carboxylic acid | (R)-nipecotic a...)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSodium- and chloride-dependent GABA transporter 1(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039249(1-{2-[(4-Methoxy-phenyl)-diphenyl-methoxy]-ethyl}-...)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 3(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM24183(4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic a...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibitory activity against human sodium and chloride dependent GABA transporter 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 1(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50003624((RS)-nipecotic acid | CHEMBL277498 | Nipecotic | P...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSodium- and chloride-dependent GABA transporter 1(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039252(1-{2-[(3-Fluoro-4-methoxy-phenyl)-(3-fluoro-phenyl...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 3(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039234(1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-pipe...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibitory activity against human sodium and chloride dependent GABA transporter 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 1(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50020883((R)-Piperidine-3-carboxylic acid | (R)-nipecotic a...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 1(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039238(1-{2-[Bis-(4-fluoro-phenyl)-(4-methoxy-phenyl)-met...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 3(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039235(1-{2-[(4-Methoxy-phenyl)-di-p-tolyl-methoxy]-ethyl...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibitory activity against human sodium and chloride dependent GABA transporter 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039246((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 3(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039240(1-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibitory activity against human sodium and chloride dependent GABA transporter 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 3(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039238(1-{2-[Bis-(4-fluoro-phenyl)-(4-methoxy-phenyl)-met...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibitory activity against human sodium and chloride dependent GABA transporter 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 1(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039245(CHEMBL309357 | Dimethyl-[2-(1,7,7-trimethyl-2-phen...)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 3(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039242(1-{2-[Bis-(4-chloro-phenyl)-(4-methoxy-phenyl)-met...)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibitory activity against human sodium and chloride dependent GABA transporter 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039245(CHEMBL309357 | Dimethyl-[2-(1,7,7-trimethyl-2-phen...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039234(1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-pipe...)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent betaine transporter(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM24183(4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic a...)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of human GABA transporter (hBGT-1) activity.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50003624((RS)-nipecotic acid | CHEMBL277498 | Nipecotic | P...)
Affinity DataIC50:  3.90E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent betaine transporter(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039245(CHEMBL309357 | Dimethyl-[2-(1,7,7-trimethyl-2-phen...)
Affinity DataIC50:  3.90E+4nMAssay Description:Inhibition of human GABA transporter (hBGT-1) activity.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039242(1-{2-[Bis-(4-chloro-phenyl)-(4-methoxy-phenyl)-met...)
Affinity DataIC50:  3.90E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 1(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039240(1-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl...)
Affinity DataIC50:  4.30E+4nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 1(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039244(1-(2-Tritylsulfanyl-ethyl)-piperidine-3-carboxylic...)
Affinity DataIC50:  4.30E+4nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039235(1-{2-[(4-Methoxy-phenyl)-di-p-tolyl-methoxy]-ethyl...)
Affinity DataIC50:  4.50E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 3(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039245(CHEMBL309357 | Dimethyl-[2-(1,7,7-trimethyl-2-phen...)
Affinity DataIC50:  4.60E+4nMAssay Description:Inhibitory activity against human sodium and chloride dependent GABA transporter 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039238(1-{2-[Bis-(4-fluoro-phenyl)-(4-methoxy-phenyl)-met...)
Affinity DataIC50:  4.90E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039233(1-{2-[9-(4-Methoxy-phenyl)-9H-fluoren-9-yloxy]-eth...)
Affinity DataIC50:  5.10E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 3(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50020883((R)-Piperidine-3-carboxylic acid | (R)-nipecotic a...)
Affinity DataIC50:  5.10E+4nMAssay Description:Inhibitory activity against human sodium and chloride dependent GABA transporter 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50:  5.80E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 1(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039253(1-{2-[Tris-(4-fluoro-phenyl)-methoxy]-ethyl}-piper...)
Affinity DataIC50:  5.80E+4nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039240(1-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl...)
Affinity DataIC50:  6.20E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 1(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039241(1-{2-[(4-Methoxy-3-trifluoromethyl-phenyl)-phenyl-...)
Affinity DataIC50:  7.30E+4nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 1(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039236(1-{2-[Tris-(4-methoxy-phenyl)-methylsulfanyl]-ethy...)
Affinity DataIC50:  7.80E+4nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039236(1-{2-[Tris-(4-methoxy-phenyl)-methylsulfanyl]-ethy...)
Affinity DataIC50:  8.40E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039244(1-(2-Tritylsulfanyl-ethyl)-piperidine-3-carboxylic...)
Affinity DataIC50:  8.50E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 3(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039248((R)-1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-...)
Affinity DataIC50:  8.60E+4nMAssay Description:Inhibitory activity against human sodium and chloride dependent GABA transporter 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent betaine transporter(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039242(1-{2-[Bis-(4-chloro-phenyl)-(4-methoxy-phenyl)-met...)
Affinity DataIC50:  8.80E+4nMAssay Description:Inhibition of human GABA transporter (hBGT-1) activity.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 3(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039244(1-(2-Tritylsulfanyl-ethyl)-piperidine-3-carboxylic...)
Affinity DataIC50:  9.10E+4nMAssay Description:Inhibitory activity against human sodium and chloride dependent GABA transporter 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039237(1-{3-[Tris-(4-methoxy-phenyl)-methoxy]-propyl}-pip...)
Affinity DataIC50:  1.03E+5nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent GABA transporter 3(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50003624((RS)-nipecotic acid | CHEMBL277498 | Nipecotic | P...)
Affinity DataIC50:  1.06E+5nMAssay Description:Inhibitory activity against human sodium and chloride dependent GABA transporter 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSodium- and chloride-dependent betaine transporter(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039235(1-{2-[(4-Methoxy-phenyl)-di-p-tolyl-methoxy]-ethyl...)
Affinity DataIC50:  1.09E+5nMAssay Description:Inhibition of human GABA transporter (hBGT-1) activity.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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